Clinical trials: Knee Surgeries
Osteoarthritis, Sarcopenia
The Strong Brain Study
To evaluate operational aspects of studying pre to post surgery/hospitalization changes in the integrity of a major white matter pathways and how these contribute to reductions in the ability to produce forceful muscle…
- Trial name
- NCT02320864
- Testing
- Total knee replacement surgery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Florida
Postoperative Pain, Acute
The Effect of Adding an IPACK Block to the Adductor Canal Block on Total Knee Arthroplasty Surgery
Total knee arthroplasty (TKA) is a frequently performed major orthopedic surgery, where most patients experience severe postoperative pain.
- Trial name
- NCT06586840
- Testing
- rescue analgesia, Adductor Canal Block, Adding an IPACK Block to the Adductor Canal Block
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Arthroplasty, Replacement, Knee
Postoperative Hypothermia Control In Older Patients With Total Knee Arthroplasty: Effect Of Electric And Woolen Blanket
The purpose of this studywas to assess as experimental whether if electric blanket together withwoolen blanketwere effective in the postoperative period at patients with TKA.
- Trial name
- NCT05389579
- Testing
- electric blanket
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Esra Demirarslan
Strength, Range of Motion
Low-Load Blood Flow Restriction Training vs Traditional Resistance Training Exercises Following ACLR Surgery
The main objective/s of the study is to compare the effectiveness of low load blood flow restriction training (LL-BFR) with traditional resistance training exercises (T-RT) at improving skeletal muscle hypertrophy, strength…
- Conditions
- Strength, Range of Motion, Pain-Knee, Skeletal Muscle Hypertrophy
- Trial name
- NCT06480032
- Testing
- Blood Flow Restriction band
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Abasyn University Peshawar
Anxiety, Surgery
Could Music be an Alternative to Sedation in Patients Treated Total Knee Arthroplasty With Regional Anesthesia?
Background: Anxiety is a common phenomenon in hospitalized patients. In order to reduce it during the surgical procedure, sedatives and anxiolytics are used, which can cause undesirable side effects for patients.
- Conditions
- Anxiety, Surgery, Drug Toxicity, Anesthesia
- Trial name
- NCT03882541
- Testing
- Music therapy, Sedation with midazolam
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari de l'Anoia
Postoperative Pain
Arthroplasty Inflammation Prophylaxis With Celecoxib
This double blinded, placebo controlled, study seeks to determine the efficacy of preoperative anti-inflammatory therapy on the reduction of postoperative pain in knee arthroplasty surgery.
- Trial name
- NCT00533247
- Testing
- Celecoxib
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zanbilowicz, Adam, DPM MS
Anesthesia, Spinal, Arthroplasty, Replacement, Knee
Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty
The purpose of this study is to determine if a shorter-acting spinal anesthetic called mepivacaine has advantages over a longer-acting medication called bupivacaine.
- Conditions
- Anesthesia, Spinal, Arthroplasty, Replacement, Knee, Pain Management, Early Ambulation
- Trial name
- NCT02980926
- Testing
- Mepivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Total Knee Arthroplasty (TKA)
VRAS (Velys Robot-Assisted Solution) Operational Excellence Study
The aim of this study is to investigate the differences in process set-up, efficiency, OR team workload, instrument trays and OR financial performance when using the VRAS (Velys Robotic Assisted Solution) of DePuy Synthes…
- Trial name
- NCT06563843
- Testing
- Robotic-assisted TKA, Conventional TKA
- Where
- 10 sites in Austria, Belgium and 6 more
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- DEO NV
Pressure Sore, Orthopedic Disorder
Body Temperature Changes and Early Postoperatıve Pressure Sore
This study aims to determine effect of body temperature changes during total knee arthroplasty surgery on early postoperative pressure sore formation.
- Conditions
- Pressure Sore, Orthopedic Disorder, Hypothermia, Nursing Caries
- Trial name
- NCT05552599
- Testing
- woolen blanket
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Hitit University
Wound Surgical, Diabetes
Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty
This study is a single-center, prospective, randomized, open-label clinical trial evaluating three commercially available closed-incision negative pressure wound therapy (ciNPWT) devices: NPseal, PICO, and Prevena, in adult…
- Conditions
- Wound Surgical, Diabetes, Obesity, Chronic Kidney Diseases
- Trial name
- NCT07770633
- Testing
- NP Seal, PICO, Prevena
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Knee Arthropathy
Motivational Feedback Following Total or Unicompartmental Knee Arthroplasty
The goal of this randomized controlled trial (RCT) nested in a prospective cohort study is to investigate whether physical activity (PA) following total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA) can be…
- Trial name
- KneeActivity (NCT06005623)
- Testing
- SENS Motion + Motivational Feedback
- Where
- 4 sites in Denmark
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Blood Loss, Surgical
Arista Hemostatic Powder for Total Knee Post Operative Outcomes Study
To examine in Arista hemostatic powder results in less post-total knee arthroplasty blood loss, hematoma formation, and improved range of motion when compared to patients who did not receive the product.
- Trial name
- NCT05522153
- Testing
- Arista
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Post-operative Pain
CBD Knee Scope Study
This is a prospective, randomized, nonblinded trial to evaluate the effectiveness of Cannabidiol (CBD) oil on post-operative pain control compared to opioid medications after a knee arthroscopy.
- Trial name
- CBDS (NCT05934500)
- Testing
- Cannabidiol Oil
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Foundation for Orthopaedic Research and Education
Post Operative Pain
Comparison Between Two Blocks in Analgesia After Knee Arthroplasty
Comparative Study between Adductor canal block combined with infiltration OF The interspace between popliteal artery and the capsule of the knee block versus genicular nerves Block combined with IPACK in Postoperative analgesia…
- Trial name
- NCT07046377
- Testing
- ACB - IPACK, GNB - IPACK
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Arthroplasty Replacement, Knee, Anesthesia Conduction
Migration Rate for Continuous Adductor Canal Block Catheters After Primary Total Knee Arthroplasty Surgery: a Comparison Between Two Insertion Techniques
Continuous adductor canal block (CACB) is becoming increasingly popular for providing postoperative analgesia following knee arthroplasties.
- Trial name
- ISAFExOOPS (NCT07681622)
- Testing
- ISAFE technique for adductor canal catheter insertion, OOPS technique
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Knee Arthroscopic Surgery
Analgesic Effect Of Intra-articular Bupivacaine Fentanyl for Postoperative Pain Relief in Knee Arthroscopic Surgery
However, local anesthetic agents can produce analgesia for a limited time when used as a single injection. Bupivacaine is a local anesthetic that has an immediate action on pain by blocking peripheral afferents.
- Trial name
- NCT03847792
- Testing
- Group DB/Dexamethasone-Bupivacaine, Group FB /Fentanyl-Bupivacaine
- Where
- 2 sites in Egypt
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction
Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair
The anterior cruciate ligament (ACL) is the primary structure responsible for controlling anterior-posterior translation and rotational stability of the knee joint.
- Conditions
- Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction, Isokinetic Test
- Trial name
- NCT07318272
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Gazi University
Post-operative Pain
Post-operative Efficacy and Safety Study
The purpose of this study was to compare the analgesic efficacy of 5 mg oxymorphone IR with placebo in patients with mild to moderate pain following outpatient knee arthroscopy.
- Trial name
- NCT00904085
- Testing
- Oxymorphone IR
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Arthroplasty, Replacement
Efficacy of Surgical Preparation Solutions in Knee Surgery
The goal of this study is to determine the superiority of surgical scrub preparations in total knee arthroplasty based on the bacterial counts present on the skin surface and in the deep joint tissues.
- Trial name
- NCT01857349
- Testing
- Chlora Prep, Dura Prep
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
ACL Injury
Effects of HMB Supplementation on Recovery Following ACL Surgery
The anterior cruciate ligament (ACL) is a primary stabilizer of the knee, and thus when ACL injury occurs participation in physical activity is compromised.
- Trial name
- NCT02602561
- Testing
- HMB
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Metabolic Technologies Inc.