Clinical trials: Movement Disorders, Functional
Ataxia Telangiectasia
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside
Study design: Single arm open-label clinical trial in ataxia-telangiectasia to test the effects of nicotinamide riboside on ataxia scales, immune function, and neurofilament light chain.
- Trial name
- ATNAD (NCT06324877)
- Testing
- Nicotinamide riboside
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- The University of Queensland
Parkinson Disease, Neuro-Degenerative Disease
Conventional Physical Therapy Action Observation Therapy on Freezing of Gait and Functional Mobility in Parkinson's Disease
The goal of this study is to determine the effects of action observation therapy with conventional physical therapy on freezing gait and functional limitation in participants with Parkinson's disease.
- Trial name
- NCT07244900
- Testing
- Conventional Physical Therapy, Action Observation plus conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- University of Lahore
Parkinson Disease
Deep Brain Stimulation on Dual-task Gait Performance in PD
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Motor symptoms include rigidity, bradykinesia, tremor, and postural instability, these motor symptoms can cause gait…
- Trial name
- NCT05314322
- Testing
- Deep brain stimulation with high frequency, Deep brain stimulation with low frequency
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- National Yang Ming Chiao Tung University
Weakness of Extremities as Sequela of Stroke, Modified Constraint Induced Movement Therapy After Stroke
Peer Group Regulated mCIMT Program for Adult Stroke Patients: Effects on Functional Activities
Each year more than 17 million people in the world are experiencing a stroke. Stroke is a major cause of mortality and one of the prevalent causes of serious disablement.
- Conditions
- Weakness of Extremities as Sequela of Stroke, Modified Constraint Induced Movement Therapy After Stroke, Upper Extremity Functional Performance After Stroke
- Trial name
- PEPS-MIT (NCT04264195)
- Testing
- Constraint-induced movement therapy: PEPS-MIT, Bimanual manipulation exercises (PEPS-Bimanual)
- Where
- Bangladesh
- Volunteers
- 140 people
- Sponsor
- Centre for the Rehabilitation of the Paralysed, Bangladesh
Huntington Disease
Effects of EGCG (Epigallocatechin Gallate) in Huntington's Disease (ETON-Study)
Huntington's disease (HD) is an inherited autosomal dominant, progressive neurodegenerative disease. Clinically, HD is characterized by a triad of movement disorders, cognitive impairments and psychiatric disturbances.
- Trial name
- ETON (NCT01357681)
- Testing
- (2)-epigallocatechin-3-gallate (EGCG)
- Where
- 3 sites in Germany
- Volunteers
- 54 people
- Sponsor
- Charite University, Berlin, Germany
Cerebral Palsy (CP)
Intensive Rehabilitation Program for Upper Limb in Children and Adolescents With Cerebral Palsy
Cerebral palsy is the most common motor disability in children. Individuals with CP often experience significant difficulties in the use of their upper limbs, which affects their autonomy and quality of life.
- Trial name
- NCT07285837
- Testing
- Intensive Rehabilitation
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Fondation Ellen Poidatz
Conversion Disorder
Feasibility Study of Physiotherapy for Functional Motor Symptoms
The aim of this study is to develop and assess the feasibility of a physiotherapy intervention for people with functional motor symptoms (also known as psychogenic neurological symptoms and conversion disorder).
- Trial name
- NCT02275000
- Testing
- 5 Day Physiotherapy Programme, Physiotherapy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Parkinson Disease, Epilepsy
In Vivo Imaging of Therapeutic Electric Current Flow
The purpose of this research study is to measure current flow inside the head using magnetic resonance imaging (MRI). The data from this study will be used to map the current flow caused from the electrical stimulation inside the…
- Conditions
- Parkinson Disease, Epilepsy, Alzheimer's Disease, Stroke
- Trial name
- tDCS (NCT02453763)
- Testing
- Transcranial direct current stimulation, MRI
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cerebral Palsy Spastic Hemiplegic
Therapeutic Effects of Constraint-Induced Movement Therapy on Young Children With Cerebral Palsy
This study evaluates the therapeutic effects of constraint-induced movement therapy on infants and children with hemiplegic cerebral palsy.
- Trial name
- NCT03858335
- Testing
- Constraint-induced movement therapy
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Spinal Cord Injuries
Use of Neural Functional Electrical Stimulation for the Recovery of Grasping Movements for Patient With Quadriplegia.
Functional electrical stimulation (FES) has been used for decades in rehabilitation centers. Having demonstrated efficacy for prevention of muscle atrophy following spinal cord injury (SCI), FES can also be considered for…
- Trial name
- NCT03721861
- Testing
- Intra-operative neural cuff stimulation
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Clinique Beau Soleil
Parkinson Disease
Dietary Intervention and Gastrointestinal Function in Patients With Parkinson's Disease
In this prospective, intervention study, participants with diagnosed Parkinson's disease will be instructed to follow a Mediterranean diet for five weeks. Gut permeability will be assessed using food-grade sugar molecules.
- Trial name
- MED (NCT03851861)
- Testing
- Mediterranean Diet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Presbylarynx, Aspiration
Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort
A previous study completed in 2022 (NCT05158179) was conducted using cohorts of healthy controls, and adults with general laryngopharyngeal disorders.
- Conditions
- Presbylarynx, Aspiration, Spasmodic Dysphonia, Globus Pharyngeus
- Trial name
- NCT06078527
- Testing
- Cheung-Bearelly Aesthesiometer, Transnasal Laryngoscopy, Questionnaires
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Parkinson Disease (PD)
Inhibitory Control and Gait Adaptability in Parkinson's Disease
People with Parkinson's disease (PD) may have difficulty stopping or changing their movements, especially when walking around obstacles.
- Trial name
- NCT07494461
- Where
- 2 sites in Taiwan
- Volunteers
- 50 people
- Sponsor
- National Yang Ming Chiao Tung University
Ischemic Stroke, Cerebral Infarct
Consequences of Post Stroke Polysomnographic Abnormalities on Functionnal Recovery and Survival After an Ischemic Stroke
Ischemic stroke is a major public health issue, likely to cause functional disability. It is well known that sleep has an impact on brain plasticity, and after an ischemic stroke, studies have shown subjective sleep quality…
- Conditions
- Ischemic Stroke, Cerebral Infarct, Sleep Apnea, Periodic Limb Movement Disorder
- Trial name
- PSG-AVC (NCT04816136)
- Testing
- Sleep recording (already done)
- Where
- France
- Volunteers
- 227 people
- Sponsor
- University Hospital, Montpellier
Parkinson's Disease
Continuous Behavior Assessment of the Effects of a Physical Therapy Program for Patients With Parkinson's Disease
Introduction: Parkinson's disease (PD) results from dysfunction of the dopaminergic system of degenerative and progressive, with changes in the nigrostriatal pathway, and decreased concentration of dopamine.
- Trial name
- NCT02745171
- Testing
- physical therapy
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Parkinson Disease
Individualized Precise Localization of rTMS on Primary Motor Area
Parkinson's disease (PD) patients have some problem with self-initiated movement task. Compared with health controls, task meta-analysis found that PD patients showed abnormal activation in pre-supplementary motor area (pre-SMA)…
- Trial name
- NCT03497884
- Testing
- rTMS
- Where
- 2 sites in China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Parkinson Disease
The Effectiveness of Telerehabilitation in Improving Upper Extremity in Parkinson's Patients
Parkinson's Disease (PD) is a disease that affects the functional skills of the upper extremity with clinical findings such as bradykinesia, rigidity, and hypokinesia and causes limitations in the daily life activities of the…
- Trial name
- NCT04835649
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Osteoarthritis, Knee
Unicompartmental Versus Total Knee Replacement for Medial Compartment Knee Osteoarthritis
For patients with osteoarthritis affecting only the inner part of the knee, surgeons can offer either a partial knee replacement, which resurfaces the worn compartment alone, or a total knee replacement.
- Conditions
- Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
- Trial name
- FLEX-UNI (NCT04913987)
- Testing
- Persona Partial Knee (PPK), Triathlon cruciate-retaining total knee system.
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Golden Jubilee National Hospital
Parkinson Disease
High-intensity Group Vocal Exercise to Improve Laryngeal Function in Patients With Parkinson Disease
The overall goal of this T2 translational research project is to pilot an interdisciplinary high-intensity group singing program to improve speech and swallowing in patients with Parkinson's Disease (PD) and to explore the impact…
- Trial name
- NCT03263793
- Testing
- Choral (group) singing therapy sessions
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- NYU Langone Health
Huntington Disease, Sarcopenia
Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease
Huntington's disease (HD) is a rare neurodegenerative disorder in which accelerated loss of muscle mass, strength and autonomy (physical frailty and sarcopenia) contributes to functional decline.
- Conditions
- Huntington Disease, Sarcopenia, Frailty
- Trial name
- SARCO-HD (NCT07902206)
- Testing
- Creatine monohydrate, Beta-hydroxy-beta-methylbutyrate (HMB), Home-based multicomponent exercise program
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Universidad de Burgos