Clinical trials: Metabolic Bone Disease
Osteoporosis, Sarcopenia
Effectiveness of Creatine Supplementation and Exercise on Muscle and Bone
As we age, we experience a reduction in muscle and bone which inevitably decreases strength and the ability to perform tasks of daily living such as gardening, carrying groceries, and climbing stairs.
- Trial name
- NCT01057680
- Testing
- creatine monohydrate
- Where
- 2 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Osteoporosis
Effects of Proteins Fraction Derived From Milk on Osteoporosis Prevention
Osteoporosis is defined as a systemic skeletal disease characterised by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture.
- Trial name
- NCT01478724
- Testing
- Milk proteins fraction
- Where
- France
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Soredab
Postmenopausal Osteoporosis, Compliance
Clinical Study of Raloxifene and Strontium Ranelate in Postmenopausal Osteoporosis
The purpose of this study was to compare compliance and efficacy of raloxifene and strontium ranelate in a group of women with postmenopausal osteoporosis.
- Trial name
- NCT01544894
- Testing
- Raloxifene, Strontium ranelate
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Bone Loss, Arteriosclerosis
Beneficial Effects of Long Term Menaquinone-7
From all K-vitamins, menaquinone-7 (MK-7) has been identified now as the most effective cofactor for the carboxylation reaction of Gla-proteins such as osteocalcin (in bone) and matrix-Gla protein (in the arterial vessel wall).
- Trial name
- NCT00642551
- Testing
- menaquinone-7
- Where
- Netherlands
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Osteoporosis, Postmenopausal
A Study of Blosozumab (LY2541546) in Postmenopausal Female Participants
The purpose(s) of this study is to measure how much of the study drug gets into the blood stream and how long it takes the body to get rid of it when given in multiple doses, subcutaneously (SC) (by inserting a needle just under…
- Trial name
- NCT02109042
- Testing
- Blosozumab
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Osteoporosis, Osteoarthritis
The Effect of Exercise Training in the Community-dwelling Adults With Chronic Disorders
Previous studies have demonstrated that resistance training (RT) is beneficial to increase muscle strength, improve functional ability and the ability to rapidly produce force, known as the contractile rate of force development…
- Trial name
- NCT02017067
- Testing
- hydraulic resistance circuit training
- Where
- Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Type 2 Diabetes Mellitus
Effects of Gut Peptides on Bone Remodeling. KS-4-Diabetes-19
Both GLP-2 and GIP reduce the bone resorption (measured as CTX) in healthy persons. In this study, we will investigate wether GLP-2 and GIP is reducing CTX in persons with type 2 diabetes.
- Trial name
- NCT03867656
- Testing
- GLP-2, GIP
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Postmenopausal Osteoporosis
Phase 1 Study to Compare CMAB807 Injection to Prolia® in Healthy Volunteers
CMAB807 is a human monoclonal antibody targeting the key bone resorption mediator RANKL. The drug is administered via subcutaneous injection once six months and is approved for various indications, including the treatment of…
- Trial name
- NCT03925051
- Testing
- Prolia®, CMAB807
- Where
- China
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Shanghai Biomabs Pharmaceutical Co., Ltd.
Postmenopausal Osteoporosis
Comparing of the Pharmacokinetic, Safety and Immunogenicity of HS-20090-2 Injection and Prolia® in Healthy Adults
A randomized, single-blind and parallel group study to compare the pharmacokinetic, safety and immunogenicity of HS-20090-2 60mg#1ml#and Prolia® in healthy adults.
- Trial name
- NCT04940845
- Testing
- HS-20090-2, Prolia
- Where
- China
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Shanghai Hansoh Biomedical Co., Ltd
Bone Loss, Partial Edentulism Class 1
Short Implant Versus Crestal Standard Length Implant to Retain Class 1 Removable Partial Denture.
Objective: To report the implant survival rates, clinical, and radiographic outcomes of subcrestal short implant versus crestal standard length implant supported removable partial denture (RPD).
- Trial name
- NCT06666595
- Testing
- Titanium dental implant (Conical SPI, Vitronix, Italy), Medical device that interfaces with the jawbone to support a dental prosthesis.
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Bone Resorption, Osteoporosis
The Effect of Protein Supplementation on Bone Health in Healthy Older Men and Women
Women and men consuming a low protein diet may be at risk for bone loss. The purpose of this study is to determine whether a daily protein supplement will improve bone health among healthy older adults.
- Trial name
- NCT00421408
- Testing
- Whey protein supplement
- Where
- 2 sites in United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Yale University
Ergocalciferol
Pilot Study: The Effect of Ergocalciferol on Plasma Mucin-1 Levels
To determine if a one-time oral administration of ergocalciferol results in a decline in plasma mucin-1 levels in healthy individuals and individuals with ADTKD-MUC1.
- Trial name
- NCT03747523
- Testing
- Ergocalciferol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Type 1 Diabetes, Osteoporosis
Bone Health in Type 1 Diabetes
An increased skeletal fracture risk in diabetes has only recently been recognized. This human study is designed to elucidate the effect of Type 1 diabetes on bone remodeling and on structure.
- Trial name
- DMB (NCT00651196)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Creighton University
Missing Teeth, Bone Loss
Clinical and Radiographic Evaluation of the Effect of Hyaluronic Acid Surface Treatment Versus Sandblasted Acid Etched on Stability of Delayed Dental Implant in Posterior Maxilla.
Clinical and Radiographic Evaluation of the Effect of Hyaluronic Acid Surface Treatment Versus Sandblasted Acid Etched on Stability of Delayed Dental Implant in Posterior Maxilla.
- Trial name
- NCT06033989
- Testing
- Hyaluronic acid, sandblasted, and acid-etched, Delayed dental implant
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postmenopausal Osteoporosis, Postmenopausal Osteopenia
High Intensity Multi-Modal Exercise Training in Postmenopausal Women
in Pakistan 9.9 million people are osteoporotic and 7.2 million amongst them are women. Globally after every 3 seconds there is occurrence of fragility fracture.In Pakistan females carries different risk factors based on distinct…
- Trial name
- HIT-MMEX (NCT04653350)
- Testing
- High Intensity Exercises, General Exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Bone Growth Abnormal, Inflammation
Effects of Increased Greek Yogurt Consumption in Youth and Young Adult Athletes
Physical activity and dairy consumption during growth and development are each known to improve peak bone mass in young adults. Peak bone mass, the maximum amount of bone a person will have in their lifetime, is typically reached…
- Trial name
- NCT05922462
- Testing
- Greek yogurt, Whey protein
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brock University
Osteopenia
A Study to Evaluate the Effect of Romosozumab (AMG 785) on Bone Quality of the Forearm in Postmenopausal Women With Low Bone Mass
The purpose of this study is to evaluate the effect of romosozumab on parameters of bone quality of the forearm using peripheral quantitative computed tomography (pQCT) following multiple subcutaneous dose administrations of…
- Trial name
- NCT00950950
- Testing
- Romosozumab
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Amgen
Vitamin D Status, Osteoporosis
Vitamin D Status and Bone Health of Older Adults in Care Facilities
Vitamin D deficiency is proposed to be prevalent in community-dwelling older adults, with prevalence substantially higher among older adults in residential care facilities.
- Conditions
- Vitamin D Status, Osteoporosis, Sarcopenia
- Trial name
- NCT04399291
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Osteoporosis, Cardiovascular Diseases
Effect of Soy Bread on Markers of Bone Metabolism and Cardiovascular Disease
A study was designed with two specific aims: (1) to assess the effect of soy bread, compared with wheat bread, on markers of bone metabolism and cardiovascular health, and (2) to evaluate whether soy bread consumption affects the…
- Trial name
- NCT00366860
- Testing
- Soy bread
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Osteoporosis
Jogging in the Change of Osteoporosis
To test the changes in osteoarthritis according to the X-rays, and changes in bone quality before and 1 or more years after beginning the jogging
- Trial name
- NCT03359317
- Testing
- jogging
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital