Clinical trials: Medicine
Poor Drug Response
The Prevalence of Sub Optimal Anti Coagulation
A study on warfarin administration to show whether noncompliance of the patient will affect our target (INR) during therapy or not beside its drug and dietary interactions.
- Trial name
- NCT03485300
- Testing
- Liver and kidney function tests for patients with chronic liver or kidney diseases, Non compliance of the patient, Drug or food interactions
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
NSCLC
Drug Concentration Monitoring of Pembrolizumab in Non-Small Cell Lung Cancer Patients
This observational study explores associations between drug trough-levels and clinical outcomes in Non Small Cell Lung Cancer (NSCLC) patients treated with immunotherapy (pembrolizumab) either alone or combined with chemotherapy.
- Trial name
- Oncomabs (NCT04557007)
- Testing
- Pembrolizumab
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Pseudomonas Infections, Pseudomonas Aeruginosa
Antimicrobial Therapy for Difficult-to-treat Pseudomonas Aeruginosa
The primary objective of the ADDICT study is to assess and compare the clinical efficacy of available options for antimicrobial therapy (new beta-lactam/beta-lactamase inhibitor combination, cefiderocol or older agents such as…
- Conditions
- Pseudomonas Infections, Pseudomonas Aeruginosa, Prognosis, Drug Resistance, Multiple, Bacterial
- Trial name
- ADDICT (NCT06738771)
- Where
- 48 sites in France, Reunion
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cancer (Solid Tumors), Interaction Drug Food
Dietary Supplements Among Cancer Patients: Tolerance, Impact on Medications, and Potential Drug Interactions
The goal of this observational study is to To assess the prevalence and patterns of dietary supplement use among patients with cancer and to analyze the impact of these supplements in the context of anticancer medical treatments…
- Trial name
- Dietary Supple (NCT07670234)
- Testing
- Dietary Supplement Use Assessment
- Where
- Morocco
- Volunteers
- 1,000 people
- Sponsor
- Centre Mohammed VI de la Recherche et de l'Innovation (CM6RI)
General Anesthetic Drug Adverse Reaction, Perioperative/Postoperative Complications
Observational of Emergence Time Between Patients Receive General Anesthesia With BIS or Spectrogram EEG Monitor
The bispectral index parameter is used to guide the titration of general anesthesia, however; conflicting results between different studies cannot prove the benefit of EEG monitor on improvement of OR efficiency.
- Trial name
- NCT05208502
- Testing
- DSA monitor
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- National Taiwan University Hospital
Ragweed Allergy
Ragweed Observational Study
This is an observational to evaluate Total Rhinoconjunctivitis Symptom Score and rescue medication usage (as measured by Rescue Medication Score as a Combined Score to inform the design of a phase III field study with ToleroMune…
- Trial name
- NCT01398137
- Where
- 10 sites in United States
- Volunteers
- 90 people
- Sponsor
- Circassia Limited
Irritable Bowel Syndrome
The Efficacy of Tradition Chinese Medicine in Patients With Irritable Bowel Syndrome
To test the efficacy of Traditional Chinese Medicine in relieving symptoms and change of quality of life of patients with Irritable Bowel Syndrome.
- Trial name
- TCM-IBS (NCT00676975)
- Testing
- Traditional Chinese Medicine
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
HIV Infections
Trial to Evaluate Steady State Pharmacokinetic Parameters, Efficacy and Safety of Nevirapine in Antiretroviral Drug naïve Pediatric Patients
Trial to evaluate steady state pharmacokinetic parameters of nevirapine 150mg/m2 and nevirapine 4 or 7 mg/kg after 4 weeks, and efficacy and safety of the dosing when administered for 48 weeks in antiretroviral drug naïve…
- Trial name
- NCT00273975
- Testing
- Nevirapine, Lamivudine, Zidovudine
- Where
- 4 sites in South Africa
- Volunteers
- 123 people
- Sponsor
- Boehringer Ingelheim
Diode Laser Therapy, Omega 3
Adjunct Use of Diode Laser Therapy and Omega 3 Gel in Local Drug Delivery Approach on The Treatment of Localized Aggressive Periodontitis
This study aims to evaluate and compare the effect of combination therapy between diode laser and omega3 gel in the local drug delivery approach as an adjunct to scaling and root planning on the management of localized aggressive…
- Conditions
- Diode Laser Therapy, Omega 3, Localized Aggressive Periodontitis
- Trial name
- NCT07056257
- Testing
- Scaling-root planning (SRP), Scaling-root planning (SRP)+ laser therapy, Scaling-root planning (SRP)+ omega 3 gel
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Tanta University
Caregivers of Multi-pathological and Polypharmacy Adults
Safe Use of Medication at Home by Caregivers. Experimental Study
Experimental study to test the effectiveness of a psychoeducational intervention using virtual reality, aimed at caregivers of multi-pathological and polypharmacy persons to promote safer medication use at home.
- Trial name
- NCT05247801
- Testing
- Psychoeducational intervention for safe medication use at home + Medication dosing device, Medication dosing device
- Where
- Spain
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Treatment-resistant Schizophrenia
Evenamide, a Glutamate Release Modulator, as Add-On to Standard of Care in Subjects With Documented Treatment-Resistant Schizophrenia
This is a prospective, 12-week, randomized, double-blind, placebo-controlled study, designed to evaluate the efficacy, safety, and tolerability of a dose of evenamide of 15 mg bid, compared to placebo, as add-on treatment in…
- Trial name
- ENIGMA-TRS 2 (NCT07184619)
- Testing
- Evenamide 15 mg bid
- Where
- 19 sites in United States, Argentina and 2 more
- Volunteers
- 400 people
- Sponsor
- Newron Pharmaceuticals SPA
Idiopathic Anaphylaxis, Drug Anaphylaxis
Cause of Unexplained Anaphylaxis
This study will explore the possible cause of unexplained, or idiopathic, anaphylaxis. Anaphylaxis is a rapid, life-threatening, severe reaction that occurs suddenly after contact with an allergy-causing substance, usually a…
- Conditions
- Idiopathic Anaphylaxis, Drug Anaphylaxis, Venom Anaphylaxis, Food Anaphylaxis
- Trial name
- NCT00719719
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Vertebral Artery Stenosis
Drug Eluting Stenting and Short Dual Antiplatelet Therapy for Preventing Recurrent Stroke in Vertebral Stenosis Registry Study
This is a prospective, multi-center, registry study exploring the duration of dual antiplatelet therapy (DAPT) after drug-eluting stent(DES) treatment of symptomatic vertebral artery atherosclerotic stenosis.
- Trial name
- M Short DAPT (NCT06683300)
- Testing
- DAPT for 3 months after vertebral artery stenting
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Beijing Tiantan Hospital
Cancer
Detection of Chemotherapy Induced Cardiotoxicity
To identify patients that are at risk of heart damage after receiving chemotherapy (adriamycin).
- Trial name
- NCT00636844
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- George Washington University
Drug-resistant Epilepsy
Electrophysiologic Studies of Cognition in Epilepsy Patients
Interoception, or sensation from inside the body, is involved in a variety of clinical symptoms, such as tics, compulsions and negative mood.
- Trial name
- NCT05769634
- Testing
- Stereoelectroencephalography
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Healthy Subjects
Homeopathic Drug Proving Trial
The main aim of the study is to determine whether a homeopathic drug in the potency C12 provokes more characteristic homeopathic proving symptoms after three weeks compared to a placebo in healthy volunteers.
- Trial name
- HAMSV (NCT01061229)
- Testing
- Homeopathic drug C12
- Where
- Germany
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Knee Replacement Surgery, Osteoarthritis, Knee
Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty
The goal of this study is to better understand how daily treatment with cannabidiol (CBD) affects the need for opioid pain medication, as well as pain, inflammation and other related symptoms, after knee replacement surgery.
- Trial name
- CORK (NCT06234631)
- Testing
- Epidiolex oral solution
- Where
- 2 sites in United States
- Volunteers
- 380 people
- Sponsor
- Chad Brummett
Parkinson Disease, Dyskinesia, Medication-Induced
Efficacy, Safety and Pharmacokinetic Study of CPL500036 in Patients with Levodopa Induced Dyskinesia
The aim of the study is to determine potential anti-dyskinetic properties of CPL500036 (PDE10A inhibitor) in Parkinson disease patients suffering from levodopa Induced dyskinesia.
- Trial name
- NCT05297201
- Testing
- CPL500036 - low dose, CPL500036 - high dose
- Where
- 16 sites in Poland, Ukraine
- Volunteers
- 105 people
- Sponsor
- Celon Pharma SA
Healthy Volunteers, Dyslipidaemia
A Study to Look at How Safe a New Medicine (NNC0491-6075) is in Healthy People and in Participants With High Levels of Fat in the Blood
The study is testing a new study medicine to treat people with high levels of fat in the blood. The main aim of the study is to see if the new study medicine is safe and how it works in the body.
- Trial name
- NCT05979428
- Testing
- NNC0491-6075
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
HER2-negative Breast Cancer, Triple Negative Breast Cancer
Sacituzumab Govitecan in Primary HER2-negative Breast Cancer
Phase III, prospective, multi-center, randomized, open label, parallel group, study in patients with HER2-negative breast cancer with residual disease after neoadjuvant chemotherapy with 1:1 allocation to: Arm A: Sacituzumab…
- Trial name
- SASCIA (NCT04595565)
- Testing
- Capecitabine, Carboplatin, Cisplatin
- Where
- 163 sites in Austria, Belgium and 5 more
- Volunteers
- 1,332 people
- Sponsor
- GBG Forschungs GmbH
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