Clinical trials: Microparticles
Deep Vein Thrombosis, Cancer
US-Doppler and Procoagulant Microparticles for the Diagnosis of Asymptomatic DVT in Advanced Cancer Patients With Poor Performance Status
The aim of this study is to determine the prevalence of asymptomatic lower extremity DVT detected by US-Doppler and procoagulant microparticles in a selected group of cancer patients suffering from an advanced stage of the…
- Trial name
- NCT00336258
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
End Stage Heart Failure
Impact of LVAD Implantation on Micro- and Macrovascular Function
End stage heart failure is characterized by a critical inability of the heart to meet the organism's blood demand even under resting conditions.
- Trial name
- LVAD (NCT02174133)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Neoplasm, Hepatic, Pancreatic Neoplasms
Impact of Microparticles on Postoperative Complications in Surgical Patients
Microparticles are cellular fragments which are released actively or passively under conditions of inflammation and stress. The impact of surgical operations on quantity and quality of microparticles remains unknown.
- Conditions
- Neoplasm, Hepatic, Pancreatic Neoplasms, Colorectal Neoplasms
- Trial name
- NCT00677781
- Where
- Switzerland
- Volunteers
- 108 people
- Sponsor
- University of Bern
Lymphoma
Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Low- or Intermediate-Grade Non-Hodgkin's Lymphoma
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy.
- Trial name
- NCT00006241
- Testing
- filgrastim, chemotherapy, in vitro-treated peripheral blood stem cell transplantation
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Chronic Kidney Disease
Endothelial Microparticles: A Novel Marker of Vascular Dysfunction
The primary hypothesis of this proposal is that chronic kidney disease (CKD) and treatment with calcineurin inhibitors (CNIs) are each associated with the release of endothelial microparticles into the plasma.
- Trial name
- NCT02230202
- Testing
- Flow-mediated dilation, single blood draw
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acne Vulgaris
Imaging of Pilosebaceous Units and Acne Lesions by RCM and OCT Confocal Microscopy and Optical Coherence Tomography
The purpose of the study was to investigate if reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) could be used in combination to investigate the morphology of pilosebaceous units and acne lesions in…
- Trial name
- NCT03524040
- Testing
- SEB-250
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Merete Haedersdal
Critical Care
Impact of Microparticles in Blood on Transfused Patient Outcomes
During storage, red blood cells (RBCs) undergo changes collectively termed "Storage lesions". these changes may have an impact of the outcomes of transfused patients.
- Trial name
- IMIB (NCT03041974)
- Testing
- Red Blood Cell transfusion, Microparticles quantification
- Volunteers
- 280 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Breast Cancer
Rosuvastatin to Lower Circulating Tissue Factor Bearing Microparticles in Metastatic Breast Cancer
Research studies have shown a strong association between cancer and blood clots in the veins (also known as deep vein thrombosis).
- Trial name
- NCT01299038
- Testing
- rosuvastatin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Proteinuria, Hypertension
Specific Blockage of Angiotensine 2 and Podocyturia in Glomerular Nephropathies With Hypertension and Proteinuria
Chronic glomerular diseases are one of the main causes leading to end stage renal disease (ESRD). Hypertension and proteinuria are two modifiable factors promoting the progression of ESRD.
- Conditions
- Proteinuria, Hypertension, End Stage Renal Disease
- Trial name
- NCT00369538
- Testing
- losartan, hydrochlorothiazide, hydrochlorothiazide, losartan
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Thrombosis
Diagnostic Role of Antiphospholipid Antibodies and Microparticles in Immune Thrombocytopenic Patients With Thrombosis
Identify the procoagulant profile in immune thrombocytopenic patients with thrombosis. Clinical implications of antiphospholipid antibodies in ITP patients with thrombosis.
- Trial name
- NCT05830916
- Testing
- Antiphospholipid antibodies
- Volunteers
- 70 people
- Sponsor
- Assiut University
Inflammatory Acne Vulgaris
Pivotal Study of Sebacia Microparticles in the Treatment of Acne Vulgaris
Prospective, randomized multicenter study to examine the safety and effectiveness of Sebacia microparticles with or without laser in the treatment of moderate to moderately-severe inflammatory acne vulgaris
- Trial name
- NCT02217228
- Testing
- Sebacia microparticles and laser, Vehicle suspension and laser, Sebacia microparticles without laser
- Where
- 19 sites in United States
- Volunteers
- 394 people
- Sponsor
- Sebacia, Inc.
