Clinical trials: Movement Disorders, Functional
Parkinson Disease
Interactive POWER Rehabilitation System on Rehabilitation Training for Patients With Parkinson's Disease
In the previous studies, progressive resistance training (PRT) has significantly improved the muscle strength and disease severity of Parkinson's disease.
- Trial name
- NCT05046236
- Testing
- Interactive POWER rehabilitation, Conventical physical training
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Huntington's Disease
Functional Imaging of Social Cognition in Premanifest Huntington's Disease
Huntington's disease (HD) is a genetic progressive fatal neurodegenerative disorder. In the western world it affects 5-10 persons per 100000. The main brain changes include the loss of brain cells in subcortical structures.
- Trial name
- FISCIP (NCT02551705)
- Testing
- functional Imaging
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson Disease, Exercise Training
SMARTfit Training for Parkinson's Disease
This pilot study aims to investigate the effects of 8-week SMARTfit training versus conventional physical training on motor function, cognition and brain functional connectivity in individuals with PD.
- Conditions
- Parkinson Disease, Exercise Training, Cognitive Change
- Trial name
- NCT03921359
- Testing
- SMARTfit training, Conventional physical training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Southern California
Association of Heterotopic Gastric Mucosa of the Cervical Esophagus and Globus Sensations
Prevalence of Gastric Inlet Patches of the Cervical Esophagus.
As known from several observational and retrospective endoscopic studies the prevalence of gastric inlet patches (GIPs) of the cervical esophagus is estimated between 1-10%.
- Trial name
- NCT01056003
- Testing
- Endoscopy
- Where
- Germany
- Volunteers
- 4,000 people
- Sponsor
- Technical University of Munich
PARKINSON DISEASE (Disorder)
Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease
This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor…
- Trial name
- CardioParkinso (NCT07478146)
- Testing
- Aerobic training, Usual Care
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Raphael Mendes Ritti Dias
Quality of Life, Parkinson's Disease
Hippotherapy and Parkinson's Disease
BACKGROUND: Motor symptoms associated with Parkinson's disease may impair one's independence and ability to perform daily activities consequently decreases quality of life.
- Trial name
- NCT02460796
- Testing
- Hippotherapy
- Volunteers
- 18 people
- Sponsor
- University of Brasilia
Parkinson's Disease, Tremor
Pilot Study for Automated Deep Brain Stimulation Programming
The clinical utility of deep brain stimulation (DBS) for the treatment of movement disorders such as Parkinson's disease has been well established; however, there is a great disparity in outcomes among DBS recipients due to…
- Conditions
- Parkinson's Disease, Tremor, Bradykinesia
- Trial name
- NCT02046863
- Testing
- Automated Programming
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Dystonia Disorder
Impact of rTMS on Abnormal Cortical fMRI in Patients With Dystonia
By tracking resting-state fMRI scans, we aim to discover how repetitive transcranial magnetic stimulation (rTMS) changes brain connectivity in individuals with dystonia.
- Trial name
- NCT07626216
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Stroke
CIMT Versus HABIT in Late Sub-Acute Post-Stroke Rehabilitation
This study will compare the effects of Constraint Induced Movement Therapy and Hand-Arm Bimanual Intensive Training on upper extremity function in late sub-acute post-stroke patients. It will be a randomized controlled trial.
- Trial name
- CIMT-HABIT (NCT07626554)
- Testing
- Constraint Induced Movement Therapy, Hand-Arm Bimanual Intensive Training
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Parkinsons Disease (PD)
Exergaming for Improving Upper Limb Functions in Parkinson's Disease
Parkinson's Disease commonly results in impaired hand dexterity, reducing a patient's ability to perform activities of daily living.
- Trial name
- Exergaming (NCT07475741)
- Testing
- Exergaming, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Health Sciences Lahore
Functional Neurological Disorder
Clinical Evaluation of HRV Biofeedback in Functional Neurological Disorders Compared to Placebo
Evaluation of the clinical effects of the Heart Rate Variability biofeedback training with patients suffering from Functional neurological Disorders compared with placebo.
- Trial name
- HRV_BFB_FND (NCT06422819)
- Testing
- Heart rate variability Biofeedback [HRV-BFB], Pseudo HRV-BFB
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Parkinson Disease, Healthy
The Role of Dopamine in Motor Learning in Healthy Subjects and Patients With Parkinson's Disease
This study will examine and compare what happens in the brains of patients with Parkinson's disease with that of healthy normal subjects while they train to react as fast as possible to the appearance of a visual signal.
- Trial name
- NCT00032812
- Testing
- Raclopride
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Carpal Tunnel Syndrome
Neurodynamic Sequencing in Patients With Carpal Tunnel Syndrome
Carpal tunnel syndrome is a compressive neuropathy of median nerve in the fascial tunnel at wrist which causes pain, numbness ,and tingling in the extremities.
- Trial name
- NCT05905107
- Testing
- Neurodynamic Slider Technique from Proximal to Distal, Neurodynamic Slider Technique from Distal to Proximal
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Riphah International University
Functional Neurological Symptom Disorder, Paralysis
Exploring Functional Paralysis with Advanced Magnetic Resonance Modalities
In functional neurological disorder (FND), neurological symptoms are present, such as paralysis, weakness and disturbed sensation of limbs, although clinically no abnormalities can be found.
- Conditions
- Functional Neurological Symptom Disorder, Paralysis, Conversion Disorder with Weakness/Paralysis
- Trial name
- NCT05139732
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- Switzerland
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
PARKINSON DISEASE (Disorder), Mild Cognitive Impairment (MCI)
Dual-task Cognitive-motor Telerehabilitation in Persons With PD-MCI
Telerehabilitation is a promising tool for treating and preventing further disease progression in Parkinson's disease (PD) [1, 2].
- Trial name
- HomeFitPD (NCT07411365)
- Testing
- Dual-task Cognitive Motor Training, Cognitive Motor Training
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University Hospital Tuebingen
Parkinson Disease, Prodromal Stage
Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
α-Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are the second most common neurodegenerative diseases.
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases
- Trial name
- ALPHA-FIT (NCT07324330)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Osteoarthritis Hip, Joint Disease
Mobilization With Movement in Patients With Osteoarthritis of the Hip
The concept of mobilization with movement, also referred to as a Mulligan mobilization, has not been studied in patients with hip osteoarthritis, subsisting questions about the possible effects in this population.
- Conditions
- Osteoarthritis Hip, Joint Disease, Musculoskeletal Diseases, Pathologic Processes
- Trial name
- MWM (NCT02390336)
- Testing
- Real mobilization-with-movement (MWM)
- Volunteers
- 40 people
- Sponsor
- Natália Maria Oliveira Campelo
Brain Damage, Chronic
The Effect of tDCS on Subcortical Brain Functioning
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain abilities related to cognition, emotion and/or physical functioning in individuals with subcortical brain damage.
- Trial name
- NCT01602276
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Parkinson Disease
Ioflupane I123 (DaTSCAN) and Positron Emission Tomography-computed Tomography Fludeoxyglucose (PET-CT FDG) to Assess Brain Function of Parkinson Patients With Different Genetic Characteristics
Parkinson disease is one of the most common neurodegenerative illnesses. The disease is characterized by decrease in dopamine levels and decrease in the number of dopaminergic neurons and dopamine receptors.
- Trial name
- NCT01089283
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cerebral Palsy
Modified Constraint Induced Movement Therapy With And Without Cross Education In Cerebral Palsy
A nonprogressive injury to the growing brain, cerebral palsy can impair a child's speech, intellectual ability, and motor development. The kind of impairment will correspond with the affected brain region.
- Trial name
- NCT06522464
- Testing
- Group A: mCIMT with cross-education, Group B: mCIMT without cross-education
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University