Clinical trials: Knee Arthrosis,
Osteoarthritis, Knee
Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (United States)
To compare the efficacy and safety of celecoxib versus ibuprofen in subjects with osteoarthritis (OA) of the knee.
- Trial name
- NCT00620867
- Testing
- Ibuprofen, celecoxib
- Where
- 33 sites in United States
- Volunteers
- 393 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Osteoarthritis
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee…
- Trial name
- ATTAIN-OA PAIN (NCT07153471)
- Testing
- Orforglipron
- Where
- 88 sites in United States, Canada and 5 more
- Volunteers
- 800 people
- Sponsor
- Eli Lilly and Company
Pain, Knee Osteoarthritis
A Study to Evaluate the Efficacy and Safety of CG5503 Prolonged Release (PR) in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
The purpose of this study is to evaluate whether tapentadol (CG5503) prolonged-release (PR) tablets at doses of 100-250 mg twice daily provide a better pain relief in patients with moderate to severe chronic pain due to…
- Trial name
- NCT00486811
- Testing
- Tapentadol ER (100 to 250 mg twice daily), Oxycodone CR (20 to 50 mg twice daily)
- Where
- 100 sites in Austria, Croatia and 11 more
- Volunteers
- 990 people
- Sponsor
- Grünenthal GmbH
Knee Osteoarthritis
Clinical Trial to Evaluate Efficacy and Safety of SMUP-IA-01 in Patients With Knee Osteoarthritis
This clinical trial is for patients who have been diagnosed with Kellgren-Lawrence (K\&L) Grade 2 or 3 knee osteoarthritis on radiographic examination.
- Trial name
- NCT05182034
- Testing
- SMUP-IA-01(low dose), SMUP-IA-01(mid dose), Active Control Group Sodium chloride
- Where
- 5 sites in South Korea
- Volunteers
- 94 people
- Sponsor
- Medipost Co Ltd.
Osteoarthritis, Knee
Persona TKA With iASSIST Knee System and iASSIST Knee System
The purpose of this study is to compare the accuracy of knee component alignment between patients operated with iASSIST Knee (Investigational group) versus patients operated without iASSIST Knee (Control group) using the same…
- Trial name
- NCT03227692
- Testing
- Persona Knee System, Total Knee Arthroplasty, iAssist Knee
- Where
- 3 sites in Japan
- Volunteers
- 93 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
AMZ001 for the Treatment of Knee Osteoarthritis Symptoms
This is a multicenter, randomized, double-blind, placebo-controlled, parallel group, 4-week trial of a formulation of AMZ001 once or twice daily versus placebo twice daily, including a single-blind treatment group with a…
- Trial name
- NCT03691844
- Testing
- AMZ001, Comparator
- Where
- 7 sites in United States, Czechia and 1 more
- Volunteers
- 444 people
- Sponsor
- Amzell
Osteoarthritis
Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis (OA)
This 39-week, active controlled, study is designed to assess long-term efficacy, safety and tolerability of lumiracoxib 100mg od in patients with osteoarthritis (OA) of the knee who participated in the 13-week core CCOX189A2361…
- Trial name
- NCT00476034
- Testing
- lumiracoxib
- Where
- 15 sites in Australia, Austria and 13 more
- Volunteers
- 1,312 people
- Sponsor
- Novartis
Osteoarthritis
Analgesic Efficacy And Safety of Tanezumab Added On To Diclofenac SR In Patients With Osteoarthritis Of The Knee Or Hip
The purpose of this study is to investigate the analgesic efficacy and safety of tanezumab added on to diclofenac SR in patients with osteoarthritis of the knee or hip currently experiencing partial benefit from, and are…
- Trial name
- NCT00864097
- Testing
- tanezumab, diclofenac
- Where
- 77 sites in Austria, France and 8 more
- Volunteers
- 607 people
- Sponsor
- Pfizer
Knee Osteoarthritis
ACP Max™ PRP System for Knee Osteoarthritis: A Feasibility Trial
This study is a prospective, multicenter (up to 4 sites), randomized, double-blind, two-arm study. Forty-five (45) patients will be randomized to receive a single 4-6 ml intra-articular (IA) injection of either the output of ACP…
- Trial name
- NCT05765266
- Testing
- ACP Max™, Depo-Medrol®
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Arthrex, Inc.
Osteoarthritis, Knee
Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee
This is an open-label study assessing the effect of the administration of a single intra-articular (IA) injection of FX006 32 mg on synovial volume in patients with osteoarthritis (OA) of the knee.
