Clinical trials: Keratoconus
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Keratoconus
Thyroid Gland Dysfunction and Vitamin D Polymorphism in Keratoconus
This prospective study the thyroid gland dysfunction and vitamin D receptor polymorphism in keratoconus patients
- Trial name
- NCT05073601
- Testing
- ELISA,DNA extraction
- Where
- Egypt
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Keratoconus
Familial Analysis of Keratoconus Risk
The principal objective of this study is to evaluate the frequency of KC inside family of patients with confirmed KC. It's a familial, epidemiological, prospective, single-center study.
- Trial name
- AFRIK (NCT02812563)
- Testing
- genetic
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Corneal Diseases
Screening Aid to Identify Corneas That May Have Pathologies or Other Conditions
The purpose of this study is to determine the ability of a proprietary software screening tool to discriminate normal corneas (front surface of the eye) from previously diagnosed corneal conditions…
- Trial name
- NCT00396188
- Where
- 4 sites in United States
- Volunteers
- 769 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Keratoconus
Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus
The purpose of this study is to determine which surgical method makes less corneal haze
- Trial name
- NCT01809977
- Testing
- collagen cross-linking procedure (total removal), collagen cross-linking procedure (partial removal)
- Where
- Iran
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Macular Degeneration, Diabetic Retinopathy (DR)
Artificial Intelligence-assisted Diagnosis in Ophthalmology
This is a retrospective, multicenter, observational study designed to develop and validate an artificial intelligence (AI) system capable of detecting and classifying major ophthalmic diseases (glaucoma, cataract, diabetic…
- Conditions
- Macular Degeneration, Diabetic Retinopathy (DR), Glaucoma, Keratoconus
- Trial name
- AI-OPHTH-CR (NCT07497815)
- Testing
- No interventions
- Where
- 2 sites in Costa Rica
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Marisse Masis-Solano
Tomography
UNITY DX Cornea Study
The purpose of this study is to validate the clinical measurement performance of an investigational biometer. Subjects will undergo multiple measurements of the eye, and the agreement, repeatability, and reproducibility of…
- Trial name
- NCT07768735
- Testing
- UNITY DX, ANTERION
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Ocular Surface Disease, Keratoconus
Changes of Visual Function, Ocular Surface Structures and Physiology After Long-Termed Contact Lens Wear
Our study is aimed to observe the long termed effect of contact lens wear on ocular surface, especially focused on visual function and ocular inflammation mediators.
- Conditions
- Ocular Surface Disease, Keratoconus, Irregular Astigmatism
- Trial name
- NCT02894489
- Testing
- corneal lenses, large diameter lenses
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Keratoconus, Stable
Evaluation of Morphology Abnormal Cornea Stability With Corneal Biomechanical
To evaluate the corneal biomechanical properties of stable eyes with abnormal morphology, and introduce a biomechanical stable index to evaluate the stability of the eyes with abnormal morphology at the first diagnosis.
- Trial name
- NCT05748002
- Testing
- Pentacam and Corvis ST
- Where
- China
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Keratoconus
Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus
This study compares the outcomes of the Vedera KXS procedure (a microwave-based procedure, also known as Keraflex) combined with corneal collagen crosslinking to corneal collagen crosslinking alone for the treatment of…
- Trial name
- NCT01672814
- Testing
- riboflavin ophthalmic solution, Vedera KXS Microwave System
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Myopia, Keratoconus
Assessment of Corneal Biomechanical Properties Using Corvis ST and ECD Following LASIK, PRK, CXL, Veriflex IOL and Implantable Collamer Lens
To evaluate corneal biomechanical changes using the Corvis ST and ECD in patients who have under-gone LASIK, PRK, corneal cross-linking (CXL), Veriflex IOL and ICL.
- Conditions
- Myopia, Keratoconus, Refractive Surgery
- Trial name
- NCT06818461
- Testing
- Corvis St Before and after lasik, PRK, CXL, Veriflex IOL and ICL
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Keratoconus
Changes in the Tear Film With Scleral Contact Lens Wear for Keratoconic Eyes
The purpose of this study is to investigate changes in the level of inflammatory mediators in the tear film of scleral contact lens wearers in a keratoconic population.
- Trial name
- NCT02806921
- Testing
- ZenLens
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Keratoconus, Ectasia
Progressive Keratoconus or Ectasia Treatment Plan
Keratoconus and pellucid marginal degenerations are genetically based ocular conditions and post surgical ectasia is an iatrogenic condition.
- Trial name
- NCT01384773
- Testing
- Riboflavin Solution, UV-X Illumination System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stephen Trokel
Keratoconus
Evaluation of Safety and Efficacy of a Bioengineered Corneal Implant for Treatment of Keratoconus
This is a prospective, Phase I open-label safety study to evaluate the safety, feasibility and initial efficacy of a bioengineered corneal stromal substitute after implantation into the stroma of adults with advanced keratoconus.
- Trial name
- LinkCor (NCT04653922)
- Testing
- LinkCor Bioengineered Corneal Implant
- Where
- 2 sites in India, Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- LinkoCare Life Sciences AB
Keratoconus, Pellucid Marginal Corneal Degeneration
Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Trial name
- NCT04667572
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Cornea Associates of Texas
Keratoconus
Evaluation of Corneal Epithelial Mapping in Diagnosis of Early Keratoconus by Anterior Segment Optical Coherence Tomography
The cornea, as the outermost refractive structure of the eye, plays a critical role in maintaining clear vision. Its transparency and structural integrity are essential for optimal visual function.
- Trial name
- NCT06914973
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cornea; Ectasia, Refractive Errors
Corneal Elastography and Patient Specific Modeling
The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors.
- Conditions
- Cornea; Ectasia, Refractive Errors, Keratoconus
- Trial name
- NCT03030755
- Testing
- Optical coherence tomography
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Keratoconus
Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring
The purpose of this study is to postpone the corneal transplantation in keratoconus and promote the stiffness of the cornea across the riboflavin-UVA corneal collagen crosslinking , and after, corneal ring surgery.
- Trial name
- NCT00832897
- Testing
- Corneal collagen crosslinking
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Amount of Corneal Flattening (Kmax Flattening), Change in the Endothelial Cell Count
Topo-Pachymetric Customized Accelerated Epi-On Vs Accelerated Epi-Off Corneal Cross Linking in Keratoconus Management
The objective of this study is to compare the clinical effectiveness and safety of Topo-Pachymetric Customized Accelerated Epithelium-On (aCFXL) to Standard Accelerated Epithelium-Off (aCXL) Corneal Collagen Cross-Linking in the…
- Trial name
- NCT06549387
- Testing
- Corneal cross linking
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Keratoconus, Corneal Ectasia
Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light
Corneal collagen crosslinking has been demonstrated as an effective method of reducing progression of both keratoconus and post-refractive corneal ectasia, as well as decreasing the steepness of the cornea in these pathologies.
- Trial name
- NCT05027295
- Testing
- riboflavin ophthalmic solution
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute