Clinical trials: Metabolic Adaptation
Sepsis, Critical Illness
Metabolic and Functional Study of γδ T Cells in Critically Ill Patients
This prospective observational cohort study investigates the subset-specific metabolic adaptation and functional remodeling of cytotoxic γδ T cells in critically ill patients with and without sepsis.
- Conditions
- Sepsis, Critical Illness, Immunosuppression, MODS
- Trial name
- NCT07680816
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight
Study of Grape Consumption in Adaptation to Seasonal Photoperiod
The goal of this randomized clinical trial is to learn whether consuming grapes during their natural season can help the body adapt to the shorter daylight hours of winter.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight, Obesity & Overweight
- Trial name
- PhotoGrape (NCT07886788)
- Testing
- Freeze-Dried Grape Powder, Plain Low-Fat Yogurt, Mediterranean-Style Dietary Guidance
- Where
- Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Metastatic Colorectal Cancer (CRC), Volunteer Subjects
Evaluation of the Effect of Adapted Physical Activity on the Modification of Lipid Metabolism During Chemotherapy for Metastatic COLorectal Cancer
APACOL is a pilot, bicentric, randomised, open-label, prospective, category 2 study. The presence of colon cancer modifies blood lipid parameters which are likely to have an impact on the efficacy of anti-cancer treatments.
- Trial name
- APACOL (NCT06944548)
- Testing
- Lipidomic analyses, Adapted physical activity program
- Where
- 2 sites in France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Centre Georges Francois Leclerc
Monckeberg Medial Calcific Sclerosis
Mechanical Stress Effects on the Cardiovascular Adaptations of Peripheral Arterial Calcifications Among Athletes
The main objective of this study is to obtain data for the integrated analysis of morphological, functional and biomechanical parameters pertaining to lower limb arteries in various categories of elite athletes (without…
- Trial name
- MediaSport (NCT01577576)
- Where
- 2 sites in France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Asthma, Cardiovascular Diseases
Trial to Enhance Adherence to Multiple Guidelines
To evaluate whether the innovative multimethod assessment process/participatory quality improvement (MAP/PQI) intervention increases adherence to multiple cardiorespiratory guidelines in primary care practice.
- Conditions
- Asthma, Cardiovascular Diseases, Atherosclerosis, Diabetes Mellitus
- Trial name
- ULTRA (NCT00201227)
- Testing
- practice guideline adherence
- Volunteers
- 60 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Type1diabetes
Metabolic Adaptation to High-frequent Hypoglycaemia in Type 1 Diabetes
An experimental mechanistic study. The overall objective is to gain new knowledge about mechanisms involved in adaptation to recurrent hypoglycaemia in diabetes by investigating patients with type 1 diabetes and healthy controls.
- Trial name
- HypoADAPT (NCT05095259)
- Testing
- insulin human, Epinephrin, Muscle biopsy
- Where
- 2 sites in Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Diabetes Mellitus, Type 2
Consultations in Adapted Physical Activity on Behaviours in Physical Exercise by Type 2 Diabetics
Assesment the impact of three individuals consultations in adapted physical activity by type 2 diabetics
- Trial name
- NCT00403741
- Testing
- motivational interviewing
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Healthy Aging
Vegan and Omnivorous Diets and Skeletal Muscle Turnover in Healthy Older Adults
Dietary protein intake and physical activity are key to minimise the age-related loss of skeletal muscle mass. While animal-derived protein sources are considered high-quality anabolic foods, it remains unclear whether…
- Trial name
- MVP (NCT05985369)
- Testing
- Controlled diet and resistance exercise
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sarcopenia, Osteoporosis
Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
The purpose of this study is to determine if taking the pain reliever acetaminophen (ACET) interferes with some of the benefits of weight lifting on muscles and bone density in older men.
- Conditions
- Sarcopenia, Osteoporosis, Aging
- Trial name
- NCT01083901
- Testing
- Resistance training
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity and Type 2 Diabetes
Investigating Metabolic and Psychological Adaptations in a Clinical Trial
This study aims to explore how food insecurity, a lack of consistent access to enough food, may lead to changes in the body that make it harder to lose weight.
- Trial name
- IMPACT (NCT06800794)
- Testing
- Behavioral Skill Training, Meal Provisioning
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- State University of New York at Buffalo
Childhood Obesity
Family Connections: Cultural Adaptation and Feasibility Testing for Rural Latino Communities
There are marked ethnic and rural-urban disparities in the prevalence of childhood obesity (CO). Among Latino/Hispanic children, CO is almost 60% higher than that of non- Latino/Hispanic Whites, and among children in rural areas…
- Trial name
- NCT04731506
- Testing
- Family Connections
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Nebraska
Under-nutrition or Risk of Undernutrition
Clinical and Medico-economic Evaluation of Taken Care Associating Nutritional Support and Adapted Physical Activity for Malnourished, or at Risk of Undernutrition, Elderly People on Discharge From Hospital
In the hospital, one out of every two elderly people is malnourished. This condition of undernutrition generally worsens during hospitalization, where the effects of polypathology and psychological distress are added.
- Trial name
- NUTRIACTIF (NCT03979560)
- Testing
- Intervention
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Gérond'if
Osteoporosis
Bone Adaptation to Impact Loading
Ageing populations have made osteoporosis and fragility fractures a major public health concern worldwide. Half of all women and 30% of all men will suffer a fracture related to osteoporosis during their lifetime.
- Trial name
- NCT00697957
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- University of Oulu
Rheumatoid Arthritis
Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs. TNF Antibody Therapy
The present study will investigative the physiological effects of the cytokines interleukin-6 (IL-6) and tumor necrosis factor (TNF) on the adaptive changes to exercise in patients with rheumatoid arthritis.
- Trial name
- RABEX (NCT05215509)
- Testing
- Exercise, No exercise
- Where
- Denmark
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypertension, Diabetes
Interdisciplinary Collaborative Care Model Combined With Family Empowerment in Comorbid Hypertension and Diabetes
The Iinterdisciplinary collaborative care model combined with family empowerment (ICCM-FE) intervention based on the COM-B model can effectively improve blood pressure and glucose control in patients with comorbid hypertension…
- Conditions
- Hypertension, Diabetes, Blood Pressure Control, Glucose Control
- Trial name
- NCT06998511
- Testing
- interdisciplinary collaborative care and family empowerment (ICCM-FE) intervention, routine nursing intervention
- Where
- China
- Volunteers
- 187 people
- Sponsor
- Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science
Nurse's Role, Nutritional Deficiency
The Effect of Discharge Education Based on Roy Adaptation Model on Palliative Care Patients and Caregivers
This research will be carried out in order to reveal how the discharge education that will be formed in line with the Roy Adaptation Model for oncological palliative care patients and caregivers will affect the nutritional…
- Conditions
- Nurse's Role, Nutritional Deficiency, Adaptation Reaction
- Trial name
- NCT05840393
- Testing
- Discharge training based on Roy adaptation model
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Sedentary Lifestyle
Muscular and Metabolic Adaptations to Exercise to Benefit High-Risk Workforce
The purpose of this study is to investigate the effects of three different exercise programs (e.g. low-intensity, medium-intensity, high-intensity) administered for six months on health-related physical fitness, biochemical…
- Trial name
- NCT01958333
- Testing
- Exercise 1, Exercise 2, Exercise 3
- Where
- Serbia
- Volunteers
- 2,114 people, healthy volunteers welcome
- Sponsor
- Center for Health Sciences, Serbia
Diabetes, Type 2, Non-Insulin Dependent
Comparative Effectiveness of Prescribed Adapted Physical Activity (APA), Either Practiced Independently After Training, or Supervised by an APA Teacher, on Glycemic Regulation in People With Unbalanced Type 2 Diabetes.
Comparative effectiveness on glycemic balance of a non-pharmacological treatment, Adapted Physical Activity (APA), either supervised by a qualified APA instructor or unsupervised in autonomy, in individuals with inadequately…
- Conditions
- Diabetes, Type 2, Non-Insulin Dependent, Poorly Controlled Diabetes Mellitus
- Trial name
- ACTIDIAB (NCT06598865)
- Testing
- adapted physical activity
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Obesity
Randomized Trial of Healthy Family Foundations
The goal of this clinical trial is to test whether an adaptation of an evidence-based, couple-based preventive intervention at the transition to parenthood improves reduces obesity risk among infants and parents in military…
- Trial name
- HFF (NCT05630482)
- Testing
- Healthy Family Foundations, Standard of Care
- Where
- United States
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- Penn State University
Obese Adults
Evaluation of the Axomove Therapy Medical Device to Facilitate Adapted Physical Activity for Patients With Obesity
Background: Obesity affects 18.1% of adults in France and leads to numerous chronic complications as well as functional limitations (fatigability, dyspnea).
- Trial name
- ON-TRAC (NCT07903025)
- Testing
- Axomove Therapy, Standard multidisciplinary medical care
- Where
- 8 sites in France
- Volunteers
- 184 people
- Sponsor
- Axomove