Clinical trials: Low Mood
Depressive Disorder
Levodopa and Exercise for Older Adults With Depression and Psychomotor Slowing
In this new research study, 80 adults aged > 60 years with a significant depressive disorder and slowed processing and/or gait speed will be randomized to receive levodopa (L-DOPA; which the Candidate has previously shown to…
- Trial name
- NCT04650217
- Testing
- Carbidopa/levodopa, Exercise training, Control
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- New York State Psychiatric Institute
Parkinson Disease
Kick Out Parkinson's Disease 2
The benefits of exercise for general health and well-being in older adults are well-established. Balance exercises such as tai chi and yoga, along with resistance training, can improve or maintain physical function in older…
- Trial name
- NCT03882879
- Testing
- Karate Classes, Pre-Intervention Study Visit, Bimonthly Online Survey
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Rush University Medical Center
Stress Disorders, Post-Traumatic, Depression
Development of a Patient Centered Mental Health Intervention for Recent Veterans
Recent Veterans of the OIF/OEF/OND conflicts are presenting in VA care with high rates of: PTSD, depression, anxiety, and alcohol abuse, reporting significant difficulties with community reintegration, and dropping out of mental…
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Anxiety, Substance-Related Disorders
- Trial name
- PCC MH (NCT02943408)
- Testing
- person-centered mental health intervention, health and wellness
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Stroke
Exercise and Brain Stimulation for Post-stroke Depression
This project will assess the effects of aerobic exercise training (AET), repetitive transcranial magnetic stimulation (rTMS) or their combination on depressive severity as well as locomotor function in persons with post-stroke…
- Trial name
- NCT03056287
- Testing
- Aerobic exercise, Repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Medical University of South Carolina
Panic Disorder, Major Depressive Disorder
Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Panic Disorder With Comorbid Major Depression
This study will evaluate the efficacy of 1-Hz rTMS applied to the right Dorsolateral Prefrontal Cortex (DLPFC) in patients with Panic Disorder (PD) and comorbid Major Depressive Disorder (MDD) who have not fully responded to…
- Trial name
- rTMS (NCT00521352)
- Testing
- Active Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder
Transcranial Laser Therapy for Major Depressive Disorder
The purpose of this study is to see if using Transcranial LED Therapy (TLT) using the PhotoMedex's Omnilux NEw-U LED helps improve symptoms of major depressive disorder (MDD).
- Trial name
- ELATED (NCT01538199)
- Testing
- Near-infrared radiation via Transcranial LED Therapy
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Paolo Cassano
Major Depression
Motivational Interviews for Depression in Primary Care
The purpose of the study is to determine whether motivational interviewing with guideline-based medical management for depression will significantly improve time to depression recovery and increase the proportion of subjects in…
- Trial name
- NCT01114334
- Testing
- Guideline-Based Medical Management, Motivational Interviewing for Depression
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Denver Health and Hospital Authority
Depressive Disorder, Major
Safety and Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
The purpose of this study is to evaluate the efficacy, safety and tolerability of vortioxetine, once daily (QD), compared with placebo in adults with major depressive disorder.
- Trial name
- NCT01179516
- Testing
- Vortioxetine
- Where
- 61 sites in United States
- Volunteers
- 469 people
- Sponsor
- Takeda
Posttraumatic Stress Disorder, Depression
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Pilot
The goal of this pilot study is to develop and implement a larger scale, multi-site stepped collaborative care trial that targets injured patients with presentations of posttraumatic stress disorder (PTSD) and related…
- Conditions
- Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation
- Trial name
- TSOS6 (NCT02335125)
- Testing
- Motivational Interviewing, Cognitive Behavioral Therapy Elements, Psychotropic Drugs
- Volunteers
- 40 people
- Sponsor
- University of Washington
Autism Spectrum Disorder, Depression
TMS for Adults With Autism and Depression
The goal of this proposal is to investigate whether a standard rTMS protocol for depression, including multiple sessions applied to left dorsolateral prefrontal cortex (DLPFC) results in reduction of depressive symptoms for adult…
- Conditions
- Autism Spectrum Disorder, Depression, Depressive Disorder, Major Depressive Disorder
- Trial name
- TAD (NCT02939560)
- Testing
- NeuroStar® TMS device (Neuronetics, Atlanta, GA)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Major Depressive Disorder (MDD)
Brexpiprazole as Adjunctive Therapy With Major Depressive Disorder and an Inadequate Response to Previous Adjunctive Therapy
The objectives of this exploratory trial are to evaluate the efficacy, safety, and subjects' subjective satisfaction when switching to adjunctive brexpiprazole in subjects with MDD who have responded inadequately to preceding…
- Trial name
- NCT02012218
- Testing
- ADT, Brexpiprazole
- Where
- 24 sites in United States
- Volunteers
- 61 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Depression
Evaluation of a Therapeutic Mobile App for Depression
The purpose of this study is a preliminary evaluation of a gamified attention bias modification training (GAMBT) for reducing symptoms of depression and rumination.
- Trial name
- NCT05601362
- Testing
- Gamified Attention Bias Modification
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Christopher G. Beevers
Down Syndrome, Depression
Fluoxetine Treatment of Depression in Down Syndrome
The purpose of the study is to do a preliminary assessment of whether fluoxetine is effective, safe, and tolerable for the treatment of depression in adults with Down syndrome.
- Trial name
- NCT05458479
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Massachusetts General Hospital
Survivorship, Cancer
Telephone-Based Intervention to Treat Depression and Anxiety in Hispanic Cancer Survivors
The purpose of this research is to assess the feasibility of administering a telephone-based intervention to treat depression and anxiety in Hispanic cancer survivors.
- Conditions
- Survivorship, Cancer, Depression, Anxiety
- Trial name
- NCT04430335
- Testing
- Telephone interview, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University Health Sciences
Treatment Resistant Depression
Proof-of-Concept Trial of CERC-501 Augmentation of Antidepressant Therapy in Treatment-Resistant Depression
This study is looking at the efficacy, rapidity, safety, and tolerability of two doses of oral CERC-501 for treating patients with treatment resistant depression who are taking an antidepressant that is not working for them.
- Trial name
- RAPID KOR (NCT01913535)
- Testing
- CERC-501
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Depression, Suicide
Ketamine for Depression and Suicide Risk
The purpose of this research study was to find out if the medication known as ketamine could help the symptoms of depression. This drug is approved by the U.S.
- Trial name
- Ketamine (NCT02094898)
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
PostTraumatic Stress Disorder
Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Effectiveness
This is a multisite, randomized, blinded, sham-procedure-controlled study to evaluate the efficacy of right-sided stellate ganglion block (SGB) on the acute symptomatology of Post traumatic Stress Disorder (PTSD), evaluated by…
- Trial name
- NCT03077919
- Testing
- Ropivacaine
- Where
- 3 sites in United States, Germany
- Volunteers
- 113 people
- Sponsor
- RTI International
Acute Coronary Syndrome, Depression
Healthy Heart Habits
Approximately 350,000 Acute Coronary Syndrome (ACS) patients experience significant depression symptoms each year in the US. Post-ACS depressed mood interferes with patients making necessary changes to behavioral risk factors…
- Trial name
- H^3 (NCT04158219)
- Testing
- Behavioral activation for health and depression (BA-HD)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Hennepin Healthcare Research Institute
Depression, Depressive Disorder
Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD)
The purpose of this study is to compare the relative effectiveness of 20 and 60 minutes of Low-Field Magnetic Stimulation in relieving symptoms in patients with major depression who are treatment resistant.
- Conditions
- Depression, Depressive Disorder, Depressive Disorder, Treatment-resistant, Depressive Disorder, Major
- Trial name
- NCT02452892
- Testing
- LFMS
- Where
- 12 sites in United States
- Volunteers
- 122 people
- Sponsor
- Tal Medical, Inc.
Menopause, Depression
Impact of Hot Flashes on Sleep and Mood Disturbance
We plan to enroll premenopausal women in a trial investigating the impact of hot flashes developed in response to an injection of a gonadotropin-releasing hormone agonist (GnRHa), leuprolide (brand name: Lupron), on sleep…
- Conditions
- Menopause, Depression, Hot Flashes
- Trial name
- NCT01116401
- Testing
- leuprolide
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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