Clinical trials: Mortality
Chronic Kidney Disease and Hypertension
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
International, Multicenter, Double-Blind, Placebo-Controlled and Event-driven study to assess efficacy, safety and Tolerability of Baxdrostat in combination with Dapagliflozin on renal outcomes and cardiovascular mortality in…
- Trial name
- BaxDuo-Pacific (NCT06742723)
- Testing
- Baxdrostat/dapagliflozin
- Where
- 771 sites in United States, Argentina and 40 more
- Volunteers
- 5,000 people
- Sponsor
- AstraZeneca
End Stage Renal Disease
Accelerated Mortality on Renal Replacement
The purpose of this study is to prospectively identify blood markers that identify chronic hemodialysis patients at risk for early (<90 days) and late (>= 1 year) mortality
- Trial name
- ArMORR (NCT00505180)
- Volunteers
- 10,018 people
- Sponsor
- Massachusetts General Hospital
Bacteremia
Mortality of MBL-producing Enterobacteriaceae Bacteremias with the Combined Use of Ceftazidime-avibactam and Aztreonam Vs. Other Active Antibiotics. a Multicenter Target Trial Emulation.
Ceftazidime-avibactam and aztreonam combination (CAZAVI + ATM) presents a potential alternative for the treatment of metallo-beta-lactamase (MBL)-type carbapenemase-producing Enterobacteriaceae (CPE) bacteremia, particularly…
- Trial name
- NCT06419296
- Where
- 16 sites in Argentina
- Volunteers
- 265 people
- Sponsor
- Hospital Italiano de Buenos Aires
Immunoglobulin Prophylaxis, Cytomegalovirus Infections
Immunoglobiulin-specific Prophylaxis of Citomegalovirus Infections in Immunocompromised Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Human cytomegalovirus (CMV) is a globally prevalent, human-specific herpesvirus characterised by a lifelong latency after primary infection, an often asymptomatic reactivation and affecting up to 100% of adults based on region…
- Conditions
- Immunoglobulin Prophylaxis, Cytomegalovirus Infections, Allogeneic Hematopoietic Stem Cell Transplantation, Transplant-Related Disorder
- Trial name
- NCT07013370
- Testing
- Anti-CMV immunoglobulins [Megalotect (R)]
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Antonello Di Paolo, M.D., Ph.D.
Accidental Falls, Underlying Disease of Falls
Falls Of Unknown Origin (FUKNO) - Are Morbidity and Mortality Predictable in Patients Presenting With Falls?
It is the investigators goal to identify the prevalence of underlying diseases, make disposition more rational, and establish risk stratification tools in elderly patients presenting with falls.
- Trial name
- FUKNO (NCT02244983)
- Testing
- Patients History
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 587 people
- Sponsor
- University Hospital, Basel, Switzerland
Childhood Mortality
Neonates and Azithromycin, an Innovation in the Treatment of Children in Burkina Faso
Although under-5 mortality rates are declining globally, neonatal mortality remains persistently high in many regions of sub-Saharan Africa.
- Trial name
- NAITRE (NCT03682653)
- Testing
- Azithromycin
- Where
- Burkina Faso
- Volunteers
- 21,832 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy Related Complications
PRONTO: Obstetric and Neonatal Emergency Training Program: A Cluster-Randomized Trial to Measure Impact
Rates and causes of maternal mortality in Mexico have dropped only slightly; thus, reaching the internationally established Millennium Development Milestones (MDM) is still a distant goal.
- Trial name
- PRONTO (NCT01477554)
- Testing
- PRONTO training
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Major Non-cardiac Surgery
Effects of Perioperative Administration of Dexamethasone on Postoperative Complications and Mortality After Non-cardiac Major Surgery
Postoperative complications are major healthcare problems and are associated with a reduced short-term and long-term survival after surgery.
- Trial name
- PACMAN (NCT03218553)
- Testing
- Dexamethasone
- Where
- 29 sites in France
- Volunteers
- 1,222 people
- Sponsor
- Nantes University Hospital
Anemia, Low Birth Weight
Treatment and Prevention of Severe Anemia in Pregnant Zanzibari Women
The purpose of this research is to compare the efficacy of two low-cost low intervention packages to prevent and treat severe anemia in pregnant women in Zanzibar, Tanzania.
- Conditions
- Anemia, Low Birth Weight, Neonatal Mortality
- Trial name
- NCT00148629
- Testing
- multivitamin, mebendazole
- Where
- Tanzania
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Cornell University
ST-elevation Myocardial Infarction, Acute Myocardial Infarction
Should Integrilin be an Integral Part of Adjunctive Therapy in Patients Undergoing Primary PCI for ST-Elevation MI?
The aim of this observational study is to evaluate the in hospital and 6 month outcomes of the use of Glycoprotein IIb/IIIa inhibitor eptifibatide as adjunctive therapy in patients undergoing primary Percutaneous Coronary…
- Trial name
- NCT01991366
- Where
- United States
- Sponsor
- Medstar Health Research Institute
Extracorporeal Life Support, Extracorporeal Membrane Oxygenation
Quality Improvement to Reduce Mortality or Severe Intracranial Hemorrhage in Neonatal Extracorporeal Life Support
This is a three-year pre- and post- interventional study to assess the effectiveness of collaborative quality improvement interventions on reducing mortality and severe intracranial hemorrhage (ICH) for neonates receiving…
- Conditions
- Extracorporeal Life Support, Extracorporeal Membrane Oxygenation, Quality Improvement, Intracranial Hemorrhage
- Trial name
- NCT05075486
- Testing
- Collaborative quality improvement
- Sponsor
- Children's Hospital of Fudan University
Patients Undergoing Valvular Heart Surgery
A Prediction Model for 1-year Mortality After Valvular Heart Surgery
The investigators aimed to develop a predictive model for mortality incorporating nutritional, inflammatory, and perioperative factors in patients undergoing valvular heart surgery.
- Trial name
- NCT05833256
- Where
- South Korea
- Volunteers
- 2,046 people
- Sponsor
- Yonsei University
Peritoneal Dialysis
Effects of Renin-Angiotensin System Inhibitors in Peritoneal Dialysis Patients
Among antihypertensive medications, RAS inhibitor classes, namely angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) have the most prospective data on mortality and cardiovascular outcomes in…
- Trial name
- NCT04076930
- Testing
- angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB)
- Where
- Thailand
- Volunteers
- 1,468 people
- Sponsor
- Chiang Mai University
Frailty Syndrome, Surgery--Complications
Pre-frailty and Rehospitalization in Cardiac Surgery
Background: It has been demonstrated that pre-frailty has more adverse outcomes after cardiac surgery, however, data on prognosis and long-term evolution in pre-frailty patients after cardiac surgery without postoperative…
- Conditions
- Frailty Syndrome, Surgery--Complications, Coronary Artery Disease, Valve Anomalies
- Trial name
- NCT03949439
- Testing
- Elective Cardiac Surgery
- Where
- Brazil
- Volunteers
- 453 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Hypertension, Coronary Disease
Analyzing How Genetics May Affect Response to High Blood Pressure Medications
High blood pressure is one of the most common health problems in the United States. There are many medications to treat high blood pressure, but there is a large variance in how people respond to these medications.
- Conditions
- Hypertension, Coronary Disease, Cerebrovascular Accident
- Trial name
- NCT00563901
- Where
- 2 sites in United States
- Volunteers
- 37,939 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Maternal Mortality, Perinatal Mortality
Evaluation of a Smartphone Application to Reduce Adverse Pregnancy Outcomes in Ethiopia
The purpose of this trial is to determine if the safe delivery smartphone application distributed to health workers in Ethiopia will decrease perinatal mortality and the incidence of postpartum haemorrhage.
- Trial name
- NCT01945931
- Testing
- Safe Delivery Smartphone Application
- Where
- Denmark
- Volunteers
- 3,601 people
- Sponsor
- University of Copenhagen
Rectal Cancer
Early Closure of Temporary Ileostomy
The study is being conducted as a prospective randomized controlled multicenter study of patients with a temporary ileostomy due to rectal cancer.
- Trial name
- EASY (NCT01287637)
- Testing
- Early reversal of temporary ileostomy, Standard reversal of temporary ileostomy
- Where
- Denmark
- Volunteers
- 89 people
- Sponsor
- Herlev Hospital
Measles Vaccine
Trial of Additional Measles Vaccine to Reduce Child Mortality. Burkina Faso.
Background: All observational studies and a few randomised controlled trials (RCT) suggest that early measles vaccine (MV), in particular an early two-dose strategy, has a much better effect on overall mortality than later MV.
- Trial name
- NCT01668745
- Testing
- Early measles vaccine
- Where
- Burkina Faso
- Volunteers
- 4,559 people
- Sponsor
- Bandim Health Project
Covid19
Trial Efficacy of Saisei Pharma Dietary Supplements MAF Capsules, 148 mg and M Capsules, 148 mg in Hospitalized COVID-19 Patients
The SaiseiCovUKR clinical study is a multicentric, randomized trial study targeting patients hospitalized with COVID-19 who do not require mechanical ventilation.
- Trial name
- SaiseiCovUKR (NCT04762628)
- Testing
- MAF capsules 148 mg, M capsules 148 mg, Standard of care
- Where
- 2 sites in Ukraine
- Volunteers
- 600 people
- Sponsor
- Saisei Pharma
Sepsis, Respiratory Failure
Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients
This observational study aims to determine whether three blood test ratios - lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin - can predict in-hospital mortality among critically ill adults.
- Conditions
- Sepsis, Respiratory Failure, Cardiac Arrest, Circulatory Failure
- Trial name
- LAR-CAR-PAR (NCT07242027)
- Where
- Poland
- Volunteers
- 212 people
- Sponsor
- Medical University of Silesia