Clinical trials: Multimorbidity, Cardiovascular Diseases
Sleep Disordered Breathing (SDB), Sleep Apnea
Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study
Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent.
- Conditions
- Sleep Disordered Breathing (SDB), Sleep Apnea, Cardiometabolic Diseases, Multimorbidity
- Trial name
- NCT06755840
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Diabetes Type 2, Renal Failure
A Study of the Usefulness & Usability of a Healthcare IT System for Managing Multi-morbidity and Poly-pharmacy
To assess the acceptability of a personalised ICT tool that facilitates coordinated care planning, treatment optimisation and patient self-management for patients with multiple long term conditions and their team of health…
- Conditions
- Diabetes Type 2, Renal Failure, Heart Failure, Depression
- Trial name
- C3-Cloud (NCT03834207)
- Testing
- Use of the C3-Cloud IT system
- Where
- 3 sites in Spain, Sweden and 1 more
- Volunteers
- 672 people
- Sponsor
- Dr Christopher Marguerie
Coronary Heart Disease, Multimorbidity
Randomized Control Trial to Evaluate Effectiveness of a Case Managment Program Regarding Psychosocial Well-being and Disease Symptoms Health for Patients With Multimorbid Coronary Heart Disease (CHD) Patients (KHK ProMA)
This randomized controlled trial (RCT) will examine a case management program for patients suffering from coronary heart disease with multimorbidity in Mannheim, Germany.
- Trial name
- KHK ProMA (NCT01725074)
- Testing
- Case Management "CM CHD", Social Interaction
- Where
- Germany
- Volunteers
- 320 people
- Sponsor
- Genossenschaft Gesundheitsprojekt Mannheim e.G
Heart Failure
Psychosocial Syndemics of Heart Failure
Heart failure (HF) is a common and debilitating chronic disease with a poor prognosis. Many patients with HFhave psychiatric problems such as depression and other medical disorders such as lung or kidney disease.This study will…
- Trial name
- NCT04637776
- Testing
- Hospitalization
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- Washington University School of Medicine
Osteoarthritis, Knee, Osteoarthritis, Hip
Personalized Exercise Therapy and Self-management Support for Patients With Multimorbidity
Chronic conditions such as knee or hip osteoarthritis (OA), chronic obstructive pulmonary disease (COPD), heart failure (HF), coronary heart disease (CHD), hypertension, type 2 diabetes mellitus (T2DM) and depression are among…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Heart Failure, Coronary Heart Disease
- Trial name
- MOBILIZE (NCT04645732)
- Testing
- Personalized exercise therapy and self-management support program, Usual care
- Where
- 16 sites in Denmark
- Volunteers
- 228 people
- Sponsor
- University of Southern Denmark
Stroke
Optimizing Hospital-to-home Transitions for Older Adults With Stroke and Multimorbidity
Stroke is the leading cause of death and adult disability in Canada. Sixty percent of these older adults (> 65 years) will return to their homes after a stroke and will require ongoing rehabilitation.
- Trial name
- NCT04278794
- Testing
- Transitional Care Stroke Intervention (TCSI)
- Where
- 2 sites in Canada
- Volunteers
- 90 people
- Sponsor
- McMaster University
Chronic Heart Failure, Type 2 Diabetes
Prognostic Impact of Diabetes and Weight Variability in Telemonitored Heart Failure
This observational cohort study evaluates the prognostic impact of diabetes, comorbidity burden, and short-term weight variability among adults with chronic heart failure enrolled in a nationwide remote patient monitoring program…
- Conditions
- Chronic Heart Failure, Type 2 Diabetes, Diabetes (DM)
- Trial name
- DM-HF-Tele (NCT07561866)
- Testing
- Diabetes Status, Comorbidity Burden, Weight variability
- Where
- France
- Volunteers
- 16,556 people
- Sponsor
- Satelia
Arthritis, Asthma
Mobility Assessment in Multi-morbidity
Multimorbidity (the presence of two or more coexisting long-term conditions) is a significant challenge facing the NHS, especially given UK's ageing population and the association with high levels of illness burden and healthcare…
- Conditions
- Arthritis, Asthma, Atrial Fibrillation, Bronchiectasis
- Trial name
- Multi-mobility (NCT06473168)
- Volunteers
- 55 people
- Sponsor
- Northumbria University
Stroke, Traumatic Brain Injury
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems.
- Conditions
- Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
- Trial name
- OPTIMA-C (NCT06073106)
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital
Hypertension (HTN), Type 2 Diabetes
Integrating Care for Hypertension-Diabetes MULTImorbidity in Guatemala Through HEARTS Implementation
The purpose of this study is to find out whether a program called HEARTS can improve care for people who have both high blood pressure and diabetes.
- Trial name
- MULTI-HEARTS (NCT07536919)
- Testing
- HEARTS implementation strategies, Supply chain strengthening
- Volunteers
- 1,440 people
- Sponsor
- University of Michigan
Chronic Respiratory Diseases, Cardiovascular and Cerebrovascular Diseases
Chinese Population Health and Multimorbidity Study
The Chinese Population Health and Multimorbidity Study (CPHMS; initially named China Pulmonary Health Study, CPHS) was a large-scale epidemiological survey designed to investigate the pulmonary health of Chinese adults aged 20…
- Conditions
- Chronic Respiratory Diseases, Cardiovascular and Cerebrovascular Diseases, Malignant Tumors, Endocrine and Metabolic Diseases
- Trial name
- CPHMS (NCT07026370)
- Where
- China
- Volunteers
- 50,991 people, healthy volunteers welcome
- Sponsor
- China-Japan Friendship Hospital
Statin Treatment for Primary Prevention
STREAM Trial - Statins in Multimorbid Older Adults Without Cardiovascular Disease
Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older…
- Trial name
- STREAM (NCT05178420)
- Testing
- Statin discontinuation
- Where
- 24 sites in France, Netherlands and 1 more
- Volunteers
- 1,880 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Non-communicable Diseases, Cardiovascular Diseases
RegiStry Of the multiFaceted medIcal cenTer
This study is a prospective medical registry (the SOFIT Registry) that enrolls all patients hospitalized in various departments of the Tula Regional Clinical Hospital in 2021.
- Conditions
- Chronic Non-communicable Diseases, Cardiovascular Diseases, COVID-19, Multimorbidity
- Trial name
- SOFIT (NCT06803862)
- Where
- 2 sites in Russia
- Volunteers
- 21,783 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Hypertension, Diabetes
Exercise Impact in Elderly With Multimorbidity: HbA1c and Blood Pressure
The main objective of the study is to compare the effect of two different types of physical exercise modalities on glycated hemoglobin and blood pressure in elderly individuals with multimorbidity.
- Conditions
- Hypertension, Diabetes, Osteoarthritis, Depression Disorders
- Trial name
- NCT06879639
- Testing
- Exercise, Control
- Where
- Portugal
- Volunteers
- 63 people
- Sponsor
- Universidade do Porto
Cardiovascular Diseases, Multimorbidity
Factors of Potentially Dangerous Drug Interactions in Patients With Cardiovascular Diseases and Multimorbidity
This prospective observational registry aims to evaluate the prevalence and clinical significance of potentially dangerous drug interactions in outpatients with cardiovascular diseases and multimorbidity.
- Conditions
- Cardiovascular Diseases, Multimorbidity, Drug Interactions
- Trial name
- FARMISS (NCT07607574)
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Myocardial Infarction (MI), Acute Cardiovascular Disease
To Develop and Introduce Into Polyclinic Practice a Register of Patients with Experience of Myocardial Infarction and Acute Cerebrovascular Disease
This is a retrospective observational study using the methodology of creating medical registries. The expected number of patients included in the registry is about 2000 patients with myocardial infarction and/or ACVD of any…
- Trial name
- NCT06815913
- Where
- Belarus
- Volunteers
- 2,000 people
- Sponsor
- State Institution "Republican Scientific and Practical Center" Cardiology, Belarus
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Quebec
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-QC (NCT02789800)
- Testing
- DIMAC02
- Where
- 2 sites in Canada
- Volunteers
- 284 people
- Sponsor
- Université de Sherbrooke
Multimorbidity, Multiple Chronic Conditions
Effect of Aerobic Training on the Health Parameters of Postmenopausal Women With Multimorbidity
People affected by multiple chronic diseases have a greater chance of hospitalization, longer hospital stays, worse general health, worse physical and mental function and lower functional capacity, with an average risk of 50% of…
- Conditions
- Multimorbidity, Multiple Chronic Conditions, Hypertension, Dyslipidemias
- Trial name
- NCT05075902
- Testing
- Aerobic training
- Where
- Brazil
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Stroke, Hypertension
CEEEC-II: A 12-Week Physical and Cognitive Enrichment Extension Study in Older Stroke Survivors With Multimorbidity
CEEEC-II is a 12-week, community-based, prospective extension study conducted in 32 community health service stations in Kunshan, China.
- Conditions
- Stroke, Hypertension, Type 2 Diabetes Mellitus (T2DM), Multimorbidity
- Trial name
- CEEEC-II (NCT07778771)
- Testing
- Physical Enrichment, Cognitive Enrichment
- Where
- China
- Volunteers
- 365 people
- Sponsor
- Duke Kunshan University
Chronic Obstructive Pulmonary Disease, Heart Failure
Multidimensional Approach for COPD and High Complexity
The MACH Study trial will examine the impact on high complexity COPD patients of a multidimensional approach (moderate-intensity physical activity program and clinic-therapeutic re-evaluation of the participants)
- Conditions
- Chronic Obstructive Pulmonary Disease, Heart Failure, Chronic Disease
- Trial name
- MACH (NCT04986332)
- Testing
- Physical activity program, Global therapeutic remodeling
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo