Clinical trials: Lymphedema
Lymphatic Diseases, Lymphatic Abnormalities
A Prospective Natural History Study of Lymphatic Anomalies
Background: The lymphatic system is a network of vessels that carry a clear fluid called lymph through the body. Problems in the lymphatic system can cause pain, fluid buildup, and issues with immunity.
- Trial name
- NCT05731141
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Lymphedema, Breast Cancer
The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema
The aim of this study is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, (Lymphedema Functioning Disability and health questionnaire for upper limb lymphedema)) 15 months after randomization…
- Trial name
- LYMPH (NCT05890677)
- Testing
- Surgical Intervention, Conservative Complex Physical Decongestion Therapy
- Where
- 36 sites in United States, Austria and 13 more
- Volunteers
- 280 people
- Sponsor
- University Hospital, Basel, Switzerland
Lymphedema
Use of Reconstructive Microsurgery for the Treatment of Lymphedema
Lymphedema is a chronic condition characterized by the accumulation of lymphatic fluid in tissues, frequently resulting from oncological treatments, trauma, or cancer.
- Trial name
- NCT07889856
- Testing
- Surgery with and without the aid of Indocyanine Green (ICG)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Breast Carcinoma, Lymphedema
Remotivation Process for Improving Adherence to Lymphedema Treatment Programs in Patients With Breast Cancer-Related Lymphedema
This trial studies how well the Remotivation Process in an occupational therapy program works in improving adherence to lymphedema treatment programs in patients with breast cancer-related lymphedema.
- Trial name
- NCT04465253
- Testing
- Best Practice, Motivational Interviewing, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- City of Hope Medical Center
Lymphedema, Secondary Lymphedema
Efficacy of Complete Decongestive Therapy for Limb Lymphedema: Response Profile and Predictive Modeling
Background: Complete decongestive therapy (CDT) is the standard treatment for lymphedema, but response varies by localization and laterality.
- Conditions
- Lymphedema, Secondary Lymphedema, Breast Cancer-Related Lymphedema, Upper Extremity Lymphedema
- Trial name
- LYMPH-PROG (NCT07878598)
- Testing
- Intensive phase of Complete Decongestive Therapy
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Ryazan State Medical University
Lymphedema of Upper Limb
Auto-Adjustable MOBIDERm Autofit Armsleeve in the Management of Upper Limb Lymphedema.
This study aims to assess Auto-Adjustable MOBIDERM® Autofit Armsleeve effect on upper limb volume excess compared to the compression bandages to manage the volume of upper limb lymphedema in patients with breast cancer related…
- Trial name
- LyberT (NCT06264817)
- Testing
- MOBIDERM Autofit Armsleeve, Compressive bandaging
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Thuasne
Breast Cancer
Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery
This trial is to investigate if in patients with clinically node positive breast cancer undergoing upfront surgery, treatment with TAS and ART is superior to ALND in terms of arm-related Quality of Life (QoL) and occurrence of…
- Trial name
- OPBC-10/ NOAX (NCT07140172)
- Testing
- Axillary lymph node dissection (ALND), Axillary radiotherapy (ART)
- Where
- 55 sites in United States, Austria and 9 more
- Volunteers
- 1,060 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast Neoplasms, Radiotherapy
Hypofractionated LocoRegional Radiotherapy in Breast Cancer
The primary objective of this study is to determine if hypofractionated RT delivered over 1 week to the breast or chest wall and regional nodes (26Gy in 5 daily fractions) following BCS or mastectomy, is non-inferior to…
- Conditions
- Breast Neoplasms, Radiotherapy, Lymphedema
- Trial name
- RHEAL (NCT04228991)
- Testing
- Locoregional radiation treatment - Conventional fractionation, Locoregional radiation treatment - Hypofractionation
- Where
- 20 sites in Canada
- Volunteers
- 588 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Lymphedema, Breast Cancer, Mastectomy Related Lymphedema
Complete Decongestive Therapy Versus Non-pneumatic Compression Therapy in Post Mastectomy Lymphedema
The aim of the study is to compare the effectiveness of Complete Decongestive Therapy and Non-Pneumatic Compression Therapy, both combined with routine physical therapy, in reducing pain and edema volume, improving range of…
- Conditions
- Lymphedema, Breast Cancer, Mastectomy Related Lymphedema, Post Mastectomy Lymphedema
- Trial name
- CDT (NCT07217288)
- Testing
- Non Pneumatic compression device, Complete Decongestive therapy
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Open Surgery, Lymphedema
A Global, Prospective, Real-World, Investigation of the Symani® Surgical System for Microsurgical Anastomosis
The objective of this clinical study is to evaluate the Symani System's safety and effectiveness for microsurgical anastomosis during free tissue transfer surgery and lymphatic surgery.
- Conditions
- Open Surgery, Lymphedema, Free Tissue Transfer, Microsurgery
- Trial name
- PRIME (NCT06628219)
- Testing
- Symani Surgical System
- Sponsor
- MMI (Medical Microinstruments, Inc.)
Lymphedema Primary
Inelastic Compression Use in Primary Lymphedema
Primary lymphedema in children is a rare, chronic condition caused by congenital or inherited developmental abnormalities in the lymphatic system that lead to persistent fluid buildup and swelling.
- Trial name
- Primary LE (NCT07866599)
- Testing
- Compression device with medium pressure (23-32 mmHg)
- Volunteers
- 30 people
- Sponsor
- University School of Physical Education, Krakow, Poland
Breast Cancer Lymphedema
Radial Shock Wave Treatment Alongside Decongestive Care for Arm Swelling After Breast Cancer
Arm swelling can persist after breast cancer treatment and may interfere with comfort, movement, and everyday activities. Decongestive care combines several approaches to manage this swelling.
- Trial name
- NCT07862296
- Testing
- Complex decongestive therapy, Radial extracorporeal shock wave therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Selcuk University
Head and Neck Cancer
Preventing Lymphedema in Patients Undergoing Surgical Treatment for Head and Neck Cancer Through Vein Reconstruction
The goal of this clinical trial is to learn if facial vein reconstruction after neck dissection works to reduce rates of lymphedema in adults getting surgical treatment for head and neck cancer.
- Trial name
- NCT07694726
- Testing
- Facial Vein Reconstruction
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Pittsburgh
Lymphedema
Biorepository of Biomarkers for Optimization of Microvascular Treatment of Lymphedema
Researchers are collecting information, saliva, blood and tissue from subjects with lymphedema to store for future research.
- Trial name
- NCT04123457
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Breast Cancer Related Lymphedema
EFFECT OF ESWT ON BREAST-CANCER RELATED LYMPHEDEMA
The aim of this study is to evaluate the effectiveness of extracorporeal shock wave therapy (ESWT) combined with complete decongestive therapy (CDT) compared with CDT alone in patients with breast cancer-related lymphedema.
- Trial name
- NCT07854262
- Testing
- Complete Decongestive Therapy, Extracorporeal Shock Wave Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ankara City Hospital Bilkent
Lymphedema, Inflammatory Breast Cancer (IBC)
Prediction Of Lymphedema In Patients With Inflammatory BreastCancer Using Preoperative Bioimpedance Measurements
To find out whether the BIA test can help identify participants with IBC who are at risk for developing lymphedema.
- Conditions
- Lymphedema, Inflammatory Breast Cancer (IBC), Preoperative, Bioimpedance Measurement
- Trial name
- NCT07855627
- Testing
- Neoadjuvant therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- M.D. Anderson Cancer Center
Vascular Anomaly, Osler Rendu Disease
Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study
There are no prospective studies of pregnancies for the diseases studied here in (Heredity Hemorrhagic Telangiectasia, Marfan syndrome or related, primary lower limb lymphedema, superficial arteriovenous malformations, and…
- Conditions
- Vascular Anomaly, Osler Rendu Disease, Marfan Syndrome or Related, Lymphedema Primary
- Trial name
- COGRare5 (NCT04194619)
- Testing
- Questionnaire
- Where
- 37 sites in France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Breast Neoplasms, Lymphedema Due to Radiation
ICG Lymphography Changes Before and After Radiotherapy in Breast Cancer Patients
The goal of this observational study is to learn how the lymphatic system changes before and after radiotherapy in female patients with breast cancer.
- Trial name
- ICG_prepostRT (NCT07297927)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Inah Kim
Lymphedema
Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.
To learn if reconstruction of the lymphatic system at the time of axillary lymphadenectomy can reduce the risk of developing lymphedema.
- Trial name
- NCT06989099
- Testing
- Immediate Lymphatic Reconstruction (ILR)/, Prophylactic Lymphovenous Bypass (pLVB)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Lymphedema
A Study Comparing Quality of Life in Patients With Lymphedema Who Undergo Surgical Treatment Versus Non-Surgical Management
This study is being done to see the long-term results for patients who choose to have surgery for lymphedema (with the vascularized lymph node transfer), compared to patients who choose not to have surgery.
- Trial name
- NCT03248310
- Testing
- Quality of Life Assessments
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- Memorial Sloan Kettering Cancer Center