Clinical trials: Major Hepatectomy
Liver Cancer
Bone Marrow Derived Adult Liver Stem Cell Recruitment After Major Liver Resections: Correlation With Liver Regeneration and Hepatic Function
The results of this study may or may not establish useful baseline data, which will help us understand how bone marrow derived adult liver stem cells behave in normal healthy adults/volunteers (the control group), and in patients…
- Trial name
- NCT00605800
- Testing
- blood drawn
- Volunteers
- healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer, Tumour
Tranexamic Acid Versus Placebo for Blood to Reduce Perioperative Bleeding Post-liver Resection
Tranexamic acid (TXA) is an antifibrinolytic agent that has been shown to reduce blood loss and blood transfusion requirements in the following patient populations: multisystem trauma, liver transplantation, cardiac surgery and…
- Conditions
- Cancer, Tumour, Surgery
- Trial name
- NCT01651182
- Testing
- No tranexamic acid, Tranexamic Acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Liver Function After Partial Liver Resection
Xenon-anesthesia on Patients Undergoing Major Liver-resection
The aim of this study is to compare the postoperative outcome of patients undergoing major liver resection under xenon- compared to desflurane-anesthesia.
- Trial name
- XeLiv (NCT03504033)
- Testing
- Xenon, Desflurane
- Where
- Germany
- Sponsor
- RWTH Aachen University
Surgery-Complications
Restrictive- vs Individualized Goal Directed Fluid Therapy in Liver Surgery
"Low central venous pressure (low-CVP) or a restrictive fluid administration strategy is usually used worldwide during major liver resection surgery.
- Trial name
- REVOLUTION (NCT05704387)
- Testing
- individualized GDFT, Restrictive fluid therapy strategy
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Resection, Liver Failure
Terlipressin Administration in Patients Undergoing Major Liver Resection
This study investigates if the administration of terlipressin reduces complications after major liver surgery.
- Trial name
- NCT01921985
- Testing
- Terlipressin
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
MRI, Liver Resection
May the Risk of PHLF be Predicted With Preoperative Liver Gadoxetate MRI
Post hepatectomy liver failure (PHLF) is one of the most severe complications after liver re-section. Preoperative evaluation of liver function is complicated and imprecise.
- Conditions
- MRI, Liver Resection, Liver Failure as A Complication of Care
- Trial name
- MR-Predict (NCT04692259)
- Testing
- MRI
- Where
- 7 sites in Denmark, Finland and 2 more
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping
Ischaemic Type Biliary Lesion
Ischemic Preconditioning in Major Hepatectomy
To evaluate the accuracy of ischemic preconditioning (IPC) as a protective maneuver against ischemia/reperfusion lesion in patients undergoing major liver resection with intermittent portal triad Clamping (IPTC).
- Trial name
- HECLA (NCT00908245)
- Testing
- Control, Preconditioning ischemia
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fatty Liver, Surgery
Liver Fat Quantification by Magnetic Resonance Imaging (MRI) - Prediction of Postoperative Complications
The purpose of this study is to objectively quantify liver fat content (LFC) by Magnetic Resonant Imaging (MRI) prior to major liver surgery, and to investigate its association with post-operative complications.
- Trial name
- MRsteatosis (NCT01234714)
- Testing
- Non-invasive Magnetic Resonance Imaging (MRI), Major liver resection
- Where
- 2 sites in Switzerland
- Volunteers
- 84 people
- Sponsor
- University of Zurich
Major Hepatectomy
Segment IV Hypertrophy After Liver Venous Deprivation
before major hepatectomy, in case of insufisant future liver remanent volume or function, portal embolization is a routinely used method to enable growth of the future liver remnant.
- Trial name
- NCT04370132
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Intrahepatic Cholangiocarcinoma
Role of Bile Duct Resection in Major Hepatectomy Due to Intrahepatic Cholangiocarcinoma
To investigate the prognosis due to presence or absence of bile duct resection in intrahepatic cholangiocarcinoma that require hepatic lobectomy.
- Trial name
- NCT01862276
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Kansai Hepatobiliary Oncology Group
Intraoperative Hypotension, Hepatectomy
Remimazolam Versus Propofol for Maintenance of Anaesthesia During Major Hepatectomy Under Low Central Venous Pressure
The goal of this clinical trial is to learn whether remimazolam helps prevent low blood pressure better than propofol during major liver surgery in adults.
