Clinical trials: Leg Injuries and Disorders
Knee Pain, Hip Pain
Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response
The purpose of this study is to gain a better understanding of the effects of lumbopelvic manual therapy on lower extremity biomechanics and arthrogenic muscle response.
- Conditions
- Knee Pain, Hip Pain, Ankle Pain, Lumbopelvic Pain
- Trial name
- NCT00601341
- Testing
- lumbosacral joint manipulation, lumbar passive range of motion, No active intervention
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes, Wound Infection
Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients With Lower Limb Infections
This study will determine the tissue penetration of ceftolozane/tazobactam (Zerbaxa, Merck \& Co.), a novel β-lactam/β-lactamase combination antibiotic, into the extracellular, interstitial fluid of soft tissue in diabetic…
- Conditions
- Diabetes, Wound Infection, Healthy Volunteers
- Trial name
- NCT02620774
- Testing
- Ceftolozane/tazobactam, Microdialysis Catheter Insertion
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Diabetic Foot Ulcer, Wound Healing
Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery
This observational prospective cohort study will evaluate whether routine blood tests are associated with the functional quality of calcaneal bone marrow aspirate mesenchymal stem cells in adults undergoing clinically indicated…
- Conditions
- Diabetic Foot Ulcer, Wound Healing, Foot Ulcer Due to Type 2 Diabetes Mellitus, Diabetes Mellitus Type 2
- Trial name
- IQF-BMA (NCT07802106)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Sao Francisco
Infection, Soft Tissue, Infection, Wound
Direct Antibiotic Delivery of Cefazolin Into Soft Tissue Infections Using Subcutaneous Injection and Ultrasonic Dispersion
This study focuses on a new drug delivery system (Direct Antibiotic Delivery) to treat soft tissue infections. In this study, cefazolin is delivered directly to the target tissues using subcutaneous injection of antibiotic…
- Conditions
- Infection, Soft Tissue, Infection, Wound, Cellulitis, Diabetic Foot Ulcer
- Trial name
- DAD (NCT01238276)
- Testing
- Cefazolin, Silberg Tissue Preparation System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sonescence, Inc.
Injury, Knee, Injury, Ankle
Prevention of Patellar and Achilles Tendinopathies in Youth Basketball
This study seeks to determine the prevalence of knee and ankle tendinopathies in youth basketball players, as well as determine the efficacy of a Basketball specific Neuromuscular training warm-up in reducing injuries.
- Conditions
- Injury, Knee, Injury, Ankle, Tendinopathy, Sports Injuries in Children
- Trial name
- NCT04363398
- Testing
- Comprehensive Follow-up, Standard Follow-up
- Where
- Canada
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Sport Injury Prevention Research Centre
Ankle Injuries, Ankle Injuries and Disorders
The Effect of Taping on Plantar Pressure Distribution in Players With Chronic Ankle Instability
The goal of this study is to investigate whether there exists a difference in baropdometric readings of plantar pressure between individuals with chronic ankle instability and normal health individuals, in addition another goal…
- Conditions
- Ankle Injuries, Ankle Injuries and Disorders, Ankle Sprains
- Trial name
- NCT06499935
- Testing
- Rigid Taping, Kinesio-Taping
- Where
- Lebanon
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cairo University
Osteoporosis, Diet Habit
Soft Drinks and Osteoporosis in WHI Participants
Osteoporotic fractures, as a consequence of a reduced mineral bone density (BMD) represents a major public health problem. The lifetime risk of fractures exceeds 40% for women and 13% for men.
- Trial name
- NCT03371433
- Testing
- Soft drinks
- Volunteers
- 79,885 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Osteoarthritis, Knee, Knee Injuries
Impact of Mulligan Squeeze Technique on Meniscal Derangement in Knee Osteoarthritis Patients
The objective of this study is to find out the effects of Mulligan's Squeeze technique added as a complementary treatment to the conventional physiotherapy for the management of meniscal derangement in knee osteoarthritis…
- Conditions
- Osteoarthritis, Knee, Knee Injuries, Meniscus; Derangement, Meniscus Tear
- Trial name
- NCT06391047
- Testing
- Mulligan's Squeeze Technique - manual therapy, Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Faisalabad
Patellar Dislocation
Comparison of Two Graft Choices in Mediale Patellofemoral Ligament Reconstruction (MPFL)
The purpose of this study is to elucidate surgical techniques for reconstructing MPFL in the treatment of chronic patella instability.
- Trial name
- NCT05706363
- Testing
- Quadriceps graft
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Wound Healing
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Single and Repeated Doses of Topical GSK1278863
This is a randomized, placebo-controlled, single-blind (subjects and investigators will be blinded, GSK internal personnel will not be blinded), parallel-group, two part (Part A, Part B) trial in healthy volunteers and subjects…
- Trial name
- NCT01831804
- Testing
- GSK1278863
- Where
- 7 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Abnormality, Congenital
Relationship of Muscular Agenesis: Thin Plantar and Palmar Long as a Biomarker of Injury and Performance Marker in the Lower Limb and Upper Limb Respectively
This study investigates muscle agenesis, specifically the absence of the palmaris longus and plantaris muscles, and its effects on injury risk, strength, and performance.
- Trial name
- MA-TP-PL (NCT06448832)
- Testing
- Ultrasound
- Where
- Spain
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Seville
Hip Fractures, Acetabular Fracture
Static Balance Disorders in Patients After Surgical Treatment of Hip Acetabular Fractures
The mechanism of maintaining balance is a complex phenomenon, involving numerous systems of human body. High-energy trauma resulting in acetabular fracture damages some of the elements composing this delicate mechanism…
- Conditions
- Hip Fractures, Acetabular Fracture, Balance; Distorted, Disability Physical
- Trial name
- NCT04902209
- Testing
- postural stability measurements
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Diabetic Foot Ulcer
Clinical Outcomes After Treatment With RestrataTM Wound Matrix in Diabetic Foot Ulcers (DFU)
The primary objective of this study is to determine the outcomes of patients who receive a certain type of skin substitute called RestrataTM Wound Matrix (Restrata™).
- Trial name
- NCT03312595
- Testing
- Restrata TM Wound Matrix
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Acera Surgical, Inc.
Ankle Fracture
The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture
The use of prophylactic treatment with vitamin c may prevent complex regional pain syndrome (CRPS)
- Trial name
- CRPS (NCT01338129)
- Testing
- vitamin c
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Knee Injuries and Disorders
Different Arm Positions During Single Leg Squat
The aim of this study is to compare the effects of different arm positions on muscle activity during single leg squat.
- Trial name
- NCT05420675
- Testing
- Single Leg Squat
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Muscle Atrophy, Cachexia
Vitamin K2 Supplements for Muscle Recovery
Ankle injury is one of the most common injuries which can have long term consequences. Ankle immobilization is often applied for up to six weeks to ensure healing of the soft tissue and fractured bones after such an injury.
- Trial name
- Recovery (NCT05161975)
- Testing
- Vitamin K2
- Where
- 2 sites in Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Venous Ulcer
Effectiveness of XCell on Autolytic Debridement of Venous Ulcers
This clinical trial is designed to evaluate the effect of XCell cellulose wound dressing for its ability to naturally (autolytically) remove nonviable tissue and create a healthy vascular wound bed.
- Trial name
- XCell (NCT00446823)
- Testing
- XCell cellulose wound dressing, Impregnated gauze dressing
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Xylos Corporation
Spinal Cord Injuries
Lower Extremity Outcome Measures in SCI
Lower extremity (LE) function of patients with a spinal cord injury (SCI) will be assessed in an observational project with a cross-sectional and a longitudinal study design.
- Trial name
- NCT04032314
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Compartment Syndrome
Study of New Catheter & Pressure Monitor System to Help Prevent Compartment Syndrome From Developing in the Injured Leg
An investigation of a new catheter and pressure monitor system that may help to prevent a complication called compartment syndrome from developing in an injured leg.
- Trial name
- TS2 (NCT00681616)
- Testing
- Compartment Monitoring System (CMS), Compartment Monitoring System with Active Fluid Removal, Compartment Monitoring System without fluid removal
- Where
- 13 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Twin Star Medical, Inc.
Spinal Cord Injury
Lower Limb Function After Spinal Cord Injury
This is a randomized, experimental study that examines the physiology of central nervous system pathways contributing to the control of bilateral movements in individuals with spinal cord injuries and promotes the recovery of…
- Trial name
- NCT02635893
- Testing
- D-Cycloserine, Training, Stimulation
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab