Clinical trials: MicroRNAs
Autism Spectrum Disorder
Combination of Predictive Biomarkers to Increase Diagnostics Efficiency of Autism Spectrum Disorder
Early identification and diagnosis of autism spectrum disorder (ASD) is necessary to promote access to early treatment. Despite the high incidence, in Italy it is estimated that 1 in 77 children (age 7-9 years) (Narzisi et al.…
- Trial name
- NCT05796310
- Testing
- Salivary collection, eye-tracking recorder, neuropsychological assessment
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Leukemia
RNA Biomarkers in Tissue Samples From Infants With Acute Myeloid Leukemia
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in RNA and identify biomarkers related to cancer.
- Trial name
- NCT01229124
- Testing
- RNA analysis, nucleic acid sequencing, reverse transcriptase-polymerase chain reaction
- Volunteers
- 20 people
- Sponsor
- Children's Oncology Group
Cardiovascular Diseases, Periodontal Diseases
Impact of Periodontal Treatment on Local miRNA Expression
To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 125-5p, miRNA 200b-3p and miRNA…
- Trial name
- NCT05275127
- Testing
- changes of gingival crevicular fluid miRNA
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Catania
Endometriosis
Salivary microRNA in Endometriosis: Correlation With Response to Progestin Therapy
This study aims to analyze the salivary miRNA specific for patients diagnosed with endometriosis, specifically evaluating the miRNA profile of patients who respond versus those who do not respond to progestin therapy.
- Trial name
- ENDOmiRNA (NCT06414720)
- Testing
- Dienogest 2 MG
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Udine
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
PANS, Pediatric Acute-Onset Neuropsychiatric Syndrome
Biomarkers for Diagnosis and Treatment Response in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a complex neuropsychiatric disorder characterized by the abrupt onset of symptoms and currently diagnosed mainly on clinical criteria, as reliable diagnostic biomarkers…
- Trial name
- BIOMA-PANS (NCT07718958)
- Testing
- Psycodiagnostic evaluation, Polysomnography, 1H-NMR analysis
- Where
- 5 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Astrocytoma, Oligodendroglioma
Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas
MicroRNAs (miRNA) are molecular biomarkers that post-transcriptionally control target genes. Deregulated miRNA expression has been observed in diverse cancers.
- Conditions
- Astrocytoma, Oligodendroglioma, Oligoastrocytoma, Anaplastic Astrocytoma
- Trial name
- NCT01849952
- Where
- 4 sites in United States
- Volunteers
- 94 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Concussion, Mild
Predicting Concussion Outcomes With Salivary miRNA
The purpose of this study is to identify changes in salivary ribosomal nucleic acid (RNA) expression that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.
- Trial name
- NCT02901821
- Testing
- salivary RNA collection
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Rheumatoid Arthritis
Evaluation of Pain Sensitization in Rheumatoid Arthritis: Analysis on a Cohort of Tofacitinib Treated Patients
Persistent pain and chronic fatigue are very common complaints in rheumatoid arthritis (RA) patients, whatever the anti-inflammatory treatment response.
- Trial name
- TOPRA (NCT03815578)
- Testing
- Clinical examination, Pain assessment, blood sample
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Heart Transplanted Patients, Lung Transplanted Patients
Unraveling Mechanism of Action of Extracorporeal Photopheresis in Heart and Lung Transplant Patients
This is a prospective observational single center national study. Lung and heart transplant patients with a definite diagnosis of chronic lung allograft dysfunction (CLAD) or cardiac allograft vasculopathy (CAV) will be assigned…
- Conditions
- Heart Transplanted Patients, Lung Transplanted Patients, Chronic Lung Allograft Dysfunction (CLAD), Cardiac Allograft Vasculopathy
- Trial name
- URRAH (NCT06899828)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Breast Cancer
Oncoliq: Test for Early Breast Cancer Detection.
Oncoliq is a novel early breast cancer detection test based on liquid biopsies and microRNAs. This innovative test will allow improving the accuracy of cancer detection which will impact on health, reducing the patient mortality…
- Trial name
- NCT04906330
- Testing
- Oncoliq: test for early breast cancer detection.
- Where
- Argentina
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich
Conjunctivitis, Allergic
OJO-miR: microRNA Expression in Allergic Conjunctivitis.
Allergic conjunctivitis (AC) causes inflammation of the conjunctiva in response to environmental allergens, affecting a significant percentage of the world population and reducing quality of life.
- Trial name
- OJO-miR (NCT07385495)
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Breast Cancer
miRNA and Relevant Biomarkers of BC Patients Undergoing Neoadjuvant Treatment
MicroRNA (miRNA) is a type of endogenous non-coding RNA. They are responsible for post-transcriptional regulation and participate in many vital biological processes.
- Trial name
- NCT03779022
- Testing
- microRNA
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Cui Yimin
Rheumatoid Arthritis
Filgotinib Effect on Proteomic Profile and Micro-RNA Expression in Patients With Active Rheumatoid Arthritis (RA)
Purpose: The study aims to investigate how Filgotinib affects proteins and micro-RNA in the blood of patients with rheumatoid arthritis. This could help understand its impact on inflammation and bone health in these patients.
- Trial name
- FILRA (NCT06527534)
- Testing
- Filgotinib, Adalimumab
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Universita di Verona
Congestive Heart Failure Chronic, Atrial Fibrillation (Permanent)
Inflammation, Epigenetics in CHF Patients With AF
the goal of this case-control cross-sectional study is assessing in a cohort of patients with CHF and permanent AF The serum levels of some candidate cytokine variables and their relationship with some selected metabolic…
- Trial name
- NCT07152301
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- University of Palermo
Sarcopenia, Anabolic Resistance
Strength Training and Resveratrol
The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether…
- Trial name
- STaR (NCT06585865)
- Testing
- Resistance training, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Diabetes, Exercise
Differential Regulation of miRNA and Protein in Human Plasma Extracellular Vesicles by Different Types of Exercise.
Aims/hypothesis: Both continuous aerobic training (CAT) and high intensity interval training (HIIT) are recommended to promote health and prevent diseases.
- Conditions
- Diabetes, Exercise, Lifestyle Intervention
- Trial name
- NCT06609785
- Testing
- Exercise
- Where
- China
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Smoking, Smoking Cessation
Smoking Cessation on the Human Airway: Mucus Secretion, Inflammatory and Proteomic Profile in Nose and miRNAs in Blood
Smoking cessation improves health conditions with reduction of the risk factors for cardiovascular and respiratory disease, as functional capacity and quality of life.
- Trial name
- NCT02136550
- Testing
- Smoking cessation
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hydrocephalus
Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research
In normal patients, blood and cerebrospinal fluid (CSF) contain circulating cells and other molecules such as proteins and nucleic acids.
- Trial name
- NCT01556178
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Knee Osteoarthritis, Hip Osteoarthritis
Adipose-derived Mesenchymal Stem Cells in Osteoarthritis
This phase I/II study will enroll 100 subjects with mild to moderate osteoarthritis of the hip/knee/glenohumeral joints will be enrolled according to strict inclusion and exclusion criteria.
- Conditions
- Knee Osteoarthritis, Hip Osteoarthritis, Glenohumeral Osteoarthritis, Osteoarthritis
- Trial name
- NCT03869229
- Testing
- Intra-articular injection of ADMSC
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw