Clinical trials: Low Grade
Obesity, Metabolic Diseases
Fibrosis a New Pathological Actor in Adipose Tissue
Adipose tissue (AT) has specific alterations in obesity in particular increased fibrosis amount compared to lean subjects. Fibrosis amount measured by immunohistochemistry on adipose biopsies appears to to predict weight loss…
- Conditions
- Obesity, Metabolic Diseases, Fibrosis, Body Weight
- Trial name
- fibrota (NCT01655017)
- Testing
- biopsy
- Where
- 2 sites in France
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Syndrome, Inflammation
The Effect of Probiotics on Low-grade Inflammation, Microbiota and Risk Factors for Metabolic Syndrome in Obese Children
Metabolic syndrome and thereby obesity is associated with low-grade systemic inflammation and it is likely that this is also the case in children (Ley et al., 2005).
- Conditions
- Metabolic Syndrome, Inflammation, Obesity
- Trial name
- NCT01020617
- Testing
- Ls-33
- Where
- Denmark
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Glioma
Everolimus for Children With NF1 Chemotherapy-Refractory Radiographic Progressive Low Grade Gliomas
The purpose of this research study is to learn if the study drug RAD001 can shrink or slow the growth of low-grade gliomas in children with Neurofibromatosis type 1 (NF1). Additionally, the safety of RAD001 will be studied.
- Trial name
- NFC-RAD001 (NCT01158651)
- Testing
- RAD001 (Everolimus)
- Where
- 12 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Metabolic Syndrome, Obesity
Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue
This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in…
- Conditions
- Metabolic Syndrome, Obesity, Insulin Sensitivity
- Trial name
- NCT00774488
- Testing
- Glucose dependent insulinotropic polypeptide (GIP)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Human Papillomavirus Clearance at 12 Months
Cryotherapy for Human Papillomavirus Clearance in Biopsy-confirmed Cervical Low-grade Squamous Intraepithelial Lesions
Persistent human papillomavirus (HPV) infections is the single necessary cause of cervical cancer. Cervical cancer is still the major health problem in the developing countries.
- Trial name
- Cryotherapy (NCT00566579)
- Testing
- Cryotherapy
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Human Papillomavirus Infection, Cervical Cancer
Clinical Evaluation of Detection of High Risk HPV in Urine
Cervical cancer is one of the most common tumors in women, which seriously threatens women's life quality and safety. Human papilloma virus (HPV) infection is the most common cause of cervical cancer.
- Conditions
- Human Papillomavirus Infection, Cervical Cancer, Human Papilloma Virus, Negative for Intraepithelial Lesion or Malignancy
- Trial name
- Urine-hrHPV (NCT05210348)
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Metabolic Disease, Obesity, Infant
Metabotyping of Overweight and Obese Children
Today's children are increasingly facing metabolic-related health issues, among which the worldwide prevalence of overweight and obesity is rising at an alarming pace.
- Trial name
- RecSAMP (NCT04632511)
- Testing
- MetaSAMP
- Where
- 10 sites in Belgium
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University Ghent
Aged, Healthy
Low Grade Inflammation, Gut Microbiota and Barrier Function in Elderly Humans
Cardiovascular diseases (CVD) are the main cause of death in the European Union. A large part of the aging process, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks…
- Trial name
- NCT01218165
- Testing
- Probiotic drink, Control Group
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Diabetes, Dyslipidemia
The Effects of Hypolipemic and Antidiabetic Treatment on Cytokines
The study is planned to show whether combined hypolipemic and antidiabetic therapy with various daily dosages influence the fasting plasma glucose, insulin sensitivity and proinflammatory cytokines in diabetic and dyslipidemic…
- Conditions
- Diabetes, Dyslipidemia, Inflammation, Cytokines
- Trial name
- MSF (NCT01101204)
- Testing
- Metformin 1000mg, simvastatin 10mg and fenofibrate 100mg
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Obesity, Chronic Inflammation
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)
Omega-3 fatty acids, especially EPA and DHA have long been acknowledged for their capacity to counteract inflammatory responses in the human body.
- Trial name
- EPICO (NCT05068557)
- Testing
- Dietary plan along with fish oil capsules (3 capsules daily. Containing EPA+DHA: 1.8 g)., Dietary plan along with chia/linseed oil capsules (3 capsules daily. Containing ALA 1.6 g).
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Inflammation
The PROtective Effect of SulforAphaNe on Chronic Low-grade Inflammation in Healthy Participants
Rationale: Most non-communicable diseases are partially affected by low-grade chronic inflammation. Research has shown that sulforaphane, an ingredient found in abundance in broccoli, shows promise as a potent anti-inflammatory…
- Trial name
- PRO SANI (NCT05146804)
- Testing
- BroccoCress, Affilla Cress
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Isthmic Spondylolisthesis
Relationship Between Spinopelvic Parameters and Clinical Symptoms of Low-grade Lumbar Isthmic Spondylolisthesis
This was a retrospective study.PI and LL greatly influence IS and its progression. However, relationships between the spinopelvic parameters and clinical symptoms of patients with IS were not fully investigated in previous…
- Trial name
- NCT04968626
- Testing
- PI-LL
- Where
- China
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Phenylketonuria
Study of Low-grade Systemic Inflammation in Adult Patients With Phenylketonuria
Patient suffering from phenylketonuria have chronic hyperphenylalaninemia. Hyperphenylalaninemia is known to be toxic to central nervous system and cardiovascular system in particular through oxydative stress.
- Trial name
- INGRAPH (NCT04879277)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Atypical Squamous Cell of Undetermined Significance, Cervical Carcinoma
Home-Based or Clinic-Based Human Papillomavirus (HPV) Screening
This randomized clinical trial studies home-based HPV or clinic-based Pap screening for cervical cancer. It is not yet known whether home-based screening is more effective, cost-effective, and/or acceptable than clinic-based…
- Conditions
- Atypical Squamous Cell of Undetermined Significance, Cervical Carcinoma, Cervical Intraepithelial Neoplasia Grade 2/3, Health Status Unknown
- Trial name
- NCT01550783
- Testing
- Cervical Papanicolaou Test, Cytology Specimen Collection Procedure, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 1,335 people, healthy volunteers welcome
- Sponsor
- University of Washington
Overweight or Obesity
Juice Plus Inflammaging and Cardiovascular Disease Prevention Study
Low- grade inflammation is a pathological feature of a wide range of chronic conditions, including the metabolic syndrome, cardiovascular diseases (CVD) and the accelerated reduction in bone density.
- Trial name
- NCT04003935
- Testing
- Juice Plus+ Complete, Juice Plus+ Premium
- Where
- 2 sites in Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Green Beat
Myopia, Corneal Crosslinking
Advanced Cross Linking for Low-grade Myopia
To evaluate the improvement in myopic refractive error and the corneal endothelial safety with a corneal crosslinking treatment regimen for mild myopia.
- Trial name
- PiXLO2 (NCT03197272)
- Testing
- PiXL
- Where
- Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Umeå University
Mild Gastrointestinal Symptoms in Healthy Adults, Low-grade Chronic Inflammation
Fungal Fiber for Gut Health
This study compares effects of plant based fiber vs fungi based fiber on clinical outcomes related to gut function (immunity, emotions, stress) and explores the role of gut microbiome structure and function on individual…
- Conditions
- Mild Gastrointestinal Symptoms in Healthy Adults, Low-grade Chronic Inflammation, Stress, Gut Health
- Trial name
- FUN4GUT (NCT06404749)
- Testing
- fungal fiber, inulin
- Where
- Argentina
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Future Biome SA
Low-grade Chronic Inflammation, Intestinal Permeability
Diet and Systemic Inflammation
People with chronic low-grade inflammation have a higher risk for certain diseases such as cardiovascular disease or type 2 diabetes.
- Conditions
- Low-grade Chronic Inflammation, Intestinal Permeability, Type 2 Diabetes Mellitus, Cardiovascular Disease
- Trial name
- DASI (NCT01424306)
- Testing
- Fructose-sweetened beverages, Glucose-sweetened beverages, High-fructose corn syrup-sweetened beverages
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Acute Low Back Pain
Efficacy and Safety of Dexketoprofen/Vitamin B Vs Dexketoprofen for Post-traumatic Cervical Sprain Grade I-II
Phase IIIb, multicenter, prospective, randomized, double-blind study to evaluate the fixed combination of Desketoprofen / Vitamin B in the management of acute pain in patients with cervical sprain grade I-II of the Quebec scale.
- Trial name
- WHIPLASH (NCT05001555)
- Testing
- Dexketoprofen/Vitamin B, Dexketoprofen
- Where
- Mexico
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Laboratorios Silanes S.A. de C.V.