Clinical trials: Mechanism
Energy, Cardiovascular Disease
Energy Value of Macronutrients From Pistachio Nuts and Mechanisms of Nutrient Action
The objective of this study is to measure the energy value of pistachios in the human diet and study molecular mechanisms that may help explain the beneficial health effects of pistachios.
- Conditions
- Energy, Cardiovascular Disease, Cancer
- Trial name
- NCT00942695
- Testing
- 1.5PD, 3.0PD, control
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Department of Agriculture (USDA)
Glucose Metabolism
Glucose-Level During Endurance Exercise
As part of the mandatory annual assessment of physical fitness, soldiers are required to complete a standardized military march.
- Trial name
- GLEE (NCT07543705)
- Testing
- Standardized military march
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Obesity, Glucose Intolerance
Age, Lifestyle, Muscle Mechanisms in Insulin Resistance
The purpose of this study is to investigate the mechanisms by which physical inactivity and obesity alter skeletal muscle insulin signaling to cause insulin resistance and increase the development of impaired glucose tolerance…
- Conditions
- Obesity, Glucose Intolerance, Exercise Capacity
- Trial name
- NCT00971594
- Testing
- Dietary counseling, AEX
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Cryotherapy Effect
The Effect of Brief Skin Cooling on Isometric Muscle Strength
There is sympathetic innervation of the muscular spindle. The application of cold to the skin provides an increase in sympathetic activity.
- Trial name
- NCT06079437
- Testing
- Cheer, The cold pressure test
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Well-Being, Psychological
Behavioral Mechanisms and Health Outcomes of Positive Psychological Intervention
The goal of this clinical trial is to learn if engaging in a multi-activity positive psychology intervention increases emotional well-being The main aims of this project are to: 1.
- Trial name
- NCT06483568
- Testing
- Pathways to Happiness Intervention, Personal Organization Activities
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Healthy, Substance-related Disorders
Influence of Bupropion on the Effects of MDMA
The purpose of this study is to determinate the effect of a pre-treatment with bupropion, a dopamine and norepinephrine transporter inhibitor, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine…
- Trial name
- NCT01771874
- Testing
- MDMA, Bupropion
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Experimental Dental Pain
Mechanisms of Acupuncture Analgesia on Experimental Dental Pain - A Psychophysical Study (Phase1)
The investigators will assess the effects of manual acupuncture on experimental dental pain in 36 healthy subjects by means of subjective pain intensity ratings and pain-specific autonomic nervous system (ANS) reactions.
- Trial name
- MAC-DENT1 (NCT02589418)
- Testing
- Acupuncture, No Acupuncture
- Where
- 2 sites in Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Children, Adult
Standing Balance Control Across the Lifespan
Falls are the leading cause of nonfatal injuries in children and elderly. To understand the causes of falling in these populations, fundamental knowledge of how ageing affects balance control is of utmost importance.
- Trial name
- BaCoMech (NCT04050774)
- Testing
- Balance boards
- Where
- Belgium
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Methicillin-Resistant Staphylococcus Aureus, Atopic Dermatitis
The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA)
Staphylococcus aureus (S.aureus) is a bacterium that causes many painful skin and soft tissue conditions, such as scalded-skin syndrome, boils, or impetigo.
- Conditions
- Methicillin-Resistant Staphylococcus Aureus, Atopic Dermatitis, Eczema Herpeticum, MRSA
- Trial name
- MRSA (NCT00822276)
- Where
- 2 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neuropathic Pain
'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug
Introduction Treatment of neuropathic pain has been a goal of numerous research projects for the last half century, with overall disappointing results.
- Trial name
- 0381-16 (NCT03276689)
- Testing
- Duloxetine, Pregabaline
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Parkinson Disease
Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease
The investigators are investigating the brain activity associated with sensory information in movement disorders in order to improve treatment of these symptoms beyond what is currently available.
- Trial name
- NCT05482126
- Testing
- Intraoperative Behavioral Testing, Behavioral Testing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Vitamin D Deficiency, Recurrent Spontaneous Abortion
Study on Clinical Value of Vitamin D in Recurrent Spontaneous Abortion
The observational study is to compare vitamin D deficiency and related indicators among different spontaneous abortions in describe female reproductive health.The main question aim to answer is: the possible pathogenesis of…
- Trial name
- NCT06002035
- Testing
- Binom Vitamin D drops
- Where
- China
- Volunteers
- 1,421 people, healthy volunteers welcome
- Sponsor
- Jianmei Xia
Diabetes Mellitus, Type 2, PreDiabetes
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
This 12-week controlled diet and weight intervention study seeks to define the molecular pathways that link excess body weight to the development of insulin resistance (IR).
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Insulin Resistance, Obesity
- Trial name
- NCT05165706
- Testing
- Dietary Intervention Mediterranean Low Carbohydrate Diet, Dietary Intervention Standard Low Carbohydrate Diet, Dietary Intervention Standard Low Fat Diet
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Stanford University
Atherosclerosis
Study on the Mechanism of Prevotella Copri Promoting the Occurrence and Development of Atherosclerosis
Mainly studying the correlation between the abundance of Prevotella copri （P.copri） in the gut microbiome and the progression of clinical coronary atherosclerotic heart disease（CAD） patients, and confirming that an increase in…
- Trial name
- SOMOFPcopri (NCT06047249)
- Testing
- KAP Popular Science Research, No KAP Popular Science Research
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hai Tian
Exercise, Energy
The Comparison of Energy in Take and Body Weight EXERCISE
This study will compare the effect of two doses of exercise on energy intake and body weight. The comparison will be between three groups; two exercise groups and a control group.
- Conditions
- Exercise, Energy, Body Weight
- Trial name
- E-MECHANIC (NCT01264406)
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Irritable Bowel Syndrome (IBS), Sucrase Isomaltase Deficiency
Genetic Carbohydrate Maldigestion as a Model to Study Food Hypersensitivity
Irritable bowel syndrome (IBS) affects one in seven people with gastrointestinal (GI) symptoms. IBS strongly impacts quality of life, is a leading cause of work absenteeism, and consumes 0.5% of the healthcare annual budget.
- Trial name
- GenMalCarb (NCT05795049)
- Testing
- Stool and saliva sample collection, Questionnaire completion
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Allergic Asthma
House Dust Mite Induced Inflammasome Activation on Corticosteroid Resistance
In this project, PBMCs will be isolated from HDM allergic and non allergic patient and then stimulated with HDM crude extract. The expression of inflammasome and the correlation of inflammasome activation and steroid resistance…
- Trial name
- NCT03307278
- Testing
- House dust mite
- Volunteers
- healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Lymphoma,Non-Hodgkin, Diffuse Large B Cell Lymphoma
The Value and Mechanisms for Monocytes Subpopulations in Predicting the Prognosis of Lymphomas
The purpose of this study is to determine whether the CD16- monocyte/CD16+ monocyte ratio could help predict the prognosis of DLBCL and PTCL.
- Conditions
- Lymphoma,Non-Hodgkin, Diffuse Large B Cell Lymphoma, Peripheral T-Cell Lymphoma
- Trial name
- NCT03000738
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Maltreatment by Parent
Connected Through Coaching for Flourishing Families
Despite the known association between the quality of participant relational engagement with service providers and clinical outcomes, limited studies have examined caregiver Relational Responsiveness (RR) as a mechanism to achieve…
- Trial name
- CCFF (NCT06145451)
- Testing
- Family Success Network
- Where
- 3 sites in United States
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Autism Spectrum Disorder
Understanding the Mechanisms of Autism : an MRI and Social Cognition Study
The main goal of this study is to investigate anatomo-functional brain abnormalities associated with autism spectrum disorders using a multimodal brain imaging approach, as well as its links to social cognition difficulties…
- Trial name
- ECLAT (NCT06334588)
- Testing
- MRI, Eye-tracking, Clinical Scales
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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