Clinical trials: Low Tidal Volume Ventilation
on Invasive Mechanical Ventilation, ARDS
Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure
Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury.
- Conditions
- on Invasive Mechanical Ventilation, ARDS, Respiratory Failure
- Trial name
- NCT04035915
- Testing
- Limited driving pressure, Conventional mechanical ventilation strategies
- Where
- Thailand
- Volunteers
- 126 people
- Sponsor
- Mahidol University
Ventilator Lung, Liver Cirrhosis
Effect of Low Tidal Ventilation on Intraoperative Bleeding in Laparoscopic Major Hepatectomy
This randomized controlled study's objective is to find a safer mechanical ventilation strategy to reduce intraoperative bleeding in liver cancer patients undergoing laparoscopic major liver resection.
- Conditions
- Ventilator Lung, Liver Cirrhosis, Hepatocellular Carcinoma, Blood Loss, Surgical
- Trial name
- NCT05490147
- Testing
- conventional tidal volume (tidal volume [ml]= ideal body weight [kg]* 10~12) group, low tidal (tidal volume [ml]= ideal body weight [kg] * 6~8) volume
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Spinal Cord Injury, Respiratory Insufficiency
A Comparison of High vs. Low Tidal Volumes in Ventilator Weaning for Individuals With Cervical Spinal Cord Injuries
The study will compare outcomes between individuals with sub-acute, ventilator-dependent tetraplegia using high (20 cc/kg) vs. low (10 cc/kg) tidal volumes during mechanical ventilator support.
- Trial name
- NCT00412308
- Testing
- Tidal volume used in mechanical ventilation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Craig Hospital
ARDS, Acute Lung Injury
Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO
The acute respiratory distress syndrome (ARDS) is the most severe form of respiratory failure, presented in 10% of all intensive care patients and carrying a high mortality rate.
- Conditions
- ARDS, Acute Lung Injury, Extracorporeal Membrane Oxygenation, Respiratory Distress Syndrome
- Trial name
- NCT03764319
- Testing
- Ultra-protective ventilator settings, Standard ventilator settings
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Medical University of Vienna
Acute Respiratory Distress Syndrome
Effects of End-inspiratory Pause on Ventilation
This study aims to evaluate the effect of reducing tidal volume and respiratory rate together with an end-inspiratory pause setting on ventilatory efficiency and the distribution of inspired gas within the lungs in ARDS patients.
- Trial name
- NCT06692634
- Testing
- mechanical ventilation setting
- Where
- 2 sites in Chile
- Volunteers
- 20 people
- Sponsor
- Clinica las Condes, Chile
Mechanical Ventilation Complication
Lung-protective Mechanical Ventilation for Abdominal Laparoscopic Surgeries
This was a double-blind, randomized controlled clinical trial. 62 patients were randomly assigned to receive either lung-protective ventilation (LPV) with a tidal volume (Vt) of 7 ml/kg ideal body weight (IBW), 10 cmH2O positive…
- Trial name
- NCT04546932
- Testing
- Lung-protective mechanical ventilation
- Where
- Vietnam
- Volunteers
- 62 people
- Sponsor
- Vietnam Military Medical University
Ventilator-free Days
PRotective VENTilation in Patients Without ARDS
The purpose of this national multicentre randomized controlled trial is to compare a ventilation strategy using lower tidal volumes and higher respiratory rates with a ventilation strategy using higher tidal volumes and a lower…
- Trial name
- PReVENT-NL (NCT02153294)
- Testing
- low tidal volume, high tidal volume
- Where
- Netherlands
- Volunteers
- 952 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Lung Injury, Adult Respiratory Distress Syndrome
Acute Lung Injury Ventilator Evaluation (ALIVE)
This study will compare two ventilator modes in mechanically ventilated patients with acute lung injury. Acute lung injury (ALI) is a condition in which the lungs are badly injured and are not able to absorb oxygen the way…
- Trial name
- ALIVE (NCT01901354)
- Testing
- Low-tidal-volume ventilation, Airway Pressure Release Ventilation (APRV)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Wisconsin, Madison
Acute Respiratory Distress Syndrome, Prone Position
Effect of PP in Patients With Ultra-low VT
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with similar clinicopathological feathers caused by different etiologies.
- Conditions
- Acute Respiratory Distress Syndrome, Prone Position, Tidal Volume
- Trial name
- NCT06215209
- Testing
- position
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Southeast University, China
Inflammation
Study of the Influence of Various Tidal Volumes on Exhaled Breath Condensate (EBC) in Mechanically Ventilated Patients
The aim of the present study is to evaluate the effect of low (6 ml/kg) and high (12 ml/kg) tidal volume ventilation on inflammatory and oxidative stress biomarkers in the exhaled breath condensate (EBC) of ICU patients without…
- Trial name
- TDEBC (NCT00910026)
- Testing
- low tidal volume ventilation, high tidal volume ventilation
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Larissa University Hospital
Lung Diseases
Low Tidal Volume and EVLWI During OLV
The use of low tidal volume (TV) during one lung ventilation (OLV) for thoracic surgery decreases the incidence of postoperative acute lung injury (ALI).
- Trial name
- NCT01762709
- Testing
- The VT 4 ml/kg group, The VT 6 ml/kg group, The VT 8 ml/kg group
- Where
- Saudi Arabia
- Volunteers
- 39 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Anesthesia, General, Surgery
Physiological Effects of Lung Recruitment During General Anesthesia and Low-tidal Volume Ventilation
Low-tidal volume ventilation is arising as a tool to optimize the ventilatory management and to improve clinical outcome in patients undergoing general anesthesia for abdominal surgery.
- Trial name
- PEEP-RM (NCT03083457)
- Testing
- Fluid resuscitation or amine administration, General anesthetic, Fluid administration
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Catholic University of the Sacred Heart
Respiratory Distress Syndrome
Effect of Different Ventilatory Strategies on Cardiac Function in Patients With Acute Respiratory Failure
Mechanical ventilation with low tidal volume (about 6 ml.kg-1) reduces mortality in ALI/ARDS patients respect to high tidal volume ventilation (about 12 ml.kg-1).
- Trial name
- VITALI (NCT00713713)
- Testing
- Mechanical ventilation with low and high tidal volume
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
ARDS (Acute Respiratory Distress Syndrome)
Pressure Release Ventilation Compared to Lung Protective Ventilation in Moderate and Severe ARDS
This study compares two different ways of providing mechanical ventilation to patients with moderate to severe acute respiratory distress syndrome (ARDS), a serious condition in which the lungs become inflamed and make it…
- Trial name
- NCT07803614
- Testing
- Arm 1 Intervention Name: Low-Tidal-Volume Ventilation (LTV)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Koot Ahmad
Acute Respiratory Distress Syndrome, ARDS
Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure
This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a proven standardized lung protective ventilation protocol in the new electronic medical record system iCentra…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS, Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
- Trial name
- IMPROVENT (NCT03225807)
- Where
- United States
- Volunteers
- 8,692 people
- Sponsor
- Intermountain Health Care, Inc.
Lung-protective Ventilation
Lung-protective Ventilation During Robot-assisted Laparoscopic Radical Cystectomy
Robot-assisted laparoscopic radical cystectomy (RARC) increases the incidence of postoperative complications. We conducted a study to determine the effect of lung-protective ventilation strategy.
- Trial name
- LPV-RARC (NCT03868319)
- Testing
- lung protective ventilation strategy, nonprotective ventilation
- Where
- China
- Volunteers
- 258 people
- Sponsor
- RenJi Hospital
Protective Lung Ventilation Using:, Low Tidal Volume (6-8 mL/kg Predicted Body Weight)
Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study)
The purpose of this study is to compare the influence of a lung protective ventilation with conventional ventilation on postoperative complications following major abdominal surgery.
- Conditions
- Protective Lung Ventilation Using:, Low Tidal Volume (6-8 mL/kg Predicted Body Weight), PEEP of 6-8 cmH2O, Intraoperative RMs
- Trial name
- NCT01282996
- Testing
- Abdominal surgery
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Lung Injury, Adult Respiratory Distress Syndrome
Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation
Traditional modes of ventilation have failed to improve patient survival. Subsequent observations that elevated airway pressures observed in traditional forms of ventilation resulted in barotrauma and extension of ALI lead to the…
- Conditions
- Acute Lung Injury, Adult Respiratory Distress Syndrome, Kidney Injury
- Trial name
- PRESSURE (NCT00793013)
- Testing
- Volume-Cycled Assist-Control (AC) mode, Airway Pressure Release Ventilation (APRV) mode
- Where
- United States
- Sponsor
- University of Tennessee, Chattanooga
Acute Respiratory Distress Syndrome
Very Low Tidal Volume vs Conventional Ventilatory Strategy for One-lung Ventilation in Thoracic Anesthesia
The purpose of this study is to determine if a protective ventilatory strategy during one-lung ventilation (OLV) based on low tidal volume, PEEP and alveolar recruitment maneuver can reduce Acute Respiratory Distress Syndrome…
- Trial name
- NCT01504893
- Testing
- Protective one lung ventilation
- Where
- 16 sites in Italy
- Volunteers
- 984 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Low Tidal Volume Ventilation
A Feasibility Study of a Low Tidal Volume Ventilation Strategy in One Lung Ventilation
A study of two ventilatory strategies for low tidal volume ventilation compared to a control group to elucidate if low tidal volumes of 3ml/kg or 4ml/kg were feasible for one lung ventilation.
- Trial name
- NCT03467607
- Testing
- tidal volume ventilation
- Where
- Ireland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College