Clinical trials: Knee Surgeries
Blood Loss
Tranexamic Acid for Unilateral Total Knee Arthroplasty
Total knee arthroplasty is often associated with excessive postoperative bleeding due to increased fibrinolysis. Hence, the objective of the proposed of this multicentre study is to determine the peri-operative bleeding comparing…
- Trial name
- TRANEXTOP (NCT01594671)
- Testing
- Tranexamic Acid, haemostasia
- Where
- 2 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Pain, Total Knee Replacement
Analysis of Postoperative Analgesic of Different Nerve Blocks for Total Knee Replacement Surgery
This study is a retrospective analysis using the accumulated clinical database from 2017/09-2023/12 to analyze patients who underwent total knee arthroplasty and received nerve blocks.
- Conditions
- Pain, Total Knee Replacement, Motor Function
- Trial name
- NCT06521619
- Testing
- Femoral and sciatic nerve blocks
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Fu Jen Catholic University Hospital
Continuous Adductor Canal Block, Infiltration Between The Popliteal Artery and Capsule of The Knee
Effect of Continuous Adductor Canal Block Versus Continuous Adductor Canal Block With Additional Infiltration Between The Popliteal Artery and Capsule of The Knee (IPACK) After Arthroscopic Knee Surgeries
This study aims to evaluate the effect of Continuous Adductor Canal Block only versus adding posterior knee block, known as the Infiltration between the Popliteal Artery and Capsule of the Knee (IPACK) block with Continuous…
- Conditions
- Continuous Adductor Canal Block, Infiltration Between The Popliteal Artery and Capsule of The Knee, Arthroscopic Knee Surgeries
- Trial name
- NCT06802419
- Testing
- Continuous adductor canal block, Continuous Adductor Canal Block with additional Infiltration between The Popliteal Artery and Capsule
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Pain, Postoperative
A Multicentre, Double-Blind, Double-Dummy, Randomised Study of the Analgesic Efficacy and Safety of Valdecoxib Compared to Diclofenac Sodium in Patients Undergoing Knee Arthroscopy for Anterior Cruciate Ligament (ACL) Reconstruction
To demonstrate non-inferiority of valdecoxib 20 mg twice daily (BID) (with an initial loading dose of 40 mg followed by a second dose of 20 mg on the first day only) with diclofenac sodium delayed release 75 mg BID in analgesic…
- Trial name
- NCT00650598
- Testing
- valdecoxib, diclofenac
- Where
- 25 sites in Australia, Hong Kong and 7 more
- Volunteers
- 328 people
- Sponsor
- Pfizer
Osteoarthritis
The Press Fit Condylar (P.F.C.) Sigma Rotating Platform (RP) TC3 Revision Knee in Revision Knee Arthroplasty
The purpose of this study is to evaluate the long-term clinical and functional performance of the P.F.C. Sigma Rotating Platform TC3 knee system in revision knee surgery and to determine whether the implant design results in a…
- Trial name
- TC3 (NCT00733681)
- Testing
- PFC Sigma RP TC3 Revision knee system
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 181 people
- Sponsor
- DePuy International
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Postoperative Complications, Memory Disorders
A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events
The purpose of this study is to determine if the use of a carbon dioxide lavage device (CarboJet) to clean bone surfaces during total knee surgery decreases intraoperative embolic events when compared with standard orthopedic…
- Trial name
- NCT00736125
- Testing
- pulsatile saline lavage, carbon dioxide lavage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kinamed Incorporated
Post-Operative Pain
A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain
The study is intended to show that the Sufentanil NanoTab PCA System is as effective as morphine intravenous patient-controlled analgesia (IV PCA) for treating pain after surgery.
- Trial name
- NCT01539538
- Testing
- Sufentanil NanoTab PCA System/15 mcg, morphine IV PCA
- Where
- 16 sites in United States
- Volunteers
- 357 people
- Sponsor
- Talphera, Inc
Joint (Knee or Hip Replacement)
The Impact of Extending Sleep Before Joint-replacement Surgery on Post-surgical Pain
This study will evaluate the impact of sleep banking on joint replacement surgery recovery.
- Trial name
- NCT07383584
- Testing
- Sleep banking
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Osteoarthritis
JOINTS Study - Joint Replacement Outcome in Inpatient Rehabilitation Facilities and Nursing Treatment Sites
1. What are the characteristics of joint replacement patients (DRGs 209 \& 210) served in IRFs and SNFs? How are they similar or different? 2.
- Trial name
- JOINTS (NCT00499278)
- Testing
- Rehabilitation after joint replacement surgery
- Where
- United States
- Volunteers
- 2,384 people
- Sponsor
- MedStar National Rehabilitation Network
Anterior Cruciate Ligament Rupture, Surgery
ALL Ultrasound Predicts the Success of ACL Repair?
This case series evaluates whether patients with an anterior cruciate ligament (ACL) repair have better outcome if the anterolateral ligament (ALL) was repaired or not considering the ultrasound (US) pre-surgical recommendation.
- Trial name
- ALL_US (NCT04373408)
- Testing
- ACL repair without anterolateral repair, ACL repair with anterolateral repair
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Adrien Schwitzguebel
Knee Arthroplasty, Total
Surgical Approach in Fast Track Knee Arthroplasty
Nowadays, due to the demands to improve life and health conditions of osteoarthritis patients, more effective surgical treatment methods are needed to obtain satisfactory results when performing total knee arthroplasty (TKA).
- Trial name
- NCT04450485
- Testing
- Total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Pamukkale University
Total Knee Replacement
Qualitative Interviews With Healthcare Professionals
PLANNING PHASE- Qualitative interviews with Healthcare Professionals to assist in the development of a new Patient Reported Outcome Measure (PROM) to assess patient's emotional wellbeing, and perceptions of Total Knee Replacement…
- Trial name
- NCT05597046
- Testing
- Interview
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Invibio Ltd
Osteoarthritis, Hip, Osteoarthritis, Knee
Evaluation of Teleconsulting on Rehabilitation After Hip and Knee Surgical Procedures
The objective of this study is to assess the medical and economic relevance of teleconsulting for Rehabilitation After Hip and Knee Surgical Procedures.
- Trial name
- SSRHAD (NCT02229279)
- Testing
- Teleconsulting
- Where
- France
- Volunteers
- 430 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intravenous Drug Usage, Ibuprofen
Postoperative Analgesic Effects of Ibuprofen Versus Ketorolac in Patients Undergoing in Orthopedic Surgery
Objectives: To compare the postoperative analgesic effects of ibuprofen versus ketorolac in patients undergoing orthopedic surgery at Combined Military Hospital, Rawalpindi.
- Conditions
- Intravenous Drug Usage, Ibuprofen, Ketorolac, Knee Arthroscopy
- Trial name
- NCT05695664
- Testing
- Ibuprofen 800 mg, Ketorolac Injection
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Benazir Bhutto Hospital, Rawalpindi
Anterior Cruciate Ligament Rupture, Knee Instability
Single and Double Bundle ACL Reconstructions, in Term of Cartilage Damage Due to Remaining Instability After Surgery.
The prevalence of ACL (Anterior Cruciate Ligament) ruptures is relatively high, primarily due to sports and military training injuries.
- Conditions
- Anterior Cruciate Ligament Rupture, Knee Instability, Cartilage Damage
- Trial name
- ACL (NCT04626999)
- Testing
- Single Bundle ACL Reconstruction, Double Bundle ACL Reconstruction
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Indonesia
Osteo Arthritis of the Knee
Minimal-Incision Technique With Modified Tracking Pin Placement Versus Standard Robotic-Assisted Total Knee Arthroplasty
This randomized controlled trial will compare a minimal-incision and soft-tissue-preserving (MISI) technique with the standard surgical technique in patients undergoing robotic-assisted total knee arthroplasty for knee…
- Trial name
- MISI (NCT07765771)
- Testing
- MISI Robot-Assisted Total Knee Arthroplasty, Standard Robotic-Assisted Total Knee Arthroplasty
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Surgical Blood Loss, Total Knee Arthroplasty
Topical Tranexamic Acid for Total Knee Arthroplasty
Total knee arthroplasty (TKA), the definitive treatment of osteoarthritis, is often associated with excessive postoperative bleeding due to increased fibrinolysis.
- Trial name
- NCT00985920
- Testing
- tranexamic acid
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- University Health Network, Toronto
Central Sensitisation, Postoperative Pain
Evaluation of the Effect of Central Sensitivity on Pain and Functional Status After Total Knee Joint Replacement Surgery
The study is a prospective observational study designed to determine the effects of central sensitization on pain and functional status of patients before and after total knee joint replacement surgery.
- Conditions
- Central Sensitisation, Postoperative Pain, Arthritis
- Trial name
- NCT06553118
- Testing
- Total knee arthroplasty
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Arthroplasty, Replacement, Knee, Recovery of Function
The Influence of Rapid Recovery on Sleep Quality Following Total Knee Replacement Surgery
The purpose of this study is to evaluate the influence of rapid recovery on sleep quality following total knee replacement surgery.
- Conditions
- Arthroplasty, Replacement, Knee, Recovery of Function, Arthritis, Rheumatoid
- Trial name
- NCT02845960
- Testing
- rapid recovery
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Southwest Hospital, China
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