Clinical trials: Metabolic Control
Overweight , Obesity
Phase 1 Clinical Study of MWN110 Injection in Healthy Participants and Overweight or Obese Participants
This study is a multicenter, randomized, double-blind, placebo-controlled, single and multiple ascending-dose phase 1 clinical trial aimed at evaluating the safety, tolerability, PK, PD, and immunogenicity of MWN110 Injection in…
- Trial name
- NCT07779980
- Testing
- MWN110
- Where
- China
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Diet, Healthy, Blood Sugar; High
Barley Beta-glucan, Glycemic Control, and Appetite
Novel barley varieties high in the soluble fiber β-glucan have the capacity to improve population health through improving glycemic control.
- Conditions
- Diet, Healthy, Blood Sugar; High, Diabetes, Appetite and General Nutritional Disorders
- Trial name
- NCT06146322
- Testing
- WR, LB, MB
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Washington State University
Obesity & Overweight
Xanthigen and Its Impact on Weight and Metabolic Health
Randomized, controlled, triple-blind clinical trial with three parallel arms based on the product consumed (low-dose experimental product, high-dose experimental product, and placebo product) and conducted at a single center to…
- Trial name
- XAN (NCT07519980)
- Testing
- Experimental group: Xanthigen®, Control product
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Abdominal Obesity
Effects of a Polyphenol-rich Cranberry Extract on Cardiometabolic and Neurocognitive Health
The objective of this double-blind, parallel, randomized placebo-controlled clinical trial is to evaluate the effects of consumption of polyphenol-rich cranberry extract standardized in PACs (36 mg PACs/capsule) on…
- Trial name
- Neurocan (NCT05062954)
- Testing
- Polyphenol-rich cranberry extract supplement standardized in proanthocyanidins
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Laval University
Alcohol Abuse, Obesity
Project ACTIVE a Clinical Intervention
This is a clinical Randomized Controlled Trial where the study personnel will run a personalized prevention clinic with patients in attempts to improve their preventive health outcomes and compare their health outcomes with a…
- Trial name
- NCT04211883
- Testing
- ACTIVE intervention
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hypertension, Prehypertension
Effects and Safety of Menthol on Blood Pressure and Metabolic Parameters in Prehypertensive and Mild Hypertensive Patients
Prehypertension and mild hypertension are associated with an increased risk of atherosclerosis and coronary artery disease, and often complicated with the metabolic disorder of glucose and lipid.
- Trial name
- ESMAB (NCT01408446)
- Testing
- Menthol
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Zhiming Zhu
Healthy Subjects, Heme Oxygenase
Effects of Heme Arginate in Healthy Male Subjects
Heme oxygenase 1 (HO-1) serves as a protective gene. It has been shown that one factor modulating HO-1 activity is a genetic variation in the HO-1 gene (functional GT length polymorphism in the promotor region).
- Conditions
- Healthy Subjects, Heme Oxygenase, Genetic Polymorphism
- Trial name
- HEMAHS (NCT00682370)
- Testing
- saline solution, heme arginate
- Where
- Austria
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Daniel Doberer
Sedentary Lifestyle
The Health Action Process Approach and Movement Patterns in Adult Office Workers
Societal changes have resulted in reduced demands to be active and increased daily time spent sitting. Excessive sitting has been shown to be a health hazard.
- Trial name
- NCT03091686
- Testing
- HAPA SB Intervention Slideshow, HAPA MVPA Attention-Control Slideshow
- Where
- Canada
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Electric Stimulation Therapy, Obesity
Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
This study will determine whether electrical stimulation of an area of the brain called the dorsolateral prefrontal cortex, which is important in determining the feeling of fullness after eating, affects how much food a person…
- Conditions
- Electric Stimulation Therapy, Obesity, Weight Loss, Eating
- Trial name
- NCT00739362
- Testing
- Transcranial Direct Current Stimulation (TDCS)
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease
Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS)
This single-center, prospective, observational, cross-sectional mechanistic pilot study will evaluate whether polycystic ovary syndrome (PCOS) contributes to hepatic steatosis in adolescent girls independently of adiposity.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity, Hyperandrogenism
- Trial name
- COMPASSpedPCOS (NCT07731373)
- Testing
- Extended Serum Biomarker and Hormonal Panel, Liver Elastography with Controlled Attenuation Parameter, Targeted Genotyping of PNPLA3 rs738409 and HSD17B13 rs72613567
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Obesity, Type II Diabetes
Using EEG Operant Conditioning to Improve Trait Self-Control and Promote Healthy Behavior
The field of neuroeconomics has begun to elucidate neural mechanisms underlying self-control; however, researchers have not yet harnessed neuroeconomics findings to develop interventions for improving self-control ability.
- Conditions
- Obesity, Type II Diabetes, Cardiovascular Disease, Health Behavior
- Trial name
- NCT01801254
- Testing
- STRIDES
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Metabolic Syndrome, Physical Activity
The Effect of Health Provider's Feedback on Physical Activity Surveillance Using Wearable Device-Smartphone Application for Resolution of Metabolic Syndrome
The Effect of Health Provider's Feedback on Physical Activity Surveillance using Wearable Device-Smartphone Application for Resolution of Metabolic Syndrome; a 12-Week Randomized Control Study
- Trial name
- NCT05630456
- Testing
- Receving feedback, No regular feedback
- Where
- South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Dental Implant, Bone Loss
Influence of the Implant-prosthetic Connection in the Marginal Bone Loss and Bacterial Leakage
This study consists in a double-blinded randomized controlled trial which objective is to assess the effect of the implant-abutment connection type -external hexagon, internal hexagon and conical connection- in the periimplant…
- Conditions
- Dental Implant, Bone Loss, Bacterial Infections
- Trial name
- NCT04328051
- Testing
- Dental Implant Placement
- Where
- Spain
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Metabolic Dysfunction-Associated Steatohepatitis(MASH)
Safety, Tolerability, PK, PD, and Immunogenicity of QL2401 in Healthy Chinese Adults
This is a first-in-human, Phase I, randomized, double-blind, placebo-controlled clinical trial to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of QL2401 following single and multiple…
- Trial name
- NCT07331545
- Testing
- QL2401
- Where
- China
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Ketosis
Markers of Appetite Regulation During Exogenous Ketosis
The aim of this study is to investigate the relationship, if any, between markers of satiety, desire to eat, hunger, and metabolic markers of the regulation hereof during ketosis as compared with a Glucose-containing and a…
- Trial name
- MARK (NCT04156477)
- Testing
- Ketone ester, Glucose, Tap water
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Central Jutland Regional Hospital
Diabetes Mellitus, Diabetes Mellitus, Type 2
Single Dose Study of PF-04991532 in Healthy Subjects
The purpose of this study is to characterize the safety, tolerability, pharmacokinetics (PK) and preliminary food effect of PF-04991532 following single escalating oral doses in healthy adult subjects.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders
- Trial name
- NCT01102673
- Testing
- PF-04991532
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Overweight and Obesity
The Effect of Alginate Supplementation on Weight Management
This project will assess the effect of the alginate (in a capsules) on the weight of generally healthy volunteers over a 12 week period.
- Trial name
- NCT04589273
- Testing
- Alginate
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Overweight, Weight Loss
Testing the Efficacy of a Spousal Support Enhanced Weight Loss Program on Weight Loss Among African American Men
The purpose of this study is to determine the effect of a spousal support enhanced weight loss program on weight loss among African American men.
- Conditions
- Overweight, Weight Loss, Obese
- Trial name
- TEAM (NCT02458053)
- Testing
- Attends with partner, Couples Skill Training, Face to face group sessions
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Diabetic Retinopathy, Diabetic Macular Edema
Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathy
The objective of this study is to evaluate the safety and efficacy of APX3330 to treat diabetic retinopathy (DR) and diabetic macular edema (DME).
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, NPDR - Non Proliferative Diabetic Retinopathy, PDR - Proliferative Diabetic Retinopathy
- Trial name
- ZETA-1 (NCT04692688)
- Testing
- APX3330
- Where
- 24 sites in United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Opus Genetics, Inc
Iron-deficiency, Postural Orthostatic Tachycardia Syndrome
Iron Sucrose in Patients With Iron Deficiency and POTS
This study aims to investigate whether the treatment of non-anemic iron deficiency with intravenous iron sucrose will result in decreased symptom reporting and improved cardiovascular indices in patients with Postural Orthostatic…
- Trial name
- NCT04855266
- Testing
- Sucrose, Tilt Table Test
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic