Clinical trials: Macronutrients
Obesity, Brain Function
Food Intake-Related Brain and Metabolic Responses in Obesity
This study is a prospective, single-center, randomized, controlled, crossover intervention trial. A total of 60 participants, including 30 patients with obesity and 30 healthy controls, will be enrolled.
- Conditions
- Obesity, Brain Function, Metabolomics, Feeding Behavior
- Trial name
- NCT07392905
- Testing
- Glucose Liquid Meal, Fat Liquid Meal, Protein Liquid Meal
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Appetite and General Nutritional Disorders
Protein Quality on Appetite Control, Reward-driven Eating, & Subsequent Food Intake
To determine whether the consumption of a beef-rich lunch improves appetite control, satiety, and energy intake regulation while reducing food reward and food cravings compared to the consumption of a soy-rich lunch when matched…
- Trial name
- NCT02285907
- Testing
- Macronutrient and Fiber Matched BEEF, Macronutrient and Fiber Matched SOY, Serving Size Matched BEEF
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Muscle Protein Synthesis
Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis
Muscle mass is normally maintained through the regulated balance between the processes of protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old muscle proteins).
- Trial name
- NCT01885429
- Testing
- Positive Control, Negative Control, Low Protein Low Leucine Spike
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Excess Intake of Macronutrients, Excess Intake of Micronutrients
Water and Coffee Intervention in Humans
39 healthy subjects without medication (except oral contraceptives) aged 20-70 years are recruited via advertisements or through telephone contacts with individuals that had previously participated in population-based cohort…
- Conditions
- Excess Intake of Macronutrients, Excess Intake of Micronutrients, Vasopressin Low
- Trial name
- NCT06165185
- Testing
- Water, Coffee, Control
- Where
- Sweden
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Region Skane
Healthy
A Study of the Impact of Different Delivery Modes on Specific Macronutrient Components in Human Milk
The aim of the study is to evaluate the impact of different delivery modes on specific macronutrient components in human milk.
- Trial name
- ZoomMING (NCT05516940)
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Obesity
FB4 (Framingham, Boston, Bloomington, Birmingham, and Baylor)
This study will evaluate the effects of dietary carbohydrate and sugar consumption, independent of energy content, on body fatness and metabolism in a rigorous feeding study.
- Trial name
- NCT03394664
- Testing
- Feeding Study
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Nutritional and Metabolic Diseases
Blood Lipid Responses to Diet Macronutrients
The macronutrient composition of a diet (proportions of carbohydrates, fats and proteins) strongly influences the way the body stores and utilises substrates (e.g., fats and sugars), which in turn influences the risk of…
- Trial name
- BoLD (NCT05973539)
- Testing
- Diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy Volunteers
Gut Hormone Secretion and Macronutrients
The role of gut hormone (GLP-1, GIP, PYY...) in glucose homeostasis has been widely demonstrated. Furthermore modifications in their pattern of secretion seem to be involved in the improvement of glucose control in obese patients…
- Trial name
- NCT00869453
- Testing
- test meal, glucose, fat
- Where
- 2 sites in Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Prediabetic State, Insulin Resistance
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
This study compares the effects of a one-month diet high in saturated fat (SF), glycemic index (GI), and salt (Na+) to a diet low in these nutritional parameters on memory and other cognitive functions, on MRI measures of brain…
- Conditions
- Prediabetic State, Insulin Resistance, Middle Age, Prehypertension
- Trial name
- MEAL-2 (NCT02463084)
- Testing
- Low Diet, High Diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Breastmilk, Breastmilk Expression
Comparison of Macronutrient Content of Breast Milk Collected From Mothers Using Three Different Milking Methods
The aim of this study is to compare the macronutrient content of mature milk obtained from mothers using three different methods: hand milking, manual pumping and electric machine.
- Conditions
- Breastmilk, Breastmilk Expression, Breastmilk Collection, Human Milk/Breastfeeding
- Trial name
- NCT07046962
- Testing
- Intervention Type Device: Manual pump expressing breast milk, Intervention Type Device: Hand pumping breast milk, Intervention Type Device: Electric pumping breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Eating Behavior
The Effect of Macronutrients on Satiety and Gut Hormone Responses
This study is part of a research theme aiming at elucidating the physiological mechanisms of action of weight loss after gastric bypass surgery.
- Trial name
- Microcapsule (NCT03466047)
- Testing
- Protein stomach, Protein distal small intestine, CHO stomach
- Where
- Ireland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Dietary Fats, Carbohydrates
Macronutrients and Postprandial Vascular Function
Vascular function decreases following the intake of a mixed meal in some, but not all studies. Differences in the relative amounts of dietary fat, carbohydrates and protein present in the mixed-meal challenges may have…
- Conditions
- Dietary Fats, Carbohydrates, Proteins, Macronutrients
- Trial name
- NCT03139890
- Testing
- High-fat (HF-LC-LP) milkshake, High-carbohydrate (LF-HC-LP) milkshake, High-protein (LF-LC-HP) milkshake
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Overweight and Obesity
The Effects of Combined Energy and Carbohydrate Restriction on Exercise Capacity
The effect of calorie restriction combined with low or moderate carbohydrate availability on exercise capacity, metabolism and metabolic health indicators will be measured in a randomized parallel group design.
- Trial name
- CHO-EX (NCT06381908)
- Testing
- Calorie-restriction with low carbohydrate, Calorie-restriction with moderate carbohydrate
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Overweight
Energy Expenditure, Sleep and Macronutrients
The purpose of this study is to determine energy expenditure and sleep in response to protein/carbohydrate and fat ratio of the diet over a short-term and long-term period of time.
- Conditions
- Obesity, Overweight, Overnutrition, Nutrition Disorders
- Trial name
- NCT01551238
- Testing
- Differences in protein content of meals
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Dietary Manipulation
Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise
This study will investigate the effect of dietary macronutrient manipulation on glycogen (stored carbohydrate) levels in the muscle and substrate oxidation during exercise.
- Trial name
- NCT02605291
- Testing
- Diet with a different macronutrient content A, Diet with a different macronutrient content B, Diet with a different macronutrient content C
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Healthy
Endogenous vs. Exogenous Ketone Bodies
Aim of the study is to compare the origin of ketone bodies: endogenous ketone bodies due to 36 hours fasting or 24 hours of ketogenic diet vs. exogenous ketone bodies as supplements additional to normal diet.
- Trial name
- NCT04490226
- Testing
- Beta-Hydroxybutyrate as Ca-Mg-salt, active, ketogenic diet (KetoCal® 4:1 Neutral, Nutricia GmbH, Erlangen, Germany), active, fasting, active
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Kiel
Energy, Cardiovascular Disease
Energy Value of Macronutrients From Pistachio Nuts and Mechanisms of Nutrient Action
The objective of this study is to measure the energy value of pistachios in the human diet and study molecular mechanisms that may help explain the beneficial health effects of pistachios.
- Conditions
- Energy, Cardiovascular Disease, Cancer
- Trial name
- NCT00942695
- Testing
- 1.5PD, 3.0PD, control
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Department of Agriculture (USDA)
Obesity, Body Composition
Study of Macronutrients and Heart Disease Risk
The objective of this trial is to examine the long-term effects of a diet low in carbohydrates, as compared to one low in fat, on cardiovascular disease risk factors, including blood pressure (BP), body weight and composition…
- Conditions
- Obesity, Body Composition, Blood Pressure, Cardiovascular Diseases
- Trial name
- MACRO (NCT00609271)
- Testing
- low carbohydrate diet, low fat diet
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tulane University Health Sciences Center
Sleep, Diet Modification
Diet and Sleep Monitoring
This study will investigate the effect of two dietary patterns on sleep outcomes and measures of reported appetite. Participants will be given two different diets on two separate stays.
- Trial name
- NCT03257137
- Testing
- Diet Quality
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Lack of Satiety, Excess Intake of Macronutrients
Casinomacropeptide and Satiety
Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle.
- Conditions
- Lack of Satiety, Excess Intake of Macronutrients, Appetite Disorders
- Trial name
- CMP2 (NCT01587911)
- Testing
- Whey, Whey-CMP, Control
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis