Clinical trials: Movement Abnormalities
Parkinson Disease, Healthy
Analysis of Cortical Biomarkers for PD
Previous studies revealed changes in the pattern of cortical electrical activity of patients with Parkinson's disease (PD) and suggested that these changes may be dependent on the phenotypes of the disease and other related…
- Trial name
- NCT03645538
- Testing
- Parkinson's disease patients, No drug
- Where
- 2 sites in Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Pantothenate Kinase-Associated Neurodegeneration
Long-term Deferiprone Treatment in Patients With Pantothenate Kinase-Associated Neurodegeneration
Patients with PKAN will be treated with the iron chelator deferiprone for 18 months. Only patients who have completed the earlier study TIRCON2012V1 (NCT01741532), a double-blind placebo-controlled trial in which participants…
- Trial name
- TIRCON-EXT (NCT02174848)
- Testing
- Deferiprone oral solution
- Where
- 4 sites in United States, Germany and 2 more
- Volunteers
- 68 people
- Sponsor
- ApoPharma
Parkinson Disease, Mild Cognitive Impairment
tDCS on Parkinson's Disease Cognition
Parkinson's disease (PD) has been classically regarded as a "movement disorder", so earlier work has focused on treating motor symptoms only.
- Trial name
- tDCS-PD-fMRI (NCT03025334)
- Testing
- High-definition transcranial direct current stimulation
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University of Manitoba
Parkinson's Disease, Mild Cognitive Impairment
Cognitive Rehab for Parkinson's
This study will examine the feasibility of an at-home cognitive training program that incorporates both memory training and online computerized cognitive training (CCT) software.
- Trial name
- NCT03836963
- Testing
- cognitive training, active control cognitive training, memory strategy training
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- VA Office of Research and Development
Parkinson's Disease
Safety, Tolerability, and Effectiveness of Rasagiline Mesylate in Patients With Parkinson's Disease
Patients who completed the study TVP-1012/232 are eligible to enter the extension study to continue their rasagiline therapy for their Parkinson's disease (PD).
- Trial name
- NCT00203138
- Testing
- rasagiline mesylate
- Volunteers
- 306 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Essential Tremor, Parkinson's Disease
Intraoperative Microelectrode Recordings Using MAVEN Compared to Standard Recording Apparatuses
The purpose of this research is to determine if the electrophysiologic data collected from standard-of-care microelectrode recordings during human deep brain stimulation (DBS) surgery will be the same using the MAVEN device…
- Conditions
- Essential Tremor, Parkinson's Disease, Dystonia
- Trial name
- NCT07868614
- Testing
- Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Parkinson's Disease (PD), Dysphagia
Biomechanical Effects of EMST® on Swallowing Function in Parkinson's Disease
The aim of this non-randomized intervention study is to investigate the detailed effects of a structured four-week EMST® training program on the biomechanics of swallowing function in dysphagic Parkinson's patients.
- Trial name
- NCT07606547
- Testing
- exspiratory muscle strength training
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Parkinson Disease
Efficacy of Transcranial Direct Current Stimulation In Parkinson's Disease MCI
The aim of the present study is to investigate the efficacy of prefrontal transcranial Direct Current Stimulation (tDCS) on cognitive functions and electrophysiological measures in Parkinson's Disease Mild Cognitive Impairment…
- Trial name
- PDMCIStim (NCT04171804)
- Testing
- Transcranial direct current stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Istanbul University
Parkinson's Disease
Effects of Monoamine Reuptake Inhibitor NS2330 in Parkinson's Disease
This study will evaluate the effects of an experimental drug called NS2330 on Parkinson's disease symptoms and on dyskinesias (involuntary movements) that develop as a result of long-term treatment with levodopa.
- Trial name
- NCT00006077
- Testing
- NS2330, Levodopa and Domperidone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Essential Tremor
Study to Evaluate SAGE-324 in Participants With Essential Tremor
The primary purpose of this study is to evaluate the dose-response relationship of different doses of SAGE-324 on upper extremity tremor in participants with essential tremor (ET) in the monotherapy cohort.
- Trial name
- NCT05173012
- Testing
- SAGE-324
- Where
- 51 sites in United States
- Volunteers
- 146 people
- Sponsor
- Sage Therapeutics
Parkinson Disease
Transcranial Low Voltage Pulsed Electromagnetic Fields (T-PEMF) in Patients With Parkinson's Disease
The aim of this study, is to determine whether treatment using transcranial low voltage pulsed electromagnetic fields (T-PEMF) can reduce the symptoms patients with Parkinson's Disease (PD) experience.
- Trial name
- NCT02125032
- Testing
- Transcranial low voltage pulsed electromagnetic fields (T-PEMF)
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Odense University Hospital
Sporadic Dystonia, Dystonia, Familial
Imaging Neuromelanin and Iron in Dystonia/Parkinsonism
To generate pilot data to investigate the potential to use in vivo iron- and neuromelanin-quantification as imaging tools for the diagnostic evaluation of movement disorders with predominant dystonia / parkinsonism.
- Conditions
- Sporadic Dystonia, Dystonia, Familial, Parkinson Disease, Juvenile, Neurodegeneration With Brain Iron Accumulation 5
- Trial name
- NCT03572114
- Testing
- 3Tesla MRI, Burke-Fahn-Marsden Dystonia Rating scale, MDS-United Parkinsons Disease Rating Scale, Part III
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University College, London
Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, Including, Sickle Cell Disease
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
Cell-free fetal DNA (cffDNA) is present in the maternal blood from the early first trimester of gestation and makes up 5%-20% of the total circulating cell-free DNA (cfDNA) in maternal plasma.
- Conditions
- Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, Including, Sickle Cell Disease, Cystic Fibrosis, Fragile X Syndrome
- Trial name
- DANNIgene (NCT06147414)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease
Aquatic High-Intensity Interval Training for Parkinson's Disease
This randomized, single-center, parallel-group superiority trial will evaluate the effect of an 8-week aquatic High-Intensity Interval Training (HIIT) program on balance, physical function, and sarcopenia-related outcomes in…
- Trial name
- NCT07264114
- Testing
- Aquatic HIIT with adherence/support package
- Where
- Iran
- Volunteers
- 56 people
- Sponsor
- Pardis Specialized Wellness Institute
Parkinson's Disease, Parkinsonism
Modifiable Variables in Parkinsonism (MVP)
We are trying to identify factors associated with improved quality of life and fewer PD symptoms. We are attempting to identify practices, beliefs, and therapies used by individuals who report excellent quality of life, few PD…
- Conditions
- Parkinson's Disease, Parkinsonism, MSA - Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NCT02194816
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Bastyr University
Parkinson Disease
Lipoprotein Metabolism and Bacterial Lipopolysaccharide in Parkinson's Disease
Patients with Parkinson's disease (PD) present an impaired intestinal permeability with consequent lipopolysaccharide (LPS) translocation in the systemic circulation.
- Trial name
- LiMBaLiP (NCT03937284)
- Testing
- Patients not treated
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Milan
Parkinson's Disease
PET Imaging in Parkinson Disease Dementia
The purpose of this study is to use a brain imaging method called PIB PET to determine dementia subtypes in patients with Parkinson's disease.
- Trial name
- NCT01052350
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Parkinson Disease
The Benchmark Clinic: An Interdisciplinary Comprehensive Care Model for People With Parkinson Disease
The purpose of this study is to determine if an interdisciplinary clinic can help people with Parkinson's disease care for themselves, improve their ability to follow recommended treatments, and have fewer problems like falls or…
- Trial name
- NCT04555720
- Testing
- Interdisciplinary Visit
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Duke University
Parkinson's Disease
BIIB014 Phase 2a Monotherapy
To assess the preliminary safety and tolerability of multiple oral doses of BIIB014 in subjects with early PD.
- Trial name
- NCT00451815
- Testing
- active drug (BIIB014) at 10, 30, 100, or 300 mg once daily.
- Sponsor
- Biogen
Alzheimer Disease, Dementia With Lewy Bodies
Cerebro Spinal Fluid Collection (CSF)
Cognitive neurodegenerative diseases are a major public health issue. At present, the diagnosis of certainty is still based on anatomopathological analyses.
- Conditions
- Alzheimer Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Parkinson's Disease Dementia
- Trial name
- Analzheimer (NCT04844060)
- Testing
- Lumbar punction
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Strasbourg, France
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