Coronary Artery Disease, Carotid Artery Disease
Assessment Of Vascular Health After Niacin Therapy (AVANT)
This study is looking to see if niacin will lessen atherosclerotic plaque inflammation and favorably affect circulating levels of endothelial progenitor cells and microparticles in people with atherosclerotic disease on chronic…
- Conditions
- Coronary Artery Disease, Carotid Artery Disease, Peripheral Artery Disease
- Trial name
- AVANT (NCT02003638)
- Testing
- Niacin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pennsylvania
Brain Ischemia, Cerebral Ischemia
PROgnostic Value of MicroParticles and Markers of Hemostasis in TIA and Ischemic Stroke
The purpose is to investigate if different microparticles and markers of hemostasis predict outcome after TIA or ischemic stroke and to study the association between these variables and stroke subtype or etiology.
- Conditions
- Brain Ischemia, Cerebral Ischemia, Extracellular Vesicles, Hemostasis
- Trial name
- PROMPTS (NCT05524506)
- Where
- Sweden
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Endothelial Dysfunction
Endothelial Microparticles as Potential Biomarkers of Endothelial Dysfunction
Endothelial microparticles (EMP) have a promising role as a diagnostic and prognostic tool in the assessment of endothelial function.
- Trial name
- NCT04512404
- Testing
- HMG-CoA Reductase Inhibitor
- Where
- Malaysia
- Volunteers
- 48 people
- Sponsor
- Universiti Sains Malaysia
Acne Vulgaris
Non-Significant Risk Study of Sebacia Microparticles in the Treatment of Facial Acne Vulgaris
Prospective, randomized, controlled, parallel group clinical study with blinded assessment evaluating Sebacia Microparticles (SM) with Nd:Yag laser in facial inflammatory acne vulgaris
- Trial name
- NCT03303170
- Testing
- Sebacia Microparticles, Nd:Yag Laser
- Where
- 11 sites in United States
- Volunteers
- 168 people
- Sponsor
- Sebacia, Inc.
Systemic Lupus Erythematosus, Systemic Scleroderma
Microparticles's Role in the Pathophysiology of Systemic Lupus Erythematosus and Systemic Sclerosis
Our study aims at defining the role of circulating microparticles in the physiopathology of two rare auto-immune diseases: systemic lupus erythematosus (SLE) and systemic scleroderma (SSc).
- Trial name
- MICROLUPS (NCT03575156)
- Testing
- blood sample, urine sample
- Where
- France
- Volunteers
- 208 people
- Sponsor
- University Hospital, Bordeaux
Type 2 Diabetes
Pioglitazone Versus Metformin in Type 2 Diabetes
Type 2 diabetes is an epidemic. Its long-term consequences translate into enormous human suffering and economic costs; however, much of the morbidity associated with long-term microvascular and neuropathic complications can be…
- Trial name
- NCT00815399
- Testing
- Pioglitazone, Metformin
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Crohn's Disease, Ulcerative Colitis
Microparticles in Pediatric Inflammatory Disease
The purpose of this study is to provide data correlating levels of microparticles that circulate in the blood and disease activity in children with inflammatory bowel disease (IBD).
- Trial name
- NCT00979485
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Giant Cell Arteritis, Acute Phase
Study of Circulating Microparticles in Giant Cell Arteritis
To demonstrate that microparticles (MPs), having a powerful procoagulant potential, are in larger amounts in the blood of patients with histologically proven giant cell arteritis (GCA), compared with patients matched for age, sex…
- Trial name
- MicroGiant (NCT02333708)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Infertility, Hyperstimulation Syndrome, Ovaian
Vascular Cell Activation, Cell-Derived Microparticles and In Vitro Fertilisation, and In Vitro Fertilisation
Introduction: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic phenomenon, poorly understood and difficult to predict, complicating intense ovarian stimulation cycle.
- Conditions
- Infertility, Hyperstimulation Syndrome, Ovaian, Thrombosis
- Trial name
- PREDHSO (NCT03051230)
- Volunteers
- 50 people
- Sponsor
- Poissy-Saint Germain Hospital