Clinical trials: Modification
Abdominal Cancer, Blood Pressure
The Effect of Patient Position Changes on Advanced Cardiac Indices in Cancer Surgery
Esophageal Doppler Monitoring (Deltex CardioQ Esophageal Doppler Monitor, ODM) is used to manage patients' fluid therapy by non-invasively measuring continuous cardiac output with an esophageal probe.
- Conditions
- Abdominal Cancer, Blood Pressure, Cardiac Indices
- Trial name
- NCT06293391
- Testing
- cardiac indices in supine and trendelenburg position
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Periodontal Diseases
DKK-3 rs11544814 and CFH rs10737680 Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontitis Patients With and Without CAD
Untreated periodontal infection may result in transient bacteremia and toxaemia which may be the cause of adverse systemic events, leading to various systemic disorders.
- Trial name
- NCT05828368
- Testing
- Non surgical periodontal therapy
- Where
- 2 sites in India
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Congenital Urine Flow Impairment
Change of Urinary Metabolic Profile Secondary to a Congenital Urine Flow Impairment (UFI) by Nuclear Magnetic Resonance (NMR) and Metabolomics Analysis
For the new-born, diagnosis and prognosis of congenital urine flow impairment (UFI) are difficult to confirm only with morphological examination (ultrasonography, intravenous pyelography) and functional examination (dynamic renal…
- Trial name
- ACEU (NCT02792348)
- Testing
- Laboratory biomarker analysis on urine sample
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Hereditary Angioedema
Phase 1 Crossover Study in Healthy Subjects to Evaluate the PK Profile of KVD824 Following Single and Multiple Doses of Modified Release (MR) Formulations
This is a 3 part, phase 1 crossover study in healthy subjects to evaluate the pharmacokinetic profile of KVD824 following single and multiple doses of novel KVD824 modified-release formulations compared with a reference KVD824…
- Trial name
- NCT05118958
- Testing
- KVD824 Prototype 1 modified-release tablet, KVD824 Prototype 2 modified-release tablet, KVD824 Immediate-Release Capsule
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- KalVista Pharmaceuticals, Ltd.
Healthy Volunteer
Study to Estimate the Pharmacokinetics, Bioavailability and Effect of Food on Single Dose Modified-release Lersivirine 500 mg in Healthy Subjects
The purpose of this study is to estimate the pharmacokinetics (PK) of 3 different modified-release formulations of lersivirine and compare it to the PK of the immediate-release tablet.
- Trial name
- NCT01603485
- Testing
- Lersivirine Immediate-Release (fasted), Lersivirine Modified-Release #1 (fasted), Lersivirine Modified-Release #2 (fasted)
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Antimicrobial Resistance, Attitude to Health
Testing New Ways to Name Antimicrobial Resistance
This study aims to investigate the public's views on antibiotics and the impact of different ways to name the potential consequences of antibiotics not working in the future.
- Trial name
- NCT06356285
- Testing
- Presentation of Antimicrobial Resistance
- Where
- United Kingdom
- Volunteers
- 4,296 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Arthritis, Rheumatoid, Knee Osteoarthritis
Can 4 Weeks of Exercise Program Change Quadriceps Architecture in Patients With Rheumatoid Arthritis
Quadriceps femoris (QF) atrophy is seen in rheumatoid arthritis and knee osteoarthritis (OA) patients. Exercise therapy is mile stone in knee OA patients also it can help thicken QF muscle of RA patients.
- Conditions
- Arthritis, Rheumatoid, Knee Osteoarthritis, Quadriceps Muscle Atrophy, Ultrasonography
- Trial name
- NCT04834050
- Testing
- Quadriceps femoris isometric home-based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ovgu Bickici
Arthroplasties, Replacement, Weight Loss
Weight Loss Before Total Joint Arthroplasty Using A Remote Dietitian and Mobile App
The purpose of this trial is to assess the impact of a 12-week remote dietitian supervised dietary and physical activity weight loss intervention and mobile app for patients with morbid obesity prior to undergoing total joint…
- Conditions
- Arthroplasties, Replacement, Weight Loss, Nutrition
- Trial name
- NCT04330391
- Testing
- Remote dietitian supervised weight loss intervention and mobile app
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Weight Gain
Effect of Olive Oil Massage on Growth in Preterm Low Birth Weight Neonate: A Randomized Controlled Clinical Trial
STUDY TITLE: Effect of olive oil massage on growth of preterm low birth weight neonate: A randomized controlled clinical trial." SUMMARY: Preterm low birth weight (LBW) babies have more the risk of the neurological complications…
- Trial name
- NCT05944991
- Testing
- Olive oil message
- Where
- Bangladesh
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Medication Adherence, Renal Transplant
Efficacy of Envarsus XR and Digital Health Technology in Reducing Tacrolimus Fluctuation and Frequency of Dose Changes
Tacrolimus is an immunosuppressive agent prescribed to prevent organ rejection in post transplant patients, in combination with other immunosuppressants.
- Trial name
- NCT04711291
- Testing
- Conversion to Envarsus-XR and use of smart phone app, TransMedAx, Convert to Envarsus XR once daily
- Volunteers
- healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity, Weight Loss
Implementation of Medical Weight Management by Telemedicine
As the prevalence and associated healthcare costs of obesity continue to increase, the need for obesity treatments that contribute to weight loss maintenance are needed.
- Conditions
- Obesity, Weight Loss, Telemedicine
- Trial name
- NCT03283618
- Testing
- Video Conferencing Group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- California State University, Long Beach
Processing Health Information
Media Effects Study on Health-Related Content
A media lab study will be conducted to determine the mechanism by which podcasting may exert an effect. This study will examine both physiological (heart rate, skin conductance, etc.) and psychosocial (knowledge, perceived…
- Trial name
- NCT00775008
- Testing
- electronic health information
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Reproductive Physiological Phenomena
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.
The specific objective of this study was to investigate the sensitivity of Kisspeptin receptor 1 (KISS1R) by determining the responsiveness of GnRH neuron to kisspeptin administration across the pubertal stages and adult group…
- Trial name
- NCT03286517
- Testing
- Kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany)
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ghulam Nabi
Labor Complication
Traditional WHO Partograph and Korle-Bu Modified WHO Partograph for Uncomplicated Labour
Brief Background: The partograph is a graphical representation of the events in the first stage of labour. It is an instrument used in monitoring the well being of both the pregnant woman and her fetus (es) as they go through the…
- Trial name
- NCT05837559
- Testing
- Korle-Bu Modified WHO Partograph for Uncomplicated Labour
- Where
- Ghana
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Ghana Medical School
Dental Caries
Occlusal Bite Force Changes After Placement of Stainless Steel Crowns in Children
The aim of this study was to determine if restoring primary molars with SSCs would improve children's OBF.
- Trial name
- OBF (NCT03254069)
- Testing
- Stainless Steel Crowns
- Where
- Jordan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Nasal Valve Incompetence, Alar Collapse
Measurement of Age and Sex Related Changes in Nasal Tip Support Using Digital Newton Meter
Background: It is predicted that the nasal tip support will decrease with aging due to weakening of cartilage and connective tissues. However, there is no consensus on the age at which this change began.
- Trial name
- NCT04017923
- Testing
- measurement of nasal tip support in different age groups.
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Treatment Adherence and Compliance, Resistance Exercise
Testing a Smartphone App to Support a Mediterranean Diet and Strength Exercise
Eating a Mediterranean-style diet and doing regular resistance training are both known to lower the risk of heart disease. However, most people find it hard to stick to these habits over time, and few smartphone apps support both…
- Conditions
- Treatment Adherence and Compliance, Resistance Exercise, Mediterranean Diet, Healthy Volunteers
- Trial name
- App-etite (NCT07885254)
- Testing
- MedEx Tracker, Printed dietary and resistance exercise programme
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Obesity, Weight Loss
Evaluation of a Commercial Program on Weight Loss and Health Outcomes
To examine weight loss and acceptability of a modified WW program. This study is designed to detect differences in weight loss at the end of 24 weeks of intervention.
- Trial name
- NCT03928483
- Testing
- Modified WW Food program
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
NIDDM
APAD2: Effects of Rehabilitation Programme in Adapted Physical Activity (APA) Among Type 2 Diabetics
The principal objective is to assess and analyze the effects of a six month programme in Adapted Physical Activity (APA) on physical activity, compliance, and insulin resistance among type 2 diabetics.
- Trial name
- NCT00234273
- Testing
- Rehabilitation programme in Adapted Physical Activity (APA), Therapeutic education primarily focused on dietary
- Where
- 4 sites in France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Parent-Child Relations, Child Mental Disorder
Co-production and Feasibility RCT of Intervention to Improve the Mental Health of Children With a Social Worker
Feasibility RCT to ask: Can the investigators coproduce, with parent collaborators, a new service, Infant Parent Support (IPS), to improve the mental health of children with a social worker? Can the investigators test the…
- Conditions
- Parent-Child Relations, Child Mental Disorder, Child Maltreatment
- Trial name
- NCT06003582
- Testing
- Infant Parent Support
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
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