Clinical trials: Left Main Coronary Artery Disease
Myocardial Infarction, Myocardial Ischemia
Does OCT Optimise Results of Stenting on the Left Main Stem
The DOCTORS-LM study will investigate the impact of using optical coherence tomography (OCT) to guide the procedure in angioplasty of lesions of the left main stem responsible for myocardial ischemia.
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Non ST Segment Elevation Myocardial Infarction
- Trial name
- DOCTORS-LM (NCT04391413)
- Testing
- Use of OCT to guide the angioplasty procedure
- Where
- 12 sites in France
- Volunteers
- 197 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Coronary Artery Stenosis, Myocardial Revascularization
Study of Unprotected Left Main Stenting Versus Bypass Surgery (LE MANS Study)
Unprotected left main coronary artery (ULMCA) stenting, offering restoration of a native flow to left coronary artery, is the subject of intense investigations as a potential alternative to bypass surgery.
- Conditions
- Coronary Artery Stenosis, Myocardial Revascularization, Myocardial Ischemia
- Trial name
- NCT00375063
- Testing
- Percutaneous Coronary Intervention, Coronary Artery Bypass Grafting
- Where
- 5 sites in United States, Poland
- Volunteers
- 130 people
- Sponsor
- Ministry of Science and Higher Education, Poland
Acute Coronary Syndrome, Stable Chronic Angina
Angiographic Control Vs. Ischemia-driven Management of Patients Treated with PCI on Left Main with Drug-eluting Stents
The present study aims to compare a planned angiographic control (PAC) follow-up strategy vs. conservative management for patients treated with drug-eluting stents on unprotected left main artery in a prospective, randomized…
- Conditions
- Acute Coronary Syndrome, Stable Chronic Angina, Coronary Artery Disease, Left Main Coronary Artery Disease
- Trial name
- PULSE (NCT04144881)
- Testing
- coronary computed tomography
- Where
- 3 sites in Italy
- Volunteers
- 606 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
ST Elevation Myocardial Infarction (STEMI)
Effect of Very Early and Rapid Lowering Cholesterol With Evolocumab on Left Ventricular Remodeling in Patients With Anterior STEMI Undergoing Primary PCI
For patients with anterior ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), whether early application of proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors to…
- Trial name
- EVALUATE-STEMI (NCT05613426)
- Testing
- Rosuvastatin 20 mg, Evolocumab 140 mg/1 ml Subcutaneous Solution [REPATHA]
- Where
- 6 sites in China
- Volunteers
- 119 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
ST Elevation Myocardial Infarction
Effect of DLBS1033 After Primary PCI in Patients With STE-ACS
This is a prospective, randomized, double-blind, double-dummy, and controlled clinical study over a total of 4-week therapy with DLBS1033 in the management of STE-ACS after a primary PCI.
- Trial name
- NCT02976701
- Testing
- DLBS1033, Standard therapy
- Where
- Indonesia
- Volunteers
- 23 people
- Sponsor
- Dexa Medica Group
Coronary Artery Disease (CAD), Chronic Coronary Syndrome
"Expert IVUS-Eye" vs. IVUS-guided Left Main Bifurcation PCI
This is a prospective, randomized, controlled trial comparing two strategies for optimizing stent implantation during bifurcation stenting of the left main coronary artery (LM): an intravascular ultrasound (IVUS)-guided approach…
- Conditions
- Coronary Artery Disease (CAD), Chronic Coronary Syndrome, Left Main Coronary Artery Disease, Coronary Bifurcation Lesion
- Trial name
- EYE-IVUS LM (NCT07711106)
- Testing
- IVUS-Guided LM PCI, "Trained Eye" (Angiography-Guided) LM PCI
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Coronary Artery Disease
Outcomes of Surgically Ineligible Patients With Multivessel CAD
The OPTIMUM registry is a minimal risk observational study that uses a prospective cohort design to follow patients who have multivessel or left main coronary artery disease ("surgical anatomy" according to ACC/AHA…
- Trial name
- OPTIMUM (NCT02996877)
- Where
- 21 sites in United States
- Volunteers
- 750 people
- Sponsor
- Saint Luke's Health System
Coronary Artery Disease Left Main
Imaging and Physiology for Intermediate Left Main Stem Stenosis
The present research aims to determine the impact of stenoses in downstream vessels on the FFR and iFR measurements of left main coronary artery (LMCA) stenoses of intermediate severity as determined by coronary angiography.
- Trial name
- VIP-LMS (NCT04531007)
- Testing
- iFR/ FFR/ IVUS/ OCT
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Multivessel Coronary Artery Disease
Insights From the FAST-TRACK CABG Trial: a Clinical Outcome Study in Patient With Previous Surgical Revascularization for Complex Three-vessel or Left Main Coronary Artery Disease Based on Coronary Computed Tomography Angiogram, and Fractional Flow Reserve Derived by Computed Tomography
Coronary computed tomography angiography (CCTA) is a non-invasive imaging tool that characterizes coronary artery anatomy and provides detailed assessments of plaque morphology, composition , inflammation, and hemodynamics, which…
- Trial name
- FAST-CABG (NCT07628270)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Centro Cardiologico Monzino
Restenosis, Coronary, Left Main Coronary Artery Disease
PCI vs. CABG in UPLM-ISR
Left main (LM) coronary artery disease is associated with high morbidity and mortality owing to the large myocardial territory at risk for ischemia.
