Clinical trials: Lung Transplant
Vaccination, Respiratory Syncytial Virus (RSV)
Immunogenicity and Safety of Respiratory Syncytial Virus Vaccine in Lung Transplant Recipients
The purpose of this study is to compare the immunogenicity and safety of respiratory syncytial virus (RSV) vaccination between lung transplant recipients and immunocompetent adults and to provide evidence to guide RSV vaccination…
- Conditions
- Vaccination, Respiratory Syncytial Virus (RSV), Lung Transplant Recipient
- Trial name
- NCT07895394
- Testing
- RSVPreF3 vaccination
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Lung Cancer, Bilateral Cancer
DREAM: Double Lung Transplant REgistry Aimed for Lung-limited Malignancies
This is a prospective observational registration trial for patients who undergo lung transplantation for the treatment of the select groups of medically refractory cancers affecting the lungs alone without extrapulmonary nodal…
- Conditions
- Lung Cancer, Bilateral Cancer, Lung Transplant
- Trial name
- DREAM (NCT05671887)
- Testing
- Double Lung Transplantation
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Northwestern University
Heart Transplant Patients, Kidney Transplant Patients
Multidisciplinary Non-Pharmacological Intervention to Improve Quality of Life in Solid Organ Transplant Recipients
This is a single-center interventional study aimed at evaluating the feasibility of a multidisciplinary non-pharmacological approach based on acupuncture, telerehabilitation-based physical rehabilitation, and brain health…
- Conditions
- Heart Transplant Patients, Kidney Transplant Patients, Lung Transplant, Liver Transplanted Patients
- Trial name
- TAO (NCT07870811)
- Testing
- Acupuncture, Telerehabilitation-Based Physical Rehabilitation, Psychological Support Program
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Lung Transplant
Tocilizumab in Lung Transplantation
This is a trial in which 100 primary lung transplant recipients will be randomized (1:1) to receive either Tocilizumab (six doses over 20 weeks) plus standard triple maintenance immunosuppression or placebo (sterile normal…
- Trial name
- ALL IN LUNG (NCT06033196)
- Testing
- Tocilizumab
- Where
- 21 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Transplant, ABO Incompatibility
A2 to O Lung Transplants
Blood group A2 to blood group O kidney and liver transplants have been shown to be safe and successful, especially in recipients with low pre-operative anti-A antibody titers and with the use of peri-operative antibody-depleting…
- Trial name
- NCT05581745
- Testing
- Blood group A2 donor to blood group O recipient lung transplant surgery
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Kidney Transplant, Kidney Transplantation
Proteogenomic Biomarker Panels in a Serial Blood & Urine Monitoring Study of Kidney Transplant Recipients
There is a need to develop blood and/or urine tests that will help to detect early signs of rejection in people who have had kidney transplant.
- Trial name
- PROGENI-KI (NCT01289717)
- Where
- 5 sites in United States
- Volunteers
- 307 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Transplant, Post Lung Transplantation
CLAD Phenotype Specific Risk Factors and Mechanisms
While many patients experience benefits from transplant, complications such as infections and lung rejection may affect long term survival and quality of life.
- Trial name
- NCT02631720
- Testing
- Blood Draw, Bronchoscopy
- Where
- 5 sites in United States, Canada
- Volunteers
- 884 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Transplant
PREDICT Cytomegalovirus (CMV)
The overall objective of this study is to establish a personalized test to measure individualized cytomegalovirus (CMV) specific immunity in lung transplant recipients in an effort to guide antiviral prophylaxis duration in…
- Trial name
- PREDICT CMV (NCT03300882)
- Testing
- Procedure
- Where
- 4 sites in United States, Canada
- Volunteers
- 84 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Transplant Recipients, Muscle Weakness
Efficacy of Early Inspiratory Muscle Training in Lung Transplanted Patients
Lung transplantation is an effective therapeutic option in the end-stage of chronic respiratory diseases. Lung transplantation improves lung function in terms of capacity and volume.
- Conditions
- Lung Transplant Recipients, Muscle Weakness, Respiratory Insufficiency, Pulmonary Rehabilitation
- Trial name
- NCT05271019
- Testing
- Threshold load device
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Puerta de Hierro University Hospital
Lung Transplant Rejection
A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction
This double-blind, randomized, placebo-controlled, multinational, multicenter, parallel-group, Phase 3, 2-arm, study will investigate the efficacy and safety of belumosudil compared with placebo, both administered on top of…
- Trial name
- ROCKaspire (NCT06082037)
- Testing
- Belumosudil, Azithromycin
- Where
- 82 sites in United States, Australia and 17 more
- Volunteers
- 180 people
- Sponsor
- Sanofi
HSCT, Lung Transplant Recipient
Technical Development of Xe MRI
The goal of this study is to develop and optimize new proton (1H; conventional MRI) and Xe gas MRI techniques to assess regional cardiopulmonary structure and function in the clinical setting.
- Trial name
- NCT07823010
- Testing
- Hyperpolarized 129 Xenon
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Transplant-Related Lung Cancer
Non-ablative Oligofractionated Radiation Therapy Before Surgical Transplantation As Radiovaccination
This is a prospective phase I study to determine the safety and feasibility of non-ablative oligofractionated radiation therapy (NORT) before lung transplantation for patients with underlying pulmonary malignancy.
- Trial name
- NORThSTAR (NCT04782752)
- Testing
- Radiation: Varying Doses of RT
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Marc de Perrot
Lung Transplant
A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation
The purpose of this research study is to compare the technique of performing bilateral lung transplantation off-pump vs venoarterial ECMO (VA ECMO).
- Trial name
- NCT05547698
- Testing
- Off-pump lung transplantation, Venoarterial ECMO lung transplantation
- Where
- 10 sites in United States, Belgium
- Volunteers
- 228 people
- Sponsor
- Mayo Clinic
Antibody Mediated Rejection of Lung Transplant
A Phase 1 Clinical Trial of Siltuximab for the Treatment of Antibody-Mediated Rejection After Lung Transplantation
Antibody-mediated rejection after lung transplantation commonly results in allograft failure and death in spite of current therapeutic regimens.
- Trial name
- Siltux-AMR (NCT06990711)
- Testing
- Siltuximab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Lung Transplant Recipient
BRIDGE - Blocking Receptor of IL-1β for Donor Graft Edema Reduction
This study will determine if primary graft dysfunction (which causes low blood oxygen levels and fluid or inflammation in the lungs) after lung transplant can be prevented through the use of the study drug (IL-1 receptor…
- Trial name
- NCT07410312
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Lung Transplant
Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients
The purpose of this study is to see if taking the study drug, Belumosudil, for 52 weeks in addition to your usual care and medication, will prevent Chronic Lung Allograft Dysfunction (CLAD) in participants who have a lung biopsy…
- Trial name
- CLAD (NCT06476132)
- Testing
- Belumosudil
- Where
- 12 sites in United States, Canada
- Volunteers
- 234 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Transplant; Complications, Lung Transplant; Infection or Inflammation
Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes
This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers.
- Conditions
- Lung Transplant; Complications, Lung Transplant; Infection or Inflammation, Lung Transplant Rejection, Lung Transplant Failure
- Trial name
- PROMISE (NCT06399302)
- Where
- 19 sites in United States, Canada
- Volunteers
- 2,600 people
- Sponsor
- Duke University
Lung Transplant, Pulmonary Hypertension
Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension
The purpose of this study is to determine if transseptal extra-corporeal membrane oxygenation (ECMO) can bridge pulmonary hypertension- right heart failure (PH-RVF) patients to lung transplant safely.
- Trial name
- NCT06770023
- Testing
- Protek Solo Transseptal Cannula
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Cystic Fibrosis, Lung Transplant; Complications
Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis
Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis
- Trial name
- NCT04687475
- Testing
- Clinical Tool (Mobile Spirometry and Survey)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cleveland Clinic
Lung Transplant, End Stage Lung Disease
GRAfT 2.0. A Multimodal Prospective Approach to Define the Mechanisms and Clinical Features of Acute and Chronic Rejection in Lung Transplantation
Background: Lung transplants can save lives, but the procedure has risks. Some people develop donor-specific antibodies (DSA) after the procedure-that is, their bodies create proteins that treat the new lungs as foreign and mount…
- Conditions
- Lung Transplant, End Stage Lung Disease, Rejection
- Trial name
- NCT07516379
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)