Clinical trials: Malaria Anaemia
Severe Malaria, Severe Anaemia
Post-discharge Malaria Chemoprevention Implementation Trial in Benin
The proposed research aims to conduct implementation trials in Benin, co-designed with national stakeholders, to evaluate different delivery strategies for optimizing health system delivery of post-discharge malaria…
- Trial name
- PDMC-SL (NCT06601712)
- Testing
- Adherence support strategy A, Adherence support strategy B, Control
- Where
- 2 sites in Benin
- Volunteers
- 648 people
- Sponsor
- Institut de Recherche Clinique du Benin
Malaria, Severe Malaria
Monoclonal Antibodies in Children With Severe Anaemia or Severe Malaria to Prevent Malaria After Hospital Discharge
Background and rationale: Hospitalised children with severe anaemia remain at high risk of dying or requiring hospital readmission for at least 6 months after discharge.
- Conditions
- Malaria, Severe Malaria, Severe Anaemia, Post Discharge
- Trial name
- L9LS-pd (NCT07082205)
- Testing
- Antimalarial monoclonal antibodies, Dihydroartemisinin - Piperaquine (DP)
- Where
- 2 sites in Kenya
- Volunteers
- 398 people
- Sponsor
- Liverpool School of Tropical Medicine
Schistosomiasis in Children, Soil Transmitted Helminth (STH) Infections
Burden of Schistosomiasis and Soil-transmitted Helminth Infections in Schoolchildren in Banfora, Burkina Faso
A cross-sectional study will be conducted among 300 schoolchildren in the Banfora region, including 120 in urban and 180 in rural areas, to assess the prevalence of schistosomiasis and soil-transmitted helminth infections.
- Conditions
- Schistosomiasis in Children, Soil Transmitted Helminth (STH) Infections, Malaria Infection, Anaemia
- Trial name
- NTDs_SAC (NCT06973200)
- Testing
- Dihydroartemisin-piperaquine
- Where
- Burkina Faso
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre MURAZ/Institut National de Santé Publique
Malaria, Anaemia
Efficacy of Three Novel Bi-treated Long Lasting Insecticidal Nets
The massive scale-up of Long Lasting Insecticidal Nets (LLIN) has led to a major reduction in malaria burden (up to 50%) in many sub-Saharan African countries.
- Trial name
- NCT03554616
- Testing
- Chlorfenapyr LLIN, pyriproxyfen LLIN, Piperonyl butoxide LLIN
- Where
- Tanzania
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Anaemia
Evaluation of a Novel Long Lasting Insecticidal Net and Indoor Residual Spray Product
The proposed study is a four-arm randomized control trial (RCT) in 48 villages in the Lakes region in Tanzania comparing the relative effectiveness of 4 vector control interventions for reducing malaria transmission and…
- Trial name
- NCT02288637
- Testing
- Olyset Plus LLIN, Conventional Olyset LLIN, IRS
- Where
- Tanzania
- Volunteers
- 3,840 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria Parasitaemia, Birth Weight
Different Approaches for Delivery of IPT in Pregnancy in Burkina Faso
IPT/SP was adopted in 2005 by The Ministry of Health (MoH) of Burkina Faso to replace chemoprophylaxis with CQ in pregnancy. The new strategy is being implemented but no delivery approach was defined and presumably IPT/SP will…
- Conditions
- Malaria Parasitaemia, Birth Weight, Anaemia
- Trial name
- NCT00494416
- Testing
- delivery approaches of malaria intermittent preventive treatment in pregnancy
- Where
- Burkina Faso
- Volunteers
- 11,523 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Anaemia, Malaria
Intermittent Preventive Treatment for Malaria in Infants in Navrongo Ghana
Evaluation of the safety and effectiveness of malaria intermittent chemotherapy and iron supplementation delivered through Expanded Programme on Immunisation vaccination clinics.
- Trial name
- NCT00857077
- Testing
- Sulfadoxine-pyrimethamine
- Where
- Ghana
- Volunteers
- 2,485 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria in Pregnancy, Birth Weight
Relationships Between the Use of Antimalarial Drugs in Pregnancy and Plasmodium Falciparum Resistance
Plasmodium falciparum resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) continue to spread, impeding control of this important disease.
- Conditions
- Malaria in Pregnancy, Birth Weight, Anaemia
- Trial name
- NCT00140517
- Testing
- sulphadoxine-pyrimethamine, chloroquine
- Where
- Burkina Faso
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Anaemia
Intermittent Preventive Treatment (IPTp) Versus Rapid Diagnostic Testing (RDT) and Treatment of Malaria in Pregnancy
Among the best practices recommended for malaria control during pregnancy is ensuring effective case management of malaria illness.
- Conditions
- Malaria, Anaemia, Pregnancy
- Trial name
- NCT00432367
- Testing
- Amodiaquine plus artesunate combination; sulphadoxine-pyrimethamine
- Where
- Ghana
- Volunteers
- 3,333 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Hyper-reactive Malarial Splenomegaly, Malaria
Prednisone Plus Chloroquine for the Treatment of Hyper-reactive Malarial Splenomegaly
This randomized clinical trial will address a complication related to recurrent episodes of malaria in endemic areas - hyper-reactive malarial splenomegaly.
- Conditions
- Hyper-reactive Malarial Splenomegaly, Malaria, Anaemia
- Trial name
- LiHMS (NCT01785979)
- Testing
- prednisone induction - chloroquine, Chloroquine
- Where
- Papua New Guinea
- Sponsor
- Lihir Medical Centre
Malaria, Anaemia
Seasonal Malaria Chemoprevention Versus Home Management of Malaria in Children Under 5 Years in Ghana
In areas of Africa where malaria is only a problem during a short rainy season, monthly courses of antimalarial drugs can provide very effective prevention of malaria in children.
- Trial name
- NCT01651416
- Testing
- Artemether-lumefantrine combination, Dihydroartemisinin Piperaquine combination, Amodiaquine plus sulphadoxine-pyrimethamine combination
- Where
- Ghana
- Volunteers
- 2,400 people
- Sponsor
- Centre for Global Health Research, Ghana
Anaemia
Parenteral Artesunate Compared to Quinine as a Cause of Late Anaemia in African Children With Malaria
Delayed anaemia has been reported in European travellers with malaria cured by artesunate. Although no deaths related to this delayed anaemia have been reported so far, blood transfusion has been necessary in some affected…
- Trial name
- DHART (NCT02092766)
- Testing
- artesunate, quinine
- Where
- Democratic Republic of the Congo
- Volunteers
- 217 people
- Sponsor
- University of Oxford
Fever, Anaemia
Acceptability and Cost Effectiveness of Home Based Management of Fever: Different Strategies
Malaria remains a major cause of morbidity and mortality particularly among children < 5 years in Uganda. Due to inaccessibility many children die before they reach the health facility.
- Conditions
- Fever, Anaemia, Malaria
- Trial name
- NCT00259142
- Testing
- Chloroquine, sulphadoxine-pyrimethamine
- Where
- Uganda
- Volunteers
- 1,314 people
- Sponsor
- DBL -Institute for Health Research and Development
Malaria Anaemia
Chloroquine and Post Malaria Anaemia Study
The pathogenesis of post-malaria anaemia is multifactorial. Iron supplementation remains the mainstay of management of moderate and severe anaemia; however the management of mild anaemia (Hb 80-110g/l) is problematic as…
- Trial name
- CQ-PMA (NCT00473837)
- Testing
- Chloroquine
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Medical Research Council Unit, The Gambia
Anaemia, Malaria
Schistosome and Intestinal Worm Infections and Malaria Morbidity Among School and Pre-school Children in, Tanzania
The proposed study has as the main objective to investigate the effect of schistosome and STH infections and the effect of an anthelminthic intervention on P.
- Conditions
- Anaemia, Malaria, Hepatosplenomegaly
- Trial name
- NCT00347113
- Testing
- Albendazole and praziquantel
- Where
- Tanzania
- Volunteers
- 620 people
- Sponsor
- DBL -Institute for Health Research and Development
Malaria, Pregnancy
Intermittent Preventive Treatment Versus Scheduled Screening and Treatment of Malaria in Pregnancy
The incidence of malaria, including the incidence in pregnant women, is declining in many African countries. Thus, there is a need to re-examine the efficacy and cost effectiveness of giving intermittent preventive treatment with…
- Conditions
- Malaria, Pregnancy, Anaemia
- Trial name
- IPTp_IST (NCT01084213)
- Testing
- Intermittent screening and treatment of malaria in pregnancy (IST), SP-IPTp
- Where
- 4 sites in Burkina Faso, Ghana and 2 more
- Volunteers
- 5,354 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Anaemia, Malaria
Impact of Malaria Prevention on Health and Education in Kenyan Schoolchildren
While malaria represents one of the main health problems afflicting schoolchildren, the evidence base for policy development and programme implementation for school-based malaria control remains inadequate.
- Trial name
- NCT00878007
- Testing
- Intermittent screening and treatment for malaria, Teacher training on literacy instruction, IST plus literacy instruction programme
- Where
- Kenya
- Volunteers
- 5,177 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria in Pregnancy, Sexually Transmitted Infections
Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea
The purpose of this study is to determine whether repeated courses of sulphadoxine-pyrimethamine (SP) in combination with azithromycin given at Antenatal Clinic, leads to lower rates of low birth weight deliveries (<2.5 kg) among…
- Conditions
- Malaria in Pregnancy, Sexually Transmitted Infections, Anaemia
- Trial name
- IPTp in PNG (NCT01136850)
- Testing
- chloroquine, sulphadoxine pyrimethamine, LLIN, azithromycin, sulphadoxine pyrimethamine, LLIN
- Where
- Papua New Guinea
- Volunteers
- 2,793 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Malaria, Anaemia
Intermittent Parasite Clearance (IPC) in Schools: Impact on Malaria, Anaemia and Cognition
Although the risk of malaria is greatest in early childhood, significant numbers of schoolchildren remain at risk from malaria infection, clinical illness and death.
- Trial name
- NCT01454752
- Testing
- Intermittent parasite clearance
- Where
- Senegal
- Volunteers
- 860 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Anaemia
IMPACT2: Monitoring Interventions to Improve Artemisinin-based Combination Therapy (ACT) Access and Targeting
It is generally agreed that artemisinin-based combination therapy (ACT) is the malaria therapy of choice but there is much less agreement about the best ACT-deployment strategies.
- Trial name
- IMPACT2 (NCT01130155)
- Where
- Tanzania
- Volunteers
- 33,900 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine