Clinical trials: Leg Injuries
ACL - Anterior Cruciate Ligament Rupture
BioACL Reconstruction With Amnion Collagen Matrix Wrap and Stem Cells Case Series
The objective of this study is to evaluate the use of wrapping an ACL graft with a collagen matrix tissue wrap and injecting autologous bone marrow aspirate concentrate under the wrapping and into the graft.
- Trial name
- BioACL(CS) (NCT03294720)
- Testing
- Bio-ACL, amnion wrap and BMAC
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Andrews Research & Education Foundation
Gait Analysis, Hip Fractures
Gait Pattern Between a Cemented and Non-cemented Femur Stem
Acute cervical femoral neck fracture patients randomized to either cemented or non-cemented stem. The investigators used gait analysis to evaluate if patients operated with a cemented stem showed more favourable hip kinematics…
- Conditions
- Gait Analysis, Hip Fractures, Hip Arthroplasty, Randomized
- Trial name
- NCT04791605
- Testing
- Gait analysis
- Where
- Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Non-healing Wounds
Effect of Natrox Oxygen Wound Therapy on Non-healing Wounds and Implication of Remote Monitoring and Telehealth for Management in the Home.
Single center pilot study examining the effect of Natrox topical oxygen therapy on chronic wounds along with the introduction of remote monitoring and telehealth for home care management.
- Trial name
- NCT04746573
- Testing
- Natrox Topical Oxygen Therapy
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Inotec AMD Limited
Amputation, Wound; Foot
Comparing Wound Complication Following TMA With Aid of Electrospun Fiber Matrix
Transmetatarsal amputation (TMA) patient populations commonly have poor healing outcomes and a large number of complications. There has been little study on the benefits of augmenting a TMA with a synthetic graft substitute.
- Conditions
- Amputation, Wound; Foot, Wound Complication
- Trial name
- NCT06063694
- Testing
- Synthetic electrospun fiber matrix
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Lower Limb Amputation Below Knee (Injury)
The Effects of Small Variations in Shoe Heel Height on Gait in People With a Transtibial Amputation
Prosthetic alignment is important for walking function and walking comfort in people with a transtibial amputation (TTA). Prosthetic alignment is defined as the position of prosthetic parts relative to the body and to each other.
- Trial name
- NCT04641845
- Testing
- Cork inlay wedge
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Sint Maartenskliniek
ACL, ACL Injury
Acupuncture ACL (Anterior Cruciate Ligament)
Acupuncture research in regards to PONV has been fairly well established, however, studies about perioperative pain control and acupuncture are a little more murky.
- Conditions
- ACL, ACL Injury, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
- Trial name
- NCT03711734
- Testing
- Acupuncture + Standard of Care
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Menopause, Vitamin D Deficiency
Effect of Consumption of Yogurt Fortified in Calcium and Vit. D on Circulating Levels of 25OHD in Postmenopausal Women
The purpose of this study is to evaluate the effect of daily consumption of one or two CALIN+ pot(s) versus no intake of product, after 4, 8, 12 and 16 weeks, on the evolution of the serum concentration of 25-hydroxy vitamin D…
- Trial name
- NCT02534064
- Testing
- CALIN+
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Yoplait France SAS
Anterior Cruciate Ligament Injuries
Efficacy of Adductor Canal Block for Anterior Cruciate Ligament Surgery
The goal of this study is to objectify the postoperative pain level, the use of opiates and postoperative nausea and vomiting after adding the adductor canal block to the standard pain regiment after anterior cruciate ligament…
- Trial name
- DUAL (NCT05532618)
- Testing
- Adductor canal block, Levobupivacaine
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Lateral Malleolus Fractures
PRCT-study of Different Non-operative Treatment Protocols of ER-stress Negative Weber-B Unimalleolar Ankle Fractures.
PRCT multicenter study to evaluate non-operative treatment protocols for treating ER-stress negative unimalleolar Weber-B type fibular fractures. Groups are: 1. 3 weeks in a removable splint 2. 3 weeks in a cast and 3.
- Trial name
- NCT01758835
- Testing
- Splint 3 weeks, Cast 3 weeks, Cast 6 weeks
- Where
- Finland
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Hip Fracture
A Comparison of Two Pain Control Techniques on Deliruim in Hip Fracture Patients
The purpose of this study is compare the rates of post-operative delirium between a group of people receiving intravenous (IV) pain control after hip fracture surgery and a group of people receiving a femoral nerve catheter for…
- Trial name
- NCT01547468
- Testing
- Femoral Nerve Catheterization, Intravenous Opioids
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Leslie Thomas
Knee Injuries, Knee Osteoarthritis
Blood-Flow Restriction Exercise Following a Knee Replacement
This study will determine the safety and efficacy of using blood-flow restriction exercise enhancement (B-FREE) to overcome persistent quadriceps muscle weakness that occurs following a total knee replacement (TKR).
- Conditions
- Knee Injuries, Knee Osteoarthritis, Knee Arthritis
- Trial name
- NCT04018638
- Testing
- B-FREE
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Michigan Technological University
Knee Injuries, Inflammation Knees
Accute Effect of B-Turmactive Both on Mild and Moderate Knee Pain on Healthy Volunteers
The goal of this study is to assess the short (acutte) effect of B-Turmactive (one week treatment) both on mild/moderate knee pain
- Trial name
- TURMACTIVE (NCT03202901)
- Testing
- B-turmactive
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Rupture of Anterior Cruciate Ligament
A Pilot Study to Investigate Biomarkers in Anterior Cruciate Ligament (ACL) Patients and Healthy Controls
Incident rates of ACL rupture are greatest in 16-39 year olds at almost 1 in 1,000. Performance Based Investigations (PBIs) can be used to evaluate and select correct approaches to patient treatment, and biochemical…
- Trial name
- NCT02300012
- Testing
- Surgeons knowledge of pre-operative PBIs
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- United Lincolnshire Hospitals NHS Trust
Pelvic Fracture
Outcome of the Anterior Subcutaneous Internal Fixator (INFIX) for Pelvic Ring Disruptions
With a prospective case series study of 15 patients The aim of this study is to estimate the clinical outcomes in patients with unstable anterior pelvic ring fractures ( B\&C ) after treatment with (INFIX)
- Trial name
- NCT05354531
- Testing
- anterior subcutaneous internal fixator ( INFIX)
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Strength, Exercise
Impact of Pilates on Running Mechanics
INTRODUCTION: Core strengthening, balance, and flexibility programs such as Pilates have been advocated to affect running mechanics and prevent lower extremity injuries positively.
- Conditions
- Strength, Exercise, Knee Injuries
- Trial name
- NCT04815980
- Testing
- Exercise
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of the Incarnate Word
Anterior Cruciate Ligament Injury
Light Load Blood Flow Restriction Training in Anterior Cruciate Ligament Reconstruction Patient Rehabilitation
This study is examining the post-operative rehabilitation of anterior cruciate ligament (ACL) reconstruction patients within the National Health Service (NHS).
- Trial name
- NCT03419169
- Testing
- Light load BFR resistance training, Heavy load resistance training
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Neuromuscular Control, Healthy
RIIP REPS Neuromuscular Training
The purpose of this study is to assess both the feasibility and efficacy of a 6-week mobile-application-based neuromuscular training program in high school athletes by measuring adherence rates and examining changes in agility…
- Conditions
- Neuromuscular Control, Healthy, Athletic Performance and Injury Risk
- Trial name
- NCT07221305
- Testing
- Neuromuscular Control Training
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Tibial Fractures, Vitamin D Deficiency
Vitamin D Supplementation and Tibia Fracture. Does it Improve Healing Rate?
This study evaluates the effect of Vitamin D3 supplementation in healing rate of tibia fractures in adult patients with low vitamin D.
- Conditions
- Tibial Fractures, Vitamin D Deficiency, Fracture Healing
- Trial name
- ViDco (NCT03232216)
- Testing
- Vitamin D3.
- Where
- Chile
- Volunteers
- 682 people, healthy volunteers welcome
- Sponsor
- Hospital del Trabajador de Santiago
ACL Injuries
Exercise Program for Knee Recovery in Football Players with ACL Injuries
This study aims to evaluate the effectiveness of a structured exercise program in improving knee function, muscle strength, and range of motion in football players recovering from anterior cruciate ligament (ACL) injuries.
- Trial name
- NCT06808763
- Testing
- Knee Rehabilitation Exercise Program
- Where
- Saudi Arabia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- King Saud University
Lower-limb Orthoses, Frailty/Sarcopenia
Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses
The overall goal of this project is to develop modular, lower-limb, powered orthoses that fit to user-specific weakened joints and control force/torque in a manner that enhances voluntary motion in broad patient populations.
- Conditions
- Lower-limb Orthoses, Frailty/Sarcopenia, Chronic Overuse Musculoskeletal Injuries
- Trial name
- NCT05240014
- Testing
- Modular powered orthosis
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Michigan