Clinical trials: Modification
MS (Multiple Sclerosis)
Brain Functional Connectivity Changes Following Cognitive Rehabilitation in Multiple Sclerosis: an fMRI Study
This trial seeks to investigate brain network changes following cognitive rehabilitation in MS patients. The investigators hypothesize that rehabilitation interventions improve connectivity in the brain.Novel Magnetic Resonance…
- Trial name
- NCT01628276
- Testing
- Cog Rehab
- Where
- Iran
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sina Hospital, Iran
Normal Control, SIRS
Sepsis Metabolomics
The occurrence of sepsis and its relevant multiple organ dysfunction remain a major problem in intensive care units with high morbidity and mortality.
- Conditions
- Normal Control, SIRS, Sepsis, Severe Sepsis
- Trial name
- NCT01649440
- Where
- China
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
IUGR, Pregnancy
Transplacental Gradients and Transport in Intrauterine Growth Restricted (IUGR) Pregnancies Compared to Normal Pregnancies.
The purpose of this study is to determine whether the transplacental gradients for 6 polyols and mannose are altered in intrauterine growth restricted (IUGR) pregnancies compared to normal pregnancies and b) to determine the…
- Trial name
- NCT02397291
- Testing
- Mannose, Myoinositol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Fissure Sealant
Clinical Efficacy of Different Fissure Sealant Materials in the Newly Erupted Non-Carious First Permanent Molars
The aim of this study is to compare the clinical retention rates, marginal adaptation, marginal discoloration and secondary caries formation of two different types of resin-modified glass ionomers (Fuji® II LC; Clinpro™ XT…
- Trial name
- NCT04854720
- Testing
- Fuji® II LC CAPSULE, Clinpro™ XT Varnish, Beautifil Flow
- Where
- Turkey (Türkiye)
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Diabetes Mellitus, Type 2
Feasibility Study on the Impact of Economic Incentives to Improve the Management of Type 2 Diabetes Mellitus
This feasibility study aims to compare the implementation process of three different interventions that use economic incentives to promote lifestyle behavioral changes in patients with type 2 diabetes mellitus, and to identify…
- Trial name
- REDEEM-Pilot (NCT02891382)
- Testing
- Diabetes education, Goal setting, Companion Support
- Where
- Peru
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
Changes in Brain Network Connectivity
Anesthesia and Functional Connectivity: An Analysis of fMRI Changes
Functional connectivity is defined as a correlation in neural activity between distinct regions of the brain. Several recent studies have demonstrated areas of low-frequency functional connectivity inherent to brain tissue at…
- Trial name
- NCT02196259
- Testing
- Anesthetics, Dissociative
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Osteoarthritis, Knee, Inflammation Knees
How TKA Implants Affect Muscle Quality and Activity During Daily Living and Immunological Response
This study compares two total knee replacement implants to asses muscle function and quality, and the immune response to the implants.
- Trial name
- NCT04105179
- Testing
- Zimmer NexGen LPS-Flex, Smith & Nephew Journey II
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Churg-Strauss Syndrome, Eosinophilic Asthma
Identification of Autoantigens in EGPA and Severe Eosinophilic Asthma
In this project the investigators will look for auto-antibodies to relevant proteins both in native form and importantly in post-translationally modified forms.
- Conditions
- Churg-Strauss Syndrome, Eosinophilic Asthma, Eosinophilic Esophagitis, Eosinophilic Pneumonia
- Trial name
- IDEA (NCT04671446)
- Testing
- Autoantibody ELISA, Granulocyte Immunofluorescence
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Periodontitis, Gingivitis
Evaluation of Mandibular Bone Microstructure Changes After Periodontal Treatment (M-BONE Study)
This prospective study evaluates how non-surgical treatment for gum disease affects the bone of the mandible. Gum disease (periodontitis) can lead to changes in the bone supporting the teeth, but these changes are not always easy…
- Trial name
- NCT07488403
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Appetite, Weight Loss
Dietary Pork, Appetite and Weight Loss in Human
The entire study protocol will last 13 weeks. Women will be randomly assigned to one of two experimental groups: high and low protein.
