Clinical trials: Lung-protective Ventilation
COVID-19
Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine
This is a double blind, placebo controlled study in approximately 2,000 health care workers at risk for being exposed to COVID-19.
- Trial name
- HERO-HCQ (NCT04334148)
- Testing
- Hydroxychloroquine
- Where
- 34 sites in United States
- Volunteers
- 1,360 people, healthy volunteers welcome
- Sponsor
- Adrian Hernandez
Acute Respiratory Distress Syndrome
Enhanced Lung Protective Ventilation for ARDS Patients With PrismaLung
Acute Respiratory Distress Syndrome (ARDS) still remains associated with a mortality rate of 30 - 45 % despite improvement in mechanical ventilation.
- Trial name
- PROVAP (NCT03004885)
- Testing
- PrismaLung
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Hôpital Européen Marseille
ARDS, Human, Mechanical Ventilation Pressure High
Lung Protection in ARDS Using Neurally Adjusted Ventilatory Assist
The aim of this study is to investigate the use neurally adjusted ventilatory assist (NAVA) as lung protective strategy in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- NAVA (NCT03868982)
- Testing
- Neurally adjusted ventilatory assist
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Fu Jen Catholic University
ARDS, Lung Injury, Ventilator Induced
Mechanical Ventilation in Patients With Lung Impairment Controlled by the Mechanical Energy of the Respiratory System
A project aimed at expanding the monitoring of mechanical energy (ME) in patients on mechanical ventilation (MV), with the aim of contributing to reducing the influence of the device for mechanical ventilation of patients on the…
- Trial name
- NCT06035146
- Testing
- Mechanical energy monitoring, Conventional mechanical ventilation
- Where
- Czechia
- Volunteers
- 34 people
- Sponsor
- University Hospital Ostrava
Mechanical Power, Alveolar Recruitment Maneuvers
The Role of Periodic Alveolar Recruitment Maneuvers in Intraoperative Protective Ventilation
The goal of this clinical trial is to compare three open-lung strategies on respiratory function and lung injury in protective ventilation for laparoscopic anterior resection.
- Conditions
- Mechanical Power, Alveolar Recruitment Maneuvers, Protective Ventilation, Postoperative Pulmonary Complications
- Trial name
- REMAIN-2 (NCT05962125)
- Testing
- periodic alveolar recruitment maneuvers, positive end-expiratory pressure
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Acute Respiratory Distress Syndrome
Assessment of Occult Lung Stress During Lung Protective Mechanical Ventilation
The present study will utilize esophageal manometry to measure the presence and magnitude of persistent patient effort during lung protective ventilation, allowing identification and mitigation of occult lung stress.
- Trial name
- NCT05675696
- Testing
- Esophageal Catheter
- Where
- United States
- Sponsor
- NYU Langone Health
Acute Respiratory Distress Syndrome
The Oscillation for ARDS Treated Early (OSCILLATE) Trial Pilot Study
Acute respiratory distress syndrome (ARDS) is a common and catastrophic complication of critical illness related to burns, motor vehicle accidents, or overwhelming infection. ARDS kills 40-70% of affected patients.
- Trial name
- OSCILLATE (NCT00474656)
- Testing
- High-frequency oscillation, Conventional lung-open mechanical ventilation
- Where
- 12 sites in Canada, Saudi Arabia
- Volunteers
- 94 people
- Sponsor
- Canadian Critical Care Trials Group
Peep Titration in Lung Protective Ventilation
Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery
Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery.
- Trial name
- NCT07044089
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Acute Respiratory Distress Syndrome
Mechanical Ventilation With Neurally-Adjusted Ventilatory Assist in Patients With ARDS
Neurally-Adjusted Ventilatory Assist (NAVA) is a ventilatory mode that uses the electrical activity of the diaphragm to control the mechanical ventilator, offering inspiratory assistance in proportion to respiratory effort to…
- Trial name
- NCT01519258
- Testing
- Pressure Support ventilation, NAVA
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Intraoperative Lung Protective Ventilation
Intraoperative Lung Protective Ventilation in Czech Republic
This questionnaire-based study aims to evaluate the adherence to and current clinical practices regarding intraoperative lung-protective ventilation (IOLPV) among anesthesiologists in the Czech Republic.
- Trial name
- IOLPVCZ (NCT07282899)
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Abdominal Surgery, Obese Patients
Open Lung Approach Versus Conventional Protective Ventilation in Obese Patients Undergoing Open Abdominal Surgery
the purpose of this study is to compare open lung approach versus conventional protective ventilation in obese patients undergoing open abdominal surgery
- Trial name
- NCT04506736
- Testing
- ARM, spontanous ventilation
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Zagazig University
ARDS, Volumetric Capnography
Clinical and Physiological Assessment of a Nearly Ultra-protective Lung Ventilation Strategy: A Quasi-experimental Preliminary Study in ARDS Patients
This study aims to determine whether a protective mechanical ventilator strategy generates a reduction in the Bohr´s dead space in patients with moderate or severe acute respiratory distress syndrome (ARDS).
- Trial name
- NCT04435613
- Testing
- protective mechanical ventilation strategies
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Clinica las Condes, Chile
Postoperative Pulmonary Complications, Mechanical Ventilation
Driving Pressure-Guided Individualized PEEP Versus Standard PEEP: Effects on Postoperative Pulmonary Complications in Upper Abdominal Digestive Surgery
This randomized clinical trial compares two methods of setting positive end-expiratory pressure (PEEP) during general anesthesia in adults undergoing upper abdominal digestive surgery who are at moderate or high risk of…
- Trial name
- NCT07885124
- Testing
- Driving Pressure-Guided Individualized PEEP, Standard PEEP
- Where
- Tunisia
- Volunteers
- 210 people
- Sponsor
- Hopital Charles Nicolle
Pneumoperitoneum
Moderate vs Deep Neuromuscular Block on Biotrauma During Laparoscopy
The purposes of this study is to investigate the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy.
- Trial name
- NCT03576118
- Testing
- Deep neuromuscular block, Moderate neuromuscular block
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Ajou University School of Medicine
Postoperative Respiratory Complications
PROVHILO:Protective Ventilation During General Anesthesia for Open Abdominal Surgery
The purpose of this international, multicentre, double-blinded randomized controlled trial is to determine if the "open lung approach" providing recruitment maneuvers and PEEP(Positive End Expiratory Pressure) during general…
- Trial name
- PROVHILO (NCT01441791)
- Testing
- Lung protective strategy ventilation
- Where
- 30 sites in United States, Austria and 8 more
- Volunteers
- 900 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Respiratory Distress Syndrome
Factors Associated With the Use of Lung Protective Ventilation Strategy (LPV) in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients in Intensive Care Unit (ICU)
In 1967, Ashbaugh et al first described 12 patients with a syndrome characterized by the acute onset dyspnea, severe hypoxemia, diffuse lung infiltrates on the chest radiography and decreased lung compliance.
- Trial name
- NCT01102322
- Testing
- Quality
- Where
- Taiwan
- Volunteers
- 111 people
- Sponsor
- National Taiwan University Hospital
Robotic Surgery, Post Operative Pulmonary Complications
Low-Intensity Mechanical Ventilation in the Operating Room: a Pilot Study
The aim of the study is to assess whether a bundle of protective low-intensity mechanical ventilation interventions reduces perioperative atelectasis and postoperative pulmonary complications, compared with standard care in a…
- Trial name
- VIOLET (NCT07277244)
- Testing
- Low Intensity Mechanical Ventilation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Beth Israel Deaconess Medical Center
Burn, Mechanical Ventilation
BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury
Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures.
- Conditions
- Burn, Mechanical Ventilation, Mechanical Ventilation Complication, ICU
- Trial name
- BURN-ASV (NCT07674563)
- Testing
- Adaptive Support Ventilation (ASV), Conventional Lung-Protective Mechanical Ventilation
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Adult Respiratory Distress Syndrome
Protective Ventilation With Carbon Dioxide (CO2) -Removal Technique in Patients With Adult Respiratory Distress Syndrome (ARDS)
30% of ARDS patients ventilated according to NIH protocol presents morphological (CT) and functional (Stress Index>1) conditions of hyperinflation even with Plateau pressure (Pplat) < 30 cmH2O; values of Pplat lower than 26 cmH2O…
- Trial name
- NCT00465309
- Testing
- protective ventilation with CO2 removal technique
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Postoperative Pulmonary Complications, Respiratory Insufficiency
The PROtective Ventilation Using Open Lung Approach Or Not Trial
Postoperative Pulmonary Complications (PPC) are very common. It severely affects postoperative recovery, particularly in the abdominal surgery.
- Trial name
- PROVOLON (NCT03160144)
- Testing
- open lung approach
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University