Clinical trials: Left Ventricular Failure
Heart Failure
Effects of CCM-therapy in Patients With Heart Failure
The effects of Cardiac Contractility Modulation (CCM) treatment are observed in patients with heart failure.
- Trial name
- CCM-HF (NCT02895048)
- Where
- Germany
- Volunteers
- 184 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Aortic Valve Regurgitation, Mitral Valve Regurgitation
Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation
Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse…
- Conditions
- Aortic Valve Regurgitation, Mitral Valve Regurgitation, Left Ventricle Dilated, Left Atrium Dilated
- Trial name
- ORMIX (NCT06805253)
- Testing
- Not applicable - observational study
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Left Bundle-Branch Block, Heart Failure
The Left Bundle Cardiac Resynchronization Therapy Trial
Cardiac resynchronization therapy (CRT) via biventricular (BiV) pacing significantly reduces morbidity and mortality in patients with left bundle branch block (LBBB), impaired LV function and heart failure in spite of optimal…
- Conditions
- Left Bundle-Branch Block, Heart Failure, Impaired Left Ventricular Function
- Trial name
- NCT05434962
- Testing
- Cardiac resynchronization therapy
- Where
- 10 sites in Spain
- Volunteers
- 176 people
- Sponsor
- Óscar Cano Pérez
Left Ventricular Assist Device, Heart Failure
Pulse Wave Analysis in Advanced Heart Failure
A comparison of pulse wave characteristics, as measured by peripheral tonometry, in pre and post Left Ventricular Assist Device (LVAD) patients.
- Conditions
- Left Ventricular Assist Device, Heart Failure, Intra-aortic Balloon Pump, LVAD Clot
- Trial name
- PWA-HF (NCT01642927)
- Where
- United States
- Sponsor
- University of Minnesota
Heart Failure
International Study to Determine if AdreView Heart Function Scan Can be Used to Identify Patients With Mild or Moderate Heart Failure (HF) That Benefit From Implanted Medical Device
This is an event-driven Phase IIIb, multicentre, randomised, clinical study to demonstrate the efficacy of AdreView™ imaging for appropriately guiding the decision of implantable cardioverter defibrillator (ICD) implantation, in…
- Trial name
- ADMIRE-ICD (NCT02656329)
- Testing
- Iobenguane I -123 Injection, Implantable Cardioverter Defibrillator, Thyroid blocking
- Where
- 94 sites in United States, Canada and 8 more
- Volunteers
- 395 people
- Sponsor
- GE Healthcare
Hypotension, Heart Failure
Dapagliflozin on Hypotensive Heart Failure Patients After Sacubitril/Valsartan Therapy
The DAPA-HF trial demonstrated that dapagliflozin was able to reduce the risk of worsening heart failure events and cardiovascular death comparing to placebo in patients with reduced ejection fraction further to standard of care.
- Trial name
- NCT04575675
- Testing
- Dapagliflozin, Sacubitril-Valsartan, Beta blocker
- Where
- Taiwan
- Volunteers
- 78 people
- Sponsor
- Cheng-Hsin General Hospital
Myocardial Infarction, Percutaneous Coronary Intervention
Text Message Intervention to Improve Cardiac Rehab Participation
Cardiac rehabilitation (CR) is strongly recommended for patients with coronary heart disease. However, patient enrollment and completion of cardiac rehabilitation is low.
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Bypass Surgery, Heart Valve Repair or Replacement
- Trial name
- NCT03346278
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Washington
Myocardial Infarction, Left Ventricular Systolic Dysfunction
Objective Systolic Function Recuperation Assessed by Echocardiography
The purpose of this study is to evaluate left ventricular systolic ejection fraction and anterior or apical akinesis 1 month and 3 months after a myocardial infarction treated with primary PCI to determine whether improvement at…
- Conditions
- Myocardial Infarction, Left Ventricular Systolic Dysfunction, Anterior Akinesis, Apical Akinesis
- Trial name
- ROSE (NCT01086124)
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Paul Farand
Heart Failure
Sacubitril/Valsartan Versus Valsartan in Heart Failure
The objective of this study was to identify potential prognostic factors of sacubitril/valsartan vs Valsartan treatment response.
- Trial name
- NCT05881720
- Testing
- Sacubitril / Valsartan Oral Tablet, Valsartan 80 mg
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Damanhour University
Heart Failure
Prospective Multi-Center Randomized Study for Evaluating the EVAHEART®2 Left Ventricular Assist System
This is a prospective, multi-center, unblinded, randomized, controlled, and non-inferiority study comparing the EVA2 LVAS to the most recent magnetically levitated centrifugal LVAS (HM3 LVAS).
- Trial name
- COMPETENCE (NCT01187368)
- Testing
- EVAHEART Left Ventricular Assist System (LVAS), HeartMate 3
- Where
- 12 sites in United States
- Volunteers
- 399 people
- Sponsor
- Evaheart, Inc.
Impaired Left Ventricular Ejection Fraction
Validation of Kinocardiography, New Technology for Cardiac Linear and Torsional Contractility Measurement, to Assess Heart Failure Patient With Low Ejection Fraction
Measuring cardiac contractility is commonly realized with gold standard echocardiography or MRI. Portable devices to measure this contractility are not available as for rhythm and electric function assessment.
- Trial name
- NCT03157115
- Testing
- Kinocardiography
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Brugmann University Hospital
Heart Failure With Reduced Ejection Fraction
First in Humans to Evaluate Collagen Patches With Stem Cells in Patients With Ischemic Left Ventricular Dysfunction
It´s a first open-label trial in humans to evaluate the safety and efficacy of epicardial delivery of collagen patches with adipose-derived stem cells in patients with ischemic heart disease and left ventricular dysfunction that…
- Trial name
- CARDIOMESH (NCT03746938)
- Testing
- VB-C01
- Where
- 2 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Viscofan
HFpEF - Heart Failure With Preserved Ejection Fraction, HFmrEF
US Benchmarking Clinical Study
The goal of this observational study is to measure shear wave velocity (SWV) in patients with non-reduced left ventricular ejection fraction (LVEF) heart failure and left ventricular hypertrophy, with or without transthyretin…
- Conditions
- HFpEF - Heart Failure With Preserved Ejection Fraction, HFmrEF, ATTR-CM (Transthyretin Amyloid Cardiomyopathy), Left Ventricular Hypertrophy
- Trial name
- EMS-CT-1 (NCT07215715)
- Where
- 3 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- eMyosound SAS
Heart Failure
Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction
This was a randomized, double-blinded, placebo-controlled, multiple-dose study in subjects with stable heart failure (HF) with reduced ejection fraction (HFrEF).
- Trial name
- NCT02788747
- Testing
- 4 mg elamipretide, 40 mg elamipretide
- Where
- 15 sites in Italy, Netherlands and 1 more
- Volunteers
- 71 people
- Sponsor
- Stealth BioTherapeutics Inc.
Heart Failure With Preserved Ejection Fraction (HFPEF), Left Ventricular End Diastolic Pressure (LVEDP)
Evaluation of Left Ventricular Filling Pressures During Exercise
Heart failure with preserved ejection fraction (HFPEF) is common and is a real public health issue. Diagnosis, especially when there are no congestive signs, is difficult.
- Trial name
- PREFFORT (NCT01714752)
- Testing
- measure of left ventricular and diastolic pressure at exercise
- Where
- France
- Volunteers
- 60 people
- Sponsor
- French Cardiology Society
Acute Heart Failure With Reduced Left Ventricular Ejection Fraction
Telemonitoring to Optimize Medication Titration for Heart Failure: a Feasibility Study
Problem: Aggressive titration of guideline-directed medical therapy is the cornerstone of heart failure management to reduce heart failure related hospitalization and mortality.
- Trial name
- TOM-HF (NCT07016815)
- Testing
- Wearable wrist heart rate and activity monitor, Bluetooth enabled body weight scale with bioimpedance analysis, Bluetooth enabled electronic blood pressure device
- Where
- 2 sites in Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Chagas Cardiomyopathy, Heart Failure
A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy
Chronic Chagas cardiomyopathy causes substantial morbidity and mortality in Latin America. Whether RAS inhibitors and beta-blockers are safe and beneficial has been challenged because of the lack of formal trials.
- Conditions
- Chagas Cardiomyopathy, Heart Failure, Dilated Cardiomyopathy
- Trial name
- NCT01557140
- Testing
- RASi plus carvedilol
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Federal University of Minas Gerais
Heart Failure With Reduced Ejection Fraction, Hypotension
Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension
The evidence-based pharmacologic treatments available for patients with heart failure with reduced ejection fraction (HFrEF) has been established over the last few decades of cardiovascular research.
- Conditions
- Heart Failure With Reduced Ejection Fraction, Hypotension, LV Dysfunction
- Trial name
- MIDOH-HF-P (NCT06405555)
- Testing
- Midodrine Oral Tablet
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Heart Failure
Identifying and Facilitating Ventricular Recovery on Mechanical Support
Heart failure is a progressive disorder in which the weakened heart is not able to efficiently pump blood throughout the body. When the body's cells do not receive enough blood, this can result in fatigue, shortness of breath…
- Trial name
- RECOVER (NCT00687856)
- Testing
- Echocardiogram (echo)
- Where
- 5 sites in United States
- Volunteers
- 211 people
- Sponsor
- University of Pittsburgh
Heart Failure
Quartet Lead and Resynchronization Therapy Options III (QUARTO_III)
The purpose of the study is to assess prospectively at 6 months the percentage of responder patients implanted with a Cardiac Resynchronization Therapy (CRT-D) device and a Quartet Left Ventricular (LV) quadripolar lead and with…
- Trial name
- QUARTO_III (NCT02476201)
- Testing
- MPP ON
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Abbott Medical Devices