Clinical trials: Metabolic Adaptation
Weight Loss Trial, Cardiometabolic Syndrome
Peau o le Vasa: Analysis of the Efficacy and Feasibility of the PILI Lifestyle Program (PLP) + Social Determinants of Health (SDOH) Intervention and Adaptation of SDOH Measures Pilot Study
Native Hawaiians and Pacific Islanders (NHPIs) are defined as the descendants of the original peoples of Polynesia (e.g., Hawai'i, Sāmoa, and Tonga), Melanesia (e.g., Fiji), and Micronesia (e.g., Guam, Chuuk, and Marshall…
- Conditions
- Weight Loss Trial, Cardiometabolic Syndrome, Hypertension, Dyslipidemia
- Trial name
- NCT06471595
- Testing
- Partnership for Improving Lifestyle Intervention (PILI) Lifestyle Program + Social Determinants of Health (SDOH) Component
- Where
- 4 sites in United States
- Volunteers
- 242 people
- Sponsor
- University of Hawaii
Psoriatic Arthritis, Obesity
Small Changes Behavioural Weight Loss Treatment Approach for Psoriatic Arthritis Patients With Comorbid Obesity
Psoriatic Arthritis (PsA) is a type of auto-immune condition that affects roughly 90,000 Canadians. Patients with PsA often experience joint pain, skin problems, and issues with mobility that negatively impact their quality of…
- Trial name
- NCT05225623
- Testing
- BWLT, Waitlist Control for BWLT
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Calgary
Energy Expenditure, Atrophy, Muscular
Energy Balance in Extreme Environments: Finding the EI Limit
This project is feasibility study looking at extreme exercise and possible diet intervention study to counter muscle and weight loss during a 2 person Greenland Ski Traverse in April 2023.
- Conditions
- Energy Expenditure, Atrophy, Muscular, Energy Intake
- Trial name
- StOMPE (NCT05773469)
- Testing
- Exercise, Nutrition
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Obesity, Sedentary Behavior
Effect of Walking With Music in Obese People (BeatMove)
For several decades, scientists have reported encouraging effects of physical activity on functional capacities and quality of life among patients with obesity.
- Trial name
- BeatMove (NCT06486961)
- Testing
- BeatMove Application, BeatMove Application without synchronized music, BeatMove Application without music
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Clinique Beau Soleil
Obesity
How Gas-Filled Intragastric Balloons or Endoscopic Sleeve Gastroplasty Affect Hunger, Hunger Hormones, and Gastric Emptying Compared to Meal Replacements
The disease obesity continues to be a major health issue in the US with over one third of the population having a mass index >30 kg/m2.
- Trial name
- NCT04306445
- Testing
- GF-IGB: Obalon Balloon, Medically Supervised Meal Replacement Program: My New Weigh, Endoscopic sleeve gastroplasty: (ESG)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
COVID
Functional and Respiratory Rehabilitation and Nutritional Care of COVID-19 Patients (RECOVER-19)
Following the acute phase of COVID, some patients may have sequelae, such as breathing difficulties or malnutrition. We hypothesize that a functional and respiratory rehabilitation program associated with personalized nutritional…
- Trial name
- RECOVER-19 (NCT04466800)
- Testing
- Intervention group_rehabilitation program
- Where
- 5 sites in France
- Volunteers
- 160 people
- Sponsor
- Rennes University Hospital
Childhood Obesity
Development and Pilot Testing of a Childhood Obesity Treatment Program
The primary aims were to assess community capacity to develop, implement, and sustain a childhood obesity reduction initiative in the health-disparate Dan River Region as well as to pilot test iChoose to determine the potential…
- Trial name
- NCT03513510
- Testing
- iChoose
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Exercise Training
Exercise-Induced Metabolic Compensation; a Physiological Adaptive Response to Exercise Training
The primary aim of this proposal is to identify changes in the volume of highly metabolic organs (liver, kidneys, and brain) that occur as a physiological adaptation to exercise training and lower the resting energy expenditure.
- Trial name
- NCT04460040
- Testing
- Exercise training
- Where
- Israel
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Cognitive Function Abnormal, Diabetes Mellitus, Type 2
Adaptation of a Cognitive Training Intervention for Diabetes Self-Management
The aims of this project are: (1) to refine an existing cognitive rehabilitation intervention and tailor it for persons with T2DM by using current literature and interview data from 10 participants with T2DM and (2) to conduct a…
- Trial name
- NCT03221452
- Testing
- Memory, Attention, and Problem Solving Skills for Diabetes
- Volunteers
- 29 people
- Sponsor
- University of Texas at Austin
Type 2 Diabetes, Stress
Intervention Mapping to Adapt a Mindfulness-based Intervention for Adults With Diabetes and Emotional Distress
We will conduct a single-arm pilot study of an integrated mindfulness-based stress reduction (MBSR)/diabetes self-management education (DSME) intervention in a small group of participants, low-income adults with type 2 diabetes…
- Trial name
- NCT03987841
- Testing
- Integrated MBSR/DSME intervention
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Alabama at Birmingham
Chronic Renal Failure, Mechanistic Effects of SGLT2 Inhibition and/ or MR Antagonism on Body Fluid and Electrolyte Homeostatis
A Study to Investigate the Mechanistic Effects of Dapagliflozin Alone or in Combination With Balcinrenone, Compared to Balcinrenone and Placebo on Body Fluid and Electrolyte Handling and Energy Metabolism in Participants Over 50 Years of Age With Chronic Kidney Disease.
The purpose of this study is to investigate the mechanistic effects of dapagliflozin 10 mg, alone or in combination with balcinrenone 150 mg, with balcinrenone 150 mg and placebo, on the way the body handles electrolytes and…
- Conditions
- Chronic Renal Failure, Mechanistic Effects of SGLT2 Inhibition and/ or MR Antagonism on Body Fluid and Electrolyte Homeostatis, Chronic Kidney Disease Stage 3, Electrolyte and Fluid Balance Conditions
- Trial name
- DapaBalci-Leap (NCT05884866)
- Testing
- Dapagliflozin 10mg Tab, Balcinrenone 50mg Capsule, Balcinrenone 100mg Capsule
- Where
- 2 sites in France, Germany
- Volunteers
- 103 people
- Sponsor
- Klinikum Nürnberg
Type 1 Diabetes Mellitus
At Home Study of a Zone-Model Predictive Control (MPC) Controller and a Health Monitoring System (HMS) With the Diabetes Assistant (DiAs) System and Run-to-Run Adaptation
This clinical trial is a study to assess the performance of an automated glucose control system (Artificial Pancreas, AP) device in home settings for subjects with type 1 diabetes.
- Trial name
- NCT02705053
- Testing
- CGM and Insulin Pump, Closed-Loop Control System
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes Mellitus
Crossover Feasibility Study of Portable AP Device With Zone-MPC and HMS and Adapted I:C and Basal Insulin
The purpose of this trial is to assess the performance of an Artificial Pancreas (AP) device using the Portable Artificial Pancreas System (pAPS) platform for subjects with type 1 diabetes using an insulin pump and rapid acting…
- Trial name
- DP3 (NCT01929798)
- Testing
- portable Artificial Pancreas
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Sansum Diabetes Research Institute
Obesity & Overweight, Childhood Obesity
Combined Inspiratory Muscle Training and Functional High-Intensity Interval Training in Boys With Obesity
Childhood obesity is associated with reduced cardiorespiratory fitness, impaired exercise tolerance, and altered respiratory mechanics.
- Trial name
- IMT and HIIT (NCT07810361)
- Testing
- Inspiratory Muscle Training, Functional High-Intensity Interval Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gümüşhane Universıty
Obesity, Weight Change, Body
Energy Expenditure and Weight Loss Maintenance
Obesity is reaching epidemic proportions and threatens both health and quality of life of people around the world. While many individuals succeed at short term weight loss, weight loss maintenance is the greatest barrier to…
- Conditions
- Obesity, Weight Change, Body, Weight Loss, Physical Activity
- Trial name
- NCT03422380
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Colorado, Denver
Hyperoxia / High FiO₂ Exposure, Interval Training
Oxygen as a Metabolic Modulator: Divergent Physiological Adaptations to Hypoxic and Hyperoxic Tabata Training.
The purpose of this study is to examine how breathing air with different oxygen concentrations (higher or lower than normal) during high-intensity interval training affects: Aerobic capacity (VO₂max) Ventilatory thresholds Blood…
- Conditions
- Hyperoxia / High FiO₂ Exposure, Interval Training, HIIT, High Intensity Interval Training
- Trial name
- NCT07551869
- Testing
- FIO2 modulation during HIIT protocol on assault bike
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Haute Ecole Bruxelles-Brabant
Schizophrenia; Psychosis, Schizo Affective Disorder
Adapted Physical Activity Program for Patients Undergoing Antipsychotic Treatment of a First Episode of Psychosis
The purpose of this PILOT feasibility study is to verify the acceptability, feasibility, and compliance to the DYNAMO-PSY program among young adults treated with antipsychotics for a first episode of psychosis (FEP).
- Conditions
- Schizophrenia; Psychosis, Schizo Affective Disorder, First Episode Psychosis (FEP)
- Trial name
- DYNAMO-PSY (NCT06643871)
- Testing
- Adapted physical activity program involving connected bikes
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier St Anne
Obesity
Progressive Metabolic Adaptations to Low Intensity Exercise Training and Weight Loss
the investigators first aim is to determine the effect of low intensity exercise (without weight loss) on insulin sensitivity, muscle lipid metabolism, and factors regulating these processes in skeletal muscle after 1 day, 2 wks…
- Trial name
- NCT01452074
- Testing
- Exercise Training, Weight Loss with continued Exercise Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Type 1 Diabetes
Adaptation of REDCHIP Intervention for the Portuguese Context
The present Feasibility Randomized Controlled Trial (FRCT) aims to assess the acceptability and effectiveness of REDCHiP intervention, targeting parents of young children with T1D, followed in two major Portuguese hospitals.
- Trial name
- REDCHIP (NCT07201779)
- Testing
- REDCHiP, Treatment As Usual Control Group
- Volunteers
- 44 people
- Sponsor
- ISPA - Instituto Universitario de Ciencias Psicologicas, Sociais e da Vida
Type 2 Diabetes
Culturally Tailored Nutrition Therapy to Improve Dietary Adherence of Type 2 Diabetes Patients in Benin, Africa
The clinical trial aims to assess the effectiveness of the Objectif Santé Diabète Benin (OSanDiaBé), a culturally tailored medical nutrition therapy (MNT), in enhancing diabetes management and nutrition choices.
- Trial name
- OSanDiaBé (NCT07145684)
- Testing
- A culturally tailored medical nutrition therapy
- Where
- Benin
- Volunteers
- 64 people
- Sponsor
- University of Arizona