- Conditions
- Restenosis, Coronary, Left Main Coronary Artery Disease, PTCA Left Main Artery Complications
- Trial name
- LM-DRAGON (NCT04968977)
- Testing
- PCI vs. CABG
- Where
- 11 sites in Italy, Poland
- Volunteers
- 305 people
- Sponsor
- Medical University of Silesia
STEMI - ST Elevation Myocardial Infarction (MI), Primary PCI - STEMI
Early Intracoronary N-Acetylcysteine During Primary PCI in STEMI: A Pilot Randomized Trial of Reperfusion Injury Biomarkers and Functional Recovery
Myocardial ischemia-reperfusion injury still poses a major therapeutic challenge in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).
- Trial name
- NCT06850831
- Testing
- Antipac
- Where
- Indonesia
- Volunteers
- 110 people
- Sponsor
- dr. Ahmad Yasa, Sp.JP, Subsp.K.I.(K), M.Kes, FIHA, FasCC, FA
Coronary Artery Disease
PCI vs. CABG in the Treatment of Unprotected Left Main Stenosis
Coronary Artery Bypass Grafting Versus Drug Eluting Stent Percutaneous Coronary Angioplasty in the Treatment of Unprotected Left Main Stenosis.
- Trial name
- LeftMain/NOBLE (NCT01496651)
- Testing
- Percutaneous coronary intervention, Coronary artery bypass graft operation
- Where
- Denmark
- Volunteers
- 1,201 people
- Sponsor
- Evald Hoej Christiansen
Coronary Stenosis
POLish Bifurcation Optimal Treatment Strategy Study for Left Main Bifurcation Percutaneous Coronary Intervention (PCI)
The primary objective of this study is to study the safety and efficacy of the BiOSS LIM C with respect to Patient oriented Composite Endpoint (PoCE) at 12 months in a "real world" left-main bifurcation population and as compared…
- Trial name
- POLBOS-LM (NCT03508219)
- Testing
- BiOSS LIM C
- Where
- 15 sites in France, Italy and 1 more
- Volunteers
- 130 people
- Sponsor
- ECRI bv
Coronary Artery Disease, Left Main Coronary Artery Disease
IVUS VS CAG Guided PCI for Patients With LMB Lesion
To compare the 3 - year clinical follow - up results of patients with left main bifurcation lesions treated by intravascular ultrasound(IVUS) - guided and coronary angiography(CAG) - guided percutaneous coronary…
- Trial name
- Infinite (NCT04072003)
- Testing
- intravascular ultrasound (IVUS), coronary angiography
- Volunteers
- 616 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease
Observational Study for Left Main Disease Treatment
The purpose of this study is to observe clinical courses for long-term in patients with unprotected LMCA disease and to evaluate comparative results of medical treatment, coronary stenting with drug-eluting stents, and CABG for…
- Trial name
- IRIS-MAIN (NCT01341327)
- Where
- 42 sites in China, Malaysia and 3 more
- Volunteers
- 10,000 people
- Sponsor
- Seung-Jung Park
ST Elevation Myocardial Infarction, Remodeling, Left Ventricle
Predictors of Adverse Left Ventricular Remodeling and Final Infarct Size After Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction: A Strain Analysis Study Using Echocardiography and Feature Tracking Cardiac Magnetic Resonance
ST-segment elevation myocardial infarction (STEMI) is one of the most important causes of death and disability around the world.
- Trial name
- NCT04773652
- Testing
- speckle tracking echo
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Acute Myocardial Infarction, Ventricular Remodeling
Thrombectomy and Improvement of Left Ventricular Function in AMI
To study the effect of a simple and fast 'modus operandi' by aspiration of thrombus and debris with the Export catheter in an acute occlusion, on microvascular (re)perfusion and late left ventricular remodeling.
- Trial name
- NCT00288665
- Testing
- Export catheter (Medtronic)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- R&D Cardiologie
Left Main Coronary Artery Stenosis
Ultrathin-strut Biodegradable Polymer Sirolimus-eluting Stents With P2Y12 Inhibitor-based Single Antiplatelet Therapy vs. Conventional DAPT for Unprotected Left Main Coronary Artery Disease (ULTIMATE-LM)
The management of patients with unprotected left main coronary artery (LMCA) disease undergoing percutaneous coronary intervention (PCI) in contemporary interventional cardiology practice remains matter of intense debate.
- Trial name
- ULTIMATE-LM (NCT05650411)
- Testing
- LMCA PCI with Supraflex Cruz ultrathin-strut biodegradable polymer sirolimus-eluting stent (Sahajanand Medical Technologies Ltd., Surat, India)., P2Y12 inhibitor-based SAPT after short DAPT, Conventional DAPT
- Where
- Switzerland
- Volunteers
- 828 people
- Sponsor
- IGLESIAS Juan Fernando
Left Main Coronary Artery Disease, Left Anterior Descending Coronary Artery Stenosis
Prospective Evaluation for Hybrid Cardiac Procedures
Multidisciplinary team-approach in order to offer personalized treatments represents the emerging mainstream in cardiovascular medicine.
- Conditions
- Left Main Coronary Artery Disease, Left Anterior Descending Coronary Artery Stenosis, Valve Disease, Heart, Carotid Stenosis
- Trial name
- PERHAPS (NCT05143671)
- Testing
- Coronary artery bypass grafting, Percutaneous coronary intervention, Surgical valve replacement
- Where
- Italy
- Volunteers
- 134 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease, Coronary Stenosis
Ultrathin DES in Complex PCI Scenarios: the ULTRA a Multicenter Study
ULTRA is a multicenter, observational, retrospective registry, enrolling consecutive patients treated with ultrathin coronary DES (coronary stent with strut thickness < 70 um) for coronary bifurcation lesions, left main disease…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Stent Restenosis, Left Main Coronary Artery Disease
- Trial name
- ULTRA (NCT05205148)
- Testing
- Percutaneous coronary intervention with the following platforms: Orsiro; Mistent; BioMime; Supraflex Cruz
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- A.O.U. Città della Salute e della Scienza