Clinical trials: ME/CFS
Chronic Fatigue Syndrome
Structural Problems in Brainstem and Cervical Spine Cord in ME/CFS
A case control study on patients with ME/CFS and healthy controls on prevalence of cervical obstructions, Cerebro spinal fluid (CSF) pressure and laboratory findings.
- Trial name
- NCT04403854
- Testing
- MRI, Spinal Tap
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bragee Clinics
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
RESTORE ME -- RCT of Oxaloacetate on Improving Fatigue in ME/CFS
There is no approved treatment for fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a condition with as many as 2.5 million people in the US.
- Conditions
- Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, Fatigue
- Trial name
- NCT05273372
- Testing
- Medical Food - Anhydrous Enol-Oxaloacetate
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Terra Biological LLC
Fatigue Syndrome, Chronic, Myalgic Encephalomyelitis
Oral Melatonin Plus Zinc Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)
The purpose of this study is to evaluate the effects of oral melatonin plus zinc supplementation in relieving self-reported fatigue in CFS/ME
- Trial name
- MELATOZINC (NCT03000777)
- Testing
- melatonin plus zinc
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Laboratorios Viñas, S.A.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), ME/CFS Following COVID-19
Observational Study on Immunoadsorption (IA) in Patients With Autoantibody-Positive Post-Infectious ME/CFS
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe, often infection-triggered disease characterized by debilitating fatigue and post-exertional malaise lasting over 14 hours, along with pain, cognitive…
- Trial name
- IMPACT (NCT07529197)
- Testing
- IA with TheraSorb ® column (Miltenyi)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
A 3-day Course for CFS/ME
Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) can be a serious and disabling condition with a heavy symptom burden and low function. Work disability is common, and social life dramatically affected.
- Trial name
- NCT05236465
- Testing
- A 3-day course, Waiting list
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Chronic Infections and Inflammation in ME/CFS: An Observational Study
CHIIME is a study of people who have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). People who do not have this condition will also be enrolled.
- Trial name
- CHIIME (NCT07227441)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Survey and Cognitive Behavior Therapy for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
The purpose of this study is to analyze income variables in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, and to analyze the effect of short vs. long Cognitive Behaviour Therapy.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Fatigue, Pain
- Trial name
- NCT00920777
- Testing
- CBT, Control group
- Where
- Norway
- Volunteers
- 234 people
- Sponsor
- Norwegian University of Science and Technology
Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis (ME)
The Synergy Trial: Methylphenidate Plus a CFS-Specific Nutrient Formula as a Treatment for Chronic Fatigue Syndrome
The Synergy Trial will evaluate the safety and efficacy of a currently available medication (methylphenidate hydrochloride) combined with a CFS-specific dietary supplement (CFS Nutrient Formula) to treat Chronic Fatigue Syndrome…
- Trial name
- NCT01966276
- Testing
- Methyl-P plus Nutrient Formula
- Where
- 4 sites in United States
- Volunteers
- 134 people
- Sponsor
- K-PAX Pharmaceuticals, Inc.
Myalgic Encephalomyelitis
Effect of CoQ10 Plus Selenium Supplementation on Clinical Outcomes and Biochemical Markers in ME/CFS (CoSeME Study)
In recent years, it has been suggested that nutritional deficiencies may be of causal relevance in individuals with ME/CFS. These include deficiencies of vitamins and trace elements.
- Trial name
- CoSeME (NCT05128292)
- Testing
- CoQ10 plus Selenium
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Functional Disorders, Post Covid-19
AIR-program and HUS Internet Therapy Compared to Treatment as Usual in Functional Disorders and Post Covid-19 Condition
This study will compare an Amygdala and insula retraining (AIR) program to an internet therapy developed at Helsinki University Hospital. The study will be a multi-center randomized controlled trial.
- Trial name
- NCT05212467
- Testing
- AIR-program, HUS Internet therapy, Treatment as usual
- Where
- 2 sites in Finland
- Volunteers
- 360 people
- Sponsor
- Helsinki University Central Hospital
Post-COVID ME/CFS
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome
The goal of this clinical trial is to evaluate the therapeutic value of an approved drug (Vericiguat) in patients with post-COVID-19 syndrome, who suffer from profound tiredness or fatigue, regardless of bed rest.The main…
- Trial name
- NCT05697640
- Testing
- Vericiguat Oral Tablet
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Charite University, Berlin, Germany
Encephalomyelitis, Myalgic, Chronic Fatigue Syndrome
Effect of Stellate Ganglion Block on ME/CFS
The goal of this clinical trial is to study the effects of stellate ganglion block (SGB) in participants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
- Conditions
- Encephalomyelitis, Myalgic, Chronic Fatigue Syndrome, Chronic Fatigue Disorder, Chronic Fatigue and Immune Dysfunction Syndrome
- Trial name
- SGB_ME (NCT05664711)
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Neuroversion, Inc.
Chronic Fatigue Syndrome
ME/CFS: Activity Patterns and Autonomic Dysfunction
The purpose of this study is to identify daily activity patterns, negative life events and autonomic abnormalities that may be related to non-improvement in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
- Trial name
- NCT02948556
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Stony Brook University
Chronic Fatigue Syndrome (CFS)
Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This is a 16-week controlled treatment trial of an over-the -counter supplement, hydrogen water, for individuals with ME/CFS patients. An active treatment condition will be compared to a placebo-control condition.
- Trial name
- ME/CFS (NCT07753122)
- Testing
- Molecular hydrogen produced by a metallic magnesium tablet, consumed 3x a day dissolved in water. Treatment duration is 16 weeks.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Fred Friedberg
Chronic Fatigue Syndrome
Exercise-related Post-exertional Malaise
This pilot study is intended to identify sex differences in myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) during recovery from brief but high effort exercise tests.
- Trial name
- CFS/ME (NCT03331419)
- Testing
- Exercise test
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stony Brook University
ME/CFS, IBS - Irritable Bowel Syndrome
The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This clinical study aims to evaluate the use of i3.1 probiotic in participants who meet the Institute of Medicine (Canadian Consensus Criteria) case definition for ME/CFS and who may or may not be diagnosed with irritable bowel…
- Trial name
- NCT06211062
- Testing
- Floradapt Intensive GI
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nova Southeastern University
Chronic Fatigue Syndrome
ME/CFS, Hypermobility and Craniocervical Obstructions
A retrospective study on clinical and radiological findings in ME/CFS
- Trial name
- NCT04399330
- Where
- Sweden
- Volunteers
- 225 people
- Sponsor
- Bragee Clinics
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in ME/CFS
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
- Trial name
- NCT04100915
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Fatigue Syndrome, Chronic, Epstein-Barr Virus Infection
Mental Training for CFS Following EBV Infection in Adolescents
The general aim of this study is to investigate the effect of an individually tailored mental training program in adolescents developing chronic fatigue syndrome (CFS) after an acute Epstein Barr-virus (EBV) infection.
- Trial name
- NCT02499302
- Testing
- Mental training
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital, Akershus