Clinical trials: Memory Consolidation
Parkinson Disease
Triggering Motor Memory Consolidation in PD: Complex Practice of Fine Motor Tasks and Brain Activity During Learning
Parkinson's disease (PD) is characterized by severe motor symptoms, including upper limb dysfunction, that is only partially alleviated by medication.
- Trial name
- NCT04269590
- Testing
- Dual Task (DT) training, Single Task (ST) training
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KU Leuven
HIV/AIDS
Translation of Basic Research in Cognitive Science to HIV Risk
A randomized trial was conducted at drug diversion educational programs with a sample of 343 adult drug offenders who volunteered for the study.
- Trial name
- NCT03175250
- Testing
- Health Education, Action Plan, Memory Practice
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Claremont Graduate University
Sleep, Age
Age-Related Changes in Sleep-Dependent Emotional Memory
Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression.
- Conditions
- Sleep, Age, Emotional Valence
- Trial name
- NCT04141722
- Testing
- Overnight sleep, Wake
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Sleep Apnea, Temporo-central Epilepsy
Sleep and Memory in Children
Sleep exerts a dual effect on learning: on the one hand, good sleep quality allows good daytime aptitudes leading to knowledge acquisition. On the other hand, sleep after learning is necessary for knowledge consolidation.
- Conditions
- Sleep Apnea, Temporo-central Epilepsy, Narcolepsy, High Intellectual Potential
- Trial name
- EnSOM (NCT02785328)
- Testing
- memory evaluation at V1 and V2 (with treatment), memory evaluation at V1 (without treatment), memory evaluation at V1 and V2 (without treatment)
- Where
- France
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Sleep
Effects of WiFi Exposure on Sleep in Women
Effects of Wifi exposure on sleep and sleep-related memory consolidation are investigated in a double-blind, sham-controlled fully counterbalanced study design in young healthy women.
- Trial name
- NCT04583397
- Testing
- radio frequency electromagnetic fields
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Speech, Consolidation
Sensory Memory in Speech Motor Learning
The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal…
- Trial name
- NCT04818268
- Testing
- Adaptation, cTBS
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Sleep, Consolidation
Reinstatement of Context During Sleep and Its Subsequent Effect on Memory: an fMRI Study
Memory benefits from sleep and these benefits are putatively achieved through reactivation of the neural memory trace during sleep.
- Trial name
- NCT04702724
- Testing
- Targeted memory reactivation (sounds)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Multiple Sclerosis
Consolidation & Interference in Multiple Sclerosis
The purpose of this research study is to investigate whether minimizing interference improves memory in multiple sclerosis.
- Trial name
- NCT02081508
- Testing
- Interference onset
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Elderly
Chronic Effects of Exercise on Motor Memory Consolidation in Elderly People
The main purpose of this study was to investigate if a six months period of physical exercise could improve motor memory consolidation in elderly people.
- Trial name
- NCT02731261
- Testing
- Motor memory consolidation
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Instituto Politécnico de Castelo Branco
Memory Consolidation
26 Weeks' Dietary Supplementation With DHA- and EPA-enriched Oils on Memory Consolidation in Healthy Adults
The purpose of this study is to investigate the effects of EPA- and DHA-enriched omega-3 polyunsaturated fatty acid dietary supplements on overnight verbal and visual memory consolidation as well as morning alertness before and…
- Trial name
- NCT03592251
- Testing
- EPA-rich, DHA-rich
- Where
- United Kingdom
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Alzheimer Disease, Early Onset
Epileptiform Activity During REM Sleep in Alzheimer's Disease
Recent clinical data showed that patients with Alzheimer Disease (AD) might present epilepsy at early stages of the disease (Cretin et al., 2016, Vossel et al., 2016).
- Trial name
- EREMAD (NCT03923569)
- Testing
- Overnight polysomnography, blood sample, high-resolution MRI scan
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Memory Consolidation
The Impact of Reactivation During Sleep on the Consolidation of Abstract Information in Humans
In any given cognitive domain, representations of individual elements are not independent but are organized by means of structured relations.
- Trial name
- NCT05746299
- Testing
- Congruent vs. Incongruent, Immediate vs. Awake vs. Asleep, Targeted memory reactivation (TMR)
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mild Cognitive Impairment Due to Alzheimer's Disease, Subjective Cognitive Decline (SCD)
Autophagy-Enhancers to Reduce Sleep Disturbances
This clinical trial investigates the effects of spermidine supplementation on sleep quality and sleep-dependent memory consolidation in older adults with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI), two…
- Trial name
- SpSleep (NCT07383311)
- Testing
- Spermidine Supplementation
- Where
- Germany
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Dopamine Activity, Episodic Memory Consolidation
Dopaminergic Modulation of Cognition and Psychomotor Function
A recent study at our lab showed increased episodic memory consolidation and response readiness after treatment with methylphenidate in healthy volunteers. The investigators seek to replicate and extend these findings.
- Conditions
- Dopamine Activity, Episodic Memory Consolidation, Response Preparation
- Trial name
- NCT01218425
- Testing
- Methylphenidate 40 mg, Levodopa/carbidopa 125 mg, Domperidon 10 mg
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Phobias, Claustrophobia
Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training
There are two specific aims for this study. Aim 1 is to test whether low-level laser therapy (LLLT) can enhance the efficacy of fear extinction training in the modification of pathological fear.
- Conditions
- Phobias, Claustrophobia, Social Phobia
- Trial name
- NCT02926352
- Testing
- Extinction Training, Low-Level Laser Therapy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Aging
Enhancing Memory Consolidation in Older Adults
The purpose of this research study is to understand the neural mechanisms underlying long-term memory formation in older adults. Both sleep and memory decrease with age.
- Trial name
- NCT03657212
- Testing
- Zolpidem
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Sleep, Consolidation
The Effects of Direct Context Reactivation During Sleep on Memory
The context in which memories are encoded is a major factor influencing how memories are organized. Individual memories are bound to the context (e.g., the location, time and state of mind in which they are encoded) and this…
- Trial name
- NCT04702152
- Testing
- Targeted memory reactivation (sounds)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Sleep
Modulation of Memory Consolidation in Humans
The goal of the present study is to optimize effects of slow oscillatory transcranial direct current stimulation (so-tDCS) on sleep physiology and memory consolidation in humans by combining computational and experimental human…
- Trial name
- NCT04714879
- Testing
- Device: anodal tDCS, Device: no stimulation
- Where
- Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Speech, Consolidation
Sensory Basis of Speech Motor Learning
These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex…
- Trial name
- NCT04497428
- Testing
- Adaptation, cTBS
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Attention Deficit Disorder With Hyperactivity
Sleep and Memory Consolidation in Adults With Attention Deficit Hyperactivity.
Attention Deficit Disorder With Hyperactivity is associated with deficits in cognition and sleep. In healthy adults, memory consolidation processes are related to sleep spindle activity in the sleep electroencephalogram.
- Trial name
- HYPNOS (NCT05876286)
- Testing
- Neurological examinations
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse