Clinical trials: Keratoplasty
Refractive Error, Corneal Implantation
Piggyback Sulcoflex Toric IOL for Correcting Refractive Error Following Corneal Transplantation
A prospective study to evaluate the safety and efficacy of a piggyback sulcoflex toric intraocular lens in pseudophakic patients for correcting refractive errors following corneal transplantation
- Conditions
- Refractive Error, Corneal Implantation, Intraocular Lens Implantation
- Trial name
- NCT01718184
- Testing
- toric intraocular lens implantation, Sulcoflex intraocular lens implantation
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Cataract, Fuchs Endothelial Corneal Dystrophy
Partial Range Of Field IOLs in DMEK-Enabled Procedures
Study Overview This study aims to evaluate the visual outcomes, quality of vision, and patient satisfaction after receiving an extended range PRoF intraocular lens (IOL) during triple Descemet Membrane Endothelial Keratoplasty…
- Trial name
- PROFIDE (NCT07441616)
- Testing
- combined cataract and lamellar endothelial keratoplasty
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Corneal Graft Rejection, CD160
CD160 Expression in Corneal Vessels
Despite improvements in corneal transplantation, anti-angiogenic and anti-lymphangiogenic factors remain to be be identified. CD160 is an anti-angiogenic target: its expression seems to be restricted to some immune cells and to…
- Conditions
- Corneal Graft Rejection, CD160, Angiogenesis, Lymphangiogenesis
- Trial name
- NCT05009407
- Testing
- Immunohistochemistry and clinical analyses on patients and corneas
- Where
- France
- Volunteers
- 43 people
- Sponsor
- CHU de Reims
Corneal Transplantation
The German Keratoplasty Registry of the German Ophthalmological Society (DOG)
Aim of this study is to reflect on the changing trends in absolute numbers, surgical techniques and indications of corneal transplantations being performed in Germany.
- Trial name
- NCT03381794
- Testing
- Corneal transplantation
- Where
- Germany
- Volunteers
- 100,000 people
- Sponsor
- Universität des Saarlandes
Corneal Transplantation
Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea
The performance of keratoplasty is hampered by the limited availability of donor cornea in many countries, especially in Asia. For this reason, attempts have been made to fabricate artificial substitutes for natural human cornea.
- Trial name
- NCT03105466
- Testing
- Deep anterior lamellar keratoplasty, Acellular Porcine Cornea, Tacrolimus eye drops
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Transplantation, Glaucoma
Timing of Glaucoma Drainage Device With Boston Keratoprosthesis
Boston keratoprosthesis (KPro) is a piece of specialized plastic that replace sick cornea (transparent structure at the front of the eye) in patients who have failed or those who are expected to have poor results with traditional…
- Trial name
- GDD-KPro (NCT02084745)
- Testing
- Boston keratoprosthesis type 1, Glaucoma drainage device
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Corneal Transplantation
Safety and Efficacy of Corneal Preservation Solution for Corneal Transplantation
The goal of this clinical trial is to learn if a corneal preservation solution can safely and effectively preserve donor corneas for corneal transplantation in patients who need penetrating keratoplasty (PKP) or endothelial…
- Trial name
- NCT07874568
- Testing
- penetrating keratoplasty
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong Branden Med.Device Co.,Ltd
Fuchs Endothelial Corneal Dystrophy
Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy
This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patients with FECD.
- Trial name
- NCT04440280
- Testing
- N-acetyl cysteine (NAC) 10% solution, N-acetyl cysteine (NAC) 20% solution, Visine Dry Eye Relief eye drops
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy
The OPTIMISE Study
Rationale: The cornea is the most transplanted tissue in the Netherlands, with more than 1,500 procedures performed each year. A minimally invasive technique called Descemet Membrane Endothelial Keratoplasty (DMEK) has become the…
- Conditions
- Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy, Intraocular Pressure
- Trial name
- NCT05716945
- Testing
- Fluorometholone 0.1% Oph Susp, Dexamethasone 0.1% ophthalmic suspension, Stop steroids
- Where
- 8 sites in Netherlands
- Volunteers
- 342 people
- Sponsor
- Maastricht University Medical Center
Corneal Diseases
Functional Antigen Matching in Corneal Transplantation
Penetrating keratoplasty is one of the most commonly performed transplantation surgeries. Graft rejection is a major complication.
- Trial name
- FANCY (NCT00810472)
- Testing
- HLA Matching, Penetrating keratoplasty
- Where
- Germany
- Volunteers
- 650 people
- Sponsor
- University Hospital Freiburg
Chemical Injuries, Unspecified Complication of Corneal Transplant
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
The purpose of the pilot study is to test the efficacy and safety of riboflavin/Ultraviolet A (UVA) cross-linked human donor corneas as carriers for the Boston Keratoprosthesis (Boston KPro) in patients with higher risk for…
- Conditions
- Chemical Injuries, Unspecified Complication of Corneal Transplant, Autoimmune Diseases, Ocular Cicatricial Pemphigoid
- Trial name
- NCT01582880
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joseph B. Ciolino, MD
Limbal Stem Cells Deficiency
A Clinical Study on Co-transplantation of Autologous Limbal Stem Cells and Corneal Stromal Stem Cells to Repair Corneal Injury
This study aims to: 1) verify the feasibility of treating limbal stem cell deficiency (LSCD) caused by chemical injury with autologous limbal stem cell transplantation combined with corneal stromal stem cell transplantation; 2)…
- Trial name
- NCT06700655
- Testing
- Cornea limbal stem cell transplantation group, Corneal transplantation, Cornea limbal stem cell transplantation combined corneal stromal stem cell group
- Volunteers
- 60 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Fuchs Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy
The Postoperative Head Position as a Predictor of the Surgical Outcome After DMEK
This study aims to investigate the influence of postoperative head position on clinical outcomes after DMEK via a wearable sensor.
- Conditions
- Fuchs Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy, Chemical Burn of Cornea, Posterior Polymorphous Corneal Dystrophy
- Trial name
- NCT04387331
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Peter Wiedemann
Descemet Stripping Automated Endothelial Keratoplasty (DSAEK), Descemet Membrane Endothelial Keratoplasty (DMEK)
DSAEK/DMEK and Cystoid Macular Edema - the Role for Topical NSAIDs (Nepafenac) (DMEC)
The DMEC trial is a randomized clinical two-arm trial comparing inflammation and cystoid macular edema for the medication regimens postoperative topical NSAIDs and steroids to only postoperative topical steroids in patients…
- Trial name
- DMEC (NCT05072262)
- Testing
- Nepafenac Ophthalmic, Dexamethasone Ophthalmic
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Oslo University Hospital
Fuch's Endothelial Dystrophy, Pseudophakic Bullous Keratopathy
Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media
The goal of this clinical trial is to compare the quality of corneal grafts cultured in a serum-free culture medium with a defined composition versus corneal grafts cultured in a standard serum supplemented culture medium…
- Trial name
- SFM (NCT00623584)
- Testing
- Corneal transplantation
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Klinikum Chemnitz gGmbH
STROMAL OPACITIES
LALAK for Opacities
The purpose of this protocol is to compare and develop new surgical technique of partial-thickness corneal transplantation for treating corneal opacity.
- Trial name
- NCT01901601
- Testing
- LALAK, IEK, Retrobulbar Block or General Anesthesia
- Sponsor
- Oregon Health and Science University
Keratoconus
The Homburg Keratoconus Center (HKC)
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
- Trial name
- NCT03923101
- Testing
- Topographic, tomographic and biomechanical analysis.
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universität des Saarlandes
Corneal Graft Rejection
Evaluation of the Efficacy of 2% Cyclosporine in Preventing Graft Rejection
Aim/ Objective: Study consists of 2 separate and distinct entities A. Evaluation of the efficacy of 2% cyclosporine in preventing graft rejection in primary grafts w/o high risk characteristics study 1 (PKP study) B.
- Trial name
- NCT02206789
- Testing
- Prednisolone acetate1%,, Prednisolone acetate1%, cyclosporine 2%
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Aravind Eye Care System
Corneal Opacity
Clinical Outcomes of the Gore Synthetic Cornea Device
Study objective is to evaluate the initial safety and effectiveness of the GORE Synthetic Cornea Device in the treatment of loss of corneal clarity in patients who are candidates for corneal transplantation
- Trial name
- NCT06174376
- Testing
- GORE Synthetic Cornea Device
- Where
- 2 sites in Mexico
- Volunteers
- 10 people
- Sponsor
- W.L.Gore & Associates
Corneal Transplantation
Safety and Efficacy Study of Artificial Cornea
The purpose of this study is to evaluate the stability of artificial cornea manufactured by Aurolab and to assess its visual outcomes.
- Trial name
- AuroKPro (NCT01018888)
- Testing
- Auro KPro (Keratoprosthesis)
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Aurolab