Clinical trials: Left Side
Left Bundle-Branch Block, Electrocardiographic Pattens
Clinical, Structural and Mechanical Features in Patients With Left Bundle Branch Block.
Clinical, structural and mechanical features in patients with left bundle branch block.
- Conditions
- Left Bundle-Branch Block, Electrocardiographic Pattens, Clinical Features
- Trial name
- NCT04328649
- Volunteers
- 250 people
- Sponsor
- Policlinico Casilino ASL RMB
Atrial Fibrillation (AF)
LA Function After PFA in Paroxysmal AF
A prospective study that investigates the changes in LA echocardiographic parameters after PFA for paroxysmal AF.
- Trial name
- NCT07439016
- Testing
- LA and LAA function measurements
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Colorectal Cancer Metastatic
FOLFOXIRI Plus Panitumumab in Metastatic RAS Wild-type, Left-sided Colorectal Cancer
This is a phase II, open-label, non-randomized study in subjects with histologically confirmed diagnosis of left-sided RAS WT advanced adenocarcinoma of the colon or rectum who have not received prior systemic therapy for…
- Trial name
- NCT04169347
- Testing
- Oxaliplatin
- Where
- 8 sites in United States
- Volunteers
- 27 people
- Sponsor
- Criterium, Inc.
Brain Ischemia, Reduction of Cerebral Air Emboli
Comparative Effectiveness of Unilateral vs. Bilateral Pulmonary Collapse in Cardiac De-airing
To compare the effectiveness of unilateral pulmonary collapse (right lung) to bilateral pulmonary collapse for cardiac de-airing in open left-sided heart surgery.
- Trial name
- NCT02119871
- Testing
- Bilateral Open Pleurae, Right Pleura Open
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Lund University
Heart Failure, Exercise Tolerance
Effects of Atrial Rate-adaptive Pacing on Exercise Capacity in Patients With Chronic Heart Failure Complicated by Chronotropic Incompetence
Chronotropic incompetence consists of an insufficient increase in heart rate during effort, and its presence is recognized as a common feature in patients with heart failure due to left ventricular systolic dysfunction…
- Trial name
- NCT01016431
- Testing
- Rate-adaptive pacemaker programming, VVI at 40 bpm
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Federico II University
Atrial Fibrillation
Left Atrial Appendage Closure in Combination With Catheter Ablation
This study is a prospective cohort study aimed at investigating the efficacy and safety of left atrial appendage closure in combination with catheter ablation in patients with atrial fibrillation.
- Trial name
- LAACablation (NCT03788941)
- Testing
- left atrial appendage closure and catheter ablation
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Heart Failure
Interval Versus Continuous Training in LVAD Patients
Patients with a left ventricular assist device (LVAD) will be randomized to either a moderate continuous (MCT, 50-60% of VO2peak) or interval training (IT, 80-90% of VO2peak) group for 6 weeks with 3 sessions per week, lasting…
- Trial name
- TrainLVAD (NCT05121077)
- Testing
- Training
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital, Essen
Single Ventricle Defect
Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction
This study seeks to determine cerebral blood flow changes in single ventricle patients during staged surgical reconstruction as compared with normal children.
- Trial name
- CBF (NCT02135081)
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Children's Hospital of Philadelphia
Burns Chest Left Lateral, Burns Chest Right Lateral
Virtual Reality Distraction Technique to Improve Chest Burns With Acute Respiratory Distress Syndrome
Inhalation of toxic gases and chemical irritants during the fire leads to damage to the respiratory tract or the alveolar tissue, which is known as smoke inhalation injury.
- Conditions
- Burns Chest Left Lateral, Burns Chest Right Lateral, Acute Respiratory Distress Syndrome
- Trial name
- NCT05692557
- Testing
- Virtual reality, Progressive muscle relaxation
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Transcatheter Aortic Valve Replacement
Prognostic Factors in NOP-LBBB After TAVI
The goal of this observational study is to find prognostic factors in patients with a new-onset persistent left bundle branch block (NOP-LBBB) after transcatheter aortic valve implantation (TAVI).
- Trial name
- ProgNOP-LBBB (NCT05654792)
- Testing
- Transcatheter aortic valve implantation
- Volunteers
- 230 people
- Sponsor
- Central Hospital, Nancy, France
Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
Yiqi Fumai Lyophilized Injection for Chronic Heart Failure Caused by Coronary Heart Disease
This study will evaluate whether adding Yiqi Fumai lyophilized injection to stable guideline-directed treatment improves symptoms, physical limitations, and NT-proBNP in adults with stable chronic heart failure caused by coronary…
- Conditions
- Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Coronary Heart Disease (CHD)
- Trial name
- NCT07803471
- Testing
- Yiqi Fumai Lyophilized Injection(YQFM), Stable Guideline-Directed Medical Therapy
- Where
- 4 sites in China
- Volunteers
- 100 people
- Sponsor
- China Academy of Chinese Medical Sciences
Heart Failure
Optimal Left Ventricular Lead Positioning During Cardiac Resynchronisation Therapy; Comparison of Two Methods of Targeting
Cardiac Resynchronisation Therapy (CRT) is a well-known treatment for patients with heart failure. It is a special pacemaker that consists of three pacing wires, which are implanted in the right upper and bottom chambers of the…
- Trial name
- NCT03769272
- Testing
- Measurement of electrical delay during LV lead placement
- Volunteers
- 40 people
- Sponsor
- Peter J Pugh
Cardiogenic Shock
Early Left Atrial Septostomy Versus Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation
The use of venoarterial-extracorporeal membrane oxygenation(VA-ECMO) was associated with lower in-hospital mortality in patients with cardiogenic shock. However, VA-ECMO has a deleterious effect for hemodynamics.
- Trial name
- EARLY-UNLOAD (NCT04775472)
- Testing
- Early left atrial septostomy within 12 hours after VA-ECMO implantation, Selective left atrial septostomy
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Chonnam National University Hospital
Ischemic Heart Disease, Myocardial Infarction
Low-Dose Dobutamine Tc-99m-Mibi Gated SPECT to Predict Left Ventricular Remodelling in Patients Reperfused in the Acute Phase of MI
Left myocardial infarction (MI), has a negative impact of long term morbidity and mortality. Even in patients treated successfully by angioplasty in the acute phase of infarct, the remodelling is observed in approximately 30% of…
- Trial name
- NCT00487812
- Testing
- Low-dose dobutamine Tc-99-m-mibi gated SPECT imaging
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pregnancy Related, Deep Vein Thrombosis
SAFELY RULING OUT DEEP VEIN THROMBOSIS IN PREGNANCY WITH THE LEFt SCORE AND TRIMESTER-ADJUSTED D-DIMER CUTOFFS (the PREG-DVT Study): A PROSPECTIVE COHORT STUDY.
Venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism (PE), is a leading cause of maternal morbidity and mortality in high-income countries.1 DVT is suspected in pregnancy greater than 10 times…
- Conditions
- Pregnancy Related, Deep Vein Thrombosis, D-dimer, Diagnostic Strategy
- Trial name
- PREG-DVT (NCT07884981)
- Testing
- D-dimer
- Where
- Switzerland
- Volunteers
- 330 people
- Sponsor
- Marc Righini
NSTEMI
A Pilot Proof of Concept, Randomized Controlled, Single-Center Study of a Decision Aid Tool for Older Patients Considering LHC as Treatment for NSTEMI
This study will be a single-center, prospective, un-blinded, randomized controlled trial evaluating a decision aid tool for older patients considering left heart catheterization (LHC) as treatment for non-ST elevation myocardial…
- Trial name
- NCT04270630
- Testing
- Shared Decision Aid
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Atrial Fibrillation
Bursa Postgraduate Hospital Department of Cardiology
Ensuring and maintaining normal sinus rhythm is critical for reducing negative outcomes in patients with atrial fibrillation (AF).
- Trial name
- NCT05231967
- Testing
- Cardioversion
- Volunteers
- 120 people
- Sponsor
- Bursa Postgraduate Hospital
Colorectal Cancer, Bone Marrow Tumor Cell Infiltration
Disseminated Tumour Cells (DTC) in Left Sided Colorectal Cancer (LSCC).
Two metaanalyses of studies on the prognostic significance of circulating cancer cells in colorectal cancer indicated, that the presence of circulating tumour cells (CTC) in the peripheral blood is the negative prognostic factor.
- Trial name
- NCT03640572
- Testing
- Bone marrow analysis to identify disseminated tumour cells
- Where
- Poland
- Volunteers
- 91 people
- Sponsor
- Jagiellonian University
Renal Transplant
24 Months Follow-up, Two Arm Study to Compare the Cardiovascular Profile in a Regimen With Everolimus + Mycophenolic Acid (MPA) Versus (vs.) a Regimen of CNI+MPA in Maintenance Renal Transplant Recipients
The objective of the study is to compare the cardiovascular profile of an everolimus and mycophenolic acid immunosuppressive regimen with a calcineurin inhibitor and mycophenolic acid regimen in maintenance renal transplant…
- Trial name
- EVITA (NCT01169701)
- Testing
- Everolimus, Tacrolimus, Mycophenolic acid (MPA)
- Where
- 9 sites in Spain
- Volunteers
- 71 people
- Sponsor
- Novartis Pharmaceuticals
Danon Disease
A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease
This is a single arm Phase 2 trial to evaluate the efficacy and safety of RP-A501, a recombinant adeno-associated virus serotype 9 (rAAV9) vector containing the human lysosome-associated membrane protein 2 isoform B (LAMP2B)…
- Trial name
- NCT06092034
- Testing
- RP-A501
- Where
- 6 sites in United States, Germany and 2 more
- Volunteers
- 18 people
- Sponsor
- Rocket Pharmaceuticals Inc.
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