Clinical trials: Malaria Incidence
Anaemia, Malaria
Intermittent Preventive Treatment for Malaria in Infants in Navrongo Ghana
Evaluation of the safety and effectiveness of malaria intermittent chemotherapy and iron supplementation delivered through Expanded Programme on Immunisation vaccination clinics.
- Trial name
- NCT00857077
- Testing
- Sulfadoxine-pyrimethamine
- Where
- Ghana
- Volunteers
- 2,485 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria (Plasmodium Falciparum), Malaria Incidence
Insecticide-Treated Baby Wraps for the Prevention of Malaria
The objective is to test the protective effect of permethrin-treated and etofenprox-treated lesus against malaria in young children
- Trial name
- NCT07773350
- Testing
- Permethrin-treated lesu, Etofenprox-treated lesu, Untreated lesu
- Where
- Uganda
- Volunteers
- 1,296 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Malaria
A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Vaccine
The purpose of this pre-licensure cohort study was to estimate the incidence of adverse events of special interest (AESI), other adverse events (AE) leading to hospitalisation or death, meningitis and malaria in sub-Saharan…
- Trial name
- NCT02374450
- Testing
- Blood collection
- Where
- 5 sites in Burkina Faso, Ghana and 1 more
- Volunteers
- 36,366 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diarrhea, Malaria
Zinc Supplementation to Reduce Diarrhea Rates in Adults in Western Kenya.
Zinc deficiency is prevalent in children in developing countries. Zinc-supplementation is proven to reduce the duration and severity of childhood diarrhea in randomized controlled trials.
- Trial name
- NCT01166815
- Testing
- Zinc sulphate
- Where
- 3 sites in United States, Kenya
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Malaria Infection, Malaria Vaccines
Comparison of Two Strategies for Administering the R21-Matrix M Vaccine in a Context of Seasonal Malaria Transmission in Chad
This is a two-arm, cluster-randomised, phase IV trial conducted in Chad to assess the protective efficacy and impact in real-life conditions of a new strategy for administering the R21/MM malaria vaccine, synchronized within a…
- Trial name
- COSAV-R21 (NCT07038837)
- Testing
- "Synchronised" arm (intervention)
- Where
- Chad
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Epicentre
Malaria
Evaluation of Insecticide Treated Nets and Wall Liners for the Prevention of Malaria
The purpose of this study is to determine whether insecticide treated wall liners, in combination with insecticide treated nets, reduce the incidence of malaria infections compared to insecticide treated nets alone.
- Trial name
- MTC-ITWL (NCT01043796)
- Testing
- Insecticide treated nets and wall liners, Insecticide treated nets alone
- Where
- Kenya
- Volunteers
- 1,730 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Malaria
LLIN Evaluation in Uganda Project (LLINEUP3)
In Uganda, the National Malaria Control Division (NMCD) and implementing partners are planning to deliver long-lasting insecticidal nets (LLINs) nationwide, through a mass distribution campaign in 2023.
- Trial name
- NCT05950191
- Testing
- long lasting insecticidal nets with chlorfenapyr-pyrethroid (PermaNet Dual), long lasting insecticidal nets with PBO-pyrethroid (PermaNet), Social Behavior Change Communication
- Where
- Uganda
- Volunteers
- 215,903 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
LLIN Evaluation in Uganda Project
In Uganda, the National Malaria Control Division (NMCD) and implementing partners plan to deliver long-lasting insecticidal nets (LLINs) nationwide in 2020-21, through a mass distribution campaign supported by generous…
- Trial name
- LLINEUP2 (NCT04566510)
- Testing
- long lasting insecticidal nets with alpha-cypermethrin + pyriproxyfen (PPF LLIN, Royal Guard)), long lasting insecticidal nets with deltamethrin + piperonyl butoxide (PBO LLIN, PermaNet 3.0)), Social behaviour change communication
- Where
- Uganda
- Volunteers
- 32,895 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
EaveTubes for Vector Control
The goal of this clinical trial is to test whether In2Care EaveTubes (ETs) as a stand-alone tool can reduce malaria in an area where transmission is driven by insecticide-resistant Anopheles gambiae.
- Trial name
- NCT05736679
- Testing
- In2Care EaveTube
- Where
- Côte d’Ivoire
- Volunteers
- 1,870 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Malaria (Plasmodium Falciparum), Malaria Incidence
Permethrin-Treated Baby Wraps for Malaria Prevention in Refugee Settings
The objective is to test the protective effect of permethrin-treated lesus against malaria in young children in refugee settings
- Trial name
- NCT07903324
- Testing
- Factory-treated lesu, Soaked lesu, Untreated lesu
- Where
- Uganda
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Maternal Malaria During Pregnancy - Baby Not Yet Delivered
Malaria Burden in Pregnant Women and the Incidence of Pregnancy in a Cohort of Nulligravida
The overarching aims of this study are to longitudinally determine the occurrence of pregnancy in a cohort of nulligravida at the community level and to estimate the burden of malaria infection during the course of the pregnancy…
- Trial name
- EPI-PAM (NCT06162078)
- Where
- Burkina Faso
- Volunteers
- 2,390 people, healthy volunteers welcome
- Sponsor
- Groupe de Recherche Action en Sante
Malaria Infection, Malaria Falciparum
IGHID 12334 - After the Flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding
The purpose of this study is to test different ways to prevent malaria infections after flooding. To accomplish this, the investigators will assign villages to different control strategies and measure the number of malaria…
- Trial name
- IGHID12334 (NCT06870344)
- Testing
- Dihydroartemisinin piperaquine, Dihydroartemisinin piperaquine + Bacillus thuringiensis israelensis, Long-lasting Insecticidal Net
- Where
- Uganda
- Volunteers
- 36,000 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Malaria
Net Transition Initiative: Efficacy of Two Next-generation Nets for Control of Malaria in Cote d'Ivoire
The investigator plan to conduct a three-arm cluster-randomized control trial which compares two next generation of long-lasting Insecticidal Nets (LLINs); Veeralin®LLIN (PBO-py LLIN), Interceptor G2 (chlorfenapyr-py LLIN) to a…
- Trial name
- NCT05796193
- Testing
- Alpha-cypermethrin and PBO LLIN, Alpha-cypermethrin and Clorfenapyr LLIN, Alpha-cypermethrin only LLIN
- Where
- Côte d’Ivoire
- Volunteers
- 1,650 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria Incidence, Seasonal Malaria Chemoprevention
Leveraging the Seasonal Malaria Chemoprevention Platform to Address Malaria and Malnutrition
In the Sahel, the malaria and malnutrition seasons overlap during the rainy season, from approximately July through October. Malaria transmission increases due to the rain and collection of standing water and malnutrition risk…
- Conditions
- Malaria Incidence, Seasonal Malaria Chemoprevention, Nutrition Assessment, Acute Malnutrition in Childhood
- Trial name
- INSPIRE (NCT06599593)
- Testing
- SQ-LNS, Integrated Nutritional Screening
- Where
- Burkina Faso
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anemia
Treatment of Iron Deficiency Anemia in Malaria Endemic Ghana
Iron deficiency and iron deficiency anemia (IDA) are the most prevalent micronutrient deficiencies on a worldwide basis, especially in developing countries.
- Trial name
- NCT01001871
- Testing
- Sprinkles®, vitamin/mineral fortificant without iron
- Where
- Ghana
- Volunteers
- 3,880 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Malaria
Spatial Repellents for the Prevention of Malaria in Kenya
Spatial repellents are chemical-based devices that when placed in a room, make that room non-conducive for mosquitoes. These tools can be used to help in the fight against vector borne diseases such as malaria and dengue.
- Trial name
- AEGIS Kenya (NCT04766879)
- Testing
- Transfluthrin
- Where
- 2 sites in Kenya
- Volunteers
- 5,984 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Malaria
Spatial Repellents for Malaria Control
The primary objective of the study is to demonstrate and quantify the effectiveness of a spatial repellent (SR) product, in reducing malaria infection in humans under operational program conditions in a humanitarian assistance…
- Trial name
- AEGIS Uganda (NCT06122142)
- Testing
- Transfluthrin - delivery by paid study personnel, Transfluthrin - delivery by voucher system, Transfluthrin - delivery by village health teams
- Where
- 2 sites in Uganda
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Notre Dame
Malaria
Field Efficacy Of Insecticide Treated Uniforms And Skin Repellents for Malaria Prevention
Purpose While there is strong evidence that permethrin treated clothing prevents insect bites there is insufficient evidence from trials to demonstrate a reduction in infections.
- Trial name
- URCT (NCT02938975)
- Testing
- Ultra 30 Insect Repellent Lotion (30% Lipo DEET), Permethrin Factory-Treated Army Combat Uniforms, Army combat uniform
- Where
- Tanzania
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Ifakara Health Institute
Malaria, Malaria, Falciparum
Mass Drug Administration With Dihydroartemisinin + Piperaquine for Reducing Malaria in Southern Zambia
To quantify the relative effectiveness, cost, and cost-effectiveness of fMDA and MDA with DHAp against no mass treatment for reducing P.
- Trial name
- NCT02329301
- Testing
- MDA with DHAp (Eurartesim), Focal MDA with DHAp (Eurartesim)
- Where
- Zambia
- Volunteers
- 2,430 people, healthy volunteers welcome
- Sponsor
- PATH
Plasmodium Falciparum Malaria
Malaria Prevalence in Children
The purpose of this pilot study is to evaluate the use of (1) 'malaria prevalence', (2) 'malaria incidence' and (3) 'malaria mortality' as a measure of malaria transmission in The Gambia, while mosquito insecticides (larvicides)…
- Trial name
- NCT00322816
- Where
- The Gambia
- Volunteers
- 2,552 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)