Clinical trials: Mohs Surgery
Basal Cell Carcinoma
Vismodegib for Treatment of Basal Cell Carcinoma
The primary objectives of this study are to assess, using Mohs micrographic surgery (MMS) at the end of treatment, the efficacy (primary) and safety (secondary) of vismodegib compared to placebo in the oral adjunctive pre…
- Trial name
- Erivedge (NCT01543581)
- Testing
- Vismodegib
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Abel Torres, MD
Pain, Satisfaction, Consumer
Lidocaine Jelly for Pain Control During Mohs Surgery
Does the use of lidocaine jelly during Mohs surgery on the nose decrease the total amount of lidocaine used during surgery. Does patient satisfaction improve when lidocaine jelly is used during Mohs surgery of the nose?
- Trial name
- NCT03595449
- Testing
- Lidocaine jelly, Surgilube
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tissue Expander Disorder, Stress Strain Curve
Use of a Novel Device for Stretch Relaxation During Mohs Surgery
Closure of cutaneous defects is associated with many common and serious problems. For example, Mohs surgery involves the removal of skin and other soft tissues that have been proven to be infiltrated with cancer.
- Conditions
- Tissue Expander Disorder, Stress Strain Curve, Tissue Expansion, Mohs Surgery
- Trial name
- NCT03586960
- Testing
- Peak Force Measurement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Silver Falls Dermatology
Skin Cancer
Study to Determine if Tissue Scored With a Scalpel Results in Any Noticeable Marks
Mohs Micrographic Surgery is a well established method for treatment of cutaneous malignancies. Part of this technique requires marking skin surrounding the tumor.
- Trial name
- NCT00367042
- Testing
- Scalpel for tissue scoring, Surgical marker for tissue marking
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Suture, Suture Dermatologic
Effect of Petrolatum Coating on Fast-absorbing Gut Suture
This study is designed to evaluate the effect of using petrolatum to coat gut suture. This coating is commonly performed to make the suture more easy to handle; however, it was unknown if it affects the absorption rate of the…
- Conditions
- Suture, Suture Dermatologic, Mohs Micrographic Surgery, Suture Techniques
- Trial name
- NCT07127029
- Testing
- Petrolatum coating of fast-absorbing gut suture
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- San Antonio Uniformed Services Health Education Consortium
Pain, Postoperative, Narcotic Use
Bupivacaine for Post-operative Pain in Mohs
Mohs micrographic surgery (MMS) is regarded as the gold standard for the treatment of high-risk nonmelanoma skin cancer (NMSC). Pain after MMS peaks on the day of surgery and slowly decreases thereafter.
- Trial name
- NCT04362566
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Quality of Life
Integrative Care and Acupuncture in MOHS Surgery
MOHS method is an effective surgical technique to remove skin cancerous tumors in the head-neck area. Patients undergoing MOHS surgery are struggled with emotional stress during the day of surgery, due to fear of significant…
- Trial name
- NCT03569982
- Testing
- Integrative medicine care
- Where
- Israel
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Wound Heal
Dermabrasion in Mohs: Split-Scar Trial
The purpose of this study is to determine the potential influence of intraoperative dermabrasion on scars following Mohs Micrographic Surgery (MMS).
- Trial name
- NCT07213921
- Testing
- Dermabrasion
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Skin Cancer, Skin Wound
Preoperative Image-based Education Effect on Postoperative Satisfaction of Patients Undergoing First-time Dermatologic Surgery
This research study aims to understand whether visual and written education on wound appearance can improve patients' experience and understanding of what their wound will look like following dermatologic surgery.
- Trial name
- NCT05643755
- Testing
- Preoperative image-based education
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Timing of Subcutaneous Tranexamic Acid Injection in Mohs Micrographic Surgery
This study will compare postoperative bleeding after subcutaneous tranexamic acid (TXA) is administered during Mohs surgery either after tumor clearance and before reconstruction or after reconstruction and before bandage…
- Trial name
- NCT07807371
- Testing
- Subcutaneous TXA injection before reconstruction, Subcutaneous TXA injection after reconstruction
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System
Anesthetics, Local
Split Face Study of the Duration of Local Anesthetics
This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for.
- Trial name
- NCT05767749
- Testing
- lidocaine + epinephrine 1:100,000, Ropivacaine 0.5% Injectable Solution, Bupivacaine 0.5% Injectable Solution
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Scar, Surgical Wound
Correlation of Early Postoperative Scar Appearance With Long-term Scar Outcomes
A retrospective cohort study of early and late period postoperative scars using previously validated survey measures and clinical photographs.
- Conditions
- Scar, Surgical Wound, Quality of Life, Mohs Micrographic Surgery
- Trial name
- NCT04015453
- Testing
- Mohs micrographic surgery
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Corneal Toxicity, Ototoxicity
A Comparison of Infection Rates Between Two Surgical Sites
Does the use of chlorhexidine scrub prior to cutaneous surgery on the face increase the chances of toxicity to the eyes or ears? In addition, does the us eof chlorhexidine scrub on the face prior to cutaneous surgery decrease the…
- Conditions
- Corneal Toxicity, Ototoxicity, Surgical Site Infection
- Trial name
- NCT01263262
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Carcinoma, Basal Cell, Carcinoma, Squamous Cell
Optical Imaging for Preoperative Delineation of Nonmelanoma Skin Cancers
The purpose of the study is to evaluate the ability and efficacy of using a polarization-enhanced reflectance and fluorescence imaging device, PERFIS, (see the Device Brochure) for demarcation of nonmelanoma skin cancer margins…
- Trial name
- PERFIS (NCT02666833)
- Testing
- Polarization Enhanced Reflectance and Fluorescence System
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Non-melanoma Skin Cancer, Squamous Cell Carcinoma of Skin
Same-day Versus Separate-day Preoperative Consultation for Mohs Surgery
The purpose of this study is to determine whether separate- versus same-day preoperative consultation affects time to treatment (start to finish), utilization rate of Mohs, rate of case cancellations, cost, and patient…
- Conditions
- Non-melanoma Skin Cancer, Squamous Cell Carcinoma of Skin, Basal Cell Carcinoma
- Trial name
- NCT02321982
- Testing
- Same-day preoperative consultation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cicatrix
Comparison of Fast-Absorbing Sutures for Mohs Surgery
This study is being carried out to assess equivalence of scar outcome for two absorbable sutures used for wound closure on the face in dermatologic surgery: rapidly absorbable polyglactin 910 (VicrylRapide™) and fast-absorbing…
- Trial name
- NCT02334917
- Testing
- Surgical wound closure with superficial absorbable sutures
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Basal Cell Carcinoma, Squamous Cell Carcinoma
Effect of the Subconscious on Mohs Micrographic Surgery
The goal of this study is to determine if relaxation therapy improves patient satisfaction with Mohs micrographic surgery.
- Trial name
- NCT00374062
- Testing
- relaxation therapy 1, relaxation therapy 2, relaxation therapy 3
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Northwestern University