Clinical trials: Modification
Oesophageal Cancer
Do Changes in ctDNA Predict Response for Patients With Oesophageal Cancer Receiving Durvalumab
Patients with cancer are increasingly being treated with drugs designed to modulate the response of their immune system, broadly to boost their body's defences against cancer.
- Trial name
- CALIBRATION (NCT03653052)
- Testing
- Durvalumab
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Simon C Pacey, MD
Skin Sensitisation
Skin Sensitization Test (Modified Draize-95 Test)
Skin Sensitization Test (Modified Draize-95) to Support a Low Dermatitis Potential Claim for a Blue Non Sterile Powder Free Nitrile Examination Gloves.
- Trial name
- Draize-95 (NCT04274647)
- Testing
- NON-STERILE, POWDER FREE NITRILE EXAMINATION GLOVES, LOW DERMATITIS POTENTIAL, TESTED FOR USE WITH CHEMOTHERAPY DRUGS - BLUE
- Where
- Malaysia
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- YTY Industry (Manjung) Sdn Bhd
Intensive Care (ICU), Central Venous Catheter Related Infections
Impact of Infusion Line Change Frequency on Infectious Complications Related to Central Venous Catheters in the ICU - A Randomized Controlled Trial
In the intensive care unit, patients' care and secure drugs administration require a central venous catheter. These invasive devices can lead to complications, particularly infections.
- Conditions
- Intensive Care (ICU), Central Venous Catheter Related Infections, Critical Care Nursing, Catheter-associated Bloodstream Infections (CLABSI)
- Trial name
- TANDOORI (NCT07183592)
- Testing
- 7-day Infusion set replacement, 4-day infusion set replacement
- Where
- 27 sites in France
- Volunteers
- 2,830 people
- Sponsor
- University Hospital, Angers
Overweight and Obesity
Web-Based Weight Loss & Weight Maintenance Intervention for Older Rural Women, Also Known as Women Weigh-in for Wellness
This project will evaluate an Internet delivery strategy to address weight loss and maintenance among rural midlife and older women.
- Trial name
- NCT01307644
- Testing
- Experimental: Web-based only (WO) weight intervention, Experimental: WO plus peer-led discussion board (WD), Experimental: WO & professional email counseling (WE)
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- University of Nebraska
Tobacco Use
Address Tobacco Use Among Adolescents in Hong Kong
This study will examine the effectiveness of a social norms campaign in correcting smoking misperceptions, reducing smoking susceptibility and changing smoking-related behaviours in Hong Kong adolescents.
- Trial name
- NCT03264144
- Testing
- Social norms campaign
- Where
- Hong Kong
- Volunteers
- 12,868 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Postoperative Complications
Sleeve Gastrectomy as a Standard Bariatric Procedure
This study compared differences in weight loss, comorbidity resolution and complications and reoperations between a recently established sleeve gastrectomy (SG) and prior laparoscopic Rox-en-Y gastric bypass (RYGB).
- Trial name
- NCT05336331
- Testing
- SG or a RYGB
- Where
- Sweden
- Volunteers
- 1,015 people
- Sponsor
- Umeå University
Healthy
Effect of Garlic Extracts on Changes in Cerebral Blood Flow
The purpose of this study is to assess the safety and efficacy of Garlic extracts for improving of cerebral blood flow.
- Trial name
- NCT05349253
- Testing
- Garlic extracts
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Weight Management
Education Session to Improve Program Adherence
To examine is user knowledge of a dietary self-monitoring (DSM) calorie tracking app and improving patient adherence to daily caloric food intake to help with weight loss.
- Trial name
- NCT06428695
- Testing
- one-hour dietary self-monitoring tool education session
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Allergic Conjunctivitis
Evaluation of the Efficacy of Topical Ophthalmic Steroids in a Modified Conjunctival Allergen Challenge (CAC) Model
The purpose of this study is to evaluate the effectiveness of the modified Conjunctival Allergen Challenge (CAC) and observe how the produced allergic inflammation reacts to treatment with a proven ocular anti-inflammatory…
- Trial name
- NCT01534195
- Testing
- Prednisolone Sodium Phosphate Ophthalmic Solution 1%, Tears Naturale II Ophthalmic Solution
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- ORA, Inc.
Cerebral Palsy, Sleep Disorders in Children
Sleep Quality and Caregiver Burden in Children With Cerebral Palsy
Cerebral palsy (CP) is a lifelong condition affecting movement and posture, often requiring substantial care from family members.
- Conditions
- Cerebral Palsy, Sleep Disorders in Children, Caregiver Burden, Sleep Quality
- Trial name
- CP-SLEEP (NCT07168577)
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Selim Sezikli
Body Dysmorphic Disorders
Understanding Daily Changes in BDD Risk Using Smartphones
Body dysmorphic disorder (BDD) is associated with high risk for suicide attempts (22-28%) and substance use disorders (49%), underscoring the importance of accurate, real-time risk detection in BDD.
- Trial name
- NCT04254575
- Testing
- None, observational study only (no interventions)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Massachusetts General Hospital
Postoperative Pain
Electroencephalogram Changes Induced by Transcutaneous Electrical Acupoint Stimulation
A total of 90 subjects underwent abdominal surgery under general anesthesia at Chaoyang Hospital in Beijing. The subjects were divided into a percutaneous acupoint electrical stimulation group and a control group.
- Trial name
- NCT07819630
- Testing
- Transcutaneous electrical acupoint stimulation
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing Chao Yang Hospital
Pregnant Individuals, Obesity & Overweight
Gestational Response, Outcomes, and Weight After GLP-1 Use
The goal of this observational study is to learn if using GLP-1RA medications for weight loss before pregnancy influences gestational weight gain and pregnancy outcomes.
- Conditions
- Pregnant Individuals, Obesity & Overweight, Gestational Weight Gain
- Trial name
- GROW (NCT07743567)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
General Anesthesia-Induced Altered Consciousness
Brain Activity and Changes in Consciousness During General Anesthesia
This study aims to investigate how general anesthetics alter brain activity and consciousness across different age groups. The study will evaluate four anesthetic agents with different mechanisms of action: propofol, remimazolam…
- Trial name
- NCT07836205
- Testing
- Propofol (Group P), Remimazolam group, Esketamine group
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Obesity, Weight Loss
Hormonal Regulation of Body Weight Maintenance
The investigators here propose to perform a collaborative clinical research effort including a randomized controlled trial investigating the mechanisms of weight maintenance and their relation to a lifestyle intervention in…
- Conditions
- Obesity, Weight Loss, Weight Gain, Hormone Disturbance
- Trial name
- NCT00850629
- Testing
- multimodal lifestyle intervention
- Where
- Germany
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Body Weight Changes, Overweight and Obesity
A Self-directed Mobile Intervention to Promote Weight Control Among Employees of a Lebanese University
WaznApp study is a 12-week randomized controlled trial aimed to evaluate the feasibility and preliminary efficacy of a self-directed behavioral weight-loss intervention targeting employees of an academic institution, using two…
- Conditions
- Body Weight Changes, Overweight and Obesity, Sedentary Lifestyle, Health Behavior
- Trial name
- WaznApp (NCT03321331)
- Testing
- Lark (JITAI), MyFitnessPal (no JITAI)
- Where
- Lebanon
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Chinese Version, Fibromyalgia
Chinese Version of Fibromyalgia Criteria and Severity Scales Study
Up to now, there is no Chinese version of fibromyalgia diagnosis criteria and severity assessment scales. The aim of this study is to translate, adapt, and validate the Chinese version of the 2011 modification of the 2010 ACR…
- Conditions
- Chinese Version, Fibromyalgia, Diagnosis, Fibromyalgia Impact Questionnaire
- Trial name
- NCT03381131
- Where
- China
- Volunteers
- 327 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Intervertebral Disc Degeneration, Intervertebral Disc Displacement
Comparison of Three Approaches of Electrode Placement to Detect Changes in Motor Evoked Potentials During Spine Surgery
Motor Evoked Potentials are an aspect of intraoperative neuromonitoring, a tool used by neurophysiologists during surgery to prevent irreversible damage to the spinal cord during procedures.
- Conditions
- Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Stenosis, Spinal Curvatures
- Trial name
- NCT05098431
- Testing
- Quadriceps and Rectus Femoris MEP Recording
- Where
- United States
- Sponsor
- Allina Health System
Stroke
Enhancing Participation of Chronic Stroke Patients by Constraint Induced Movement Therapy (HOMECIMT)
The aim of this study is to evaluate the efficacy of a modified approach of constraint induced movement therapy ("CIMT at home") for chronic stroke patients, compared to conventional physiotherapy and occupational therapy…
- Trial name
- HOMECIMT (NCT01343602)
- Testing
- mod. Constraint-Induced Movement Therapy, Therapy as usual
- Where
- Germany
- Volunteers
- 156 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Obesity, Weight Loss
Low Fat Plant-based Diet Effects on Body Composition Indices
The effect of a diet free from animal-sourced nutrients on body composition in weight reduction programs is not well established.
- Trial name
- LFPBDS (NCT02906072)
- Testing
- Low fat plant-based diet, Lectures on health effects of a low fat plant-based diet.
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Barbara Jakše s.p.
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