Clinical trials: Labor, Obstetric
Premature Birth of Newborn, Critically Ill
The Use of Methadone in Newborn Infants
This proposed investigation will test the following hypotheses: 1) Enzymatic activity of CYP2B6 characterized by the formation clearance of methadone to EDDP (CLf,EDDP), is directly related to both gestational and postnatal age…
- Trial name
- Methadone (NCT01327079)
- Testing
- Methadone
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- John van den Anker
Pre-Term
MusicHyperBrain Study With Preterm Infants and Their Parents
Inter-personal brain coupling between preterm infants, their parents and a musician during Creative Music Therapy using functional near-infrared imaging (fNIRI) hyperscanning and systemic physiology measurements
- Trial name
- NCT05383586
- Testing
- Creative Music Therapy
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Premature Birth, Extreme Prematurity
The Pilot Experimental Study of the Neuroprotective Effects of Exosomes in Extremely Low Birth Weight Infants
To study the safety and efficacy of intranasal administration of exosomes derived from mesenchymal stromal cells on long-term neurodevelopmental outcome in extremely low birth weight infants born at gestational age 25/0-27/6…
- Conditions
- Premature Birth, Extreme Prematurity, Preterm Intraventricular Hemorrhage, Hypoxia-Ischemia, Cerebral
- Trial name
- NCT05490173
- Testing
- Exosomes derived from mesenchymal stromal cells (MSCs)
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Microbial Colonization, Extreme Prematurity
NICU Antibiotics and Outcomes Trial
The goal of the NANO trial is to study the longstanding clinical practice of empirically administering intravenous antibiotics to extremely low birthweight (ELBW) infants in the first days of life.
- Conditions
- Microbial Colonization, Extreme Prematurity, Early-Onset Neonatal Sepsis, Late-Onset Neonatal Sepsis
- Trial name
- NANO (NCT03997266)
- Testing
- Ampicillin, Gentamycin, Normal saline
- Where
- 14 sites in United States
- Volunteers
- 359 people
- Sponsor
- Michael Morowitz
Morbidly Adherent Placenta
Psychological Outcome of Women With Morbidly Adherent Placenta Following Hystrectomy
The purpose of this study is to investigate the risk of postoperative psychiatric disorders of depression, anxiety outcomes and sexual dysfunctions and self esteem disturbance in women with morbidly adherent placenta following…
- Trial name
- NCT03976453
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Pregnancy Related, Hemorrhage
The Effect of Fluids on Aortic VTI During C-section
Pregnancy is associated with a myriad of physiologic changes, including expansion of blood volume, decrease in oncotic pressure, and increased cardiac output. The obstetric population is associated with intrapartum hemorrhage.
- Conditions
- Pregnancy Related, Hemorrhage, Fluid Overload, Labor Complication
- Trial name
- NCT04330742
- Testing
- lactated ringers
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Preterm Birth, Complication of Prematurity
Single Dose Antenatal Corticosteroids (SNACS) for Women at Risk of Preterm Birth
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities, such as respiratory distress syndrome, in preterm infants.
- Conditions
- Preterm Birth, Complication of Prematurity, Obstetric Labor, Premature, Obstetric Labor Complications
- Trial name
- SNACS Pilot (NCT04494529)
- Testing
- 24 mg betamethasone
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Nursing Care, Mother-Infant Interaction
Preterm Newborn Mothers' Anxiety and Self-Efficacy
The aim of this study was to evaluate the effect of QR code supported infant care training given to mothers of preterm newborns on maternal self-efficacy and maternal anxiety level .
- Conditions
- Nursing Care, Mother-Infant Interaction, Education
- Trial name
- NCT06359288
- Testing
- Group receiving QR code supported training
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Maternal Infection During Pregnancy (Diagnosis), Neonatal Infection
Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic Prophylaxis
The primary aim of this study is to determine if antibiotics combined with immediate induction can significantly reduce the rate of maternal and neonatal infection compared with immediate induction alone in women presenting with…
- Trial name
- NCT02985086
- Testing
- Cefoxitin, oxytocin/misoprostol
- Where
- 2 sites in Portugal
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Hospital de Santa Maria, Portugal
Preterm Membrane Rupture, Neonatal Sepsis
Comparison of the Effectiveness of Two Different Antibiotic Regimens of the Treatment of Pregnant Women With Preterm Rupture of Membranes
There is no consensus around the world on the treatment of preterm rupture of membranes, which is one of the important causes of early neonatal sepsis and one of the common causes of prematurity.
- Trial name
- NCT04528251
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Preterm Birth, Neurodevelopmental Disorders
Swaddling to Improve Neurodevelopment for Preterm Babies
The investigators will test a new medical grade swaddling system for optimal and more appropriate positioning for preterm infants. This is a trial focused on sleep state, state regulation and long-term neurodevelopment.
- Trial name
- NCT04715451
- Testing
- Novel Swaddle
- Sponsor
- Johns Hopkins University
Pregnancy, Pregnancy Complications
AI-POCUS for Maternal and Neonatal Health in Ethiopia
Maternal and neonatal health remains one of the most pressing global health challenges, particularly in low- and middle-income countries (LMICs).
- Conditions
- Pregnancy, Pregnancy Complications, Preterm Birth, Fetal Growth Restriction
- Trial name
- AIM-ETH (NCT07171086)
- Testing
- AI-POCUS (BabyChecker, Delft Imaging), AI-POCUS (Edan, China)
- Where
- Ethiopia
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Premature Rupture of Membranes
I.V Papavrine for Labor Induction in Term PROM
This prospective randomized controlled trial aims to evaluate whether intravenous administration of papaverine 12 hours after term PROM reduces the interval from membrane rupture to delivery and improves maternal and neonatal…
- Trial name
- NCT07517796
- Testing
- Papaverine arm
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Preterm Infant, Body Temperature
Air vs. Cutaneous Control Mode for Preterm Infants ≤ 32 WG in Incubators: Impact on Body Growth and Morbidity
Previous studies have shown that mortality and morbidity in preterm neonates are correlated with the fall in body temperature on admission. Hypothermia can be decreased by reducing body heat losses to the environment.
- Trial name
- ThermoKPreterm (NCT03919188)
- Testing
- air temperature control (ATC), skin servocontrol (SSC)
- Where
- France
- Volunteers
- 164 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Placenta Accreta, Placenta Percreta
Cell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion .
Cell free fetal DNA might predict abnormal placental invasion
- Conditions
- Placenta Accreta, Placenta Percreta, Placenta Increta, Placenta Previa
- Trial name
- NCT03638024
- Testing
- Maternal plasma cell free fetal DNA levels
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams Maternity Hospital
Necrotising Enterocolitis
Imaging Modalities in Diagnosing Necrotizing Enterocolitis in Preterm Infants.
Background Necrotizing enterocolitis (NEC) is one of the most serious conditions in newborns, affecting up to 10% of very low birth weight infants (VLBW). In the most premature population mortality rates can rise as high as 60%.
- Trial name
- NCT03188380
- Testing
- Plain abdominal radiography, Abdominal ultrasound
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Antenatal Care, Maternal Health
AI Blind-Sweep Ultrasound for Antenatal Screening by Non-Specialist Health Workers in Rural DR Congo
FS2 evaluates the diagnostic accuracy and implementation feasibility of an AI-assisted blind-sweep obstetric ultrasound (SPAQ E-con AI), operated by trained non-specialist health workers, for antenatal screening in rural…
- Conditions
- Antenatal Care, Maternal Health, Gestational Age, Placenta Praevia
- Trial name
- FS2 (NCT07677670)
- Testing
- SPAQ E-con AI blind-sweep ultrasound
- Where
- Democratic Republic of the Congo
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- SOIK Corporation Sarl
Breech Presentation
Discourse on the Mother's Decision Regarding the Mode of Delivery in Cases of Breech Presentation
Breech presentation is a common occurrence in routine practice, occurring in 3-4% of all term pregnancies. Despite its frequency, breech presentation at term remains a subject of considerable controversy within the medical…
- Trial name
- DISCOURS-SIEGE (NCT07314970)
- Testing
- To complete a questionnaire
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Premature Rupture of Membranes (PROM)
Planned Early Induction of Labor vs Expectant Management for PROM
The goal of this randomized controlled trial is to compare planned early induction of labor with expectant management in women with term premature rupture of membranes (PROM) at 37-42 weeks of gestation.
- Trial name
- NCT07802041
- Testing
- Induction of labor with PGE2, Expectant management
- Where
- Pakistan
- Volunteers
- 734 people
- Sponsor
- Pakistan Institute of Medical Sciences
Psychological Distress
Preventing Premature Family Maladjustment: an e-Health Interdisciplinary Research
The consequences of preterm birth extend beyond the clinical conditions of the newborn, profoundly impacting the functioning and well-being of families.
- Trial name
- e-ParWelB (NCT06495762)
- Testing
- e-health assesment
- Where
- 6 sites in Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
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