Clinical trials: Microdialysis
Diabetes, Wound Infection
Omadacycline Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis
This study will determine the tissue penetration of the novel tetracycline antibiotic, omadacycline (Nuzyra, Paratek Pharmaceuticals, Inc.), into the extracellular, interstitial fluid of soft tissue in diabetic patients with…
- Conditions
- Diabetes, Wound Infection, Healthy Volunteers
- Trial name
- NCT04144374
- Testing
- Omadacycline, Microdialysis Catheter Insertion
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Type 1 Diabetes
Accuracy, Reliability and Safety of GlucoMen®Day, a New Generation Microdialysis Continuous Glucose Monitor
Monocenter single-arm, prospective clinical study in 20 type 1 diabetic subjects, equipped with the GlucoMen®Day system, over up to 100 hours observation after implantation of the microdialysis probe.
- Trial name
- NCT01407315
- Testing
- GlucoMenDay
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Kidney Diseases
Detecting Markers of Kidney Function With Intravenous Microdialysis
Patients will be invited to participate from an outpatient nephrology clinic at Hammersmith Hospital. They will have a microdialysis catheter inserted into a peripheral vein and connected to a sampling system.
- Trial name
- NCT03159806
- Testing
- Microdialysis sampling
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Accunea Ltd.
Microdialysis
Clinical Protocol of Sensitized Acupoint Changes in Knee Osteoarthritis Patients
Based on the research background and the preliminary research basis of the research group, in order to answer the material basis and micro-physical environment change characteristics of knee osteoarthritis sensitization acupoints…
- Trial name
- NCT03599180
- Testing
- microdialysis
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Chinese Medical Association
Healthy
Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue
The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.
- Trial name
- NCT01595373
- Testing
- Acyl ghrelin
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Esben Thyssen Vestergaard
Hypertension
Adiposity and Endothelin Receptor Function
Elevated levels of ET-1 have been implicated in cardiovascular disease and some forms of hypertension. Due to the strong, positive correlation between obesity and hypertension, the present study will explore the contribution of…
- Trial name
- END-RF (NCT03583866)
- Testing
- Candesartan
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Augusta University
Healthy
Comparison of Ertapenem Distribution in the Muscle of Six Healthy Volunteers and Six Critically Ill Patients by Microdialysis
Ertapenem is an antibiotic that is highly bound to plasma protein (> 95%). The effects of this high protein binding on tissue distribution of antibiotics have been few evaluated yet.
- Trial name
- NCT01061047
- Testing
- Ertapeneme
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Rosacea
Pharmacokinetics of Doxycycline in Skin of Healthy Volunteers
This study explored the impact of food on skin and plasma pharmacokinetics of doxycycline
- Trial name
- NCT03478436
- Testing
- Doxycycline
- Where
- Austria
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Bioequivalence
Clinical Study to Evaluate the Role of Microdialysis for the Comparison of Topical Products
The investigators hypothesize that a technique called microdialysis can be used to measure the amount of the drug diclofenac which penetrates (enters) the fatty tissue under the skin.
- Trial name
- NCT01592019
- Testing
- Reference, Patch location thigh, batch 1, Test, Patch location thigh, batch 2, Reference, Patch location abdomen, batch 1
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Florida
Endometriosis
Endometriosis and Microvascular Dysfunction: Role of Inflammation
The purpose of this study is to better understand the underlying mechanisms associated with elevated cardiovascular disease risk in women with endometriosis, and to measure the effectiveness of emerging endometriosis treatments…
- Trial name
- Endo3/SA2 (NCT05069740)
- Testing
- Salsalate Pill
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Penn State University
Middle-aged Adults, Major Depressive Disorder
Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
The goal of this pilot clinical trial is to begin to understand how day-to-day stress affects cardiovascular health and brain function in middle-aged adults.
- Trial name
- NCT06466655
- Testing
- MitoTempol, Lactated Ringer's (control)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Eating Disorder, Bulimia Nervosa
Co-Feedback Action of Growth Hormone, PP and PYY on Ghrelin in Bulimia
This study evaluates the addition of Acipimox or placebo to exercise on growth hormone release and ghrelin secretion in bulimic patients and in healthy women.
- Trial name
- NCT03338387
- Testing
- Acipimox
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Various Forms of Skeletal Muscle Dystrophy
Interaction of Muscle Dystrophy, Glucose Metabolism and Insulin Sensitivity
The aim of this project to characterize systemic and organ-specific (subcutaneous adipose tissue and skeletal muscle) metabolic responses at rest and during standardized, moderate exercise after an oral glucose load in patients…
- Trial name
- MyoMet (NCT05052073)
- Testing
- oral glucose load at rest, oral glucose load and exercise
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Healthy, Dermal Pharmacokinetic Measurement
An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sampling Techniques
This will be a single center, open label, exploratory research study to assess the dermal and systemic PK of marketed products of lidocaine/prilocaine in 26 healthy participants using dermal open flow microperfusion (dOFM) and…
- Trial name
- NCT03813030
- Testing
- Intravenous infusion of lidocaine, Lidocaine 2.5% and Prilocaine 2.5% cream", USP (2.5% lidocaine, 2.5% prilocaine, Actavis Pharma incorporated, USA), Lidocorit 2%-Ampullen" (Gebro Pharma Gesellschaft mit beschränkter Haftung, Austria)
- Where
- Austria
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Joanneum Research Forschungsgesellschaft mbH
Obesity, Insulin Sensitivity
Effects of Regular Activity on Physiology Between Recreational Athletes of Different Body Fatness
The popularity of marathons and endurance events has increased over the last few decades and, interestingly, the demographics of participants have also changed.
- Trial name
- NCT05154422
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Florida State University