Clinical trials: Movement Abnormalities
PARKINSON DISEASE (Disorder), Aged 65 Years or Older
Multidimensional Assessment of Fatigability in Older Adults Living in Southern Switzerland and Elderly With Parkinson's Disease
With our study, the investigators aim to assess the impact of the fatigue experienced during daily life activities (tiredness) and whether there is a relationship with muscle fatigue during an exercise task.
- Trial name
- LifeLike (NCT07485218)
- Where
- 5 sites in Italy, Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Parkinson Disease
Improvisational Dance for Parkinson Disease
The long-term goal of this work is to maintain or improve daily function of people with PD by addressing cognition. The overall objective is to discover interventions that aid in cognitive functioning.
- Trial name
- NCT04354298
- Testing
- Improvisational Dance Class
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Parkinson Disease
Exercise and Transcranial Magnetic Stimulation: Increasing Brain Plasticity in Parkinson's Disease
This is a feasibility and exploratory study consisting of two parts: first, a cross-sectional (one-time) biomarker measurement comparing BDNF-TrkB (Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB,) signaling and…
- Trial name
- NCT02741765
- Testing
- Real rTMS, Supervised aerobic exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Huntington Disease, HD
iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009
This is a FIH (first-in-human) study to evaluate the clinical utility of the radioligand [11C]CHDI-00491009 as a PET tracer that binds specifically to mutant huntingtin (mHTT) aggregates in Huntington's disease (HD).
- Conditions
- Huntington Disease, HD, PET Tracer, Positron Emission Tomography
- Trial name
- iMagemHTT-009 (NCT06634628)
- Testing
- Radioligand [11C]CHDI-00491009
- Where
- Belgium
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- CHDI Foundation, Inc.
Movement Disorders
Handwriting Analysis in Movement Disorders.
Movement disorders are a group of neurological conditions that cause problems with movement, either in the form of excessive, reduced, or slow movements.
- Trial name
- NCT06436287
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Dementia With Lewy Bodies (DLB)
Donepezil Therapy and Changes of Symptoms and Glucose Metabolism in Patients With Dementia With Lewy Bodies (DLB)
The purpose of this study is to evaluate change of cerebral glucose metabolism by donepezil therapy and to associate change of glucose metabolism and symptoms.
- Trial name
- NCT00776347
- Testing
- Donepezil
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Osaka University
Scapular Dyskinesis, Cervicalgia
Global Postural Reeducation and Segmental Exercises in Patients With Scapular Dyskinesis and Cervicalgia
The purpose of this study is to assess the effectiveness of global postural reeducation relative to segmental exercises in the treatment of scapular dyskinesis with cervicalgia.
- Trial name
- NCT01568840
- Testing
- Global Postural Reeducation Group, Segmental Exercises Group
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Irmandade da Santa Casa de Misericordia de Sao Paulo
Parkinson's Disease
Cough According to Stimulus Type in PD
Aspiration pneumonia (APn) occurs at a higher rate in patients with Parkinson's disease (PD) versus healthy adults. This is of particular public health concern given that death secondary to aspiration pneumonia and lung infection…
- Trial name
- NCT02390089
- Testing
- Capsaicin vapor, fog, Videofluoroscopic swallow evaluation
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease, Huntington Disease
A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions
Measurement of metabotropic glutamate receptor type 5 (mGluR5) binding capacity in the brain, may be a valuable tool in the early detection, understanding, or evaluation of Parkinson disease (PD), Huntington disease (HD), Fragile…
- Conditions
- Parkinson Disease, Huntington Disease, Autistic Spectrum Disorders, Fragile X Syndrome
- Trial name
- FPEB (NCT00870974)
- Testing
- [18F]FPEB
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinson's Disease, HIV Infections
Using Heavy Water to Study Cell Dynamics in Parkinson's Disease
This pilot study will assess the feasibility of using heavy water as a safe 'tracer' for biomarker studies of diseases of the brain and spinal cord, that, together, are also called the central nervous system (CNS).
- Trial name
- NCT00990379
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Salena Killion
Parkinson's Disease
Speech Intelligibility of Patients With P D Compared to First Degree Relatives of P D Patients
This study will examine speech intelligibility of early parkinson's disease (PD) patients, early PD patients and first degree relatives.
- Trial name
- NCT01776879
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pure Autonomic Failure, Multiple System Atrophy
Autonomic Failure Patients for RNA Blood Sampling
The purpose of this study is to identify 15 patients with autonomic failure and obtain blood samples for RNA from those participants and 15 control subjects within the same age range.
- Conditions
- Pure Autonomic Failure, Multiple System Atrophy, Parkinson's Plus Syndromes
- Trial name
- NCT00742586
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Dementia With Lewy Bodies (DLB), Mild Cognitive Impairment (MCI)
Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression
The goal of this observational study is to improve the detection of dementia with Lewy bodies (DLB) and its prodromal phases, as well as advancing our current understanding of biological mechanisms and therapeutic options.
- Conditions
- Dementia With Lewy Bodies (DLB), Mild Cognitive Impairment (MCI), Cognitively Unimpaired, Other Dementias
- Trial name
- Find-DLB (NCT07629349)
- Where
- Sweden
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Huntington Disease
Utilization of 31P-Nuclear Magnetic Resonance Spectroscopy to Monitor Brain Energy Deficit in Huntington Disease
The purpose of this project is to study brain energy profile evolution at different stages of the Huntington disease.
- Trial name
- PRO-MH2 (NCT01696708)
- Testing
- 31-Phosphorus RMN Spectroscopy
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease
Neural Correlates of Cognition in Parkinson's Disease
Cognitive impairment in Parkinson's disease (PD) has far-reaching effects on both motor outcomes and quality of life in PD patients.
- Trial name
- NCT02975193
- Testing
- Computer task assessing cognition, Impulsive-Compulsive Disorders in Parkinson's Disease, Deep Brain Stimulation Surgery
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Florida
Idiopathic Parkinson Disease
Measuring Parkinson's Disease With Tear Fluid
The purpose of this study is to assess whether tear secretion in patients with Parkinson's disease will be altered to exhibit a characteristic or diagnostic biomarker profile, that will be reflected in changes in the protein…
- Trial name
- NCT03037463
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Parkinson's Disease
A Through QT/QTc Study of KW-6356
The purpose of this study is to evaluate the effects of multiple therapeutic and supratherapeutic doses of KW-6356 on the QT interval corrected for heart rate in Japanese healthy adults.
- Trial name
- NCT04342273
- Testing
- KW-6356, Moxifloxacin
- Where
- 2 sites in Japan
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Neurodegenerative Disorders
Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases
Human fibroblasts and possibly other human somatic cells may be reprogrammed into induced pluripotent stem (iPS) cells by the forced expression of transcription factors (1-5).
- Trial name
- NCT00874783
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
PARKINSON DISEASE (Disorder), Older Adults (65-85 Years)
Perception of Action Opportunities for Obstacle Crossing in Parkinson's Disease
The study examines how individuals with Parkinson's disease, compared to healthy older adults, evaluate their ability to cross an obstacle, and the association between this evaluation, motor and cognitive status, and…
- Trial name
- NCT07907770
- Testing
- Obstacle Crossing Task
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Parkinson's Disease
Clinical, Molecular and by Neuroimaging of LRRK2 Mutations
Besides Parkinson's disease (PD), it exists rare parkinsonian syndromes clinically close to PD and that correspond to Mendelian entities.
- Trial name
- LRRK2 (NCT01085227)
- Where
- 2 sites in France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
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