- Trial name
- NCT03529942
- Testing
- FX006 32 mg
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 129 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis
A Trial to Evaluate the Safety, Tolerability, and Efficacy of NCR100 Injection in the Treatment of Subjects With KOA
This clinical study is to investigate the safety and efficacy of NCR100 injection in subjects with knee osteoarthritis (KOA). It is a dose-escalating, open label study in adult KOA subjects.
- Trial name
- NCR100 (NCT06049342)
- Testing
- NCR100 injection
- Volunteers
- 12 people
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Pain, Osteoarthritis, Knee
A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain
This is dose-finding study of GSK3858279 in participants with moderate to severe knee osteoarthritis pain. The purpose of this study is to investigate and provide the data necessary to select the optimal effective and safe…
- Trial name
- MARS-17 (NCT05838742)
- Testing
- GSK3858279
- Where
- 93 sites in United States, Argentina and 11 more
- Volunteers
- 314 people
- Sponsor
- GlaxoSmithKline
Post-Operative Pain Management
Study to Evaluate Iovera®° in Adult Patients Undergoing Total Knee Arthroplasty
Primary objective: The primary objective of this study is to evaluate postsurgical pain control, after presurgical iovera° treatment plus EXPAREL® and standardized multimodal therapy compared with presurgical sham iovera°…
- Trial name
- NCT04191031
- Testing
- ioveraº
- Where
- 7 sites in United States
- Volunteers
- 79 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Knee
A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-39439335 in Patients With Osteoarthritis
The purpose of this study is to evaluate the safety of multiple oral doses of JNJ-39439335 and to assess how JNJ-39439335 is absorbed (taken in), distributed, metabolized (broken down), and eliminated from the body (referred to…
- Trial name
- NCT01343303
- Testing
- JNJ-39439335, Naproxen
- Where
- South Africa
- Volunteers
- 43 people
- Sponsor
- Janssen Research & Development, LLC
Chronic Low Back Pain, Osteoarthritis
Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee
The primary objective of the study is to evaluate the efficacy of fasinumab in relieving Chronic low back pain (CLBP) as compared to placebo in participants with a clinical diagnosis of moderate-to-severe non-radicular CLBP and…
- Trial name
- FACT CLBP 1 (NCT03285646)
- Testing
- Fasinumab
- Where
- 56 sites in United States
- Volunteers
- 63 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis
Gait and Functional Improvement in Total Knee Arthroplasty With the Use of Verasense for Soft Tissue Balancing
The primary objectives of this study are to understand the effects of soft-tissue balancing on Gait, function and rehabilitation potential after sensor-assisted Total Knee Arthroplasty and correlate Intra-operative subjective…
- Trial name
- NCT02290119
- Testing
- Sensor-assisted TKR (Verasense), Control - Without the use of Verasense
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orthosensor, Inc.
Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical trial is to learn if GNSC-001 works to treat knee osteoarthritis in adults. It will also learn about the safety of GNSC-001. The main questions it aims to answer are: 1.
- Conditions
- Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis, Knee Arthritis, Knee Arthritis Disease
- Trial name
- RAPHAEL (NCT07831577)
- Testing
- Gene Therapy GNSC-001
- Volunteers
- 240 people
- Sponsor
- Genascence Corporation
Degenerative Arthritis, Knee Osteoarthritis
Investigator Initiated Trial to Evaluate the Efficacy and Safety of Intra-articular Injection of ADMSC Comared to Negative Control After High Tibial Osteotomy in the Osteoarthritis Patients.
The purpose of this study is to evaluate the efficacy and safety of intra-articular injection of autologous adipose tissue derived mesenchymal stem cells compared after high tibial osteotomy to negative control in the…
- Trial name
- NCT03000712
- Testing
- Autologous Adipose Tissue derived MSCs 1x10^8cells/3ml
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- R-Bio
Osteoarthritis, Knee
PAAG-OA Treatment for Knee Osteoarthritis
This is a multi-centre, prospective, open-label, uncontrolled, clinical investigation followed by an open-label extension clinical investigation to evaluate PAAG-OA in patients with knee osteoarthritis.
- Trial name
- IDA (NCT04179552)
- Testing
- PAAG-OA
- Where
- 3 sites in Denmark
- Volunteers
- 49 people
- Sponsor
- Contura
Osteoarthritis, Pain
Norspan® Patches Versus Tramadol in Subjects With Chronic, Moderate to Severe Osteoarthritis Pain in the Hip Knee and/or Lumbar Spine
The primary objective of this equivalence study is to evaluate the efficacy of Norspan® patches versus Tramadol in subjects with chronic, moderate to severe osteoarthritis pain of the hip, knee and/or lumbar spine.
- Trial name
- NCT00426647
- Testing
- Buprenorphine, Tramadol
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Norpharma A/S
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