Clinical trials: Multiple Organ Failure
Multiple Organ Failure, Critical Care
The Pharmacokinetics of Fentanyl in Intensive Care Patients
This study is part of a project intended to develop guidelines to optimise the dosing of fentanyl in intensive care patients. This study will focus on determining: Whether the pharmacokinetics of fentanyl change during the ICU…
- Conditions
- Multiple Organ Failure, Critical Care, Intensive Care
- Trial name
- FENTANYL06 (NCT02587273)
- Testing
- Fentanyl
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Oslo University Hospital
Trauma
Metabonomics Fingerprinting of Multiple Trauma
The aim of this study is to establish plasma metabonomics fingerprinting atlas for severe multiple trauma patient using 1H nuclear magnetic resonance (NMR) based metabonomics methodology and advanced mathematics tools.
- Trial name
- NCT01279239
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sichuan Academy of Medical Sciences
Infections, Critical Illness
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
The COVID-19 pandemic has led to an increased incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, in a context of high prevalence of multidrug-resistant organisms (MDROs) there is a lack of…
- Conditions
- Infections, Critical Illness, Superinfection, Organ Failure, Multiple
- Trial name
- NCT05972980
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Organ Failure, Multiple
Comparing the Prognosis of Lactate-directed and Goal-directed Therapy in Hyperthermic Intraperitoneal Chemotherapy.
Hyperthermic intraperitoneal chemotherapy is a major surgery for tumor peritoneal metastasis. For anesthesiologist, the intra-operative fluid control is always a big challenge.
- Trial name
- NCT03933930
- Testing
- Lactate-directed therapy, Goal-directed therapy
- Sponsor
- Taipei Medical University WanFang Hospital
Renal Failure Acute, Multiple Organ Failure
Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation
The purpose of this study is to assess the effectiveness and the safety of extracorporeal methods for removing mediators of systemic inflammation in patients with multiple organ dysfunction syndrome after heart and aorta surgery.
- Conditions
- Renal Failure Acute, Multiple Organ Failure, Cardiovascular Diseases
- Trial name
- NCT05182723
- Testing
- renal replacement therapy
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Bacteremia, Gram-Negative Bacterial Infections
Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis
The impact of continuous veno-venous haemofiltration (CVVH) on sepsis-induced multiple organ failure severity is controversial. We thus sought to assess the effect of early application of haemofiltration on the degree of organ…
- Conditions
- Bacteremia, Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections, Pneumonia, Bacterial
- Trial name
- NCT00406198
- Testing
- venovenous hemofiltration
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hopital Lariboisière
Acute-On-Chronic Liver Failure, Ascites
Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)®
A Phase 2, multi-center, randomized, controlled, open-label study to evaluate the effects of the intraperitoneal, liposomal formulation VS-01 in patients with an acute episode of hepatic and/or extrahepatic organ dysfunctions and…
- Trial name
- NCT05900050
- Testing
- VS-01 on top of SOC, SOC (Control Group)
- Where
- 26 sites in United States, Belgium and 5 more
- Volunteers
- 15 people
- Sponsor
- Genfit
Respiratory Failure, Multi Organ Failure
Doppler Ultrasound Renal Arterial Resistive Indices As Predictor Of Multiorgan Failure In Patients With Acute Hypoxic Respiratory Failure Admitted To Respiratory Intensive Care Unit (Cryptic Shock Index- RICU)
Patients with de novo respiratory failure undergoing non invasive ventilation (NIV) present failure rates of mechanical ventilation ranging from 4 to 50%.
- Trial name
- CSI-RICU (NCT03897920)
- Testing
- Doppler ultrasound assessment of renal arteria resistive index
- Volunteers
- 30 people
- Sponsor
- University of Modena and Reggio Emilia
Fluid Shifts, Critical Care
Effects of Fluid Balance Control in Critically Ill Patients
Most ICU patients develop a positive fluid balance, mainly during the two first weeks of their stay. The causes are multifactorial: a reduced urine output subsequent to shock state, positive pressure mechanical ventilation, acute…
- Trial name
- POINCARE (NCT02765009)
- Testing
- diuretics, albumin, fluid restriction
- Where
- 11 sites in France
- Volunteers
- 1,411 people
- Sponsor
- Central Hospital, Nancy, France
Surgery, Multiorgan Failure
The Influence of Nursing Technique Applied at the Central Venous Catheter Insertion Site Upon the Incidence of Infection
Assessing the impact of the nursing technique applied at the insertion site of the central venous catheter using hydrophilic methacrylate gel (HMG) and 2% Chlorhexidine (CHG) upon the incidence of inflammatory complications when…
- Conditions
- Surgery, Multiorgan Failure, Haematologic Disease
- Trial name
- NCT03875352
- Testing
- CHG technique, HMG technique
- Where
- Czechia
- Volunteers
- 221 people
- Sponsor
- University Hospital Ostrava
Critical Illness, Infection Complication
A Trial of Enteral Colostrum on Clinical Outcomes in Critically Ill Patients
Enteral administration of immune-modulating nutrients such as glutamine, omega-3 fatty acids, selenium, and antioxidants has been suggested to reduce infections and improve recovery from critical illness.
- Conditions
- Critical Illness, Infection Complication, Multiple Organ Dysfunction Syndrome
- Trial name
- NCT03019250
- Testing
- Colostrum, Maltodextrin
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- National Nutrition and Food Technology Institute
Multiple Organ Failure
Dynamic Monitoring of Circulating microRNA Changes in Patients With or Without Multiple Organ Failure
The objectives are to: 1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without multiple organ failure. 2.
- Trial name
- NCT03059524
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
SARS-CoV 2 Pneumonia
Calcifediol in the Treatment of SARS-CoV-2 Disease (COVID-19).
Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome…
- Trial name
- COVIDIOL (NCT06279910)
- Testing
- Calcifediol
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
COVID-19
TXA127 for the Treatment of Severe COVID-19
The purpose of this study is to determine if administration of angiotensin-(1-7) (TXA127) prevents acute kidney injury and deterioration into multi-organ failure in patients with severe COVID-19.
- Trial name
- NCT04401423
- Testing
- TXA127
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Trauma, Adult Stem Cells
MultiStem® for Treatment of Trauma Induced Multiple Organ Failure/Systemic Inflammatory Response Syndrome
Single center, prospective, randomized, double-blind, pragmatic Phase 2 clinical study in severely injured trauma patients within hours of hospitalization who have survived initial resuscitation.
- Trial name
- NCT04533464
- Testing
- MultiStem
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Healios K.K.
Critical Illness, Multiple Organ Failure
Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.
Critical illness in the ICU setting has high medical and socioeconomic importance. Critically ill patients frequently develop severe neurologic impairment during their course of disease, typically presenting as…
- Conditions
- Critical Illness, Multiple Organ Failure, Polyneuropathy, Myopathy
- Trial name
- NCT02706314
- Where
- Germany
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Rostock
Acute Pancreatitis, Complication
Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial)
Acute pancreatitis (AP) is an inflammatory condition of the pancreas following the activated pancreatic enzymes induced by varied causes, with or without other organ(s) dysfunction.
- Conditions
- Acute Pancreatitis, Complication, Mortality Rate, Organ Failure, Multiple
- Trial name
- INDOMAP (NCT03547232)
- Testing
- Indomethacin SR
- Where
- 17 sites in China
- Volunteers
- 1,504 people
- Sponsor
- Peking Union Medical College Hospital
Respiratory Failure, Multiple Organ Failure
Prevention of Severe Acute Respiratory Failure in Patients With PROOFCheck
Severe acute respiratory failure (ARF) requiring prolonged mechanical ventilation is the most common form of acute organ dysfunction in the hospital, and is often associated with multiple organ failure (MOF), high mortality, and…
- Trial name
- PROOFcheck (NCT02488174)
- Testing
- PROOFcheck, Standard Care
- Where
- 3 sites in United States
- Volunteers
- 34,040 people
- Sponsor
- Albert Einstein College of Medicine
Trauma, Inflammation
Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture
Trauma and major operation are associated with an excessive inflammation reaction due to tissue injury. This overwhelming immune response is considered to be a major risk factor in the pathogenesis of late inflammatory…
- Conditions
- Trauma, Inflammation, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- CAESAR (NCT01275976)
- Testing
- C1-esterase inhibitor, Saline 0.9%
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- UMC Utrecht
Traumatic Complication of Injury
Inflammatory Cytokine Variations in Traumatic Injury Responses
The purpose of this study is to determine if the type of surgery (orthopaedic, general surgery, thoracic, etc.) affects the level of cytokines and thus potentially the risk of multisystem organ failure.
- Trial name
- Cytokine (NCT00593892)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Alabama at Birmingham