Clinical trials: Labor, Obstetric
Fourth Degree Perineal Laceration Involving Anal Mucosa, Obstetric; Injury
Use of the Modified Beef Tongue Model for Teaching Repair of Obstetrical Fourth-Degree Laceration to Residents
This is a study evaluating the use of the modified beef tongue model for teaching repair of obstetrical fourth-degree laceration to residents.
- Conditions
- Fourth Degree Perineal Laceration Involving Anal Mucosa, Obstetric; Injury, Obstetric Labor Complications
- Trial name
- NCT03341351
- Testing
- Instructional video, Instructional workshop
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obstetric Pain
Effect of Preemptive Epidural Analgesia in Labor on Cytokine Production
During labor there is an increased production of inflammatory mediators called cytokines. Higher concentration of certain cytokines has been linked to adverse neonatal and maternal outcomes.
- Trial name
- NCT00361712
- Testing
- Preemptive epidural analgesia, Standard of care
- Where
- Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Fetal Membranes, Premature Rupture
Myometrial Thickness as a Predictor for the Latency Interval in PPROM
100 women divided into 3 groups: Group I: included 50 women with preterm premature rupture of membranes (PPROM, n=50) with gestational age from 24 to 34 weeks.
- Trial name
- NCT02380560
- Testing
- Ultrasonographic examination
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Premature Obstetric Labor
Progesterone and Aminophylline for the Prevention of Preterm Labour
The aim of this study is to investigate whether the combination of aminophylline and Progesterone (P4) is acceptable to women at high-risk of Pre-term labour (PTL).
- Trial name
- PROGRAM (NCT03152942)
- Testing
- Progesterone, Aminophylline
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- St Stephens Aids Trust
Preterm Labor
Maternal Serum Homocysteine Levels and Uterine Artery Pulsatility Indices in Preterm Labor
Study included all pregnant women admitted with threatened preterm labor during the study period. All participants underwent estimation of maternal serum homocysteine level and assessment of uterine artery Doppler indices.
- Trial name
- NCT03440281
- Testing
- Uterine artery doppler, Maternal serum homocysteine estimation
- Volunteers
- 200 people
- Sponsor
- Benha University
Preterm Labor, Preterm Birth
Biomarkers Associated With Spontaneous Preterm Birth Less Than 32 Wks Gestation
Preterm delivery (PTD) is a leading cause of neonatal mortality and continues to be a major public health concern, reaching 12.9% in 2006, despite intense research to reverse this trend.
- Trial name
- NCT02317315
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ranjith Kamity, MD
Obstetric Labour, Premature
The Safety, Tolerability And Metabolism Of GSK221149A, In Pregnant Women (30-36 Weeks), In Pre-Term Labor
Pre-Term Labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. Oxytocin is a hormone produced by the body during labor.
- Trial name
- NCT00404768
- Testing
- GSK221149A
- Where
- 57 sites in United States, Argentina and 9 more
- Volunteers
- 93 people
- Sponsor
- GlaxoSmithKline
Preterm Labor, Cerebral Palsy
Calcium Channel Blockers Compared to Magnesium Sulfate in Fetal Cerebral Blood Flow
The aim of this study is to investigate the possible use of calcium channel as a neuroprotectant in cases with PTL. This will be done by comparing the effect they have on cerebral blood vessels with the already established MgSo4.
- Trial name
- NCT02591004
- Testing
- Magesium sulphate, Nifedipine, Doppler on fetal middle cerebral artery
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Premature Birth, Premature Labor
Electrical Inhibition (EI): A Preliminary Study To Inhibit Preterm Labor And Preterm Birth
An electrical-inhibition (EI) uterine pacemaker device similar to an electrical heart pacemaker delivers a weak electrical current to the human uterus during active preterm labor to rapidly and safely inhibit the unwanted…
- Trial name
- EI (NCT02569216)
- Testing
- Electrical Inhibition (EI)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Preterm Labor
Prediction of Preterm Labor in Asymptomatic High Risk Women
Two hundred and twenty women with singleton pregnancies and risk factors for spontaneous preterm birth were included in this study.
- Trial name
- NCT03334877
- Testing
- β -human chorionic gonadotropin
- Volunteers
- 220 people
- Sponsor
- Zagazig University
Preterm Labor
A Phase 2 Study of OBE001 Versus Placebo in the Delay of Preterm Birth
The primary objective of this study is to assess the efficacy of a single dose of OBE001, an oral oxytocin antagonist, given for up to 7 days to delay preterm birth by 7 days compared to placebo.
- Trial name
- TERM (NCT02326142)
- Testing
- OBE001
- Where
- 23 sites in Belgium, Germany and 4 more
- Volunteers
- 10 people
- Sponsor
- ObsEva SA
Preterm Labor
Progestrone and Doppler Indices
The aim of our study is to assess the effect of vaginal progestrone on fetal and maternal doppler indices
- Trial name
- NCT03292939
- Testing
- A complete Doppler flow assessment of the maternal and fetal circulation
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kasr El Aini Hospital
Preterm Delivery
Efficacy of Oral Progesterone and Vaginal Progesterone After Tocolytic Therapy in Threatened Preterm Labor
The purpose of this study is to determine efficacy of vaginal and oral progesterone after tocolytic therapy in threatened preterm labor
- Trial name
- NCT02989519
- Testing
- dydrogesterone, Micronized progesterone
- Where
- Thailand
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Sanpasitthiprasong Hospital
Labor Complication, Labor Pain
Wide Use of Paperless Partograph in Evaluation of Labour
Paperless partograph wide using in labour room as simple tool in evaluation of labour
- Trial name
- labourRecord (NCT03276117)
- Where
- 6 sites in Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Labor Complication
Paperless Parotograph in Evaluation of Labour
Using Paperless partograph management of labour as simple tool to prevent obstructed labour or prolonged labour or its complications at the mother or her fetus
- Trial name
- labourRecord (NCT03272282)
- Where
- 2 sites in Egypt
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Assiut University
Preterm Labor
The Impact of Cervical Cerclage or Vaginal Progesterone on Vaginal Microbiome Distribution
A comparative evaluation to evaluate the correlation between cervical cerclage or vaginal progesterone and maternal vaginal microbiome distribution during pregnancy
- Trial name
- NCT03253016
- Testing
- vaginal swab -microbiome test and blood test for cytokines
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Western Galilee Hospital-Nahariya
Chronic Periodontitis, Preterm Labor
Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis
This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic…
- Trial name
- NCT03171675
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Preterm Labor
Maternal Serum Amyloid A Levels in Pregnancies Complicated With Preterm Labour.
The aim of the current study is to assess the accuracy of maternal serum amyloid A for prediction of preterm labor in women with threatened preterm labor.
- Trial name
- NCT03205020
- Testing
- serum amyloid a test
- Where
- Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- mona nematallah
Obstetric Labor, Labor Onset
The Prognostic Value of Cervical Elastography for Identifying Patients at Risk for Preterm Delivery
The hypothesis tested is that the physical changes associated with cervical ripening result in a detectable decrease in rigidity.
- Conditions
- Obstetric Labor, Labor Onset, Obstetric Labor, Premature
- Trial name
- ElastoMAP (NCT02021539)
- Testing
- Cervical ultrasound +elastography 1, Vaginal fibronectin measurement, Tocolytic treatment for 2 hours
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Obstetric Labour, Premature
A Two Cohort Study to Look at the Metabolites of GSK221149, the Metabolism of GSK221149 Administered With a High Fat Meal and With Ketoconazole
This is a two part study. Part A of the study will evaluate the metabolites of GSK221149 following single and repeat oral dosing and will also assess the pharmacokinetics of GSK221149 when administered with a potent CYP3A4…
- Trial name
- NCT01627587
- Testing
- GSK221149 750 mg, Ketoconazole, GSK221149 100 mg
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline