Clinical trials: Metastatic Epidural
Postdural Puncture Headache, Epidural Analgesia, Obstetric
A Prospective Cohort Study to Evaluate the Safety, Efficacy, and Usability of the EpiZact Device
The purpose of the study is to learn more about a new device, the EpiZact Epidural Device, that may be helpful for reducing the likelihood of wet tap when a labor epidural is placed.
- Trial name
- NCT06729255
- Testing
- EpiZact-assisted epidural placement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Parturient Who Underwent Epidural Anesthesia During Which an Unintentional Dural Punctur Occurred, Parturient Who Develop a Postdural Puncture Headache
Chronic Headache and Chronic Backache Following Unintentional Dural Puncture at Delivery Room.
he study is a telephone questionnaire. The study will include 400 women, 100 in each group. OBJECTIVE: To investigate the prevalence of chronic and chronic back pain following PDPH accidental dural puncture during epidyral…
- Conditions
- Parturient Who Underwent Epidural Anesthesia During Which an Unintentional Dural Punctur Occurred, Parturient Who Develop a Postdural Puncture Headache, Parturient Who Gave Informed Consent to Participation in the Study
- Trial name
- NCT03908424
- Testing
- Epidural Blood patch.
- Where
- Israel
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Spinal Tumor
Safety Evaluation of Intra-Operative MRI-Based Guidance for Laser Ablation of Epidural Metastasis
The goal of this clinical research study is to learn about the safety and accuracy of using MRI as a guidance system during laser ablation surgery of tumors that have spread to the spine.
- Trial name
- NCT02613390
- Testing
- Magnetic Resonance Imaging (MRI), Questionnaires
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Postdural Puncture Headache
Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache
PDPH is a common problem after either intentional or unintentional Dural puncture. It is especially common in young female patients and in patients undergoing Lumbar Puncture using the typical kit containing large 20 gauge…
- Trial name
- PDPH (NCT02394457)
- Testing
- Cosyntropin, Epidural Blood Patch
- Volunteers
- 29 people
- Sponsor
- United States Naval Medical Center, San Diego
Metastatic Epidural Spinal Cord Compression
Single Session Spine Stereotactic Radiosurgery in Metastatic Epidural Spinal Cord Compression
The goal of this clinical study is to learn the feasibility of using a single session of radiation, known as spine stereotactic radiosurgery (SSRS), to treat metastatic epidural spinal cord compression.
- Trial name
- NCT01256554
- Testing
- Stereotactic Radiosurgery (SSRS), Questionnaires
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Central Nervous System Infections, Pseudotumor Cerebri
A Study to Test Performance of Needle Placements for Neuraxial Procedures Using Tactile Imaging vs Control
This study will compare the VerTouch device to the conventional palpation technique for performing diagnostic and therapeutic neuraxial procedures.
- Conditions
- Central Nervous System Infections, Pseudotumor Cerebri, Neurological Disorder, Cancer
- Trial name
- NCT04796935
- Testing
- Tactile Imaging (VerTouch), Control (palpation)
- Where
- 3 sites in United States
- Volunteers
- 95 people
- Sponsor
- IntuiTap Medical, Inc
Blood Patch, Post-Dural Puncture Headache
Factors Associated With the Onset of Chronic Headaches in Patients Who Received a Blood Patch in Post Partum
The purpose of this study is to identify possible links between conditions for carrying out a blood patch (BP) to treat accidental post dural puncture acute headache (PDPH) in the early post partum period and occurrence of…
- Trial name
- CHROBLOOD (NCT05888324)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postdural Puncture Headache, Cerebrospinal Fluid Leak
Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics
The SNOB study is a prospective, randomized, double-blind, placebo-controlled, cross-over pragmatic trial that has been designed in accordance with the CONSORT guidelines.
- Conditions
- Postdural Puncture Headache, Cerebrospinal Fluid Leak, Spinal; Puncture, Complications, Headache
- Trial name
- SNoB (NCT03181464)
- Testing
- Lidocaine 4%
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Post-Dural Puncture Headache
RCT of SPG Blocks for Post-dural Headache
The purpose of the study is to assess the effectiveness of the SPG block with lidocaine vs. SPG block with placebo on preventing the need for EBP in women who develop PDPH after accidental dural puncture during placement of LEA…
- Trial name
- NCT03560349
- Testing
- Lidocaine HCl Gel 2%
- Where
- United States
- Sponsor
- University of Utah
Post-Dural Puncture Headache
Effect of Small Versus Large Epidural Needles on Postdural Puncture Headache Study
The purpose of this study is to determine the effect of 19g versus =>18g traditional Tuohy-type epidural needles on the incidence and severity of postdural puncture headache (PDPH).
- Trial name
- NCT00370604
- Testing
- 19g Tuohy-type epidural needle, 23g catheter, => 18g Tuohy-type needle
- Where
- 4 sites in Canada
- Volunteers
- 1,081 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Postdural Puncture Headache
Therapeutic Epidural Patch Versus Pain Block in the Midface for Headache
The purpose of this study is to compare a pain block in the midface, versus the traditional, more invasive, therapeutic epidural patch for the treatment of headaches
- Trial name
- NCT03112720
- Testing
- Epidural Blood Patch, Sphenopalatine Ganglion Block
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Spinal Cord Compression, Cauda Equina Syndrome
Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression
Spinal cord compression (SCC) is a devastating complication of advanced malignancy, and can cause significant deterioration in function and quality of life (QoL).
- Conditions
- Spinal Cord Compression, Cauda Equina Syndrome, Stereotactic Body Radiotherapy
- Trial name
- CRUSSH (NCT03529708)
- Testing
- 3D CRT plus SBRT boost
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Juravinski Cancer Center
Post-dural Puncture Headache, Post-dural Puncture Backache
Long-term Effects of Accidental Dural Puncture in Patients Having Had an Epidural Blood Patch (LEAP)
Accidental dural puncture (ADP) during placement of an epidural catheter for anesthesia and analgesia is a well known complication. Previous studies have found audiometric deterioration following ADP.
- Trial name
- LEAP (NCT02149680)
- Where
- 2 sites in Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Metastatic Epidural Spinal Cord Compression
Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression
The aim of this trial is to evaluate the differences in pain relief, neurological function, quality of life and survival in patients with metastatic epidural spinal cord compression (MESCC) who are managed with a combination of…
- Trial name
- MESCC (NCT00634426)
- Testing
- Surgical excision of the metastatic process, Radiotherapy of the metastatic spine process
- Where
- 10 sites in United States, Canada
- Volunteers
- 163 people
- Sponsor
- AOSpine North America Research Network
Post-Dural Puncture Headache
The Influence of Needle Diameter on Post Dural Puncture Headache
The purpose of this study is to determine whether injection needle pen point type 'PP Gauge 25' should be recommended as a primary choice of needle (in stead of 'PP Gauge 27') for healthy pregnant women who at delivery (vaginal…
- Trial name
- NCT02827058
- Testing
- G25 pencil point needle, G27 pencil point needle
- Where
- 3 sites in Norway
- Volunteers
- 65 people
- Sponsor
- Helse Nord-Trøndelag HF
Spinal Cord Compression
Spine Stereotactic Body Radiation Therapy for Metastatic Epidural Spinal Cord Compression
Metastatic epidural spinal cord compression (MESCC) is a frequent oncologic emergency that requires to be treated promptly. Although direct decompressive surgery is the most effective treatment, surgery is only used in selected…
- Trial name
- NCT01826058
- Testing
- Stereotactic body radiation therapy
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Postdural Puncture Headache, Sphenopalatine Ganglion Block
Changes in Cerebral Blood Flow (CBF) in Prone and Sitting Position Before and After GSP-block and Before and After Epidural Blood-patch: A Substudy of NCT03652714
The purpose of this optional sub-study to GSPB-2018 (NCT03652714) is to evaluate the changes in cerebral blood flow (CBF) under different conditions to understand if postdural puncture headache is caused by changes in the…
- Trial name
- NCT03966547
- Testing
- Ganglion sphenopalatine block with local anesthetic administered on study GSPB-2018
- Where
- 2 sites in Denmark
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Metastatic Epidural Spinal Cord Compression, Spinal Cord Compression
Miami "RADAR" Trial
The purpose of this study is to see if treating cancer with radiation therapy administered by the Varian Ethos system can control patient's tumor and eliminate the need for surgery used to treat nerves in the spine flattened by…
- Trial name
- RADAR (NCT06077071)
- Testing
- Stereotactic Radiosurgery (SRS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Miami
Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Multimodal Approach to the Intrathecal Catheter for Obstetric Accidental Dural Puncture
Accidental dural puncture is an uncommon complication of epidural analgesia and can cause postdural puncture headache.
- Trial name
- NCT05910086
- Testing
- collection of data from the medical record
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Secondary Malignant Neoplasm of Liver, Liver Diseases
Spinal Versus Epidural Analgesia in Laparotomic Liver Surgery
The purpose of this study is to evaluate the efficacy of spinal analgesia for minor laparotomic hepatectomy compared with epidural analgesia, monitoring visual analog scale (VAS).
- Conditions
- Secondary Malignant Neoplasm of Liver, Liver Diseases, Liver Neoplasms
- Trial name
- NCT02647047
- Testing
- Spinal analgesia, Epidural analgesia, Transversus Abdominis Plane block
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale San Raffaele