Clinical trials: Ischemic Preconditioning
Acute Coronary Syndrome, Renal Insufficiency
Remote Ischemic Preconditioning in ACS Patients
Remote ischemic preconditioning is a process of serial blood pressure cuff inflations and deflations that are performed prior to a procedure and have been shown in various other areas (coronary bypass surgery, vascular surgery…
- Conditions
- Acute Coronary Syndrome, Renal Insufficiency, Ischemia, Myocardial
- Trial name
- NCT03329612
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Sponsor
- Henry Ford Health System
Coronary Heart Disease
Electroacupuncture Preconditioning on Geriatric Noncardiac Surgery
The purpose of this study is to observe whether the electroacupuncture (EA) preconditioning for five days before operation can improve the outcomes of patients with coronary heart disease undergoing geriatric non-cardiac surgery.
- Trial name
- NCT01507805
- Testing
- EA preconditioning
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
Diabetes Mellitus, Coronary Artery Bypass
Remote Ischemic Preconditioning in Type 2 Diabetic Patients Undergoing CABG
This randomized, double-blind, prospective clinical trial aims to investigate the effect of remote ischemic preconditioning (RIPC) on myocardial protection in patients with type 2 diabetes mellitus undergoing elective coronary…
- Conditions
- Diabetes Mellitus, Coronary Artery Bypass, Remote Ischaemic Conditioning
- Trial name
- NCT06977230
- Testing
- Remote Ischemic Preconditioning
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Muğla Sıtkı Koçman University
Remote Ischaemic Preconditioning, Contrast Induced Nephropathy
Use of Remote Ischaemic Preconditioning in the Prevention of Contrast Induced Nephropathy
With an increasingly ageing population the incidence of peripheral arterial disease (PAD) is rising. With approximately one quarter of all PAD patients ultimately progressing to Critical Limb Ischaemia (CLI), increased demands…
- Trial name
- NCT02516072
- Testing
- RIPC
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Changi General Hospital
Myocardial Reperfusion Injury, Cytoprotection
The Protective Effects Of Treatment With Hyperbaric Oxygen Prior To Bypass Heart Surgery
The purpose of this study was to determine if treating patients who have coronary heart disease with hyperbaric oxygen (HBO) prior to coronary artery bypass graft (CABG) surgery reduces injury to the heart and vascular system…
- Trial name
- NCT00623142
- Testing
- Hyperbaric Oxygen
- Where
- United Kingdom
- Volunteers
- 81 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Heart Defects, Congenital, Cardiac Surgical Procedures
Myocardial Protection With Adenosine Preconditioning
Adenosine has been proved to be an important mediator of myocardial protection induced by ischemic preconditioning. The hypothesis of this study is that adenosine preconditioning can provide additional myocardial protection in…
- Conditions
- Heart Defects, Congenital, Cardiac Surgical Procedures, Myocardial Reperfusion Injury, Adenosine
- Trial name
- NCT00881686
- Testing
- adenosine
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Xijing Hospital
Cardiotoxicity
Remote Ischaemic Preconditioning in Childhood Cancer
Survival rates of children with cancers have improved significantly in the recent few decades. Nonetheless, the side effect of this class of drugs on heart function remains to be an issue of concern.
- Trial name
- NCT03166813
- Testing
- Remote Ischaemic Preconditioning, Control
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- The University of Hong Kong
Periprocedural Myocardial Infarction
Ticagrelor in Remote Ischemic Preconditioning Study
Remote ischemic preconditioning (RIPC) reduces periprocedural myocardial injury (PMI) after percutaneous coronary intervention (PCI) through various pathways, including an adenosine-triggered pathway.
- Trial name
- TRIP (NCT04174261)
- Testing
- Ticagrelor, Remote Ischemic Preconditioning, Clopidogrel
- Where
- Greece
- Volunteers
- 245 people
- Sponsor
- Hellenic Society of Interventional Cardiology
Physical Performance, Rhabdomyolysis
The Effect of Remote Ischemic Preconditioning on Physical Performance and Exertional Rhabdomyolysis
In order to examine the effect of RIPC on skeleton muscle exertional damage and on aerobic and anaerobic physical performances, 30 healthy volunteers will undergo a series of different physical tests twice; once without…
- Trial name
- NCT02518724
- Testing
- RIPC intervention exposure
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Vascular Surgery, Ischemia-reperfusion
Effects of Ischemic Preconditioning After Aortic Clamping
Open surgery for aneurysmal aortic disease can lead to cardiac, renal, pulmonary or muscular complications, essentially due to the aortic clamping. Ischemic preconditioning can be useful in order to decrease these complications.
- Conditions
- Vascular Surgery, Ischemia-reperfusion, Ischemia Preconditioning
- Trial name
- NCT02254642
- Testing
- Ischemic preconditioning during aortic clamping, Procedure/Surgery: usual surgery
- Where
- 4 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Strasbourg, France
Peripheral Vascular Diseases
Effects of Remote Ischemic Preconditioning on Restenosis Post Lower Limb Revascularization Angioplasty
The investigators will established relation between restenosis and inflammatory response to shearing stress caused by angioplasty suggest that any mechanism that affect inflammatory response can consequently affect the restenosis…
- Trial name
- NCT02406131
- Testing
- Remote Ischemic Preconditioning
- Where
- 2 sites in Ireland
- Volunteers
- 40 people
- Sponsor
- National University of Ireland, Galway, Ireland
Breast Cancer
BENEFIT OF MECHANICAL ISCHEMIC PRECONDITIONING ON TOLERANCE OF ADIPOSE TISSUE TO ISCHEMIA REPERFUSION OF TYPE DIEP (DEEP INFERIOR EPIGASTRIC PERFORATOR) FREE FLAPS.
Breast cancer is the most common cancer amongst women in terms of frequency, with more than 50 000 newly diagnosed cases per year in France. The average 5-year survival rate for women with breast cancer is around 85%.
- Trial name
- PRIMIDIEP (NCT05373069)
- Testing
- Mechanical ischemic preconditioning of diep-type flap
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Valve Surgery, Acute Kidney Injury
Effects of Remote Ischemic Preconditioning at Different Time Phases in Patients Undergoing Heart Valve Surgery
Patients undergoing heart valve surgery require cardiopulmonary bypass, a procedure that can lead to a temporary reduction in blood flow to major organs and subsequent ischemia-reperfusion injury, thereby triggering postoperative…
- Trial name
- NCT07888634
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 291 people
- Sponsor
- Fujian Medical University Union Hospital
Ischemic Preconditioning, Autonomic Nervous System (ANS) Functioning and Mood State
The Impact of Ischemic Preconditioning on Exercise Performance and Physiological Function
Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action.
- Trial name
- NCT07146399
- Testing
- Ischemic Preconditioning
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ziyue Ou
Cardiotoxicity
Effect of Remote Ischaemic Conditioning in Oncology Patients
Cancer survival has improved steadily due to earlier detection and treatment. Despite the established efficacy of anthracycline chemotherapy, its damaging effects on the heart (cardiotoxicity) limits treatment and confers acute…
- Trial name
- ERIC-ONC (NCT02471885)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Vascular Dementia, Cerebral Small Vessel Diseases
Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment
Cerebral small vessel disease is a common cause of cognitive impairment. Remote ischemic pre-conditioning (RIC) is a technique to induce brief periods of limb ischemia-reperfusion that is hypothesized to increase tolerance of the…
- Conditions
- Vascular Dementia, Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischaemic Disease, Vascular Cognitive Impairment
- Trial name
- TRIC-VCI (NCT04109963)
- Testing
- Remote ischemic conditioning
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary