Clinical trials: Memory Consolidation
Healthy Volunteers (HV)
Electrical Nerve Stimulation During Sleep for Memory Consolidation
The purpose of this study is to investigate the effects of transcutaneous electrical nerve stimulation (eTNS) applied during sleep on memory consolidation and brain-body physiological coupling.
- Trial name
- NCT07658274
- Testing
- 120 Hz Transcutaneous Electrical Nerve Stimulation, 2 Hz Transcutaneous Electrical Nerve Stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xidian University
Sleep, Age
Age-Related Changes in Sleep-Dependent Emotional Memory
Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression.
- Conditions
- Sleep, Age, Emotional Valence
- Trial name
- NCT04141722
- Testing
- Overnight sleep, Wake
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Intrusive Memories
The Effect of Dronabinol on the Acquisition and Consolidation of Trauma-Associated Memories
The aim of the current project is to investigate the impact of an activation of the cannabinoid system with an exogenous cannabinoid dronabinol (delta-9-tetrahydrocannabinol) on the formation of intrusive memories after analog…
- Trial name
- NCT04871269
- Testing
- Dronabinol
- Where
- Germany
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Sleep, Consolidation
Reinstatement of Context During Sleep and Its Subsequent Effect on Memory: an fMRI Study
Memory benefits from sleep and these benefits are putatively achieved through reactivation of the neural memory trace during sleep.
- Trial name
- NCT04702724
- Testing
- Targeted memory reactivation (sounds)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Parkinson Disease
Triggering Motor Memory Consolidation in PD: Complex Practice of Fine Motor Tasks and Brain Activity During Learning
Parkinson's disease (PD) is characterized by severe motor symptoms, including upper limb dysfunction, that is only partially alleviated by medication.
- Trial name
- NCT04269590
- Testing
- Dual Task (DT) training, Single Task (ST) training
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Brain Mapping
Regional Rates of Cerebral Protein Synthesis: Effects of Sleep and Memory Consolidation
Background: The brain needs sleep to function normally, but the purpose of sleep is not understood. Brain activity decreases during sleep, so it may be that sleep is important to maintain, repair, or reorganize brain cells.
- Trial name
- NCT00884702
- Where
- United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Obstructive Sleep Apnea
Memory Consolidation in Obstructive Sleep Apnea
The overarching goal of the research proposed here is to test the hypothesis (i) that the pathophysiological mechanisms of OSA lead to deterioration in sleep-dependent memory consolidation across memory systems, with the genetic…
- Trial name
- NCT01800786
- Testing
- CPAP
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Aging, Pain, Acute
Effects of Acute Pain on Motor Learning in Young vs Older Adults
To date, the effects of pain on motor learning have not been thoroughly investigated, particularly in older adults. Broadly, the purpose of this research is to investigate the impact of acute pain on locomotor learning and its…
- Conditions
- Aging, Pain, Acute, Cognitive Decline, Motor Activity
- Trial name
- NCT05471557
- Testing
- pain delivery
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Older Adults (50-90 Years)
Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
The beneficial effect of nocturnal as well as daytime sleep on memory consolidation is well-documented in young, healthy subjects.
- Trial name
- NCT01840839
- Testing
- brain stimulation
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
PTSD, Intrusive Memories
Estradiol and Intrusive Memories
The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma.
- Conditions
- PTSD, Intrusive Memories, Intrusion Symptom, Trauma
- Trial name
- EstraMemo (NCT07419594)
- Testing
- Estradiol Valerate
- Where
- Germany
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Intrusive Memories, PTSD
The Effect of Oxytocin on the Consolidation of Trauma-Associated Memories
The purpose of the study is to examine whether oxytocin and certain polygenic risk scores affect the development of intrusive memories, a cardinal symptom of PTSD.
- Trial name
- NCT03875391
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Multiple Sclerosis
Consolidation & Interference in Multiple Sclerosis
The purpose of this research study is to investigate whether minimizing interference improves memory in multiple sclerosis.
- Trial name
- NCT02081508
- Testing
- Interference onset
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Sleep
Memory Consolidation in Pharmacologically Enhanced Naps
This study will examine whether various drugs affecting sleep cycles can improve different kinds of memory.
- Trial name
- NCT00777829
- Testing
- zolpidem
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Speech, Consolidation
Sensory Basis of Speech Motor Learning
These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex…
- Trial name
- NCT04497428
- Testing
- Adaptation, cTBS
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Alzheimer Disease, Early Onset
Epileptiform Activity During REM Sleep in Alzheimer's Disease
Recent clinical data showed that patients with Alzheimer Disease (AD) might present epilepsy at early stages of the disease (Cretin et al., 2016, Vossel et al., 2016).
- Trial name
- EREMAD (NCT03923569)
- Testing
- Overnight polysomnography, blood sample, high-resolution MRI scan
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Phobias, Claustrophobia
Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training
There are two specific aims for this study. Aim 1 is to test whether low-level laser therapy (LLLT) can enhance the efficacy of fear extinction training in the modification of pathological fear.
- Conditions
- Phobias, Claustrophobia, Social Phobia
- Trial name
- NCT02926352
- Testing
- Extinction Training, Low-Level Laser Therapy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic
Acoustic Stimulation During Sleep: Effects on Memory and p-tau217 in MCI
The goal of this clinical trial is to determine whether acoustic stimulation during sleep can enhance slow-wave sleep (SWS), improve cognitive function, and reduce AD-related pathology in individuals with mild cognitive…
- Conditions
- Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic, Cognitively Unimpaired
- Trial name
- PAS-MCI (NCT07529015)
- Testing
- Plase-Locked Acoustic Stimulation during slow-wave sleep
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Sleep, Consolidation
Reactivating Specific Memories During Sleep in Conjunction with a Suppression Context
Forgetting is often perceived as the inability to retain information, but in fact at least some memory deterioration is due to active suppression processes, that are behaviorally adaptive.
- Trial name
- NCT04702750
- Testing
- Targeted memory reactivation (odors), Targeted memory reactivation (sounds)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Elderly
Chronic Effects of Exercise on Motor Memory Consolidation in Elderly People
The main purpose of this study was to investigate if a six months period of physical exercise could improve motor memory consolidation in elderly people.
- Trial name
- NCT02731261
- Testing
- Motor memory consolidation
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Instituto Politécnico de Castelo Branco
Dopamine Activity, Episodic Memory Consolidation
Dopaminergic Modulation of Cognition and Psychomotor Function
A recent study at our lab showed increased episodic memory consolidation and response readiness after treatment with methylphenidate in healthy volunteers. The investigators seek to replicate and extend these findings.
- Conditions
- Dopamine Activity, Episodic Memory Consolidation, Response Preparation
- Trial name
- NCT01218425
- Testing
- Methylphenidate 40 mg, Levodopa/carbidopa 125 mg, Domperidon 10 mg
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center