- Trial name
- NCT07789275
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Liver Neoplasms, Hepatectomy
Hypovolemic Phlebotomy to Reduce Blood Transfusions in Major Hepatic Resections
Major liver resection is associated with substantial intraoperative blood loss and subsequently blood transfusions. Blood transfusion in elective liver surgery is a significant factor of perioperative morbidity and mortality, as…
- Conditions
- Liver Neoplasms, Hepatectomy, Blood Transfusion, Blood Loss, Surgical
- Trial name
- PRICE2 (NCT03651154)
- Testing
- Hypovolemic Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 440 people
- Sponsor
- Ottawa Hospital Research Institute
Colorectal Liver Metastases, Colon Cancer
Multiple Minor Hepatectomies Versus Major or Extended Hepatectomies for Colorectal Liver Metastases.
The performance of multiple minor hepatectomies (MMH) instead of major hepatectomies (MH) in patients with colorectal liver metastases (CLM) is object of debate.
- Trial name
- NCT02331641
- Testing
- Hepatectomy
- Volunteers
- 554 people
- Sponsor
- University of Milan
Major Liver Surgery
Effects of Omega-3 Fatty Acids on Outcome After Major Liver Resection
To study the efficacy and safety of intravenous Omegaven™ (vs. Placebo) in reducing postoperative morbidity and mortality after major liver resection.
- Trial name
- NCT01884948
- Testing
- Omegaven™
- Where
- Switzerland
- Volunteers
- 258 people
- Sponsor
- University of Zurich
Ventilator Lung, Liver Cirrhosis
Effect of Low Tidal Ventilation on Intraoperative Bleeding in Laparoscopic Major Hepatectomy
This randomized controlled study's objective is to find a safer mechanical ventilation strategy to reduce intraoperative bleeding in liver cancer patients undergoing laparoscopic major liver resection.
- Conditions
- Ventilator Lung, Liver Cirrhosis, Hepatocellular Carcinoma, Blood Loss, Surgical
- Trial name
- NCT05490147
- Testing
- conventional tidal volume (tidal volume [ml]= ideal body weight [kg]* 10~12) group, low tidal (tidal volume [ml]= ideal body weight [kg] * 6~8) volume
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Myocardial Injury After Noncardiac Surgery (MINS), Postoperative Complications
Prediction Model for MINS After Major Hepatobiliary Surgery
This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery.
- Conditions
- Myocardial Injury After Noncardiac Surgery (MINS), Postoperative Complications, Liver Neoplasm, Hepatobiliary Diseases
- Trial name
- NCT07335042
- Testing
- Major Hepatobiliary Surgery
- Where
- 6 sites in China
- Volunteers
- 1,800 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Liver Regeneration
Study of the Protective Effect of Mechanism of Pentoxyfilline After Major Liver Resection Under Inflow Occlusion (Pringle Manoeuvre)
The investigators hypothecate that pentoxyfilline increase significantly the liver regeneration and reduces significantly ischemia and reperfusion (I/R) injury in major liver using aspartate aminotransferase (AST) and alanine…
- Trial name
- NCT00957619
- Testing
- pentoxyfilline
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Hepatectomy
A Study of Methylprednisolone in People Having Liver Surgery
The purpose of this study is to test whether receiving methylprednisolone before surgery will reduce the side effects of having surgery, such as infections and longer hospital stays.
- Trial name
- NCT07507643
- Testing
- Methylprednisolone
- Where
- 19 sites in United States
- Volunteers
- 750 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Liver Metastasis Colon Cancer, Postoperative Complications
Effect of the Laparoscopic Approach in Reducing Postoperative Severe Complications Following Hepatectomy for Colorectal Liver Metastases
The objective of this study is to demonstrate the superiority of the laparoscopic approach over the open approach in the resection of colorectal liver metastases, by examining the reduction of postoperative complications…
- Trial name
- METALAP (NCT04163887)
- Testing
- hepatectomy
- Where
- 21 sites in France
- Volunteers
- 340 people
- Sponsor
- Institut Mutualiste Montsouris
Liver Resection, Colorectal Carcinoma Liver Metastases
Safety of HRX215 in Patients After Minor and Major Liver Resection
The goal of this clinical trial is to learn if HRX215 is safe, tolerable and active in adults who have undergone liver resection due to colorectal carcinoma metastases. The objectives are: 1.
- Trial name
- NCT06638502
- Testing
- HRX215 capsules
- Where
- 14 sites in United States, France and 3 more
- Volunteers
- 80 people
- Sponsor
- HepaRegeniX GmbH