Clinical trials: LPS
Exercise Training
Effect of Aronia Supplementation on the LPS-CD14-TLR2/4 Axis in Football Players
This randomized, double-blind, placebo-controlled trial will investigate the effects of 8-week Aronia melanocarpa supplementation on exercise-induced activation of the LPS-LBP-CD14-TLR2/TLR4 axis in trained male football players.
- Trial name
- ARONIA-TLR (NCT07829523)
- Testing
- Aronia melanocarpa Extract
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hanna Dziewiecka
Caries
Reliability of Fluorescent Camera in Diagnosis of Occlusal Carious Lesion
This study will be conducted to compare the diagnostic predictive values of a light induced fluorescence camera and Caries detection dye versus visual assessment method in identification of occlusal carious lesion.
- Trial name
- NCT03224962
- Testing
- fluorescence camera
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Cairo University
Inflammation
Inflammatory Markers in Sputum After LPS Inhalation
The purpose of the study is to measure inflammatory biomarkers in sputum and peripheral blood in healthy volunteers after inhalation of single doses of LPS (20 mcg) administered as particles of different sizes.
- Trial name
- NCT01081392
- Testing
- LPS
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Brugmann
Healthy
A Clinical Study to Determine the Safety, Tolerability and Effect of RLS-0071 Doses When Given to Healthy Adults After Inhaling LPS
This is a Phase 1b, randomized, double-blind, placebo-controlled, dose range finding study to assess the safety, tolerability, pharmacodynamics (PK) and pharmacokinetics (PD) of RLS-0071 in healthy adult subjects after challenge…
- Trial name
- NCT05351671
- Testing
- RLS-0071 (10 mg/kg intravenously every 8 hours for total of 3 doses), RLS-0071 (loading dose of 120 mg/kg followed by 40 mg/kg every 8 hours for 2 additional doses)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ReAlta Life Sciences, Inc.
Cardiovascular Disease, Inflammation
Safety and Feasibility of an Endotoxemia Model
The purpose of this study is to establish the safety and feasibility of low dose LPS administration to a small subset of humans in preparation for a larger USDA funded study examining what is the lowest effective dose of EPA +…
- Trial name
- NCT01329965
- Testing
- LPS (reference endotoxin, E. coli O113:H10:K:neg, manufactured under GMP)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Penn State University
Influenza, Human
Effects of p38 MAPK Inhibitor POLB 001 on in Vivo LPS Challenge Responses
A single center trial to evaluate the effect of POLB 001 on inflammatory responses following an intradermal LPS challenge in healthy volunteers.
- Trial name
- NCT05765955
- Testing
- POLB 001
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Poolbeg Pharma plc
Infertility, Female, Infertility
Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI
Female inability to conceive a child. The purpose of this prospective randomized, double-blinded, double dummy, two-arm cross-over study is to investigate the difference on histological, transcriptional and immunological level in…
- Conditions
- Infertility, Female, Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- NCT03677336
- Testing
- Dydrogesterone Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Sepsis, Inflammation
Possible Links Between Inflammation and Lipid Metabolism
It has been recognized lately that sepsis and inflammation has an important impact on lipid metabolism and that the extent of hypocholesterolemia may even be a marker of severity of illness.
- Conditions
- Sepsis, Inflammation, LPS, Lipid Metabolism Disorder
- Trial name
- NCT03392701
- Testing
- LPS infusion
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Barmherzige Brüder Linz
Chronic Obstructive Pulmonary Disease (COPD)
Single Dose Lipopolysaccharide (LPS) Study In Healthy Volunteers
A single dose study with the inhaled anti-inflammatory agent PF-03715455 to establish if it has anti-inflammatory activity following a challenge with LPS.
- Trial name
- NCT01314885
- Testing
- PF-03715455, PH-797804
- Where
- 2 sites in United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Pfizer
Sickness Behavior
Inflammation and Brain Function - Main Study
In this randomized double blind study, 52 healthy participants were injected with either 0.6 ng/kg body weight or placebo to test if changes in pain sensitivity is associated with change in neural activity using BOLD MR scanning.
