Clinical trials: Left Main Coronary Artery Disease
Coronary Stenosis, Stent Stenosis
Culotte Versus DK-CRUSH Technique in Non-left Main Coronary Bifurcation Lesions
Randomised comparison of Culotte technique versus "Double Kissing" - Crush technique (DK-Crush) for the percutaneous treatment of de novo non-left main coronary bifurcation lesions with modern everolimus-eluting stents (DES) …
- Trial name
- BBK-3 (NCT04192760)
- Testing
- Stenting
- Where
- 13 sites in Germany
- Volunteers
- 400 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Coronary Artery Disease
Ten-Year Outcomes of PRE-COMBAT Trial
This study evaluates Ten-Year Outcomes of PREmier of Randomized Comparison of Sirolimus-Eluting Stent Implantation Versus Coronary Artery Bypass Surgery for Unprotected Left Main Coronary Artery Stenosis(PRECOMBAT trial).
- Trial name
- PRECOMBAT (NCT03871127)
- Testing
- Percutaneous coronary intervention, coronary artery bypass graft
- Where
- 9 sites in South Korea
- Volunteers
- 600 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease
Simple Crossover Versus Side Branch Opening in Patients With Non-Left Main Bifurcation Lesion
Hypothesis: Simple crossover strategy would be non-inferior to SB opening strategy in the risk of target lesion failure (TLF) in patients with angiographically compromised SB (visually SB stenosis ≥50%) after provisional MV…
- Trial name
- CROSS-COBIS (NCT05705362)
- Testing
- Simple Crossover, Side branch opening
- Volunteers
- 1,000 people
- Sponsor
- Keimyung University Dongsan Medical Center
Coronary Artery Disease
Outcomes of Surgically Ineligible Patients With Multivessel CAD
The OPTIMUM registry is a minimal risk observational study that uses a prospective cohort design to follow patients who have multivessel or left main coronary artery disease ("surgical anatomy" according to ACC/AHA…
- Trial name
- OPTIMUM (NCT02996877)
- Where
- 21 sites in United States
- Volunteers
- 750 people
- Sponsor
- Saint Luke's Health System
Coronary Arteriosclerosis, Left Main Coronary Artery Disease
Registry on Left Main Coronary Artery Bifurcation Percutaneous Intervention
The slowly accruing evidence on the treatment of patients with left main coronary artery (LMCA) disease drove evolution in guidelines, that currently establish equivalent safety and efficacy for percutaneous coronary intervention…
- Trial name
- WE REMAIN EBC (NCT04321473)
- Testing
- PCI on left main
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Coronary Artery Disease, Left Main Coronary Artery Disease
IVUS VS CAG Guided PCI for Patients With LMB Lesion
To compare the 3 - year clinical follow - up results of patients with left main bifurcation lesions treated by intravascular ultrasound(IVUS) - guided and coronary angiography(CAG) - guided percutaneous coronary…
- Trial name
- Infinite (NCT04072003)
- Testing
- intravascular ultrasound (IVUS), coronary angiography
- Volunteers
- 616 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease
Xience Versus Synergy in Left Main PCI
A prospective, randomized, multicenter study in patients with an indication for coronary artery revascularisation who have been accepted for percutaneous coronary intervention (PCI) of the left main coronary artery.
- Trial name
- IDEAL-LM (NCT02303717)
- Testing
- Percutaneous coronary intervention, Dual antiplatelet therapy
- Volunteers
- 818 people
- Sponsor
- NHS National Waiting Times Centre Board
Coronary Disease
Drug-eluting Stents to Treat Unprotected Coronary Left Main Disease
The purpose of this study is to evaluate the efficacy of two different drug-eluting stents (Everolimus and Zotarolimus-eluting) for treatment of unprotected left main coronary artery disease.
- Trial name
- LEFT-MAIN-2 (NCT00598637)
- Testing
- Everolimus-eluting stent (Xience), Zotarolimus-eluting stent (Endeavor Resolute)
- Where
- 4 sites in Germany, Italy
- Volunteers
- 650 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Coronary Artery Disease Left Main
Imaging and Physiology for Intermediate Left Main Stem Stenosis
The present research aims to determine the impact of stenoses in downstream vessels on the FFR and iFR measurements of left main coronary artery (LMCA) stenoses of intermediate severity as determined by coronary angiography.
- Trial name
- VIP-LMS (NCT04531007)
- Testing
- iFR/ FFR/ IVUS/ OCT
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
ST Elevation Myocardial Infarction, Remodeling, Left Ventricle
Predictors of Adverse Left Ventricular Remodeling and Final Infarct Size After Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction: A Strain Analysis Study Using Echocardiography and Feature Tracking Cardiac Magnetic Resonance
ST-segment elevation myocardial infarction (STEMI) is one of the most important causes of death and disability around the world.
- Trial name
- NCT04773652
- Testing
- speckle tracking echo
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Coronary Artery Disease
Double Rewire Versus Double Kissing Crush Stenting Technique in Left Main Bifurcation Lesions
The DR vs DK trial is designed to elucidate the benefits of Double Rewire crush technique (DR-Crush) over Double Kissing Crush (DK-Crush) technique in patients with Unprotected Left Main Bifurcation lesions (ULMb).
- Trial name
- DR vs DK crush (NCT05258318)
- Testing
- DK crush, DR crush
- Sponsor
- Fundación EPIC
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Coronary Artery Disease
Jailed-balloon Technique in Coronary Bifurcation Lesion PCI
This study aims to test the hypothesis that jailed-balloon technique(JBT) is superior to jailed-wire technique(JWT) in non-left main coronary bifurcation percutaneous coronary intervention(PCI) by lowering the risk of side…
- Trial name
- JBTinCBL (NCT02167230)
- Testing
- Jailed-balloon technique, Jailed-wire technique
- Where
- 2 sites in China
- Volunteers
- 410 people
- Sponsor
- Guangdong Provincial People's Hospital
LCx Occlusion STEMI, STEMI
Outcomes of Isolated LCx Occlusion
To assess procedural success and short term clinical outcomes of primary PCI to isolated LCx acute occlusion.
- Trial name
- NCT06750328
- Volunteers
- 50 people
- Sponsor
- Assiut University
Coronary Artery Disease, Coronary Artery Disease (Left Main)
Optimization of Complex Percutaneous Coronary Intervention With Liberal Use of Intracoronary Imaging Versus Contemporary Practice
Coronary artery disease remains a leading cause of mortality worldwide and is commonly treated with percutaneous coronary intervention (PCI). Typically, PCI is guided by invasive coronary angiography (ICA).
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (Left Main), Chronic Total Occlusion (CTO), Bifurcation Coronary Artery Disease
- Trial name
- OPTIMIZE-PCI 2 (NCT07114393)
- Testing
- Liberal use of intracoronary imaging during complex PCI
- Where
- Netherlands
- Volunteers
- 11,092 people
- Sponsor
- Cathreine BV
Coronary Bifurcation Lesion, Coronary Artery Disease (CAD)
Crossover vs Accurate Ostial PCI for Medina 0.0.1 and 0.1.0 Left Main Bifurcation Lesions
Coronary artery disease is a leading cause of mortality and morbidity globally. The left coronary artery system is critically important due to its supply of a large area of myocardium.
- Conditions
- Coronary Bifurcation Lesion, Coronary Artery Disease (CAD), Left Main Coronary Artery Stenosis
- Trial name
- NCT07596706
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Restenosis, Coronary, Left Main Coronary Artery Disease
PCI vs. CABG in UPLM-ISR
Left main (LM) coronary artery disease is associated with high morbidity and mortality owing to the large myocardial territory at risk for ischemia.
- Conditions
- Restenosis, Coronary, Left Main Coronary Artery Disease, PTCA Left Main Artery Complications
- Trial name
- LM-DRAGON (NCT04968977)
- Testing
- PCI vs. CABG
- Where
- 11 sites in Italy, Poland
- Volunteers
- 305 people
- Sponsor
- Medical University of Silesia
Coronary Artery Disease, Coronary Artery Bypass Grafting
Total Arterial vs. Mixed Grafting in Left Coronary CABG
This is a prospective, randomized, double-blind controlled trial comparing the clinical efficacy of total arterial grafting (internal thoracic artery and radial artery) versus conventional mixed grafting (internal thoracic artery…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Arterial Graft, Graft Patency
- Trial name
- NCT07057713
- Testing
- Total Arterial Grafting, Conventional Mixed Grafting
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Hospital of Jilin University
ST Elevation Myocardial Infarction, Ventricular Remodeling
Impact of Ischemic Post-conditioning
Study will investigate \& compare the left ventricular remodeling \& systolic function between two groups of ST-elevation myocardial infarction undergoing primary per-cutaneous coronary intervention applying ischemic…
- Conditions
- ST Elevation Myocardial Infarction, Ventricular Remodeling, Ventricular Dysfunction, Ischemic Reperfusion Injury
- Trial name
- NCT04068116
- Testing
- Primary per-cutaneous coronary intervention
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pulmonary Arterial Hypertension
COMPression of Left Main coRonary artEry in patientS With Pulmonary Arterial Hypertension aSymptomatIc fOr aNgina
The prevalence of critical ab extrinsic compression of left main coronary artery (LMCA) is very high in patients with pulmonary arterial hypertension (PAH) symptomatic for angina (up to 40% according to a recent study of 121…
- Trial name
- COMPRESSION (NCT05413109)
- Testing
- Coronary CT angiography
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna