Clinical trials: Movement Abnormalities
Parkinson Disease
DAT SPECT and Procedural Motor Skills in Parkinson's Disease
Patients with Parkinson's disease (PD) are known to be affected by subtle cognitive impairment early in the disease course, mostly in the executive field.
- Trial name
- NCT03076307
- Testing
- Procedural Motor Skills with mirror-drawing of figures
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Essential Tremor
Ventrointermediate Nucleus (VIM DBS) and Working Memory
This is part of a larger study for which participants have already completed memory and thinking tests. In this study, investigators are trying to learn how deep-brain stimulation affects memory skills in essential tremor (ET)…
- Trial name
- WMVIM (NCT00906412)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Movement, Involuntary
Mental Practice on Balance
The main objective of this research is to see the effect of two mental practice techniques on static and dynamic balance.
- Trial name
- NCT04548336
- Testing
- Motor Imagery, Action observation
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Dystonia, Dystonia; Idiopathic
Dystonia Genotype-Phenotype Correlation
The purpose of this study is to (1) investigate the effect of known dystonia-causing mutations on brain structure and function, to (2) identify structural brain changes that differ between clinical phenotypes of dystonia, and to…
- Conditions
- Dystonia, Dystonia; Idiopathic, Dystonia, Primary, Dystonia, Secondary
- Trial name
- NCT03428009
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Parkinson's Disease
The Association of Neurotoxin Exposure With Parkinson's Disease and Parkinsonism in World War II Veterans and Other Men
This program aims to investigate factors associated with development of parkinsonism or idiopathic Parkinson's Disease in an ongoing cohort of patients established in 1965 who are currently undergoing their sixth examination.
- Trial name
- NCT00018577
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Stellate Ganglion, Parkinson Disease
Clinical Study of Stellate Ganglion Block in Treatment of Patients With Advanced Primary Parkinson's Disease
At present, there are no reports on the application of stellate ganglion block in the treatment of Parkinson's disease patients at home and abroad.
- Trial name
- NCT06112392
- Testing
- Treatment （Stellate ganglion block；Oral standard anti-Parkinson's drugs）, Treatment （Oral standard anti-Parkinson's drugs）
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Parkinson Disease
Upper Extremity Skills, Trunk Control, and Body Awareness in Parkinson's Disease
Parkinson's disease is associated with impairments in upper extremity function, postural control, and sensory-motor processing that may negatively affect daily activities and quality of life.
- Trial name
- NCT07639463
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Baskent University
Huntington Disease
Metabolomic Study in Huntington's Disease (METABO-HD)
The purpose of this project is to study Huntington's disease by metabolomic approach.
- Trial name
- NCT03296176
- Testing
- blood sample
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Neurodegenerative Diseases
Exploring the Recovery Function of Sleep in Neurodegeneration
The overall objective of this study is to identify the best approach for assessing the recovery function of sleep in neurodegenerative diseases associated with abnormal protein aggregation with regard to the conception of future…
- Trial name
- RFSN (NCT05402488)
- Testing
- Auditory stimulation
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Alzheimer Disease, Parkinson Disease
Evaluation of [18F] PBR06 and PET as a Marker of Inflammation in Subjects With Neurological Conditions
The underlying goal of this study is to assess [18F] PBR06 PET imaging as a tool to detect microglial activation in the brain of Alzheimer Disease (AD), Parkinson Disease (PD) and Multiple Sclerosis (MS) research participants.
- Conditions
- Alzheimer Disease, Parkinson Disease, Multiple Sclerosis
- Trial name
- PBR06 (NCT01028209)
- Testing
- [18F] PBR06
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Functional Movement Disorders, Reproducibility of Results
Aspects of Validity of the Single Leg Squat Test: A Cohort Study of Female Soccer Players.
Movement screening tests to identify deficits or poor movement quality is commonly used in soccer and other sports to assess injury, to evaluate rehabilitation goals and return to sport after injury.
- Conditions
- Functional Movement Disorders, Reproducibility of Results, Sports Medicine
- Trial name
- NCT05289284
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Parkinson's Disease
Motion Immune Magnetic Resonance Imaging (MRI)
The purpose of this study is to evaluate our recently developed MRI reconstruction strategy for producing artifact-free neuro and abdominal MRI data.
- Trial name
- NCT02302521
- Testing
- Multiplex Sensitivity Encoding (MUSE)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Duke University
PARKINSON DISEASE (Disorder)
The Role of Priors in Hallucinatory Perception in Parkinson's Disease
The goal of this observational study is to better understand the mechanisms of hallucinations in patients with Parkinson's disease.
- Trial name
- LEAP-PARK (NCT07427498)
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Huntington's Disease
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable…
- Trial name
- HDClarity (NCT02855476)
- Where
- 40 sites in United States, Canada and 8 more
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University College, London
Parkinson Disease, Freezing of Gait
Understand FoG in PD: Behavioral Physiology and Clinical Application
The overall goals of this proposed study are to investigate the behavioral and neurophysiological mechanisms of patients with Parkinson's disease (PD) experiencing freezing of gait (FoG).
- Trial name
- NCT02987140
- Testing
- Clinical evaluations
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Progressive Supranuclear Palsy, Multiple System Atrophy
NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian Syndrome
At present, the diagnosis of Parkinsons disease(PD) mainly relies on clinical symptoms and is easily confused with atypical Parkinsonian syndrome(APS) in the early stages. There is an urgent need for reliable biomarkers.
- Conditions
- Progressive Supranuclear Palsy, Multiple System Atrophy, Parkinson's Disease
- Trial name
- NCT06490926
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Parkinson's Disease (PD)
Untreated Parkinson's Disease Work-up Assessing Resident Microbiota and Duodenal Barrier Function
The UPWARD study is a prospective hypothesis-generating study in individuals with untreated Parkinson's disease (PD) and age-matched healthy controls (HCs).
- Trial name
- UPWARD (NCT07418658)
- Testing
- Invasive sampling procedures, Non-invasive sampling procedures
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson's Disease
Multi-chip Meta-analysis of Parkinson's Disease for Clinical Validation of Small Samples of Key Genes in Disease
The research team used meta-analytical statistical methods to integrate the results of different research groups on Parkinson's disease, using meta-analysis to find key genes related to the pathogenesis and development of…
- Trial name
- NCT03848455
- Testing
- genetic diagnosis
- Where
- China
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Lewy Body Disease, Healthy Aging
Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive Brain Stimulation Treatment
Lewy body diseases (LBDs) represents a group of neurodegenerative disorders characterized by the abnormal accumulation of aggregates of α-synuclein protein leading to the formation of Lewy bodies (LB) and Lewy neurites resulting…
- Trial name
- LANG-LBD (NCT05847985)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Multiple System Atrophy, Parkinson's Disease
Prospective Multicenter Registry Study of Multiple System Atrophy in China
Multiple system atrophy is a rare, rapidly progressive neurodegenerative disease characterized by variable combinations of parkinsonism, cerebellar ataxia, and autonomic dysfunction.
- Conditions
- Multiple System Atrophy, Parkinson's Disease, Atypical Parkinsonism
- Trial name
- MSA Registry S (NCT07644013)
- Where
- China
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
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