- Trial name
- NCT01006343
- Testing
- Higher Protein (HP), Lower Protein (LP)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Purdue University
Nursing Diagnosis, Taboo Game
Motivation of Nursing Students and Perception Levels of the Taboo Game Adapted for Nursing Diagnoses
The goal of this To determine the effect of the taboo game adapted for nursing diagnoses in the professional practice course on the motivation and perception levels of nursing diagnoses in nursing students.
- Conditions
- Nursing Diagnosis, Taboo Game, Motivation
- Trial name
- NCT05756218
- Testing
- nursing diagnoses - taboo game
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Obesity, Weight Gain
Exercise, Brain Activity, and Weight Maintenance
This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.
- Conditions
- Obesity, Weight Gain, Bariatric Surgery Candidate, Appetitive Behavior
- Trial name
- NCT06511310
- Testing
- Exercise
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Disorder of Consciousness, Traumatic Brain Injury
Changes in Glutamatergic Neurotransmission of Severe TBI Patients
Studies in patients with disorders of consciousness (DOC) after severe brain injury implicate dysfunction of the anterior forebrain mesocircuit dysfunction a key underlying mechanism.
- Trial name
- NCT04244058
- Testing
- Amantadine + L-DOPA, NMDA blocker
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Papilla Reconstruction
Modified Pedicle Subepithelial Connective Tissue Graft for Interdental Papillary Reconstruction Around Delayed Implants in the Esthetic Zone: A Case Series Trail
This case series trial aims to evaluate the effect of a modified pedicle subepithelial connective tissue graft in creating anatomical papilla around one-stage delayed implant in the esthetic zone to establish better esthetics.
- Trial name
- delay implant (NCT04843826)
- Testing
- papilla reconstruction
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ahmed Sadek Mohamed
Early Childhood Caries
Study of Obstacles and Barriers to Changing Risky Eating Behaviors in Families of Children With Severe Early Childhood Caries (QUALIKIDS).
Dental caries is the most common chronic disease in children, and its early form-Early Childhood Caries (ECC)-which particularly affects children under the age of six, represents a major public health problem worldwide.
- Trial name
- QUALIKIDS (NCT07377240)
- Testing
- Interview
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity, Weight Loss
Implementation of Medical Weight Management by Telemedicine
As the prevalence and associated healthcare costs of obesity continue to increase, the need for obesity treatments that contribute to weight loss maintenance are needed.
- Conditions
- Obesity, Weight Loss, Telemedicine
- Trial name
- NCT03283618
- Testing
- Video Conferencing Group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- California State University, Long Beach
Diet Modification, Cardiovascular Diseases
The Efficacy of Front-of-package Labelling Schemes: an Experimental Study
This is an online study that aims to test the effectiveness of Interpretative Nutrition Rating Systems (INRS) such as the Health Star Rating System (HSR or Star System), traffic light system and warning labels (high sodium…
- Conditions
- Diet Modification, Cardiovascular Diseases, Nutrition
- Trial name
- NCT03290118
- Testing
- Nutrition Rating System - Traffic Light, Nutrition Rating System - Health Star, Nutrition Rating System - Warning Label
- Where
- Canada
- Volunteers
- 2,008 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Physical Inactivity, Mental Health Issue
Effects of Active Video Games on Chinese Overweight and Obese College Students' Physical and Mental Health
Globally, overweight and obesity have become a major health concern and are present at all ages in both developed and developing countries.
- Conditions
- Physical Inactivity, Mental Health Issue, Body Weight Changes
- Trial name
- NCT06078150
- Testing
- Active video games intervention（1-6weeks）, Active video games intervention（7-12weeks）
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Amputation, Congenital, Upper Limb; Amelia
CNS Changes Following Upper Limb Loss
The objective of this study is to better understand the structural and functional changes that the central nervous system (CNS) undergoes following congenital upper limb loss.
- Trial name
- NCT06043518
- Testing
- MRI
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Liver Enzymes After General or Spinal Anesthetic Techniques, In Patients With Preoperatively Elevated Liver Enzymes
Comparative Study of the Change in Liver Enzymes After General or Spinal Anesthetic Techniques in Patients With Preoperatively Elevated Liver Enzymes.
To assess the changes in liver functions postoperatively in patients with preoperatively elevated liver enzymes. To identify the most appropriate anesthesia technique for patients with preoperatively elevated liver enzymes.
- Trial name
- NCT03421990
- Testing
- General anesthesia
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
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