Clinical trials: Lung Protective Ventilation
Acute Brain Injury, Ventilator-Induced Lung Injury
Ventilator Settings on Patients With Acute Brain Injury
The present study is an explorative analysis of the relationship between cerebral blood perfusion and oxygenation and lung mechanical variables at different ventilator settings.
- Conditions
- Acute Brain Injury, Ventilator-Induced Lung Injury, Cerebrovascular Circulation
- Trial name
- NCT03278769
- Testing
- Lung protective ventilator settings
- Where
- Norway
- Volunteers
- 27 people
- Sponsor
- University Hospital of North Norway
Coronavirus Infection, Ventilatory Failure
To Compare Videolaryngoscope Against Direct Laryngoscope for Intubation When Powered Air Purifying Respirator is Worn
Various guidelines for endotracheal intubation (insertion of breathing tube for mechanical ventilation) of Coronavirus Disease 2019 (COVID-19) patients recommend the use of videolaryngoscope (medical device used for intubation…
- Conditions
- Coronavirus Infection, Ventilatory Failure, Anesthesia Intubation Complication
- Trial name
- NCT04424953
- Testing
- McGrath videolaryngoscope, Direct laryngoscope
- Where
- Singapore
- Volunteers
- 28 people
- Sponsor
- Singapore General Hospital
Observation of Neuromuscular Block, Complication of Ventilation Therapy
Deep Neuromuscular Block During General Anaesthesia in Robotic Surgery
The aim of this project is to show, whether the use of the deep neuromuscular block in certain laparoscopic robot-assisted surgery can positively influence main physiological functions compared to the use of standard…
- Conditions
- Observation of Neuromuscular Block, Complication of Ventilation Therapy, Postoperative Recovery
- Trial name
- NCT03420937
- Testing
- Sugammadex, Neostigmine, Atropin Biotika
- Where
- Czechia
- Volunteers
- 138 people
- Sponsor
- University Hospital Olomouc
Mechanical Ventilation Complication, Mechanical Power
LPP , MP and DP:Relation With Mortality and SOFA in Mechanically Ventilated Patients in ER, Ward and ICU
Prospective, observational, longitudinal study, September 2019 to March 2020 of all adult patients who required invasive mechanical ventilation treated at General Hospital of Zone 11 IMSS in Piedras Negras, Coahuila.
- Conditions
- Mechanical Ventilation Complication, Mechanical Power, Driving Pressure, Lung Protective Ventilation
- Trial name
- LUMEDRI-MORT (NCT04193254)
- Where
- Mexico
- Volunteers
- 63 people
- Sponsor
- JOSE IVAN RODRIGUEZ DE MOLINA SERRANO
Acute Respiratory Distress Syndrome (ARDS)
Immune Mechanisms and ECMO Strategies for Moderate-to-Severe ARDS
Acute respiratory distress syndrome (ARDS) poses a major threat to human health. Despite extracorporeal membrane oxygenation (ECMO) support, mortality among patients with ARDS remains high due to severe complications and…
- Trial name
- NCT07726940
- Where
- 39 sites in China
- Volunteers
- 1,776 people
- Sponsor
- Southeast University, China
Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
Optimizing the Assessment of Mechanical Ventilation by Integrating Advanced Monitoring Techniques [AVIM]
The aim of this study is to collect synchronized data from multiple monitoring techniques of mechanical ventilation (pressure/flow waves from the ventilator, electrical impedance tomography - EIT, esophageal pressure…
- Trial name
- AVIM (NCT06236685)
- Testing
- Electric impedance tomography
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Czech Technical University in Prague
Lung Injury, Acute
a Study Conducted About a New Mode of Ventilation in Laparoscopic Surgeries
Carbon dioxide insufflations of abdomen are integral part of laparoscopic operations in minimally invasive surgery era. It does cause splinting effect on diaphragm movement and set it high inside thoracic cavity too.
- Trial name
- NCT03637530
- Testing
- inverse ratio ventilation
- Volunteers
- 128 people
- Sponsor
- All India Institute of Medical Sciences, Rishikesh
Acute Respiratory Distress Syndrome
Low-Flow CO2 Removal for Mild to Moderate ARDS With PRISMALUNG
This pilot observational study will assess changes in pH /PaO2 /PaCO2, Respiratory Rate and device CO2 clearance in the first 24 hours of Extracorporeal CO2 removal (ECCO2R) following tidal volume (Vt), and plateau pressure…
- Trial name
- NCT02606240
- Testing
- CO2 removal with PRISMALUNG in ARDS
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Lung Diseases
Protective Versus Conventional Mechanical Ventilation for Peripheral Vascular Surgery.
Background and goal of the study: Postoperative complications following major surgeries are associated with a significant increase in costs and mortality.
- Trial name
- NCT03616210
- Testing
- Protective ventilation
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Mechanical Ventilation
Mechanical Power-Guided Lung Protective Ventilation (VentCoach) in Acute Hypoxemic and/or Hypercapnic Respiratory Failure
The purpose of this research is to evaluate a different way of using the mechanical ventilator device to help better protect the lungs while the patient recovers.
- Trial name
- NCT07294768
- Testing
- VentCoach, Standard of Care
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Postoperative Atelectasis
Effect of Intraoperative Dynamic Compliance Guided Individualized Positive End-expiratory Pressure on Postoperative Atelectasis After Laparoscopic Bariatric Surgery
This study intends to explore the effect of dynamic compliance guided individualized positive end-expiratory pressure titration strategy on reducing the level of postoperative atelectasis in obese patient who have laparoscopic…
- Trial name
- NCT04169607
- Testing
- Dynamic compliance guided individualized positive end-expiratory pressure titration strategy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuzhou Medical University
Prostate Cancer
Lung Protective Ventilation During Robotic Assisted Prostatectomy
Randomized study investigating the effects of lung protective ventilation (PEEP), as compared with normal ventilation (ZEEP) on lung function, treatment of the renal sodium and water, vasoactive hormones, biomarkers of…
- Trial name
- NCT02551341
- Testing
- higher PEEP ventilation
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Jørgen Bjerggaard Jensen
Driving Pressure
Driving Pressure Guided Ventilation Versus Conventional Lung Protective Strategy in Morbid Obese Patients Undergoing Laparoscopic Bariatric Surgery
This study will be conducted to evaluate the effect of driving pressure guided ventilation compared with conventional protective lung ventilation during laparoscopic bariatric surgeries in morbid obese patients.
- Trial name
- NCT04861168
- Testing
- driving pressure guided ventilation, Conventional protective lung strategy
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Anesthesia, General/Methods, Laparoscopy
Transpulmonary Driving Pressure and Intra-abdominal Pressure Relationship During Laparoscopic Surgery
Objective: The aim of this project is to evaluate how intra-abdominal pressure paired coupled with different ventilatory positive end-expiratory pressure levels affects the transpulmonary driving pressure during pneumoperiteneum…
- Conditions
- Anesthesia, General/Methods, Laparoscopy, Respiration, Artificial, Positive-Pressure Respiration
- Trial name
- NCT03435913
- Testing
- Standard PEEP ventilation, Matched PEEP ventilation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario La Fe
Mechanical Ventilation, Postoperative Pulmonary Complications (PPCs)
Flow-Controlled Ventilation to Improve Postoperative Pulmonary Outcome After Thoracic Surgery
In an international multicenter randomized clinical pilot trial, intraoperative flow-controlled ventilation (FCV) will be compared with volume-controlled ventilation (VCV) in patients scheduled for (open, video- or…
- Trial name
- PROFLOW-THORAC (NCT07623395)
- Testing
- Flow-Controlled Ventilation, Volume-Controlled Ventilation
- Where
- 7 sites in Austria, France and 2 more
- Volunteers
- 140 people
- Sponsor
- Cantonal Hospital of St. Gallen
Acute Respiratory Distress Syndrome (ARDS)
The Oscillation for Acute Respiratory Distress Syndrome (ARDS) Treated Early (OSCILLATE) Trial
What is the effect of early high frequency oscillation (HFO) versus a lung-protective conventional ventilation (CV) strategy (using HFO only as rescue therapy), on all-cause hospital mortality among patients with severe early…
- Trial name
- OSCILLATE (NCT01506401)
- Testing
- SensorMedics 3100B High Frequency Oscillatory Ventilator, Lung Protective Ventilation
- Where
- 38 sites in United States, Canada and 3 more
- Volunteers
- 548 people
- Sponsor
- Canadian Critical Care Trials Group
Acute Respiratory Distress Syndrome (ARDS), Ventilator Management
Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial
Acute respiratory distress syndrome (ARDS) is a serious and potentially life-threatening lung condition that can affect children.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Ventilator Management, Lung-protective Ventilation, Pediatric Acute Respiratory Distress Syndrome (PARDS)
- Trial name
- PARMA (NCT07123961)
- Testing
- High Driving Pressure Mechanical Ventilation, Low Driving Pressure Mechanical Ventilation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Children's Hospital of Philadelphia
ARDS, Human
Decrease of Lesions Induced by Mechanical Ventilation During ARDS
Modification of mechanically ventilated lesions by an ultra-protective multimodal strategy compared to a protective strategy in patients with veno-venous ECMO for severe ARDS.
- Trial name
- ECMO-VILI (NCT03918603)
- Testing
- ventral décubitus
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
One-lung Ventilation
Protective Ventilation Strategy
The purpose of this study is to find a proper ventilation strategy for one-lung ventilation to prevent postoperative pulmonary complications
- Trial name
- NCT03234621
- Testing
- ventilator setting during one-lung ventilation
- Where
- South Korea
- Volunteers
- 87 people
- Sponsor
- Seoul National University Hospital
Postoperative Pulmonary Complications (PPCs), Atelectasis
Evaluation of the Effectiveness of Lung-Protective Ventilation in Patients Undergoing Laparoscopic Gastrectomy
The goal of this clinical trial is to learn if lung-protective ventilation can improve perioperative oxygenation and reduce postoperative pulmonary complications in patients undergoing elective laparoscopic gastrectomy.
- Trial name
- NCT07823816
- Testing
- Conventional Ventilation, Lung-Protective Ventilation
- Where
- Vietnam
- Volunteers
- 102 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)