- Trial name
- NCT03551184
- Testing
- Endotoxin
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Parkinson Disease
Lipoprotein Metabolism and Bacterial Lipopolysaccharide in Parkinson's Disease
Patients with Parkinson's disease (PD) present an impaired intestinal permeability with consequent lipopolysaccharide (LPS) translocation in the systemic circulation.
- Trial name
- LiMBaLiP (NCT03937284)
- Testing
- Patients not treated
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Milan
Cleft Lip and Cleft Palate
Detection of Single Nucleotide Polymorphism (SNP) Rs2235371 of IRF6 Gene in Egyptian Patients with Non-Syndromic Cleft Lip and Palate
The aim of this work is to study the relation between SNP rs2235371 of IRF 6 gene and Non-Syndromic Cleft Lip and Palate in Egyptian Patients in a prospective study
- Trial name
- NCT06730880
- Testing
- PCR
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pit and Fissure Sealant
Clinical Efficiency of Bioactive Pit and Fissure Sealant
This study will compare the performance of newly introduced bioactive resin based pits and fissure sealant versus fluoride releasing filled resin based pits and fissure sealant in posterior molars prone to carious lesions of…
- Trial name
- NCT06493942
- Testing
- BioCoat® by Premier®, UltraSeal XT™ plus by Ultradent
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Inflammation
Immune Cell Response to Stimuli
This study will investigate the response of immune cells (neutrophils, monocytes) to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them.
- Trial name
- NCT00397280
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Caries; Initial, Pit and Fissure Caries
Retention Rate of Self-etch Resin Based Sealant With and Without Prior Sandblasting
The aim of the study is to clinically assess the effect of sandblasting prior to self-etch resin based sealant on its retention after one year follow up.
- Trial name
- NCT04929327
- Testing
- Self etch Pit and fissure sealant application (prevent seal), Self etch Pit and fissure sealant application (prevent seal) with prior sandblasting, Total etch resin based sealant ultraseal xt
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
Development of Novel Non-invasive Inflammometry Following Lipopolysaccharide, Endotoxin (LPS) Challenge in Healthy Volunteers
The aim of this study is to further profile and develop the Lipopolysaccharide, endotoxin (LPS) challenge models (both by instillation and inhalation) by investigating the utility of various non-invasive monitoring methods.
- Trial name
- NCT03044327
- Testing
- LPS challenge
- Where
- Germany
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Pit and Fissure Caries
Wear Resistance Of Bioactive With And Without Etching Vs. Conventional Resin-Based Fissure Sealants
This randomized clinical trial aimed to compare the wear resistance and clinical performance of bioactive versus conventional resin-based pit and fissure sealants over a 12-month period.
- Trial name
- NCT07018141
- Testing
- Bioactive Sealant with Etching: Participants in this group received a fluoride-releasing bioactive pit and fissure sealant (BeautiSealant, Shofu) applied after etching the tooth surface with 37% phosp, Bioactive Sealant without Etching: In this group, the same bioactive sealant (BeautiSealant, Shofu) was applied directly without acid etching. This simplified technique evaluates the sealant's effecti, Conventional Resin-Based Sealant with Etching (Control): This group received a conventional resin-based sealant (Fisseal, Promedica) following standard acid etching. This technique represents the trad
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cardiovascular Diseases
Happy Gut Study - Fermented Vegetables and Cardiovascular Biomarkers
The purpose of this project is to determine whether regular consumption of fermented vegetables can decrease inflammation and change the types of bacteria that are normally present in the large intestine.
- Trial name
- NCT04887662
- Testing
- Fermented vegetable
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of North Florida
Endotoxemia
The Effects of Acetylsalicylic Acid on Immunoparalysis Following Human Endotoxemia
Rationale: The last years, research focus has moved to immunostimulatory agents in order to restore or increase the functionality of the immune system during sepsis-induced immunoparalysis.
- Trial name
- SALYCENDO (NCT02922673)
- Testing
- Aspirin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Asthma
Role of TLR4 in Environmental Asthma
The overall goal of this project is to identify genes that are involved in the development of airflow obstruction and airway inflammation in asthmatics, and to determine whether polymorphisms in these differentially expressed…
- Trial name
- NCT00671892
- Testing
- Lipopolysaccharide endotoxin
- Where
- United States
- Volunteers
- 855 people, healthy volunteers welcome
- Sponsor
- John Sundy